The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
The endocytotic rate constant. A cellular parameter for quantitating receptor-mediated endocytosis.
Open accessAbstract
of endocytosis have been mainly restricted to the qualitative level (6-9).We have recently presented a set of steady state equations that accurately describe the cellular binding, internalization, and degradation of polypeptide ligands under physiological conditions (5).A central concept in our steady state model is the endocytotic rate constant ( k , ) which we defined as the probability of an occupied receptor being internalized in 1 min at 37 "C.The ligand-receptor k, is important because its value ' The abbreviations used are: CHAPS, 3[(3-~holamidopropyl)-dimethylammoniol-I-propane sulfonate; DV medium, Dulbecco's modified Eagle's medium; EGF, epidermal growth factor; HF cells, human neonatal foreskin fibroblasts; In/Sur, the ratio between internalized ligand and cell surface-bound ligand PMSF, phenylmethylsulfonyl fluoride; BSA, bovine serum albumin.
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Cites
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Coated pits, coated vesicles, and receptor-mediated endocytosis
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Cited by
The Lutropin/Choriogonadotropin Receptor, A 2002 Perspective
Ascoli, M., Fanelli, F., & Segaloff, D. L. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.2.0462 · Cited by 772
Ligand-Induced Transformation by a Noninternalizing Epidermal Growth Factor Receptor
Wells, A., Welsh, J. B., Lazar, C. S., Wiley, H. S., Gill, G. N., & Rosenfeld, M. G. (1990) · Science · doi:10.1126/science.2305263 · Cited by 411
Self-citationSheff, D. R., Daro, E. A., Hull, M., & Mellman, I. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.1.123 · Cited by 399
Endocytosis and signaling: Cell logistics shape the eukaryotic cell plan
Sigismund, S., Confalonieri, S., Ciliberto, A., Polo, S., Scita, G., & Di Fiore, P. P. (2012) · Physiological Reviews · doi:10.1152/physrev.00005.2011 · Cited by 338
Penheiter, S. G., Mitchell, H., Garamszegi, N., Edens, M., Doré, J. J. E., & Leof, E. B. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.13.4750-4759.2002 · Cited by 167
Metadata
- Authors
- Wiley, H. S., & Cunningham, D. D.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1982-04
- Volume
- 257
- Issue
- 8
- Pages
- 4222-4229
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2167983317
- Cited by
- 391
- References
- 25
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wiley, H. S., & Cunningham, D. D. (1982). The endocytotic rate constant. A cellular parameter for quantitating receptor-mediated endocytosis. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)34709-4
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
