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Coated pits, coated vesicles, and receptor-mediated endocytosis

Goldstein, Joseph L., Anderson, Richard G. W., Brown, Michael S.·1979·Nature

Abstract

Proteins and peptides can enter cells by receptor-mediated endocytosis, a coupled process by which selected extracellular proteins or peptides are first bound to specific cell surface receptors and then rapidly internalised by the cell. Internalisation follows clustering of the receptors in specialised regions of the cell surface called coated pits that invaginate to form intracellular coated vesicles. It is now recognised that receptor-mediated endocytosis has a fundamental role in the growth, nutrition and differentiation of animal cells.

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Research works printed but not linked: 72

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Metadata

Authors
Goldstein, J. L., Anderson, R. G. W., & Brown, M. S.
Venue
Nature
Published
1979-06
Volume
279
Issue
5715
Pages
679-685
ISSN
  • 0028-0836
  • 1476-4687
Cited by
1,532
References
0
Language
en

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