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Cited by 55Attention Deficit Hyperactivity DisorderPharmaceutical studies and practicesPharmacology and Obesity Treatment

Long-Term Effects of Methylphenidate Transdermal Delivery System Treatment of ADHD on Growth

FARAONE, STEPHEN V., GIEFER, ELDRED E.·2007·Journal of the American Academy of Child & Adolescent Psychiatry
DOI 10.1097/chi.0b013e31806ad1d7
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Abstract

Objective To examine the long-term effects of the methylphenidate transdermal system (MTS) on the growth of children being treated for attention-deficit/hyperactivity disorder.Method Height, weight, and body mass index (BMI) were measured in 127 children ages 6 to 12 at longitudinal assessments for up to 36 months of treatment with MTS. These data were compared with norms provided by the Centers for Disease Control and Prevention.Results MTS treatment was associated with small but significant delays in growth for height, weight, and BMI. The latter two indices were affected in a dose-dependent manner. Children who had not received prior stimulant therapy and children who entered the study with above-average height, weight, and BMI were most likely to experience growth deficits during the trial. Effects on all parameters of growth were most apparent during the first year of treatment, and attenuated over time.Conclusions Consistent with prior studies of methylphenidate, our results suggest that treatment with MTS can lead to reductions in expected height, weight, and BMI that show some attenuation over the course of treatment. Growth of patients with attention-deficit/hyperactivity disorder treated with MTS should be closely monitored, but in this study, deficits in growth in relation to MTS treatment were not a significant clinical concern for most children.

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Crossref · 10.1097/chi.0b013e31806ad1d7

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27 of 27 references verified0 citation errors · 0 not checkable

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  • Current data indicate that the initial effect of stimulants on growth appears to attenuate over time, and early studies of adult outcomes of children treated with stimulant medications have suggested that final adult height is not affected.

    “Current data indicate that the initial effect of stimulants on growth appears to attenuate over time [39, 114, 139] and early studies of the adult outcomes of children treated with stimulant medications have suggested that final adult height is not affected [55, 71].”

    From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [39]

  • The reduction in weight gain from stimulant treatment appears to be somewhat more pronounced than that for height (over a 3-year period about 3 kg less than predicted).

    “The reduction in weight gain appears to be somewhat more pronounced than that for height (over a 3-year period about 3 kg less than predicted) [39, 139].”

    From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [39]

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Authors
FARAONE, S. V., & GIEFER, E. E.
Affiliations
SUNY Upstate Medical University (US)
Corresponding author
FARAONE, STEPHEN V.
ORCID
FARAONE, STEPHEN V.
Venue
Journal of the American Academy of Child & Adolescent Psychiatry
Publisher
Elsevier BV
Published
2007-09
Volume
46
Issue
9
Pages
1138-1147
ISSN
0890-8567 (ISSN-L)
DOI
10.1097/chi.0b013e31806ad1d7
OpenAlex
W2032172480
Cited by
55
References
29
Citations by year
2023: 4 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 2
FWCI
5.23
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
Keywords
attention deficit hyperactivity disorder, growth, height, weight, body mass index, long-term effects, stimulant medication, dose-dependent effects, children
MeSH terms
Administration, Cutaneous, Attention Deficit Disorder with Hyperactivity, Child, Female, Growth, Humans, Male, Methylphenidate, Time Factors, Body Mass Index

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