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Coated pits, coated vesicles, and receptor-mediated endocytosis
Abstract
Proteins and peptides can enter cells by receptor-mediated endocytosis, a coupled process by which selected extracellular proteins or peptides are first bound to specific cell surface receptors and then rapidly internalised by the cell. Internalisation follows clustering of the receptors in specialised regions of the cell surface called coated pits that invaginate to form intracellular coated vesicles. It is now recognised that receptor-mediated endocytosis has a fundamental role in the growth, nutrition and differentiation of animal cells.
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The LDL receptor mediates cellular uptake and degradation of extracellular LDL by high affinity binding of LDL to receptors on the cell surface followed by internalization of the receptor-ligand complex in clathrin-coated vesicles.
“The low density lipoprotein (LDL) 1 receptor mediates cellular uptake and degradation of extracellular LDL by high affinity binding of LDL to receptors on the cell surface followed by internalization of the receptor-ligand complex in clathrincoated vesicles.”
From Sorting Motifs in the Intracellular Domain of the Low Density Lipoprotein Receptor Interact with a Novel Domain of Sorting Nexin-17 (2004) · cites this paper as [1]
Coated pits are specialized regions of cell membranes that are lined on the cytoplasmic surface by a protein called clathrin.
“These are specialized regions of cell membranes that are lined on the cytoplasmic surface by a protein called clathrin (3).”
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Metadata
- Authors
- Goldstein, J. L., Anderson, R. G. W., & Brown, M. S.
- Venue
- Nature
- Published
- 1979-06
- Volume
- 279
- Issue
- 5715
- Pages
- 679-685
- ISSN
- 0028-0836
- 1476-4687
- Cited by
- 1,532
- References
- 0
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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