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Cited by 482

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells.

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Maier, J A, Hla, T, Maciag, T·1990·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(19)38515-1
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Abstract

The monokine interleukin-1 (IL-1) inhibits endothelial cell growth and induces prostacyclin production in human endothelial cells. Since cyclooxygenase (Cox) is the rate-limiting enzyme in the synthesis of prostanoids, we evaluated the ability of IL-1 to stimulate Cox expression by human umbilical vein endothelial cells (HUVEC) in vitro. Our data demonstrate that 1) the Cox mRNA is expressed at low levels in untreated cells; 2) IL-1 alpha induces the Cox mRNA within 2 h, and this induction is sustained for more than 24 h; 3) IL-1 alpha induction is dose-dependent; 4) cycloheximide potentiates the induction of the Cox mRNA by IL-1 alpha while actinomycin D prevents the induction, and 5) IL-1 alpha also stimulates Cox production in a time-dependent fashion which correlates with the increase in prostacyclin synthesis. These data suggest that Cox is an immediate-early gene induced by IL-1 in HUVEC and may contribute to the regulation of the endothelial cell differentiation pathway in vitro.

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Citations

Cites

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Cited by

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Metadata

Authors
Maier, J. A., Hla, T., & Maciag, T.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1990-07
Volume
265
Issue
19
Pages
10805-10808
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(19)38515-1
OpenAlex
W1563962170
Cited by
482
References
1
FWCI
34.22
Type
journal article
Language
en
Open access
hybrid
Licence

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