The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease
Open accessAbstract
ABCA1, a cholesterol transporter expressed in the brain, has been shown recently to be required to maintain normal apoE levels and lipidation in the central nervous system. In addition, ABCA1 has been reported to modulate beta-amyloid (Abeta) production in vitro. These observations raise the possibility that ABCA1 may play a role in the pathogenesis of Alzheimer disease. Here we report that the deficiency of ABCA1 does not affect soluble or guanidine-extractable Abeta levels in Tg-SwDI/B or amyloid precursor protein/presenilin 1 (APP/PS1) mice, but rather is associated with a dramatic reduction in soluble apoE levels in brain. Although this reduction in apoE was expected to reduce the amyloid burden in vivo, we observed that the parenchymal and vascular amyloid load was increased in Tg-SwDI/B animals and was not diminished in APP/PS1 mice. Furthermore, we observed an increase in the proportion of apoE retained in the insoluble fraction, particularly in the APP/PS1 model. These data suggested that ABCA1-mediated effects on apoE levels and lipidation influenced amyloidogenesis in vivo.
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ABCA1-mediated lipidation of apoE modulates amyloid plaque formation.
“In support of this possibility, it was recently demonstrated that ATP-binding cassette transporter A1 (ABCA1)-mediated lipidation of apoE modulates amyloid plaque formation (Hirsch-Reinshagen et al., 2005; Koldamova et al., 2005; Wahrle et al., 2005; Wahrle et al., 2008).”
From Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance (2009) · cites this paper as Hirsch-Reinshagen et al., 2005
The Abstract reports that ABCA1 deficiency increased amyloid load in one mouse model and did not diminish it in another; it concludes that effects on apoE levels and lipidation *suggested* an influence on amyloidogenesis. The Discussion treats poor apoE lipidation as a possible explanation, not a demonstrated mechanism. Thus the paper supports an ABCA1–amyloid link, but not the claim that apoE lipidation itself was demonstrated to modulate plaque formation. (LLM, conf=0.86)
Experimental — accuracy not yet measuredABCA1 overexpression or LXR/RXR agonist treatment decreases amyloid deposition in APP transgenic mouse models.
“ABCA1 overexpression or LXR/RXR agonist treatment decreased amyloid deposition [66-69].”
From MicroRNAs in brain cholesterol metabolism and their implications for Alzheimer's disease (2016) · cites this paper as [66]
The paper reports that an LXR ligand reduced Aβ40 and Aβ42 levels in APP23 mice, which supports part of the treatment claim, but it does not say that the treatment reduced amyloid deposition. Its own study examines ABCA1 deficiency, not overexpression, and the cited passages do not report an RXR-agonist experiment. The relevant passages are labeled Abstract in our copy; no page number is available. (LLM, conf=0.83)
Experimental — accuracy not yet measuredABCA1 gene ablation in mice decreases APOE lipidation and levels and increases Aβ accumulation in APP transgenic mouse models.
“ABCA1 gene ablation in mice decreased APOE lipidation and levels and increased Aβ accumulation in APP transgenic mouse models.”
From MicroRNAs in brain cholesterol metabolism and their implications for Alzheimer's disease (2016) · cites this paper as [66]
The ‘Deficiency of ABCA1 Reduces Soluble ApoE Levels in Vivo’ section reports lower soluble apoE in both APP-transgenic models, and the Discussion describes apoE in ABCA1-deficient mice as poorly lipidated. The ‘ABCA1 Deficiency Increases Aβ Deposition in Tg-SwDI/B’ section reports increased Aβ deposition in Tg-SwDI/B mice, but no significant increase in APP/PS1 mice; the claim overgeneralizes the accumulation finding to both models. Page numbers were not available in our copy. (LLM, conf=0.90)
Experimental — accuracy not yet measuredModulation of ABCA1 affects Aβ levels and amyloid accumulation in vivo.
“We and others demonstrated that modulation of ABCA1 affects Aβ levels and amyloid accumulation in vivo.”
From miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression (2012) · cites this paper as Hirsch-Reinshagen et al., 2005
The Discussion reports increased amyloid deposition in one of this paper’s mouse models and describes other in vivo studies that found elevated Aβ levels with ABCA1 deficiency. But this paper found no significant change in Aβ levels in either of its models, so it does not demonstrate that ABCA1 modulation affected both outcomes in its own experiments. (LLM, conf=0.86)
Experimental — accuracy not yet measuredABCA1 deficiency leads to an increase in Aβ and amyloid deposition.
“ABCA1 deficiency leads to an increase in Aβ and amyloid deposition (Hirsch-Reinshagen et al., 2005; Koldamova et al., 2005; Wahrle et al., 2005)”
From miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression (2012) · cites this paper as Hirsch-Reinshagen et al., 2005
The Results sections report increased Aβ and amyloid deposition in ABCA1-deficient Tg-SwDI/B mice. But the Abstract states that soluble and guanidine-extractable Aβ levels were unchanged in both mouse models, and Aβ deposits did not significantly increase in APP/PS1 mice. The claim omits these distinctions; page numbers were not available in the supplied copy. (LLM, conf=0.90)
Experimental — accuracy not yet measured
ABCA1 deficiency leads to an increase in both Aβ and amyloid load in the brains of three different transgenic APP mouse models.
“However, three independent studies demonstrated that ABCA1 deficiency leads to an increase in both Aβ and amyloid load in the brains of three different transgenic APP mouse models (Hirsch-Reinshagen et al., 2005; Koldamova et al., 2005; Wahrle et al., 2005).”
From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Hirsch-Reinshagen et al., 2005
The Results section on Tg-SwDI/B mice reports a twofold increase in amyloid deposition with ABCA1 deficiency. But the paper found no significant increase in amyloid deposits in its APP/PS1 model, and its Results and Discussion report no increase in measured Aβ levels in either model. It therefore supports the deposition finding in one model, not the full claim attributed to it. (LLM, conf=0.90)
Experimental — accuracy not yet measuredDeletion of Abca1 and Lxr genes decreased apoE levels but increased or had no effect on Aβ deposition.
“Interestingly, deletion of ATP-binding cassette, sub-family A1 (Abca1) and liver x receptor (Lxr) genes decreased apoE levels but increased or had no effect on Aβ deposition (Hirsch-Reinshagen et al.,2005; Koldamova et al., 2005; Wahrle et al., 2005; Zelcer et al., 2007).”
From Haploinsufficiency of Human APOE Reduces Amyloid Deposition in a Mouse Model of Amyloid-β Amyloidosis (2011) · cites this paper as Hirsch-Reinshagen et al.,2005
The amyloid load in APP transgenic mice deficient in ABCA1 does not change, or even increases, when ABCA1−/− mice are crossed to various APP transgenic models.
“The amyloid load in APP transgenic mice deficient in ABCA1 did not change, or even increased, when ABCA1−/− mice were crossed to various APP transgenic models [40-42].”
From Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling (2012) · cites this paper as [40]
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Cites
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works
Alzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063 · see citing works
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268 · see citing works
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051 · see citing works
Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876 · see citing works
Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
Corder, E. H., Saunders, A. M., Risch, N. J., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Rimmler, J. B., Locke, P. A., Conneally, P. M., Schmader, K. E., et al. (1994) · Nature Genetics · doi:10.1038/ng0694-180 · Cited by 1,920 · see citing works
Apolipoprotein E: Far More Than a Lipid Transport Protein
Mahley, R. W., & Rall, S. C. (2000) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.1.1.507 · Cited by 1,836 · see citing works
Citron, M., Oltersdorf, T., Haass, C., McConlogue, L., Hung, A. Y., Seubert, P., Vigo-Pelfrey, C., Lieberburg, I., & Selkoe, D. J. (1992) · Nature · doi:10.1038/360672a0 · Cited by 1,757 · see citing works
Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
Brooks-Wilson, A., Marcil, M., Clee, S. M., Zhang, L.-H., Roomp, K., van Dam, M., Yu, L., Brewer, C., Collins, J. A., Molhuizen, H. O. F., et al. (1999) · Nature Genetics · doi:10.1038/11905 · Cited by 1,687 · see citing works
Self-citationJankowsky, J. L., Fadale, D. J., Anderson, J., Xu, G. M., Gonzales, V., Jenkins, N. A., Copeland, N. G., Lee, M. K., Younkin, L. H., Wagner, S. L., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh019 · Cited by 1,575 · see citing works
The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
Bodzioch, M., Orsó, E., Klucken, J., Langmann, T., Böttcher, A., Diederich, W., Drobnik, W., Barlage, S., Büchler, C., Porsch-Özcürümez, M., et al. (1999) · Nature Genetics · doi:10.1038/11914 · Cited by 1,512 · see citing works
Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
Rust, S., Rosier, M., Funke, H., Real, J., Amoura, Z., Piette, J.-C., Deleuze, J.-F., Brewer, H. B., Duverger, N., Denèfle, P., et al. (1999) · Nature Genetics · doi:10.1038/11921 · Cited by 1,433 · see citing works
Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type
Levy, E., Carman, M. D., Fernandez-Madrid, I. J., Power, M. D., Lieberburg, I. M., van Duinen, S. G., Bots, G. T. A. M., Luyendijk, W., & Frangione, B. (1990) · Science · doi:10.1126/science.2111584 · Cited by 1,380 · see citing works
CSF markers for incipient Alzheimer's disease
Blennow, K., & Hampel, H. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00530-1 · Cited by 1,291 · see citing works
Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons
Simons, M., Keller, P., Strooper, B. D., Beyreuther, K. T., Dotti, C. G., & Simons, K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6460 · Cited by 1,167 · see citing works
Apolipoprotein E polymorphism and Alzheimer's disease
Poirier, J., Bertrand, P., Poirier, J., Kogan, S., Gauthier, S., Poirier, J., Gauthier, S., Davignon, J., Bouthillier, D., & Davignon, J. (1993) · The Lancet · doi:10.1016/0140-6736(93)91705-q · Cited by 1,108 · see citing works
Self-citationAmyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts
Ehehalt, R., Keller, P., Haass, C., Thiele, C., & Simons, K. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200207113 · Cited by 1,107 · see citing works
Fassbender, K. C., Simons, M., Bergmann, C., Stroick, M., Lütjohann, D., Keller, P., Runz, H., Kühl, S., Bertsch, T., von Bergmann, K., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081620098 · Cited by 1,078 · see citing works
Holtzman, D. M., Bales, K. R., Tenkova, T., Fagan, A. M., Parsadanian, M., Sartorius, L. J., Mackey, B., Olney, J., McKeel, D., Wozniak, D., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050004797 · Cited by 937 · see citing works
Adult mouse astrocytes degrade amyloid-β in vitro and in situ
Wyss-Coray, T., Loike, J. D., Brionne, T. C., Lu, E., Anankov, R., Yan, F., Silverstein, S. C., & Husemann, J. (2003) · Nature Medicine · doi:10.1038/nm838 · Cited by 909 · see citing works
Alzheimer's disease: the cholesterol connection
Puglielli, L., Tanzi, R. E., & Kovacs, D. M. (2003) · Nature Neuroscience · doi:10.1038/nn0403-345 · Cited by 864 · see citing works
Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide
Haass, C., & Selkoe, D. J. (1993) · Cell · doi:10.1016/0092-8674(93)90312-e · Cited by 833 · see citing works
Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition
Bales, K. R., Verina, T., Dodel, R. C., Du, Y., Altstiel, L., Bender, M., Hyslop, P., Johnstone, E. M., Little, S. P., Cummins, D. J., et al. (1997) · Nature Genetics · doi:10.1038/ng1197-263 · Cited by 830 · see citing works
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10
Kojro, E., Gimpl, G., Lammich, S., März, W., & Fahrenholz, F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081612998 · Cited by 804 · see citing works
Apolipoprotein E in animal models of CNS injury and in alzheimer's disease
Poirier, J. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90156-2 · Cited by 637 · see citing works
Self-citationPlasma and Cerebrospinal Fluid Levels of Amyloid β Proteins 1-40 and 1-42 in Alzheimer Disease
Mehta, P. D., Pirttilä, T., Mehta, S. P., Sersen, E. A., Aisen, P. S., & Wisniewski, H. M. (2000) · Archives of Neurology · doi:10.1001/archneur.57.1.100 · Cited by 582 · see citing works
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides
Koistinaho, M., Lin, S., Wu, X., Esterman, M., Koger, D., Hanson, J., Higgs, R., Liu, F., Malkani, S., Bales, K. R., et al. (2004) · Nature Medicine · doi:10.1038/nm1058 · Cited by 571 · see citing works
Expression of apolipoprotein E during nerve degeneration and regeneration.
Ignatius, M. J., Gebicke‐Haerter, P. J., Skene, J. H. P., Schilling, J., Weisgraber, K. H., Mahley, R. W., & Shooter, E. M. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.4.1125 · Cited by 568 · see citing works
Isoform-specific binding of apolipoprotein E to beta-amyloid.
LaDu, M. J., Falduto, M. T., Manelli, A. M., Reardon, C. A., Getz, G. S., & Frail, D. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31529-6 · Cited by 540 · see citing works
McNeish, J. D., Aiello, R. J., Guyot, D. J., Turi, T., Gabel, C. A., Aldinger, C. E., Hoppe, K. L., Roach, M. L., Royer, L. J., de Wet, J., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4245 · Cited by 539 · see citing works
Grabowski, T. J., Cho, H. S., Vonsattel, J. P. G., Rebeck, G. W., & Greenberg, S. M. (2001) · Annals of Neurology · doi:10.1002/ana.1009 · Cited by 523 · see citing works
Bales, K. R., Verina, T., Cummins, D. J., Du, Y., Dodel, R. C., Saura, J., Fishman, C. E., DeLong, C. A., Piccardo, P., Petegnief, V., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15233 · Cited by 486 · see citing works
Wahrle, S. E., Jiang, H., Parsadanian, M., Legleiter, J., Han, X., Fryer, J. D., Kowalewski, T., & Holtzman, D. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407963200 · Cited by 474 · see citing works
Amyloid β Protein Precursor Gene and Hereditary Cerebral Hemorrhage with Amyloidosis (Dutch)
Broeckhoven, C. V., Haan, J., Bakker, E., Hardy, J., Hul, W. V., Wehnert, A., der Vlis, M. V.-V., & Roos, R. A. C. (1990) · Science · doi:10.1126/science.1971458 · Cited by 471 · see citing works
New Frontiers in Alzheimer's Disease Genetics
Tanzi, R. E., & Bertram, L. (2001) · Neuron · doi:10.1016/s0896-6273(01)00476-7 · Cited by 464 · see citing works
ApoE and Clusterin Cooperatively Suppress Aβ Levels and Deposition
DeMattos, R. B., Cirrito, J. R., Parsadanian, M., May, P. C., O'Dell, M. A., Taylor, J. W., Harmony, J. A. K., Aronow, B. J., Bales, K. R., Paul, S. M., et al. (2004) · Neuron · doi:10.1016/s0896-6273(03)00850-x · Cited by 459 · see citing works
Cholesterol Modulates α-Secretase Cleavage of Amyloid Precursor Protein
Bodovitz, S., & Klein, W. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.4436 · Cited by 447 · see citing works
ALZHEIMER'S DISEASE: Genetic Studies and Transgenic Models
Price, D. L., Tanzi, R. E., Borchelt, D. R., & Sisodia, S. S. (1998) · Annual Review of Genetics · doi:10.1146/annurev.genet.32.1.461 · Cited by 406 · see citing works
Deficiency of ABCA1 Impairs Apolipoprotein E Metabolism in Brain
Hirsch-Reinshagen, V., Zhou, S., Burgess, B. L., Bernier, L., McIsaac, S. A., Chan, J. Y., Tansley, G. H., Cohn, J. S., Hayden, M. R., & Wellington, C. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407962200 · Cited by 385 · see citing works
Self-citationDavis, J., Xu, F., Deane, R., Romanov, G., Previti, M. L., Zeigler, K., Zlokovic, B. V., & Van Nostrand, W. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312946200 · Cited by 373 · see citing works
Lack of ABCA1 Considerably Decreases Brain ApoE Level and Increases Amyloid Deposition in APP23 Mice
Koldamova, R., Staufenbiel, M., & Lefterov, I. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504513200 · Cited by 350 · see citing works
Holtzman, D. M., Bales, K. R., Wu, S., Bhat, P., Parsadanian, M., Fagan, A. M., Chang, L. K., Sun, Y., & Paul, S. M. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6179 · Cited by 349 · see citing works
Deletion of Abca1 Increases Aβ Deposition in the PDAPP Transgenic Mouse Model of Alzheimer Disease
Wahrle, S. E., Jiang, H., Parsadanian, M., Hartman, R. E., Bales, K. R., Paul, S. M., & Holtzman, D. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508780200 · Cited by 325 · see citing works
Characterization of four lipoprotein classes in human cerebrospinal fluid
Koch, S., Donarski, N., Goetze, K., Kreckel, M., Stuerenburg, H.-J., Buhmann, C., & Beisiegel, U. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31605-9 · Cited by 298 · see citing works
Wellington, C. L., Walker, E. K.-Y., Suarez, A., Kwok, A. Y. C., Bissada, N., Singaraja, R. R., Yang, Y., Zhang, L., James, E. R., Wilson, J. E., et al. (2002) · Laboratory Investigation · doi:10.1038/labinvest.3780421 · Cited by 296 · see citing works
Self-citationFagan, A. M., Watson, M., Parsadanian, M., Bales, K. R., Paul, S. M., & Holtzman, D. M. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0483 · Cited by 290 · see citing works
Nascent astrocyte particles differ from lipoproteins in CSF
LaDu, M. J., Gilligan, S. M., Lukens, J. R., Cabana, V. G., Reardon, C. A., Van Eldik, L. J., & Holtzman, D. M. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70052070.x · Cited by 285 · see citing works
Koldamova, R. P., Lefterov, I. M., Staufenbiel, M., Wolfe, D., Huang, S., Glorioso, J. C., Walter, M., Roth, M. G., & Lazo, J. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411420200 · Cited by 279 · see citing works
TOKUDA, T., CALERO, M., MATSUBARA, E., VIDAL, R., KUMAR, A., PERMANNE, B., ZLOKOVIC, B., SMITH, J. D., LADU, M. J., ROSTAGNO, A., et al. (2000) · Biochemical Journal · doi:10.1042/bj3480359 · Cited by 272 · see citing works
Fredrickson, D. S., ALTROCCHI, P. H., AVIOLI, L. V., GOODMAN, D. W. S., & GOODMAN, H. C. (1961) · Annals of Internal Medicine · doi:10.7326/0003-4819-55-6-1016 · Cited by 267 · see citing works
Apolipoprotein E and atherosclerosis
Curtiss, L. K., & Boisvert, W. A. (2000) · Current Opinion in Lipidology · doi:10.1097/00041433-200006000-00004 · Cited by 252 · see citing works
Koldamova, R. P., Lefterov, I. M., Ikonomovic, M. D., Skoko, J., Lefterov, P. I., Isanski, B. A., DeKosky, S. T., & Lazo, J. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300044200 · Cited by 237 · see citing works
Miravalle, L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003154200 · Cited by 217 · see citing works
Regulation of Cholesterol Homeostasis by the Liver X Receptors in the Central Nervous System
Whitney, K. D., Watson, M. A., Collins, J. L., Benson, W. G., Stone, T. M., Numerick, M. J., Tippin, T. K., Wilson, J. G., Winegar, D. A., & Kliewer, S. A. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.6.0835 · Cited by 211 · see citing works
Lipoproteins in the Central Nervous System
LaDu, M. J., Reardon, C. A., Eldik, L. J. V., Fagan, A. M., Bu, G., HOLTZMAN, D., & Getz, G. S. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06365.x · Cited by 206 · see citing works
Ruiz, J., Kouiavskaia, D., Migliorini, M., Robinson, S., Saenko, E. L., Gorlatova, N., Li, D., Lawrence, D., Hyman, B. T., Weisgraber, K. H., et al. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500114-jlr200 · Cited by 204 · see citing works
Presenilin, Notch, and the genesis and treatment of Alzheimer's disease
Selkoe, D. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211352598 · Cited by 202 · see citing works
Singaraja, R. R., Bocher, V., James, E. R., Clee, S. M., Zhang, L.-H., Leavitt, B. R., Tan, B., Brooks-Wilson, A., Kwok, A., Bissada, N., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102503200 · Cited by 194 · see citing works
Self-citationPurification of Apolipoprotein E Attenuates Isoform-specific Binding to β-Amyloid
LaDu, M. J., Pederson, T. M., Frail, D. E., Reardon, C. A., Getz, G. S., & Falduto, M. T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.16.9039 · Cited by 189 · see citing works
Miravalle, L., Tokuda, T., Chiarle, R., Giaccone, G., Bugiani, O., Tagliavini, F., Frangione, B., & Ghiso, J. A. (2000) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61486-9 · Cited by 180 · see citing works
Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide Secretion
Sun, Y., Yao, J., Kim, T.-W., & Tall, A. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300760200 · Cited by 179 · see citing works
Apolipoprotein E and Alzheimer's Disease A Role in Amyloid Catabolism
Poirier, J. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05564.x · Cited by 171 · see citing works
Self-citationLiang, Y., Lin, S., Beyer, T. P., Zhang, Y., Wu, X., Bales, K. R., DeMattos, R. B., May, P. C., Li, S. D., Jiang, X., et al. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02183.x · Cited by 160 · see citing works
Fukumoto, H., Deng, A., Irizarry, M. C., Fitzgerald, M. L., & Rebeck, G. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209085200 · Cited by 159 · see citing works
Demeester, N., Castro, G., Desrumaux, C. M., Geitere, C. D., Fruchart, J., Santens, P., Mulleners, E., Engelborghs, S., Deyn, P. P. D., Vandekerckhove, J. S., et al. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32039-3 · Cited by 157 · see citing works
Functions of lipoprotein receptors in neurons
Beffert, U., Stolt-Bergner, P. C., & Herz, J. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r300017-jlr200 · Cited by 156 · see citing works
ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease
Wollmer, M. A. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00094-5 · Cited by 147 · see citing works
Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation
Cheng, I. H.-J., Palop, J. J., Esposito, L., Bien‐Ly, N., Yan, F., & Mucke, L. (2004) · Nature Medicine · doi:10.1038/nm1123 · Cited by 138 · see citing works
Aleshkov, S., Abraham, C. R., & Zannis, V. I. (1997) · Biochemistry · doi:10.1021/bi9626362 · Cited by 138 · see citing works
Atwood, C., Martins, R. N., Smith, M. A., & Perry, G. L. (2002) · Peptides · doi:10.1016/s0196-9781(02)00070-0 · Cited by 137 · see citing works
Katzov, H., Chalmers, K. A., Palmgren, J., Andreasen, N., Johansson, B. E. A., Cairns, N. J., Gatz, M., Wilcock, G. K., Love, S., Pedersen, N. L., et al. (2004) · Human Mutation · doi:10.1002/humu.20012 · Cited by 128 · see citing works
Hayden, M. R., Clee, S. M., Brooks-Wilson, A. R., Genest, J. J., Attie, A., & Kastelein, J. J. P. (2000) · Current Opinion in Lipidology · doi:10.1097/00041433-200004000-00003 · Cited by 123 · see citing works
Self-citationDifferential diagnosis of Alzheimer's disease
Geldmacher, D. S., & Whitehouse, P. J. (1997) · Neurology · doi:10.1212/wnl.48.5_suppl_6.2s · Cited by 122 · see citing works
Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease
Schwab, C., Hosokawa, M., & McGeer, P. L. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.03.016 · Cited by 121 · see citing works
Lawn, R. M., Wade, D. P., Couse, T. L., & Wilcox, J. N. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.3.378 · Cited by 116 · see citing works
Co-localization of cholesterol, apolipoprotein E and fibrillar Aβ in amyloid plaques
Burns, M. P., Noble, W. J., Olm, V., Gaynor, K., Casey, E., LaFrancois, J. J., Wang, L., & Duff, K. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00647-2 · Cited by 115 · see citing works
Apolipoprotein E, Amyloid, and Alzheimer Disease
Bales, K. R. (2002) · Molecular Interventions · doi:10.1124/mi.2.6.363 · Cited by 113 · see citing works
Yang, D., Smith, J. D., Zhou, Z., Gandy, S. E., & Martins, R. N. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68020721.x · Cited by 111 · see citing works
Brain Lipoprotein Metabolism and Its Relation to Neurodegenerative Disease
Danik, M., Champagne, D. L., Petit-Turcotte, C., Beffert, U., & Poirier, J. (1999) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v13.i4.20 · Cited by 89 · see citing works
Self-citationBuxbaum, J. D., Geoghagen, N. S. M., & Friedhoff, L. T. (2001) · Journal of Alzheimer s Disease · doi:10.3233/jad-2001-3207 · Cited by 69 · see citing works
Modulation of Aβ Deposition in APP Transgenic Mice by an Apolipoprotein E Null Background
IRIZARRY, M. C., REBECK, G. W., CHEUNG, B., BALES, K., PAUL, S. M., HOLZMAN, D., & HYMAN, B. T. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06919.x · Cited by 66 · see citing works
Miao, J., Vitek, M. P., Xu, F., Previti, M. L., Davis, J., & Nostrand, W. E. V. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1306-05.2005 · Cited by 63 · see citing works
Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism
Wellington, C. L. (2004) · Clinical Genetics · doi:10.1111/j.0009-9163.2004.00280.x · Cited by 62 · see citing works
Self-citationZerbinatti, C., & Bu, G. (2005) · Reviews in the Neurosciences · doi:10.1515/revneuro.2005.16.2.123 · Cited by 62 · see citing works
Association of ABCA1 with late-onset Alzheimer’s disease is not observed in a case-control study
Li, Y., Tacey, K. M., Doil, L. M., van Luchene, R., Garcia, V., Rowland, C. M., Schrodi, S. J., Leong, D. U., Lau, K. F., Catanese, J., et al. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.05.047 · Cited by 62 · see citing works
Chapter 14 Apolipoprotein E in nerve injury and repair
Ignatius, M. J., Gebicke‐Haerter, P. J., Pitas, R. E., & Shooter, E. M. (1987) · Progress in brain research · doi:10.1016/s0079-6123(08)61822-1 · Cited by 50 · see citing works
Vaucher, E., Aumont, N., Pearson, D., Rowe, W. B., Poirier, J., & Kar, S. (2001) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(01)00120-x · Cited by 49 · see citing works
Self-citationCellular Catabolism of Lipid Poor Apolipoprotein E via Cell Surface LDL Receptor-Related Protein
Narita, M., Holtzman, D. M., Fagan, A. M., LaDu, M. J., Yu, L., Han, X., Gross, R. W., Bu, G., & Schwartz, A. L. (2002) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a003282 · Cited by 48 · see citing works
Biology of presenilins as causative molecules for Alzheimer disease
Nishimura, M., Yu, G., & George‐Hyslop, P. S. (1999) · Clinical Genetics · doi:10.1034/j.1399-0004.1999.550401.x · Cited by 32 · see citing works
Novel ABCA1 compound variant associated with HDL cholesterol deficiency
Hong, S. H., Rhyne, J., Zeller, K. I., & Miller, M. J. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(02)00066-2 · Cited by 31 · see citing works
Classification of dementia and Alzheimer's disease
Morris, J. C. (1996) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1996.tb05871.x · Cited by 30 · see citing works
Conversion of brain apolipoprotein E to an insoluble form in a mouse model of Alzheimer disease
Naidu, A., Catalano, R., Bales, K. R., Wu, S., Paul, S. M., & Cordell, B. (2001) · Neuroreport · doi:10.1097/00001756-200105080-00042 · Cited by 10 · see citing works
Diagnostic criteria for primary progressive mutiple sclerosis: a position paper.
(2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200006)47:6 · Cited by 2 · see citing works
Lake, S. (1991) · PubMed · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 95 references couldn’t be matched to a known paper.
Research works printed but not linked: 12
- Selkoe, D. J. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 11039 -11041
- Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., and Pericak-Vance, M. A. (1993) Science 261, 921-923
- Corder, E. H., Saunders, A. M., Risch, N. J., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Rimmler, J. B., Locke, P. A., Conneally, P. M., Schmader, K. E., Small, G. W., Roses, A. D., Haines, J. L., and Pericak-Vance, M. A. (1994) Nat. Genet. 7, 180 -184
- Ignatius, M. J., Gebicke-Harter, P. J., Skene, J. H., Schilling, J. W., and Weisgraber, K. H. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 1125-1129
- Bales, K. R., Verina, T., Cummins, D. J., Du, Y., Dodel, R. C., Saura, J., Fishman, C. E., DeLong, C. A., Piccardo, P., Petegnief, V., Ghetti, B., and Paul, S. M. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 15233-15238
- Fassbender, K., Simons, M., Bergmann, C., Stroick, M., Lu ¨tjohann, D., Keller, P., Runz, H., Ku ¨hl, S., Bertsch, T., von Bergmann, K., Hennerici, M., Beyreuther, K., and Hart- mann, T. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 5856 -5861
- Kojro, E., Gimple, G., Lammich, S., Ma ¨rz, W., and Fahrenholz, F. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 5815-5820
- Simons, M., Keller, P., De Strooper, B., Beyreuther, K., Dottie, C. G., and Simons, K. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6460 -6464
- McNeish, J., Aiello, R. J., Guyot, D., Turi, T., Gabel, C., Aldinger, C., Hoppe, K. L., Roach, M. L., Royer, L. J., de Wet, J., Broccardo, C., Chimini, G., and Francone, O. L. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 4245-4250
- Vaucher, E., Aumont, N., Pearson, D., Rowe, W., Poirier, J., and Kar, S. (2001) J. Chem. Neuroanat. 21, 323-329
- Holtzman, D. M., Bales, K. R., Tenkova, T., Fagan, A. M., Parsadanian, M., Sartorius, L. J., Mackey, B., Olney, J., McKeel, D., Wozniak, D., and Paul, S. M. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 2892-2897
- Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salveson, G. S., and Roses, A. D. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 1977-1981
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Xiong, H., Callaghan, D., Jones, A., Walker, D. G., Lue, L., Beach, T. G., Sue, L. I., Woulfe, J., Xu, H., Stanimirovic, D. B., et al. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.10.005 · Cited by 283 · see citing works
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Kim, J., Castellano, J. M., Jiang, H., Basak, J. M., Parsadanian, M., Pham, V., Mason, S. M., Paul, S. M., & Holtzman, D. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.11.013 · Cited by 274 · see citing works
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Self-citationRiddell, D. R., Zhou, H., Comery, T. A., Kouranova, E., Lo, C. F., Warwick, H. K., Ring, R. H., Kirksey, Y., Aschmies, S., Xu, J., et al. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.01.011 · Cited by 244 · see citing works
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Kim, W. S., Li, H., Ruberu, K. R., Chan, S. L., Elliott, D. A., Low, J. K., Cheng, D., Karl, T., & Garner, B. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4165-12.2013 · Cited by 209 · see citing works
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Donkin, J. J., Stukas, S., Hirsch-Reinshagen, V., Namjoshi, D., Wilkinson, A., May, S., Chan, J., Fan, J., Collins, J., & Wellington, C. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.108100 · Cited by 200 · see citing works
Self-citationKim, J., Jiang, H., Park, S., Eltorai, A. E. M., Stewart, F. R., Yoon, H., Basak, J. M., Finn, M. B., & Holtzman, D. M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3773-11.2011 · Cited by 199 · see citing works
“Interestingly, deletion of ATP-binding cassette, subfamily A1 (Abca1) and liver x receptor (Lxr) genes decreased apoE levels but increased or had no effect on A deposition (Hirsch-Reinshagen et al., 2005; Koldamova et al., 2005; Wahrle et al., 2005; Zelcer et al., 2007).”
BackgroundKim, W. S., Rahmanto, A. S., Kamili, A., Rye, K.-A., Guillemin, G. J., Gelissen, I. C., Jessup, W., Hill, A. F., & Garner, B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607831200 · Cited by 191 · see citing works
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Wang, N., Yvan‐Charvet, L., Lütjohann, D., Mulder, M., Vanmierlo, T., Kim, T., & Tall, A. R. (2008) · The FASEB Journal · doi:10.1096/fj.07-9944com · Cited by 184 · see citing works
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Kitazawa, M., Medeiros, R., & M. LaFerla, F. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799315786 · Cited by 178 · see citing works
Fitz, N. F., Cronican, A., Pham, T., Fogg, A., Fauq, A. H., Chapman, R., Lefterov, I., & Koldamova, R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1051-10.2010 · Cited by 175 · see citing works
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Tai, L. M., Bilousova, T., Jungbauer, L., Roeske, S. K., Youmans, K. L., Yu, C., Poon, W. W., Cornwell, L. B., Miller, C. A., Vinters, H. V., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.442103 · Cited by 165 · see citing works
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Alzheimer’s disease, cerebrovascular disease, and the β-amyloid cascade
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ATP-binding cassette transporter A1: From metabolism to neurodegeneration
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Huynh, T.-P. V., Wang, C., Tran, A. C., Tabor, G. T., Mahan, T. E., Francis, C. M., Finn, M. B., Spellman, R., Manis, M., Tanzi, R. E., et al. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0337-1 · Cited by 139 · see citing works
Fitz, N. F., Cronican, A. A., Saleem, M., Fauq, A. H., Chapman, R., Lefterov, I. M., & Koldamova, R. P. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1937-12.2012 · Cited by 138 · see citing works
Role of ABC Transporters in the Pathogenesis of Alzheimer’s Disease
Abuznait, A. H., & Kaddoumi, A. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn300077c · Cited by 134 · see citing works
Mahan, T. E., Wang, C., Bao, X., Choudhury, A., Ulrich, J. D., & Holtzman, D. M. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00516-0 · Cited by 134 · see citing works
ATP‐binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro
Chan, S. L., Kim, W. S., Kwok, J. B., Hill, A. F., Cappai, R., Rye, K., & Garner, B. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05433.x · Cited by 133 · see citing works
Nordestgaard, L. T., Tybjærg‐Hansen, A., Nordestgaard, B. G., & Frikke‐Schmidt, R. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2015.04.006 · Cited by 139 · see citing works
Nuclear receptors as therapeutic targets for Alzheimer's disease
Mandrekar-Colucci, S., & Landreth, G. E. (2011) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.594043 · Cited by 126 · see citing works
Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer’s Disease Pathogenesis
Maulik, M., Westaway, D. A., Jhamandas, J. H., & Kar, S. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8337-y · Cited by 117 · see citing works
Disease modifying therapy for AD?<sup>1</sup>
Golde, T. E. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04211.x · Cited by 117 · see citing works
Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk
Tai, L. M., Mehra, S., Shete, V., Estus, S., Rebeck, G. W., Bu, G., & LaDu, M. J. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-2 · Cited by 116 · see citing works
Reduced levels of human apoE4 protein in an animal model of cognitive impairment
Sullivan, P. M., Han, B., Liu, F., Mace, B. E., Ervin, J. F., Wu, S., Koger, D., Paul, S., & Bales, K. R. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.05.011 · Cited by 113 · see citing works
Inflammation and Alzheimer’s Disease: Mechanisms and Therapeutic Implications by Natural Products
Rather, M. A., Khan, A., Alshahrani, S., Rashid, H., Qadri, M. M., Rashid, S., Alsaffar, R. M., Kamal, M. A., & Rehman, M. U. (2021) · Mediators of Inflammation · doi:10.1155/2021/9982954 · Cited by 112 · see citing works
Pharmacogenomics in Alzheimer's Disease
Cacabelos, R. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-205-2_10 · Cited by 109 · see citing works
Jayaraj, R. L., Azimullah, S., & Beiram, R. (2019) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2019.12.028 · Cited by 105 · see citing works
Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils
Hatters, D. M., Zhong, N., Rutenber, E., & Weisgraber, K. H. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.06.080 · Cited by 105 · see citing works
Sharma, S., Shen, T., Chitranshi, N., Gupta, V., Basavarajappa, D. K., Sarkar, S., Mirzaei, M., You, Y., Krężel, W., Graham, S. L., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02709-y · Cited by 105 · see citing works
ABC Transporters and the Alzheimer’s Disease Enigma
Wolf, A. M., Bauer, B., & Hartz, A. M. S. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00054 · Cited by 105 · see citing works
Effect of Apolipoprotein E Genotype and Diet on Apolipoprotein E Lipidation and Amyloid Peptides
Hanson, A. J., Bayer-Carter, J. L., Green, P. S., Montine, T. J., Wilkinson, C. W., Baker, L. D., Watson, G. S., Bonner, L. M., Callaghan, M., Leverenz, J. B., et al. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.396 · Cited by 102 · see citing works
Impact of Apolipoprotein E on Alzheimer’s Disease
Hauser, P. S., & Ryan, R. O. (2013) · Current Alzheimer Research · doi:10.2174/15672050113109990156 · Cited by 101 · see citing works
Lipid metabolism in Alzheimer’s disease
Liu, Q., & Zhang, J. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1410-3 · Cited by 101 · see citing works
Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer’s disease
Dorey, E., Chang, N., Liu, Q. Y., Yang, Z., & Zhang, W. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1422-z · Cited by 99 · see citing works
High-Density Lipoproteins and Cerebrovascular Integrity in Alzheimer’s Disease
Stukas, S. K., Robert, J., & Wellington, C. L. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.003 · Cited by 96 · see citing works
Self-citationGreasing the wheels of Aβ clearance in Alzheimer's Disease: The role of lipids and apolipoprotein E
Fan, J., Donkin, J., & Wellington, C. (2009) · BioFactors · doi:10.1002/biof.37 · Cited by 97 · see citing works
Self-citationGosselet, F., Candela, P., Sevin, E., Bérézowski, V., Cecchelli, R., & Fénart, L. (2008) · Brain Research · doi:10.1016/j.brainres.2008.10.036 · Cited by 97 · see citing works
ABCA1 influences neuroinflammation and neuronal death
Karasinska, J. M., de Haan, W., Franciosi, S., Ruddle, P., Fan, J., Kruit, J. K., Stukas, S., Lütjohann, D., Gutmann, D. H., Wellington, C. L., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.01.018 · Cited by 104 · see citing works
Self-citationABC transporters, neural stem cells and neurogenesis – a different perspective
Lin, T., Islam, O., & Heese, K. (2006) · Cell Research · doi:10.1038/sj.cr.7310107 · Cited by 95 · see citing works
Amyloid-β Pathology and APOE Genotype Modulate Retinoid X Receptor Agonist Activity in Vivo
Tai, L. M., Koster, K. P., Luo, J., Lee, S., Wang, Y., Collins, N. C., Aissa, M. B., Thatcher, G. R. J., & LaDu, M. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.600833 · Cited by 93 · see citing works
ABC Transporters Are Key Players in Alzheimer’s Disease
Pereira, C. D., Martins, F., Wiltfang, J., Silva, O. A. B. D. C. E., & Rebelo, S. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170639 · Cited by 93 · see citing works
Role of amyloid beta in lipid homeostasis
Grösgen, S., Grimm, M. O. W., Frieß, P., & Hartmann, T. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.05.002 · Cited by 90 · see citing works
Kypreos, K. E., & Zannis, V. I. (2007) · Biochemical Journal · doi:10.1042/bj20061048 · Cited by 90 · see citing works
Lefterov, I., Bookout, A., Wang, Z., Staufenbiel, M., Mangelsdorf, D., & Koldamova, R. (2007) · Molecular Neurodegeneration · doi:10.1186/1750-1326-2-20 · Cited by 89 · see citing works
microRNA control of HDL Metabolism and Function
Rayner, K. J., & Moore, K. (2014) · Circulation Research · doi:10.1161/circresaha.114.300645 · Cited by 89 · see citing works
The effects of ABCA1 on cholesterol efflux and Aβ levels <i>in vitro</i> and <i>in vivo</i>
Burns, M. P., Vardanian, L., Pajoohesh‐Ganji, A., Wang, L., Cooper, M., Harris, D. C., Duff, K., & Rebeck, G. W. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03925.x · Cited by 106 · see citing works
Why lipids are important for Alzheimer disease?
Hirsch-Reinshagen, V., Burgess, B. L., & Wellington, C. L. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-008-0012-2 · Cited by 86 · see citing works
Self-citationRole of ABCA7 in Human Health and in Alzheimer’s Disease
Dib, S., Pahnke, J., & Gosselet, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094603 · Cited by 86 · see citing works
Sundar, P. D., Feingold, E., Minster, R. L., DeKosky, S. T., & Kamboh, M. I. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.04.005 · Cited by 78 · see citing works
Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations
Youmans, K. L., Leung, S., Zhang, J., Maus, E., Baysac, K., Bu, G., Vassar, R. J., Yu, C., & LaDu, M. J. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.12.025 · Cited by 76 · see citing works
Untangling the role of amyloid in atherosclerosis
Howlett, G. J., & Moore, K. J. (2006) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000245260.63505.4f · Cited by 79 · see citing works
Remembering your A, B, C's: Alzheimer's disease and ABCA1
Lewandowski, C. T., Laham, M. S., & Thatcher, G. R. J. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.01.011 · Cited by 76 · see citing works
Cholesterol-related genes in Alzheimer's disease
Wollmer, M. A. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.05.009 · Cited by 77 · see citing works
Rasmussen, K. L., Tybjærg‐Hansen, A., Nordestgaard, B. G., & Frikke‐Schmidt, R. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.05.006 · Cited by 75 · see citing works
Behl, T., Kaur, I., Sehgal, A., Kumar, A., Uddin, M. S., & BUNGAU, S. G. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02211-x · Cited by 74 · see citing works
Zhao, J., Fu, Y., Liu, C., Shinohara, M., Nielsen, H. M., Dong, Q., Kanekiyo, T., & Bu, G. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.526095 · Cited by 70 · see citing works
Katsouri, L., & Georgopoulos, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021880 · Cited by 72 · see citing works
ABC A-subclass proteins: Gatekeepers of cellular phospho- and sphingolipid transport
Juergen, J. W. (2007) · Frontiers in bioscience · doi:10.2741/2305 · Cited by 70 · see citing works
ABCA1, from pathology to membrane function
Zarubica, A., Trompier, D., & Chimini, G. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0108-z · Cited by 68 · see citing works
- Authors
- Hirsch-Reinshagen, V., Maia, L. F., Burgess, B. L., Blain, J.-F., Naus, K. E., McIsaac, S. A., Parkinson, P. F., Chan, J. Y., Tansley, G. H., Hayden, M. R., Poirier, J., Van Nostrand, W., & Wellington, C. L.
- Affiliations
- University of British Columbia (CA)
- McGill University Research Centre for Studies in Aging (CA)
- Corresponding author
- Wellington, Cheryl L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 280
- Issue
- 52
- Pages
- 43243-43256
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2151049459
- Cited by
- 233
- References
- 95
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 11 · 2021: 8 · 2020: 5 · 2019: 9 · 2018: 7 · 2017: 11 · 2016: 10 · 2015: 10 · 2014: 20 · 2013: 13 · 2012: 19
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Funders
- AstraZeneca
- Heart and Stroke Foundation of Canada
- Child and Family Research Institute
- Alzheimer Society
- National Institutes of Health
- Canadian Institutes of Health Research
- National Institute of Neurological Disorders and Stroke (R01NS036645, NS36645)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- ABCA1, apolipoprotein E, amyloid deposition, Alzheimer's disease, amyloid-beta, amyloid precursor protein, presenilin 1, APP/PS1 mice, cholesterol transport, amyloidogenesis
- MeSH terms
- Alzheimer Disease, Amyloid, Animals, Apolipoproteins E, Brain, Cerebral Cortex, Cholesterol, Densitometry, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Hippocampus, Humans, Immunohistochemistry, Lipids, Membrane Proteins, Mice, Inbred C57BL, Blotting, Western, ATP-Binding Cassette Transporters, Transgenes, Guanidine, Mice, Presenilin-1, ATP Binding Cassette Transporter 1
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