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Is rectal pain sensitivity a biological marker for irritable bowel syndrome: psychological influences on pain perception.
Open accessAbstract
Background & aims Rectal pain sensitivity has been called a biological marker for irritable bowel syndrome, but this conclusion may be premature. This article is a critical review of the evidence for psychological influences on perception.Methods The world literature accessible through Index Medicus from 1973 to 1997 was systematically reviewed.Results Evidence favoring a biological basis for pain sensitivity is that two thirds of patients report pain at abnormally low thresholds of rectal distention despite normal somatic pain thresholds. Pain thresholds are not correlated with anxiety or depression. Evidence favoring psychological influences on perception is that patients with the irritable bowel syndrome rate even sham distentions as more painful, and when perception tests that minimize psychological influences are used, they have normal sensory thresholds. Also, stress alters sensory thresholds. Sensitization by repeated distention has been cited as evidence of a biological basis for hyperalgesia, but it is not unique to patients with irritable bowel. Brain imaging shows that different regions are activated by painful distention in patients with irritable bowel syndrome, but this is consistent with psychological influences on perception.Conclusions Psychological factors influence pain thresholds in patients with the irritable bowel syndrome. Two cognitive traits, selective attention to gastrointestinal sensations and disease attribution, may account for increased pain sensitivity.
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“Recent investigations have found that mindfulness meditation induces changes in the activation of neural circuits implicated in interoception (awareness of stimuli originating inside the body (21)) and emotion regulation (22,23), while improving attentional control (24–27).”
From Mindfulness training reduces the severity of irritable bowel syndrome in women: Results of a randomized controlled trial (2011) · cites this paper as [25]
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Citations
Cites
(1966) · Medical Entomology and Zoology · Cited by 10,293
Signal detection theory and psychophysics
Ingleby, D. (1967) · Journal of Sound and Vibration · doi:10.1016/0022-460x(67)90197-6 · Cited by 8,616
Functional bowel disorders and functional abdominal pain
Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Müller-Lissner, S. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii43 · Cited by 2,440
Towards positive diagnosis of the irritable bowel.
Manning, A. P., Thompson, W., Heaton, K. W., & Morris, A. F. (1978) · BMJ · doi:10.1136/bmj.2.6138.653 · Cited by 1,404
Altered rectal perception is a biological marker of patients with irritable bowel syndrome
Mertz, H., Naliboff, B. D., Munakata, J., Niazi, N., & Mayer, E. A. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90267-8 · Cited by 976
Basic and clinical aspects of visceral hyperalgesia
Mayer, E. A., & Gebhart, G. F. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90086-8 · Cited by 920
A Primer of Signal Detection Theory
McNicol, D. (2005) · Psychology Press eBooks · doi:10.4324/9781410611949 · Cited by 856
Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome
Ritchie, J. (1973) · Gut · doi:10.1136/gut.14.2.125 · Cited by 832
A Primer of Signal Detection Theory.
Hawkes, A. G., & McNicol, D. (1973) · Journal of the Royal Statistical Society Series A (General) · doi:10.2307/2345017 · Cited by 654
Tolerance for Rectosigmoid Distention in Irritable Bowel Syndrome
Whitehead, W. E., Holtkötter, B., Enck, P., Hoelzl, R., Holmes, K. D., Anthony, J. C., Shabsin, H. S., & Schuster, M. M. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90332-u · Cited by 592
Self-citation
Research works printed but not linked: 6
- Metivier S, Delvaux D, Louvel D, Lagier E, Fioramonti J, Bueno L, Frexinos J. Influence of stress on sensory thresholds to rectal distension in healthy volunteers (abstr). Gastroenterology 1996; 110:A717.
- Palsson OS, McCommons JJ, Burnett CK, Bradley LA, Whitehead WE. Relationship between bowel sensations: pain, urge to defecate and rectal fullness in iritable bowel syndrome (IBS) patients and healthy subjects (abstr). Gastroenterology 1995;108: A663.
- Bradley L, Richter J, Scarinci IC, Haile JE, Schan CA. Mechanisms of altered pain perception in non-cardiac chest pain patients (abstr). Gastroenterology 1993;104:A482.
- Mertz H, Fass R, Hirsh T, Yan-Go F, Mayer EA. Amitryptiline for functional dyspepsia: effect on symptoms, gastic sensitivity and sleep (abstr). Gastroenterology 1995;108:A649.
- Bell AM, Pemberton JH, Camilleri M, Hanson RB, Zinsmeister AR. The effect of acute stress on rectal tone and anal sphincter pressure (abstr). Gastroenterology 1989;96:A38.
- Crowell M, Musial F, Kollmannsperger P, Mueller J, Orr WC. Association of rectal tone during stress with sensitivity to disten- sion in the irritable bowel syndrome (abstr). Am J Gastroenterol 1993;88:1572.
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Iovino, P., Tremolaterra, F., Boccia, G., Miele, E., Ruju, F. M., & Staiano, A. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01303.x · Cited by 56
Rubenstein, J. H., Nojkov, B., Korsnes, S. J., Adlis, S. A., SHAW, M. J., Weinman, B. M., Inadomi, J. M., SAAD, R., & Chey, W. D. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03393.x · Cited by 56
Seres, G., Kovács, Z., Kovács, Á., Kerékgyártó, O., Sárdi, K., Demeter, P., Mészáros, E., & Túry, F. (2008) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-008-9132-9 · Cited by 82
Attention to pain words in irritable bowel syndrome: Increased orienting and speeded engagement
Chapman, S., & Martin, M. (2010) · British Journal of Health Psychology · doi:10.1348/135910710x505887 · Cited by 56
Mindfulness for irritable bowel syndrome: protocol development for a controlled clinical trial
Gaylord, S. A., Whitehead, W. E., Coble, R. S., Faurot, K. R., Palsson, O. S., Garland, E. L., Frey, W., & Mann, J. D. (2009) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-9-24 · Cited by 53
Self-citationArebi, N., Gurmany, S., Bullas, D. C., Hobson, A. R., Stagg, A. J., & Kamm, M. A. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03801.x · Cited by 53
Rectal Function and Bowel Habit in Irritable Bowel Syndrome
Distrutti, E., Salvioli, B., Azpiroz, F., & Malagelada, J. R. (2004) · The American Journal of Gastroenterology · doi:10.1046/j.1572-0241.2003.04012.x · Cited by 52
Nozu, T., Kudaira, M., Kitamori, S., & Uehara, A. (2006) · Journal of Gastroenterology · doi:10.1007/s00535-005-1748-z · Cited by 51
Ghrelin: A gut hormonal basis of motility regulation and functional dyspepsia
Ogiso, K., Asakawa, A., Amitani, H., & Inui, A. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06630.x · Cited by 50
Crowell, M. D., Harris, L. A., Jones, M. P., & Chang, L. (2005) · Current Gastroenterology Reports · doi:10.1007/s11894-005-0019-8 · Cited by 50
Asian Motility Studies in Irritable Bowel Syndrome
Lee, O. Y. (2010) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2010.16.2.120 · Cited by 49
Posserud, I., Strid, H., Störsrud, S., Törnblom, H., Svensson, U., Tack, J. F., Oudenhove, L. V., & Simrén, M. (2013) · United European Gastroenterology Journal · doi:10.1177/2050640613501817 · Cited by 48
“response bias for intensity rating during distention series.(6) Other means of assessing IBS patients are clearly needed, especially to evaluate interventions, aiming at reducing visceral sensitivity.”
Corsetti, M., Cesana, B., Bhoori, S., & Basilisco, G. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(03)00291-x · Cited by 48
Traditional Thoughts on the Pathophysiology of Irritable Bowel Syndrome
Hasler, W. L. (2011) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2010.12.004 · Cited by 46
T-Helper 1, T-Helper 2, and T-Regulatory Cytokines Gene Polymorphisms in Irritable Bowel Syndrome
Barkhordari, E., Rezaei, N., Mahmoudi, M., Larki, P., Ahmadi-Ashtiani, H. R., Ansaripour, B., Alighardashi, M., Bashashati, M., Amirzargar, A. A., & Ebrahimi-Daryani, N. (2010) · Inflammation · doi:10.1007/s10753-010-9183-6 · Cited by 46
Castilloux, J., Noble, A. J., & Faure, C. C. (2008) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31814b91e7 · Cited by 46
Grinsvall, C., Törnblom, H., Tack, J. F., Oudenhove, L. V., & Simrén, M. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12689 · Cited by 46
Gibbs-Gallagher, N., Palsson, O., Levy, R. L., Meyer, K., Drossman, D. A., & Whitehead, W. E. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03759.x · Cited by 46
Self-citationSubtle involvement of the parasympathetic nervous system in patients with irritable bowel syndrome
van Orshoven, N. P., Andriesse, G. I., van Schelven, L. J., Smout, A. J. P. M., Akkermans, L. M. A., & Oey, P. L. (2006) · Clinical Autonomic Research · doi:10.1007/s10286-006-0307-x · Cited by 46
Elevated Vasoactive Intestinal Peptide Concentrations in Patients with Irritable Bowel Syndrome
Palsson, O. S., Morteau, O., Bozymski, E. M., Woosley, J. T., Sartor, R. B., Davies, M. J., Johnson, D. A., Turner, M. J., & Whitehead, W. E. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000037818.64577.ef · Cited by 46
Self-citationScanzi, J., Accarie, A., Muller, E., Pereira, B., Aissouni, Y., Goutte, M., Joubert‐Zakeyh, J., Picard, E., Boudieu, L., Mallet, C., et al. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12860 · Cited by 43
Comparison of cortical potentials evoked by mechanical and electrical stimulation of the rectum
Hobday, D. I., Hobson, A. R., Furlong, P. L., Thompson, D. G., & Aziz, Q. (2000) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2000.00231.x · Cited by 43
Managing functional bowel disorders from the top down: lessons from a well-designed treatment trial
Clouse, R. E. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00808-4 · Cited by 43
Cénac, N., Castro, M., Désormeaux, C., Colin, P., Sie, M., Ranger, M., & Vergnolle, N. (2015) · European Journal of Pain · doi:10.1002/ejp.798 · Cited by 42
“Indeed, IBS patients report visceral hypersensitivity, characterized both by allodynia and hyperalgesia, in response to colorectal distension (Whitehead and Palsson, 1998).”
BackgroundLiu, D.-R., Xu, X., & Yao, S. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i1.46 · Cited by 42
Protocol for a randomized controlled study of Iyengar yoga for youth with irritable bowel syndrome
Evans, S., Cousins, L. A., Tsao, J. C. I., Sternlieb, B., & Zeltzer, L. K. (2011) · Trials · doi:10.1186/1745-6215-12-15 · Cited by 43
“Visceral hyperalgesia is a consistent physiologic finding in a majority of patients with IBS [ 18 ] and is a leading explanatory hypothesis [19].”
BackgroundHow do SSRIs help patients with irritable bowel syndrome?
Creed, F. H. (2006) · Gut · doi:10.1136/gut.2005.086348 · Cited by 41
“This change in rectal distension tolerance and reduced somatisation were probably related to a change in how bodily sensations were perceived; with treatment, the patients probably paid less attention to gastrointestinal sensations and ceased to attribute such sensations to possible serious disease.”
BackgroundZhang, Y., Qin, G., De-rong, L., Wang, Y., & Yao, S. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i2.269 · Cited by 40
Colonic Motility: From Bench Side to Bedside
Sarna, S. K. (2010) · Cited by 40
Yang, M., Li, Z., Xu, X., Dc, F., Zou, D., Xu, G., Sun, Z., & Tu, Z. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00761.x · Cited by 41
3 Is functional dyspepsia just a subset of the irritable bowel syndrome?
Whitehead, W. E., Gibbs, N. A., Li, Z., & Drossman, D. A. (1998) · Baillière s Clinical Gastroenterology · doi:10.1016/s0950-3528(98)90017-3 · Cited by 39
Self-citationNovel mechanisms in functional dyspepsia
Choung, R. S. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i5.673 · Cited by 39
“. The level of abnormality where visceral hypersensitivity is located is not clear, but several observations suggest that alterations exist at the level of the central nervous system or in addition to hyperexcitability of visceral afferents [ 44-47 ]”
BackgroundRegional brain disorders of serotonin neurotransmission are associated with functional dyspepsia
Tominaga, K., Tsumoto, C., Ataka, S., Mizuno, K., Takahashi, K., Yamagami, H., Tanigawa, T., Kawabe, J., Watanabe, T., Fujiwara, Y., et al. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.07.023 · Cited by 38
Recurrent Abdominal Pain in Children: Forerunner to Adult Irritable Bowel Syndrome?
Jarrett, M. E., Heitkemper, M. M., Czyzewski, D. I., & Shulman, R. J. (2003) · Journal for Specialists in Pediatric Nursing · doi:10.1111/j.1088-145x.2003.00081.x · Cited by 38
El‐Salhy, M., Gilja, O. H., Gundersen, D., Hatlebakk, J. G., & Hausken, T. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1811 · Cited by 36
The role of tension receptors in colonic mechanosensitivity in humans
Corsetti, M., Gevers, A.-M., Caenepeel, P., & Tack, J. F. (2004) · Gut · doi:10.1136/gut.2004.038786 · Cited by 36
Effects of TAK-637, a Novel Neurokinin-1 Receptor Antagonist, on Colonic Function in Vivo
Okano, S., Nagaya, H., Ikeura, Y., Natsugari, H., & Inatomi, N. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29414-3 · Cited by 36
“Several pathophysiological factors are involved in IBS, and psychological stress has been reported to be closely associated with an increase in the number of bowel symptoms (Whitehead and Palsson, 1998).”
Functional brain imaging in gastroenterology: to new beginnings
Omran, Y. A., & Aziz, Q. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.89 · Cited by 35
Irritable bowel syndrome: Is it “irritable brain” or “irritable bowel”?
Padhy, S. K., Sahoo, S., Mahajan, S., & Sinha, S. K. (2015) · Journal of Neurosciences in Rural Practice · doi:10.4103/0976-3147.169802 · Cited by 38
“[30,31] Although hypersensitivity is a frequent finding in patients with IBS, it does not appear to be a consistent indicator of IBS.”
The role of mast cells in common gastrointestinal diseases
Siddiqui, A. A., & Miner, P. B. (2004) · Current Allergy and Asthma Reports · doi:10.1007/s11882-004-0043-z · Cited by 35
“These data were nearly identical to the data generated by Whitehead et al. The Role of Mast Cells in Common Gastrointestinal Diseases Siddiqui and Miner 53 [ 49 ,50] in patients with IBS.”
ResultPraško, J. P., Jelenova, D., & Mihál, V. (2010) · Biomedical Papers · doi:10.5507/bp.2010.046 · Cited by 34
Talley, N. J., & Choung, R. S. (2009) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2009.06067.x · Cited by 33
Un consenso latinoamericano sobre el síndrome del intestino irritable
Valenzuela, J. E., Alvarado, J., Cohen, H., Damiao, A. O., Francisconi, C. F. D. M., Frugone, L., González, J. C., Hernández, A., Iade, B., Lopes, M. H., et al. (2004) · Gastroenterología y Hepatología · doi:10.1016/s0210-5705(03)70470-1 · Cited by 33
Psychological stress and the severity of post‐inflammatory visceral hyperalgesia
Liebregts, T., Adam, B., Bertel, A., Lackner, C., Neumann, J. H. L., Talley, N. J., Gerken, G., & Holtmann, G. (2006) · European Journal of Pain · doi:10.1016/j.ejpain.2006.02.007 · Cited by 33
“Acute stress and stressful life events may therefore contribute to long-term alterations of gastrointestinal function (Levy et al., 1997), including perturbation of motility and sensation (Lembo et al., 1996; Whitehead and Palsson, 1998; Kellow et al., 1992).”
BackgroundColonic Motility: From Bench Side to Bedside
Sarna, S. K. (2010) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00020ed1v01y201011isp011 · Cited by 32
Gender‐related differences in visceral perception in health and irritable bowel syndrome
Kim, H. S., Rhee, P., Park, J., Lee, J. H., Kim, Y., Kim, J. J., & Rhee, P. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2005.04060.x · Cited by 32
Sidhu, H., Kern, M., & Shaker, R. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00490.2003 · Cited by 32
Sex-related differences in prepulse inhibition of startle in irritable bowel syndrome (IBS)
Kilpatrick, L. A., Ornitz, E. M., Ibrahimovic, H., Treanor, M., Craske, M. G., Nazarian, M., Labus, J. S., Mayer, E. A., & Naliboff, B. D. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.02.012 · Cited by 31
“…(“visceral hypersensitivity”) to physiologically occurring and to experimentally induced visceral stimuli are a hallmark factor in IBS, and these abnormalities are shared by other functional gastrointestinal (GI) and urological disorders (Azpiroz et al., 2007; Whitehead and Palsson, 1998).”
BackgroundColonic regular contractile frequency patterns in irritable bowel syndrome
Bassotti, G., Sietchiping-Nzepa, F., de Roberto, G., Chistolini, F., & Morelli, A. (2004) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200406000-00016 · Cited by 31
Andresen, V. (2009) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2009.04.007 · Cited by 29
Pain Perception in Irritable Bowel Syndrome
Tillisch, K., & Mayer, E. A. (2005) · CNS Spectrums · doi:10.1017/s1092852900019830 · Cited by 31
Whitehead, W. (1999) · American Journal of Medicine · doi:10.1016/s0002-9343(99)00078-9 · Cited by 34
Self-citationEvaluation and treatment of dyspepsia
Jones, M. (2003) · Postgraduate Medical Journal · doi:10.1136/pmj.79.927.25 · Cited by 30
Rangan, V., Mitsuhashi, S., Singh, P., Ballou, S., Hirsch, W., Sommers, T. F., Nee, J. W., Iturrino, J., & Lembo, A. J. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.02.020 · Cited by 29
Bueno, L. P., Beaufrand, C., Théodorou, V., & Andro-Delestrain, M.-C. (2013) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12021 · Cited by 29
Attention to metabolic hunger and its effects on Helicobacter pylori infection
Ciampolini, M. (2000) · Physiology & Behavior · doi:10.1016/s0031-9384(00)00273-0 · Cited by 29
Plasma Hormones Facilitated the Hypermotility of the Colon in a Chronic Stress Rat Model
Liang, C., Luo, H., Liu, Y., Cao, J., & Xia, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031774 · Cited by 29
Traini, C., Evangelista, S., Girod, V., Faussone‐Pellegrini, M. S., & Vannucchi, M. G. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12816 · Cited by 29
Visceral hypersensitivity: fact or fiction.
Aziz, Q. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.06.039 · Cited by 26
Zhu, Y., Wu, Z., Ma, X., Liu, H., Bao, C., Yang, L., Cui, Y., Zhou, C., Wang, X., Wang, Y., et al. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-500 · Cited by 27
Hermann, C., Zohsel, K., Hohmeister, J., & Flor, H. (2008) · Pain · doi:10.1016/j.pain.2008.01.007 · Cited by 27
“Adults [63,86] and children with IBS, but also children with functional abdominal pain, though possibly to a lesser extent, have lower rectal pain thresholds [31,77].”
BackgroundPsychophysiology of visceral pain in IBS and health
Musial, F., Häuser, W., Langhorst, J., Dobos, G., & Enck, P. (2008) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2008.02.024 · Cited by 27
“Finally, the question of whether the visceral hypersensitivity of patients with functional intestinal disorders occurs at the receptor or spinal cord neuron level, or whether and to what extent attention-dependent processes in the central nervous processing of intestinal stimuli play a role remains open, and the discu…”
BackgroundHigh Somatic Symptom Burdens and Functional Gastrointestinal Disorders
Sayuk, G. S., Elwing, J. E., Lustman, P. J., & Clouse, R. E. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.11.024 · Cited by 26
Patient satisfaction after gut‐directed hypnotherapy in irritable bowel syndrome
Lindfors, P., Ljótsson, B., Bjornsson, E., Abrahamsson, H., & Simrén, M. (2012) · Neurogastroenterology & Motility · doi:10.1111/nmo.12022 · Cited by 26
Chitkara, D. K., & Lorenzo, C. D. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00751.x · Cited by 26
Hypnosis for Irritable Bowel Syndrome:The Quest for the Mechanism of Action
Simrén, M. (2005) · International Journal of Clinical and Experimental Hypnosis · doi:10.1080/00207140500327239 · Cited by 26
Irritable Bowel Syndrome: Update on Pathogenesis and Management
Alaradi, O., & Barkin, J. S. (2002) · Medical Principles and Practice · doi:10.1159/000048654 · Cited by 25
Investigating placebo effects in irritable bowel syndrome: A novel research design
Conboy, L. A., Wasserman, R. H., Jacobson, E., Davis, R. B., Legedza, A., Park, M., Rivers, A. L., Morey, E. B., Nam, B. H., Lasagna, L. C., et al. (2006) · Contemporary Clinical Trials · doi:10.1016/j.cct.2005.11.012 · Cited by 26
“In conditions such as IBS, depression, and pain, that are primarily subjectively defined, the mechanism of selective attention probably plays a significant modulating role in placebo phenomena [6,32,33].”
BackgroundCrandall, W., Halterman, T., & Mackner, L. M. (2007) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000239733.79487.1e · Cited by 26
Chan, C. L. H., Scott, S. M., Birch, M., Knowles, C. H., Williams, N. S., & Lunniss, P. J. (2003) · Diseases of the Colon & Rectum · doi:10.1007/s10350-004-6613-2 · Cited by 27
Central Nervous System Processing of Human Visceral Pain in Health and Disease
Hobson, A. R., & Aziz, Q. (2003) · Physiology · doi:10.1152/nips.01428.2002 · Cited by 25
Psychosomatik viszeraler Schmerzsyndrome
Häuser, W., & Grandt, D. (2002) · Der Schmerz · doi:10.1007/s00482-002-0190-x · Cited by 25
Predictors of Premature Antidepressant Discontinuation in Functional Gastrointestinal Disorders
Sayuk, G. S., Elwing, J. E., Lustman, P. J., & Clouse, R. E. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318031391d · Cited by 24
Nakai, A., Dikšić, M., Kumakura, Y., D'Souza, D. L., & Kersey, K. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00615.x · Cited by 24
Goyal, O., Bansal, M., & Sood, A. (2019) · Indian Journal of Gastroenterology · doi:10.1007/s12664-019-00953-8 · Cited by 23
Kano, M., Muratsubaki, T., Morishita, J., Kono, K., Mugikura, S., Takase, K., Ly, H. G., Dupont, P. J., Oudenhove, L. V., & Fukudo, S. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000484 · Cited by 24
“Negative cognitions about IBS symptoms, including fear of pain or gastrointestinal symptoms, pain catastrophizing, and hypervigilance toward visceral sensations, are important factors in determining IBS symptom severity (8,9) and quality of life (10,11).”
Brain processing of esophageal sensation in health and disease
Hobson, A. R., & Aziz, Q. (2004) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(03)00132-8 · Cited by 22
de Medeiros, M. T. G., Carvalho, A. F., Lima, J. W. D. O., dos Santos, A. A., de Oliveira, R. B., & Souza, M. A. N. (2008) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0b013e318183f896 · Cited by 22
“This reduced tolerance to rectal distension has been proposed as a biological marker for the disorder (Mertz et al., 1995), but some investigators do not agree with this suggestion (Whitehead and Palsson, 1998).”
ResultAbdominal Symptoms and Anorectal Function in Health and Irritable Bowel Syndrome
Ragnarsson, G. (2001) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520117328 · Cited by 22
Rectal heat thresholds: a novel test of the sensory afferent pathway.
Chan, C. L. H., Scott, S. M., Birch, M., Knowles, C. H., Williams, N. S., & Lunniss, P. J. (2003) · PubMed · doi:10.1097/01.dcr.0000059331.62627.6f · Cited by 22
Role of inflammation in pediatric irritable bowel syndrome
Nardo, G. D., Cremon, C., Staiano, A., Stanghellini, V., Borrelli, O., Strisciuglio, C., Romano, C., Mallardo, S., Scarpato, E., Marasco, G., et al. (2022) · Neurogastroenterology & Motility · doi:10.1111/nmo.14365 · Cited by 21
The Use of Probiotics in Functional Bowel Disease
Quigley, E. M. M. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2005.05.008 · Cited by 20
“a fundamental pathophysiological mechanism in IBS [17].”
van der Veek, S., Derkx, B., Plak, R. D., Benninga, M. A., Boer, F., Lindauer, R., & de Haan, E. (2014) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsu004 · Cited by 20
Czimmer, J., Sütő, G., Király, Á., & Mózsik, G. (2001) · Journal of Physiology-Paris · doi:10.1016/s0928-4257(01)00020-1 · Cited by 20
Significance of anti-inflammatory effects of PPARγ agonists?
Rogler, G. (2005) · Gut · doi:10.1136/gut.2005.089946 · Cited by 18
Autonomic and Somatic Systems to the Anorectum and Pelvic Floor
Bharucha, A. E., & Klingele, C. J. (2005) · Elsevier eBooks · doi:10.1016/b978-0-7216-9491-7.50016-8 · Cited by 20
Mavroudis, G., Strid, H., Jonefjäll, B., & Simrén, M. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13998 · Cited by 19
“Age, years, mean (range) 44 (24-72) 46 (26-68) 0.”
Rustamov, N., Wagenaar-Tison, A., Doyer, E., & Piché, M. (2020) · The Journal of Physiological Sciences · doi:10.1186/s12576-020-00774-x · Cited by 20
Bowel urgency in patients with irritable bowel syndrome.
Basilisco, G., Marco, E. D., Tomba, C., & Cesana, B. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.10.029 · Cited by 18
Brain-Derived Neurotrophic Factor Contributes to Colonic Hypermotility in a Chronic Stress Rat Model
Quan, X., Luo, H., Fan, H., Tang, Q., Chen, W., Cui, N., Guang, Y., & Xia, H. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3695-8 · Cited by 19
Corsetti, M., Ogliari, C., Marino, B., & Basilisco, G. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00701.x · Cited by 19
Barostat testing in children with functional gastrointestinal disorders
van den Berg, M. M., Lorenzo, C. D., van Ginkel, R., Mousa, H. M., & Benninga, M. A. (2006) · Current Gastroenterology Reports · doi:10.1007/s11894-006-0079-4 · Cited by 19
Nozu, T., & Okumura, T. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06636.x · Cited by 18
Recent advances in the diagnosis of irritable bowel syndrome
El‐Salhy, M. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2015.1067138 · Cited by 18
Wald, A. M. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000156112.76856.26 · Cited by 18
The rationale for antidepressant therapy in functional gastrointestinal disorders
Castle, M. Z. D., Silk, D. B. A., & Libby, G. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.01879.x · Cited by 17
Sphincter of Oddi dysfunction type III: Another manifestation of visceral hyperalgesia?
Kellow, J. E. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70086-7 · Cited by 18
Challenges and prospects for pharmacotherapy in functional gastrointestinal disorders
Sanger, G. J., Chang, L., Bountra, C., & Houghton, L. A. (2010) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x10369922 · Cited by 17
Understanding and managing patients with overlapping disorders of gut–brain interaction
Balsiger, L. M., Carbone, F., Raymenants, K., Scarpellini, E., & Tack, J. F. (2023) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(22)00435-6 · Cited by 18
Andresen, V., Pehl, C., Allescher, H. ‐., Bischoff, S. C., Enck, P., Frieling, T., Haag, S., Holtmann, G., Karaus, M., Keller, J., et al. (2011) · Cited by 17
Metadata
- Authors
- WHITEHEAD, W., & PALSSON, O.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Eastern Virginia Medical School (US)
- ORCID
- PALSSON, O
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1998-11
- Volume
- 115
- Issue
- 5
- Pages
- 1263-1271
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2150287168
- Cited by
- 314
- References
- 85
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 12 · 2015: 10 · 2014: 8 · 2013: 6 · 2012: 10
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health (2k05mh000133-17)
- National Institute of Mental Health (KO5 MH00133)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK031369, R01 DK31369)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Keywords
- irritable bowel syndrome, pain threshold, rectal distension, hyperalgesia, anxiety, depression, stress, sensitization, neuroimaging, selective attention, disease attribution, biomarkers
- MeSH terms
- Colonic Diseases, Functional, Humans, Pain, Rectum, Biomarkers, Pain Threshold
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