Vitamin C prevents endothelial dysfunction induced by acute exercise in patients with intermittent claudication
Abstract
In patients with intermittent claudication, exercise is associated with a marked increase in oxidative stress, likely responsible for systemic endothelial perturbation. In 31 claudicant patients, we assessed the effect of vitamin C administration on the acute changes induced by maximal and submaximal exercise in endothelium-dependent, flow-mediated dilation (FMD), and in plasma levels of thiobarbituric acid-reactive substances (TBARS) and soluble intercellular adhesion molecule-1 (sICAM-1). In 16 claudicants, maximal exercise reduced FMD (from 8.5+/-0.9 to 3.7+/-0.8%, P<0.01), and increased plasma levels of TBARS (from 1.93+/-0.06 to 2.22+/-0.1 nmol/ml, P<0.02) and of sICAM-1 (from 282+/-17 to 323+/-19 ng/ml, P<0.01). In eight of these patients, randomized to vitamin C, exercise-induced changes in FMD and biochemistry were abolished. This beneficial effect was not observed in the eight patients randomized to saline. In 15 patients, who walked until the onset of claudication pain (submaximal exercise), and in ten control subjects, who performed maximal exercise, no changes were observed with exercise. Thus, in claudicants, vitamin C prevents the acute, systemic impairment in endothelial function induced by maximal exercise. This finding provides a rationale for trials investigating antioxidant therapy and cardiovascular risk in patients with intermittent claudication.
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Superoxide radicals produced as a consequence of intense exercise may directly remove NO.
“superoxide radicals produced as a consequence of intense exercise may directly remove NO (Li and Forstermann 2000; Silvestro et al. 2002).”
From Oral nitrate and citrulline decrease blood pressure and increase vascular conductance in young adults: a potential therapy for heart failure (2016) · cites this paper as Silvestro et al. 2002
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Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725 · see citing works
[42] Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal
Esterbauer, H., & Cheeseman, K. H. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86134-h · Cited by 3,360 · see citing works
Mortality over a Period of 10 Years in Patients with Peripheral Arterial Disease
Criqui, M. H., Langer, R. D., Fronek, A., Feigelson, H. S., Klauber, M. R., McCann, T. J., & Browner, D. (1992) · New England Journal of Medicine · doi:10.1056/nejm199202063260605 · Cited by 2,579 · see citing works
Stephens, N. G., Parsons, A., Brown, M. J., Schofield, P. M., Kelly, F., Cheeseman, K., & Mitchinson, M. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90866-1 · Cited by 2,148 · see citing works
Close Relation of Endothelial Function in the Human Coronary and Peripheral Circulations
Anderson, T. J., Uehata, A., Gerhard, M. D., Meredith, I. T., Knab, S., Delagrange, D., Lieberman, E. H., Ganz, P., Creager, M. A., Yeung, A. C., et al. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00327-4 · Cited by 2,033 · cited 1× · see citing works
“Brachial artery endotheliumdependent vasodilation is mediated by nitric oxide [17], correlates well with the coronary artery response to acetylcholine [18], is impaired in the presence of classical risk factors also in the absence of overt atherosclerotic disease [19], and the degree of impairment is related to degree…”
BackgroundVitamin E Supplementation and Cardiovascular Events in High-Risk Patients
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420302 · Cited by 1,957 · see citing works
Ascorbate is an outstanding antioxidant in human blood plasma
Frei, B., England, L., & Ames, B. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6377 · Cited by 1,870 · see citing works
Joannidès, R., Haefeli, W. E., Linder, L., Richard, V. J., Bakkali, E. H., Thuillez, C., & Lüscher, T. F. (1995) · Circulation · doi:10.1161/01.cir.91.5.1314 · Cited by 1,622 · see citing works
Antioxidants and Atherosclerotic Heart Disease
Diaz, M. N., Frei, B. B., Vita, J. A., & Keaney, J. F. (1997) · New England Journal of Medicine · doi:10.1056/nejm199708073370607 · Cited by 1,347 · see citing works
Celermajer, D. S., Sørensen, K. E., Bull, C., Robinson, J. T. C., & Deanfield, J. E. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90141-4 · Cited by 1,228 · see citing works
Prognostic Significance of Endothelial Dysfunction in Hypertensive Patients
Perticone, F., Ceravolo, R., Pujia, A., Ventura, G., Iacopino, S., Scozzafava, A., Ferraro, A., Chello, M., Mastroroberto, P., Verdecchia, P., et al. (2001) · Circulation · doi:10.1161/01.cir.104.2.191 · Cited by 1,059 · see citing works
Boaz, M., Smetana, S. S., Weinstein, T., Matas, Z., Gafter, U., Iaina, A., Knecht, A., Weissgarten, Y., Brunner, D., FAINARU, M., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02783-5 · Cited by 1,021 · see citing works
Glutathione-ascorbic acid antioxidant system in animals
Meister, A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36891-6 · Cited by 812 · see citing works
Vascular Superoxide Production by NAD(P)H Oxidase
Guzik, T. J., West, N. E. J., Black, E., McDonald, D., Ratnatunga, C., Pillai, R. G., & Channon, K. M. (2000) · Circulation Research · doi:10.1161/01.res.86.9.e85 · Cited by 584 · see citing works
Superoxide Excess in Hypertension and Aging
Hamilton, C., Brosnan, M. J., McIntyre, M., Graham, D., & Dominiczak, A. F. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.529 · Cited by 438 · see citing works
Kanani, P. M., Sinkey, C. A., Browning, R. L., Allaman, M. M., Knapp, H. R., & Haynes, W. G. (1999) · Circulation · doi:10.1161/01.cir.100.11.1161 · Cited by 418 · see citing works
Jackson, T. S., Xu, A., Vita, J. A., & Keaney, J. F. (1998) · Circulation Research · doi:10.1161/01.res.83.9.916 · Cited by 400 · see citing works
Title, L. M., Cummings, P. M., Giddens, K., & Nassar, B. A. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00980-3 · Cited by 331 · see citing works
Stephens, N., Parsons, A., Schofield, P. M., Mitchinson, M., & Mj, B. (1996) · Clinical Science · doi:10.1042/cs091016pb · Cited by 327 · see citing works
Infection, inflammation, and infarction: does acute endothelial dysfunction provide a link?
Vallance, P. J., Collier, J., & Bhagat, K. (1997) · The Lancet · doi:10.1016/s0140-6736(96)09424-x · Cited by 308 · see citing works
Circulating Endothelial Cell/Leukocyte Adhesion Molecules in Atherosclerosis
Blann, A. D., & McCollum, C. N. (1994) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1648827 · Cited by 258 · see citing works
Gissi-Prevenzione Investigators (2000) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200003000-00011 · Cited by 256 · see citing works
Bergholm, R., Mäkimattila, S., Valkonen, M. M., Liu, M., Lahdenperä, S., Taskinen, M., Sovijärvi, A. R. A., Malmberg, L. P., & Yki-Järvinen, H. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00089-1 · Cited by 182 · see citing works
Langlois, M. R., Duprez, D. A., Delanghe, J. R., Buyzere, M. D., & Clement, D. L. (2001) · Circulation · doi:10.1161/01.cir.103.14.1863 · Cited by 174 · see citing works
Brendle, D. C., Joseph, L., Corretti, M. C., Gardner, A. W., & Katzel, L. I. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)01367-9 · Cited by 166 · see citing works
Bainton, D., Sweetnam, P. M., Baker, I. A., & Elwood, P. C. (1994) · Heart · doi:10.1136/hrt.72.2.128 · Cited by 139 · see citing works
Radomski, M. W., & Salas, E. (1995) · Atherosclerosis · doi:10.1016/0021-9150(95)90075-6 · Cited by 125 · see citing works
Murohara, T., Kugiyama, K., Ohgushi, M., Sugiyama, S., & Yasue, H. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.3.h874 · Cited by 124 · see citing works
Effects of vitamin E on chronic and acute endothelial dysfunction in smokers
Neunteufl, T., Priglinger, U., Heher, S., Zehetgruber, M., Söregi, G., Lehr, S., Huber, K., Maurer, G., Weidinger, F. F., & Kostner, K. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00542-2 · Cited by 120 · see citing works
Activation and decreased deformability of neutrophils after intermittent claudication.
Neumann, F., Waas, W., Diehm, C., Weiss, T., Haupt, H. M., Zimmermann, R., Tillmanns, H., & Kübler, W. (1990) · Circulation · doi:10.1161/01.cir.82.3.922 · Cited by 114 · see citing works
Endothelial reactivity and cardiac risk factors in older patients with peripheral arterial disease
Yataco, A. R., Corretti, M. C., Gardner, A. W., Womack, C. J., & Katzel, L. I. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00984-9 · Cited by 107 · see citing works
Martone, V., de Cristofaro, T., Corrado, S., Silvestro, A., Donato, A. M. D., Bucur, R., Scopacasa, F., & Brevetti, G. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1612905 · Cited by 93 · see citing works
Self-citationExercise Training Reduces the Acute Inflammatory ResponseAssociated with Claudication
Turton, P., Coughlin, P. A., Kester, R. C., & Scott, D. J. A. (2002) · European Journal of Vascular and Endovascular Surgery · doi:10.1053/ejvs.2002.1599 · Cited by 67 · see citing works
Does Acute Exercise Affect the Susceptibility of Low Density Lipoprotein to Oxidation?
Wetzstein, C. J., Shern-Brewer, R., Santanam, N., GREEN, N. R., White-Welkley, J. E., & Parthasarathy, S. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00320-1 · Cited by 66 · see citing works
Brevetti, G., Caterina, M. D., Martone, V. D., Ungaro, B., Corrado, F., Silvestro, A., de Cristofaro, T., & Scopacasa, F. (2001) · PubMed · Cited by 65 · see citing works
Self-citationBelch, J. J. F., Mackay, I. R., Hill, A., Jennings, P. E., & McCollum, P. T. (1995) · PubMed · Cited by 54 · see citing works
Assessment of intermittent claudication by quantitation of exercise induced microalbuminuria
Hickey, N. C., Shearman, C. P., Gosling, P. J., & Simms, M. H. (1990) · European Journal of Vascular Surgery · doi:10.1016/s0950-821x(05)80815-1 · Cited by 45 · see citing works
Khaira, H. S., Nash, G. B., Bahra, P., Sanghera, K., Gosling, P. J., Crow, A. J., & Shearman, C. P. (1995) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/s1078-5884(05)80195-9 · Cited by 40 · see citing works
Kirk, G., Hickman, P., McLaren, M., Stonebridge, P. A., & Belch, J. J. F. (1999) · European Journal of Vascular and Endovascular Surgery · doi:10.1053/ejvs.1999.0927 · Cited by 38 · see citing works
Intestinal permeability is increased in patients with intermittent claudication
Iwata, H., Matsushita, M., Nishikimi, N., Sakurai, T., & Nimura, Y. (2000) · Journal of Vascular Surgery · doi:10.1067/mva.2000.105004 · Cited by 26 · see citing works
Guzik, T. J., West, N. E. J., Black, E., McDonald, D., Ratnatunga, C., Pillai, R. G., & Channon, K. M. (2000) · European Heart Journal · Cited by 8 · see citing works
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1 of the 43 references couldn’t be matched to a known paper.
Cited by
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Exercise for intermittent claudication
Lane, R., Harwood, A. E., Watson, L. C., & Leng, G. C. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000990.pub4 · Cited by 864 · see citing works
Acute exercise and oxidative stress: a 30 year history
Fisher‐Wellman, K. H., & Bloomer, R. J. (2009) · Dynamic Medicine · doi:10.1186/1476-5918-8-1 · Cited by 684 · see citing works
Endothelial Dysfunction and Cardiovascular Risk Prediction in Peripheral Arterial Disease
Brevetti, G., Silvestro, A., Schiano, V., & Massimo Chiariello, A. (2003) · Circulation · doi:10.1161/01.cir.0000095273.92468.d9 · Cited by 482 · see citing works
Self-citationRakobowchuk, M., Tanguay, S., Burgomaster, K. A., Howarth, K. R., Gibala, M. J., & MacDonald, M. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00069.2008 · Cited by 335 · see citing works
Inflammation in Peripheral Artery Disease
Brevetti, G., Giugliano, G., Brevetti, L., & Hiatt, W. R. (2010) · Circulation · doi:10.1161/circulationaha.109.918417 · Cited by 317 · see citing works
Self-citationJuraschek, S. P., Güallar, E., Appel, L. J., & Miller, E. R. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.027995 · Cited by 294 · see citing works
Circulating markers of endothelial function in cardiovascular disease
Constans, J., & Conri, C. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.12.030 · Cited by 277 · see citing works
Exercise for intermittent claudication
Watson, L. C., Ellis, B., & Leng, G. C. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000990.pub2 · Cited by 251 · see citing works
Soluble intercellular adhesion molecule-1 (sICAM-1): an overview.
Witkowska, A. M., & Borawska, M. H. (2004) · PubMed · Cited by 231 · see citing works
Mitochondrial defects and oxidative damage in patients with peripheral arterial disease
Pipinos, I. I., Judge, A. R., Zhu, Z. H., Selsby, J. T., Swanson, S. A., Johanning, J. M., Baxter, B. T., Lynch, T. G., & DODD, S. L. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.04.003 · Cited by 231 · see citing works
Environmental factors and unhealthy lifestyle influence oxidative stress in humans—an overview
Aseervatham, G. S. B., Thilagar, S., Jeyadevi, R., & Ananth, D. A. (2013) · Environmental Science and Pollution Research · doi:10.1007/s11356-013-1748-0 · Cited by 230 · see citing works
Effects of acute exercise on flow-mediated dilatation in healthy humans
Dawson, E. A., GREEN, D. J., Cable, N. T., & Thijssen, D. H. J. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00450.2013 · Cited by 207 · see citing works
Ashor, A. W., Lara, J., Mathers, J. C., & Siervo, M. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.04.004 · Cited by 185 · see citing works
A Review of the Pathophysiology and Potential Biomarkers for Peripheral Artery Disease
Krishna, S. M., Moxon, J. V., & Golledge, J. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160511294 · Cited by 179 · see citing works
Pipinos, I. I., Judge, A. R., Selsby, J. T., Zhu, Z. H., Swanson, S. A., Nella, A. A., & DODD, S. L. (2008) · Vascular and Endovascular Surgery · doi:10.1177/1538574408315995 · Cited by 174 · see citing works
Exercise for intermittent claudication
Lane, R., Ellis, B., Watson, L., & Leng, G. C. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000990.pub3 · Cited by 170 · see citing works
Brevetti, G., Silvestro, A., Giacomo, S. D., Bucur, R., Donato, A. D., Schiano, V., & Scopacasa, F. (2003) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(03)00124-1 · Cited by 165 · see citing works
Self-citationBrevetti, G., Schiano, V., & Massimo Chiariello, A. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.11.002 · Cited by 164 · see citing works
Self-citationIntermittent claudication: An overview
Meru, A. V., Mittra, S., Thyagarajan, B., & Chugh, A. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.11.027 · Cited by 139 · see citing works
Fisher‐Wellman, K. H., Bell, H. K., & Bloomer, R. J. (2008) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.1.7732 · Cited by 131 · see citing works
Exercise Training and Peripheral Arterial Disease
Haas, T. L., Lloyd, P. G., Yang, H., & Terjung, R. L. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110065 · Cited by 141 · see citing works
The exercise dose affects oxidative stress and brachial artery flow-mediated dilation in trained men
Johnson, B. D., Padilla, J., & Wallace, J. P. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-1946-8 · Cited by 124 · see citing works
Effects of Exercise Intensity on Flow Mediated Dilation in Healthy Humans
Birk, G., Dawson, E. A., Batterham, A. M., Atkinson, G., Cable, N. T., Thijssen, D. H. J., & GREEN, D. J. (2012) · International Journal of Sports Medicine · doi:10.1055/s-0032-1323829 · Cited by 122 · see citing works
McGowan, C. L. M., Levy, A. S., Millar, P. J., Guzmán, J. C., Morillo, C. A., McCartney, N., & MacDonald, M. J. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01113.2005 · Cited by 121 · see citing works
Weiss, D. J., Casale, G. P., Koutakis, P., Nella, A. A., Swanson, S. A., Zhu, Z. H., Miserlis, D., Johanning, J. M., & Pipinos, I. I. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-230 · Cited by 121 · see citing works
Obesity Exacerbates Oxidative Stress Levels after Acute Exercise
Vincent, H. K., MORGAN, J. W., & Vincent, K. R. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000126576.53038.e9 · Cited by 116 · see citing works
Muller, M. D., Drew, R. C., Blaha, C., Mast, J. L., Cui, J. G., Reed, A. B., & Sinoway, L. I. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.241281 · Cited by 112 · see citing works
Skin microcirculation in peripheral arterial obliterative disease
Rossi, M., & Carpi, A. (2004) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2004.08.004 · Cited by 105 · see citing works
Badrov, M. B., Horton, S., Millar, P., & McGowan, C. (2013) · Psychophysiology · doi:10.1111/psyp.12031 · Cited by 93 · see citing works
Vitamin C supplementation for the primary prevention of cardiovascular disease
Al-Khudairy, L., Flowers, N., Wheelhouse, R., Ghannam, O., Hartley, L., Stranges, S., & Rees, K. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011114.pub2 · Cited by 94 · see citing works
Sellami, M., Bragazzi, N. L., Prince, M. S., Denham, J., & Elrayess, M. A. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.652497 · Cited by 91 · see citing works
Oxidative Stress and Arterial Dysfunction in Peripheral Artery Disease
Ismaeel, A., Brumberg, R. S., Kirk, J. S., Papoutsi, E., Farmer, P. J., Bohannon, W. T., SMITH, R. S., Eidson, J. L., Sawicki, I., & Koutakis, P. (2018) · Antioxidants · doi:10.3390/antiox7100145 · Cited by 88 · see citing works
Flow-Mediated Dilation Is Acutely Improved after High-Intensity Interval Exercise
Currie, K. D., McKelvie, R. S., & MacDonald, M. J. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318260ff92 · Cited by 82 · see citing works
Vascular Dysfunction and Chronic Obstructive Pulmonary Disease
Ives, S. J., Harris, R. A., Witman, M. A., Fjeldstad, A. S., Garten, R. S., McDaniel, J., Wray, D. W., & Richardson, R. S. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.02255 · Cited by 82 · see citing works
Soluble ICAM-1: A marker of vascular inflammation and lifestyle
Witkowska, A. M. (2005) · Cytokine · doi:10.1016/j.cyto.2005.04.007 · Cited by 78 · see citing works
Testosterone-Induced Effects on Lipids and Inflammation
Vodo, S., Bechi, N., Petroni, A., Muscoli, C., & Aloisi, A. M. (2013) · Mediators of Inflammation · doi:10.1155/2013/183041 · Cited by 75 · see citing works
Silvestro, A., Scopacasa, F., Ruocco, A., Oliva, G., Schiano, V., Zincarelli, C., & Brevetti, G. (2003) · Vascular Medicine · doi:10.1191/1358863x03vm503oa · Cited by 75 · see citing works
Self-citationMitochondriopathy of Peripheral Arterial Disease
Makris, K. I., Nella, A. A., Zhu, Z. H., Swanson, S. A., Casale, G. P., Gutti, T. L., Judge, A. R., & Pipinos, I. I. (2007) · Vascular · doi:10.2310/6670.2007.00054 · Cited by 70 · see citing works
Impact of sympathetic nervous system activity on post‐exercise flow‐mediated dilatation in humans
Atkinson, C. L., Lewis, N. C. S., Carter, H. H., Thijssen, D. H. J., Ainslie, P. N., & GREEN, D. J. (2015) · The Journal of Physiology · doi:10.1113/jp270946 · Cited by 65 · see citing works
ROS and NO Dynamics in Endothelial Cells Exposed to Exercise-Induced Wall Shear Stress
Wang, Y.-X., Liu, H.-B., Li, P.-S., Yuan, W.-X., Liu, B., Liu, S.-T., & Qin, K.-R. (2019) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-018-00557-w · Cited by 61 · see citing works
Oxidative stress and antioxidant treatment in patients with peripheral artery disease
Koutakis, P., Ismaeel, A., Farmer, P. J., Purcell, S. T., SMITH, R. S., Eidson, J. L., & Bohannon, W. T. (2018) · Physiological Reports · doi:10.14814/phy2.13650 · Cited by 59 · see citing works
Arterial dysfunction and functional performance in patients with peripheral artery disease: A review
Coutinho, T. A., Rooke, T. W., & Kullo, I. J. (2011) · Vascular Medicine · doi:10.1177/1358863x11400935 · Cited by 56 · see citing works
Oxidative Stress in Peripheral Arterial Disease (PAD) Mechanism and Biomarkers
Signorelli, S. S., Scuto, S., Marino, E., Xourafa, A., & Gaudio, A. (2019) · Antioxidants · doi:10.3390/antiox8090367 · Cited by 55 · see citing works
Pathophysiology of Peripheral Arterial Disease (PAD): A Review on Oxidative Disorders
Signorelli, S. S., Marino, E., Scuto, S., & Raimondo, D. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124393 · Cited by 56 · see citing works
Tauler, P., Aguiló, A., Gimeno, I., Noguera, A., Agustí, A. G. N., Tur, J. A., & Pons, A. (2003) · Free Radical Research · doi:10.1080/1071576031000150454 · Cited by 54 · see citing works
Gresele, P., & Momi, S. (2006) · Cardiovascular Drug Reviews · doi:10.1111/j.1527-3466.2006.00148.x · Cited by 53 · see citing works
Migliacci, R., Procacci, A., Monte, P. D., Bonizzoni, E., & Gresele, P. (2007) · Thrombosis and Haemostasis · doi:10.1160/th06-10-0555 · Cited by 49 · see citing works
Judge, A. R., & DODD, S. L. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00684.2003 · Cited by 49 · see citing works
Gonzales, J. U., Thompson, B. C., Thistlethwaite, J. R., & Scheuermann, B. W. (2011) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h10-097 · Cited by 47 · see citing works
Hallmark, R. A., Patrie, J. T., Liu, Z., Gaesser, G. A., Barrett, E. J., & WELTMAN, A. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085450 · Cited by 44 · see citing works
Cellular adhesion molecules and peripheral arterial disease
Brevetti, G., Schiano, V., & Massimo Chiariello, A. (2006) · Vascular Medicine · doi:10.1191/1358863x06vm645ra · Cited by 44 · see citing works
Self-citationEffects of acute exercise on endothelial function in patients with abdominal aortic aneurysm
Bailey, T. G., Perissiou, M., Windsor, M., Schulze, K., Nam, M. C. Y., Magee, R., Leicht, A. S., GREEN, D. J., Greaves, K., Golledge, J., et al. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00344.2017 · Cited by 43 · see citing works
Life-style Modification in Peripheral Arterial Disease
Khan, S. A., Cleanthis, M., Smout, J. D., Flather, M. D., & Stansby, G. P. (2004) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2004.09.020 · Cited by 38 · see citing works
Padilla, J., Harris, R. A., & Wallace, J. P. (2007) · Cardiovascular Ultrasound · doi:10.1186/1476-7120-5-45 · Cited by 38 · see citing works
Alsop, P., & Hauton, D. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-016-3418-7 · Cited by 37 · see citing works
Johnson, B. D., Mather, K. J., Newcomer, S. C., Mickleborough, T. D., & Wallace, J. P. (2012) · Cardiovascular Ultrasound · doi:10.1186/1476-7120-10-34 · Cited by 37 · see citing works
Acute and Chronic Impact of Dynamic Exercise on Arterial Stiffness in Older Hypertensives
Aizawa, K., & Petrella, R. J. (2008) · The Open Cardiovascular Medicine Journal · doi:10.2174/1874192400802010003 · Cited by 37 · see citing works
Impact of acute exercise on brachial artery flow-mediated dilatation in young healthy people
Hwang, I., Kim, K., Choi, W. S., Kim, H.-J., Im, M.-S., Kim, Y.-J., Kim, S., Kim, M., Sohn, D., & Zo, J. (2012) · Cardiovascular Ultrasound · doi:10.1186/1476-7120-10-39 · Cited by 37 · see citing works
Husmann, M. J. W., Dörffler-Melly, J., Kalka, C., Diehm, N., Baumgärtner, I., & Silvestro, A. (2008) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2008.06.039 · Cited by 36 · see citing works
Self-citationVascular Function and the Role of Oxidative Stress in Heart Failure, Heart Transplant, and Beyond
Witman, M. A., Fjeldstad, A. S., McDaniel, J., Ives, S. J., Zhao, J., Barrett‐O’Keefe, Z., Nativi, J. N., Stehlik, J., Wray, D. W., & Richardson, R. S. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.193318 · Cited by 36 · see citing works
Gardner, A. W., Parker, D. E., Montgomery, P. S., Blevins, S. M., Teague, A. M., & Casanegra, A. I. (2013) · Angiology · doi:10.1177/0003319713489769 · Cited by 35 · see citing works
The relationship between shear rate and flow‐mediated dilation is altered by acute exercise
Llewellyn, T. L., Chaffin, M. E., Berg, K. E., & Meendering, J. R. (2012) · Acta Physiologica · doi:10.1111/j.1748-1716.2012.02417.x · Cited by 34 · see citing works
Vitamin C prevents the acute decline of flow-mediated dilation after altered shear rate patterns
Johnson, B. D., Mather, K. J., Newcomer, S. C., Mickleborough, T. D., & Wallace, J. P. (2012) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0169 · Cited by 34 · see citing works
Ozemek, C., Hildreth, K. L., Blatchford, P. J., Hurt, K. J., Bok, R., Seals, D. R., Kohrt, W. M., & Moreau, K. L. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00488.2019 · Cited by 33 · see citing works
A comparison between active- and reactive-hyperaemia-induced brachial artery vasodilation
Padilla, J., Harris, R. A., Fly, A. D., Rink, L. D., & Wallace, J. P. (2006) · Clinical Science · doi:10.1042/cs20050328 · Cited by 33 · see citing works
Hemilä, H. (2014) · Allergy Asthma and Clinical Immunology · doi:10.1186/1710-1492-10-58 · Cited by 33 · see citing works
Relationship Between Noninvasively Measured Endothelial Function and Peripheral Arterial Disease
Medina-Maldonado, F. J., Haro, J. D., Aguilar, E. M., González, A. F., García, J. R. M., & García, F. A. (2008) · Angiology · doi:10.1177/0003319708327787 · Cited by 32 · see citing works
Lombardini, R., Marchesi, S., Collebrusco, L., Vaudo, G., Pasqualini, L., Ciuffetti, G., Brozzetti, M., Lupattelli, G., & Mannarino, E. (2008) · Manual Therapy · doi:10.1016/j.math.2008.08.002 · Cited by 31 · see citing works
Effects of Alpha-Lipoic Acid Supplementation in Peripheral Arterial Disease: A Pilot Study
Vincent, H. K., Bourguignon, C. M., Vincent, K. R., & Taylor, A. G. (2007) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2007.6177 · Cited by 30 · see citing works
Giugliano, G., Serafino, L. D., Perrino, C., Schiano, V., Laurenzano, E., Cassese, S., Laurentis, M. D., Schiattarella, G. G., Brevetti, L., Sannino, A., et al. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.06.055 · Cited by 29 · see citing works
Haro, J. D., Acín, F., López-Quintana, A., Medina, F. J., Martínez-Aguilar, E., Florez, A., & March, J. R. (2008) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2007.10.016 · Cited by 29 · see citing works
Tymko, M. M., Tremblay, J. C., Hansen, A. B., Howe, C. A., Willie, C. K., Stembridge, M. R., GREEN, D. J., Hoiland, R. L., Subedi, P., Anholm, J. D., et al. (2016) · The Journal of Physiology · doi:10.1113/jp273183 · Cited by 28 · see citing works
Oxidative damage to skeletal muscle following an acute bout of contractile claudication
Judge, A. R., & DODD, S. L. (2003) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2003.08.022 · Cited by 28 · see citing works
Joras, M., & Poredoš, P. (2008) · Vascular Medicine · doi:10.1177/1358863x08096347 · Cited by 27 · see citing works
Shahin, Y., Cockcroft, J. R., & Chetter, I. C. (2013) · British journal of surgery · doi:10.1002/bjs.9198 · Cited by 26 · see citing works
Thomas, K. N., Cotter, J. D., Williams, M. J. A., & van Rij, A. M. (2016) · Vascular and Endovascular Surgery · doi:10.1177/1538574416639150 · Cited by 25 · see citing works
Use of hyperspectral imaging to assess endothelial dysfunction in peripheral arterial disease
Sumpio, B. J., Citoni, G., Chin, J. A., & Sumpio, B. E. (2016) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2016.03.463 · Cited by 25 · see citing works
Gardner, A. W., Montgomery, P. S., Zhao, Y. D., Silva-Palacios, F., Ungvari, Z. I., Csiszár, A., & Sonntag, W. E. (2017) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2016.12.108 · Cited by 25 · see citing works
Gresele, P., Migliacci, R., Arosio, E., Bonizzoni, E., Minuz, P., & Violi, F. (2012) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2012.05.064 · Cited by 25 · see citing works
Lehr, H., Germann, G., McGregor, G. P., Migeod, F., Roesen, P., Tanaka, H., Uhlig, C., & Biesalski, H. K. (2006) · PubMed · Cited by 25 · see citing works
da Silva, N. D., Roseguini, B. T., Chehuen, M. D. R., Fernandes, T. M., da Mota, G. D. F. A., Martin, P. K. M., Han, S. W., Forjaz, C. L. M., Wolosker, N., & de Oliveira, E. M. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00158.2015 · Cited by 23 · see citing works
Silvestro, A., Schiano, V., Bucur, R., Brevetti, G., Scopacasa, F., & Massimo Chiariello, A. (2006) · Angiology · doi:10.1177/000331970605700203 · Cited by 23 · see citing works
Self-citationCarter, S. E., Faulkner, A., & Rakobowchuk, M. (2013) · Journal of Hypertension · doi:10.1097/hjh.0000000000000033 · Cited by 22 · see citing works
Kals, J., Kampus, P., Kals, M., Pulges, A., Teesalu, R., & Zilmer, M. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.06.014 · Cited by 22 · see citing works
Lyall, G. K., Davies, M. J., Ferguson, C., Porter, K. E., & Birch, K. M. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00156.2019 · Cited by 21 · see citing works
Roseguini, B. T., Hirai, D. M., Alencar, M. C. N., Ramos, R. P., Silva, B. M., Wolosker, N., Neder, J. A., & Nery, L. E. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00183.2014 · Cited by 21 · see citing works
Endothelial dysfunction in patients with Buerger disease
Igari, K., Kudo, T., Toyofuku, T., & Inoue, Y. (2017) · Vascular Health and Risk Management · doi:10.2147/vhrm.s139892 · Cited by 21 · see citing works
Komai, H., Higami, Y., Tanaka, H., Honda, K., Juri, M., & Okamura, Y. (2008) · Angiology · doi:10.1177/0003319707303442 · Cited by 21 · see citing works
Andrade-Lima, A., Miranda, A. S., Correia, M. D. A., Germano-Soares, A. H., Cucato, G. G., Filho, D. C. S., Gomes, S. L., & Ritti‐Dias, R. M. (2015) · Journal of Vascular Nursing · doi:10.1016/j.jvn.2015.09.001 · Cited by 19 · see citing works
Does nutrition have a role in peripheral vascular disease?
Carrero, J. J., & Grimble, R. F. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20051616 · Cited by 19 · see citing works
Andrade-Lima, A., Correia, M. D. A., Germano-Soares, A. H., Farah, B. Q., Forjaz, C. L. M., Silva, A. S., Brasileiro‐Santos, M. S., dos Santos, A. C., & Ritti‐Dias, R. M. (2016) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.12384 · Cited by 19 · see citing works
Yan, J., Tie, G., & Messina, L. M. (2012) · Molecular Medicine · doi:10.2119/molmed.2011.00103 · Cited by 18 · see citing works
Currie, K. D., McKelvie, R. S., & MacDonald, M. J. (2014) · BioMed Research International · doi:10.1155/2014/591918 · Cited by 18 · see citing works
Vascular Nitric Oxide–Superoxide Balance and Thrombus Formation after Acute Exercise
Przyborowski, K., Proniewski, B., Czarny, J., Smęda, M., SITEK, B., Zakrzewska, A., Zoladz, J. A., & Chłopicki, S. (2018) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001589 · Cited by 18 · see citing works
Tymko, M. M., Tremblay, J. C., Steinback, C. D., Moore, J. P., Hansen, A. B., Patrician, A., Howe, C. A., Hoiland, R. L., GREEN, D. J., & Ainslie, P. N. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00583.2017 · Cited by 18 · see citing works
Antioxidants attenuate oxidative damage in rat skeletal muscle during mild ischaemia
Judge, A. R., Selsby, J. T., & DODD, S. L. (2008) · Experimental Physiology · doi:10.1113/expphysiol.2007.040972 · Cited by 18 · see citing works
François, M. E., & Little, J. P. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3649-2 · Cited by 16 · see citing works
Ritti‐Dias, R. M., Correia, M. D. A., Andrade-Lima, A., & Cucato, G. G. (2018) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2019.1553676 · Cited by 16 · see citing works
Coolen, S. A. J., Daykin, C. A., van Duynhoven, J., van Dorsten, F. A., Wülfert, F., Mathot, J. N. J. J., Scheltinga, M. R., Stroosma, O. B., Vader, H. L., & Wijnen, M. H. W. A. (2008) · NMR in Biomedicine · doi:10.1002/nbm.1242 · Cited by 17 · see citing works
de Oliveira, G. V., Cordeiro, E. M., Volino‐Souza, M., Rezende, C., Conte‐Júnior, C. A., & Álvares, T. S. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17145194 · Cited by 16 · see citing works
- Authors
- Silvestro, A., Scopacasa, F., Oliva, G., de Cristofaro, T., Iuliano, L., & Brevetti, G.
- Affiliations
- Federico II University Hospital (IT)
- Sapienza University of Rome (IT)
- Corresponding author
- Silvestro, Antonio
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 165
- Issue
- 2
- Pages
- 277-283
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W2069490874
- Cited by
- 159
- References
- 43
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 1 · 2023: 1 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 8 · 2017: 9 · 2016: 9 · 2015: 10 · 2014: 14 · 2013: 11 · 2012: 17
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- vitamin C, intermittent claudication, endothelial dysfunction, acute exercise, oxidative stress, flow-mediated dilation, TBARS, soluble intercellular adhesion molecule-1, antioxidant therapy, peripheral arterial disease, submaximal exercise
- MeSH terms
- Antioxidants, Ascorbic Acid, Brachial Artery, Endothelium, Vascular, Exercise Test, Female, Humans, Intermittent Claudication, Male, Middle Aged, Vasodilation, Exercise, Treatment Outcome, Oxidative Stress, Intercellular Adhesion Molecule-1
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