Chronic nicotine and mecamylamine treatment increase brain nicotinic receptor binding without changing alpha 4 or beta 2 mRNA levels
Abstract
It has recently been shown using regionally dissected tissue that both chronic mecamylamine treatment and chronic nicotine treatment increase the number of [3H]-nicotine binding sites in mouse brain, and that additive increases in the number of binding sites is observed after cotreatment with the two drugs. The studies reported here extend these findings by using quantitative autoradiographic methods to analyze the brains of chronically treated mice at a finer anatomical level of resolution. DBA/2 mice were chronically infused (i.v.) with saline, 4.0 mg/ kg/hr nicotine, 4.0 mg/kg/hr mecamylamine or both drugs for 7 days. The brains of these mice were subsequently analyzed to determine the effects of chronic drug treatment on [3H]-nicotine binding and on the levels of mRNA encoding the nicotinic receptor subunits, alpha 4 and beta 2. [3H]-Nicotine binding was increased in 37 of 46 brain regions after chronic nicotine treatment (average increase = 66.5%), in 41 of 46 regions after chronic mecamylamine treatment (average increase = 56.5%), and in 45 of 46 brain regions after chronic treatment with both drugs (average increase = 107.1%). The changes in [3H]-nicotine binding produced by the two drugs across brain regions were highly (r = 0.98) and significantly correlated. These results are consistent with the proposal that the same receptors are affected by agonist or antagonist treatment. Chronic treatment had no significant effect on the levels of alpha 4 or beta 2 mRNA as measured by in situ hybridization. Therefore, the increases in [3H]-nicotine binding do not arise from changes in the steady-state levels of either alpha 4 or beta 2 mRNA which are believed to encode the subunits of this nicotinic receptor subtype.
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The present finding of no chronic nicotine-associated change in hippocampal α4 or β2 mRNA levels replicates prior in situ hybridization work.
“Our finding replicates prior in situ hybridization work that found no chronic nicotine-associated change in hippocampal (and other areas) α4 or β2 mRNA levels (Marks et al., 1992; Pauly et al., 1996)”
From The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation (2012) · cites this paper as Pauly et al., 1996
Upregulation induced in animal models and transfected cells by chronic nicotine is certainly not transcriptional and is probably post-translational.
“Upregulation induced in animal models and transfected cells by chronic nicotine is certainly not transcriptional and is probably post-translational (47).”
From Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery (2009) · cites this paper as [47]
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Neuronal nicotinic receptors in the human brain
Paterson, D., & Nordberg, A. K. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00045-3 · Cited by 782 · see citing works
Nicotinic acetylcholine receptors in health and disease
Lindstrom, J. (1997) · Molecular Neurobiology · doi:10.1007/bf02740634 · Cited by 443 · see citing works
Human neuronal nicotinic receptors
Gotti, C., Fornasari, D., & Clementi, F. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00034-8 · Cited by 413 · see citing works
Reward, addiction, withdrawal to nicotine
De Biasi, M., & Dani, J. A. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113734 · Cited by 366 · see citing works
“…differs among the diverse subtypes, varies among brain regions for the same nAChR subtype, and depends on the contingency of nicotine administration (Gaimarri et al. 2007, Marks et al. 1983, McCallum et al. 2006, Metaxas et al. 2010, Nguyen et al. 2004, Pauly et al. 1996, Schwartz & Kellar 1983).”
BackgroundGovind, A. P., Vezina, P., & Green, W. N. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.06.011 · Cited by 338 · see citing works
Nicotine and the adolescent brain: insights from an animal model
Slotkin, T. (2002) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(02)00199-x · Cited by 284 · see citing works
Nashmi, R., Xiao, C., Deshpande, P., McKinney, S., Grady, S. R., Whiteaker, P., Huang, Q., McClure-Begley, T., Lindstrom, J. M., Labarca, C., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2199-07.2007 · Cited by 274 · see citing works
Self-citationDonny, E. C., Caggiula, A. R., Rowell, P. P., Gharib, M. A., Maldovan, V., Booth, S., Mielke, M. M., Hoffman, A., & McCallum, S. E. (2000) · Psychopharmacology · doi:10.1007/s002130000497 · Cited by 265 · see citing works
Trauth, J. A., Seidler, F. J., McCook, E. C., & Slotkin, T. A. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01994-0 · Cited by 230 · see citing works
Invertebrate models of drug abuse
Wolf, F. W., & Heberlein, U. (2002) · Journal of Neurobiology · doi:10.1002/neu.10166 · Cited by 214 · see citing works
Functional brain imaging of tobacco use and dependence
BRODY, A. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.04.012 · Cited by 207 · see citing works
Peng, X.-D., Gerzanich, V., Anand, R., Wang, F., & Lindstrom, J. M. (1997) · Molecular Pharmacology · doi:10.1124/mol.51.5.776 · Cited by 191 · see citing works
Wang, F., Nelson, M. E., Kuryatov, A., Olale, F., Cooper, J., Keyser, K., & Lindstrom, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.28721 · Cited by 187 · see citing works
Pharmacodynamics of Memantine: An Update
Parsons, C. G., Rammes, G., & Danysz, W. (2008) · Current Neuropharmacology · doi:10.2174/157015908783769671 · Cited by 185 · see citing works
Tobacco addiction and the dysregulation of brain stress systems
Bruijnzeel, A. W. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.02.015 · Cited by 172 · see citing works
Desensitized nicotinic receptors in brain
Wang, H., & Sun, X. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.09.003 · Cited by 175 · see citing works
Neuronal nicotinic receptors: from structure to function
Bertrand, D. (2001) · Nicotine & Tobacco Research · doi:10.1080/14622200110050213 · Cited by 175 · see citing works
Lester, H. A., Xiao, C., Srinivasan, R., Son, C. D., Miwa, J., Pantoja, R., Banghart, M. R., Dougherty, D. A., Goate, A. M., & Wang, J. C. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9090-7 · Cited by 163 · see citing works
Dual role of nicotine in addiction and cognition: A review of neuroimaging studies in humans
Jasinska, A. J., Zorick, T. S., Brody, A. L., & Stein, E. A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.02.015 · Cited by 163 · see citing works
Nguyen, H. N., Rasmussen, B. A., & Perry, D. C. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.056408 · Cited by 148 · see citing works
Xiao, Y., & Kellar, K. J. (2004) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.066787 · Cited by 148 · see citing works
Whiteaker, P., Sharples, C. G., & Wonnacott, S. (1998) · PubMed · doi:10.7270/q2b856pt · Cited by 147 · see citing works
Ke, L., Eisenhour, C. M., Bencherif, M., & Lukas, R. J. (1998) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37658-x · Cited by 136 · see citing works
Striatal α6* Nicotinic Acetylcholine Receptors: Potential Targets for Parkinson’s Disease Therapy
Quik, M., & McIntosh, J. M. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.094375 · Cited by 127 · see citing works
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Zachariou, V. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00224-4 · Cited by 115 · see citing works
Lin, L., Jeanclos, E. M., Treuil, M. W., Braunewell, K., Gundelfinger, E. D., & Anand, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206857200 · Cited by 105 · see citing works
Parker, S. L., Fu, Y., McAllen, K., Luo, J., McIntosh, J. M., Lindstrom, J. M., & Sharp, B. M. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.3.611 · Cited by 105 · see citing works
Inside-out neuropharmacology of nicotinic drugs
Henderson, B. J., & Lester, H. A. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.01.022 · Cited by 102 · see citing works
Lai, A., Parameswaran, N., Khwaja, M., Whiteaker, P., Lindstrom, J. M., Fan, H., McIntosh, J. M., Grady, S. R., & Quik, M. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.006429 · Cited by 112 · see citing works
Klein, L. C., Stine, M. M., Vandenbergh, D. J., Whetzel, C. A., & Kamens, H. M. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.01.005 · Cited by 95 · see citing works
Quik, M., Perez, X. A., & Grady, S. R. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.06.001 · Cited by 94 · see citing works
Tomizawa, M., & Casida, J. E. (2000) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2000.9057 · Cited by 94 · see citing works
In vivo Brain Imaging of Human Exposure to Nicotine and Tobacco
Sharma, A., & Brody, A. L. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-69248-5_6 · Cited by 88 · see citing works
Mugnaini, M., Tessari, M., Tarter, G., Merlo Pich, E., Chiamulera, C., & Bunnemann, B. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02220.x · Cited by 88 · see citing works
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Ursula, H. W.-S. (2007) · Frontiers in bioscience · doi:10.2741/2708 · Cited by 89 · see citing works
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Li, X., & Wang, H. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.08.031 · Cited by 84 · see citing works
Falk, L. L., Nordberg, A. K., Seiger, Å., Kjældgaard, A., & Hellström‐Lindahl, E. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.12.049 · Cited by 82 · see citing works
Smoking kills (alcoholics)! shouldn't we do something about it?
Littleton, J., Barron, S., Prendergast, M., & Nixon, S. J. (2007) · Alcohol and Alcoholism · doi:10.1093/alcalc/agm019 · Cited by 82 · see citing works
Hellström‐Lindahl, E., Moore, H., & Nordberg, A. K. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740777.x · Cited by 81 · see citing works
Nicotinic acetylcholine receptors: an overview on drug discovery
D’hoedt, D., & Bertrand, D. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220902841045 · Cited by 79 · see citing works
Whiteaker, P., Sharples, C. G. V., & Wonnacott, S. (1998) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)13263-4 · Cited by 152 · see citing works
Nicotine addiction: insights from recent animal studies
Mathieu-Kia, A.-M., Kellogg, S. H., Butelman, E. R., & Kreek, M. J. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1096-0 · Cited by 62 · see citing works
Neurochemical alterations produced by daily nicotine exposure in periadolescent vs. adult male rats
Collins, S. L., Wade, D., Ledon, J., & Izenwasser, S. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.08.039 · Cited by 62 · see citing works
Nicotinic receptor agonists and antagonists increase sAPPα secretion and decrease Aβ levels in vitro
Mousavi, M. T., & Hellström‐Lindahl, E. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.12.001 · Cited by 60 · see citing works
Behavioral and Molecular Analysis of Nicotine-Conditioned Place Preference in Zebrafish
Kedikian, X., Faillace, M. P., & Bernabeu, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069453 · Cited by 59 · see citing works
Gould, T. J., Portugal, G. S., André, J. M., Tadman, M. P., Marks, M. J., Kenney, J. W., Yildirim, E., & Adoff, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.003 · Cited by 56 · see citing works
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Self-citationVerbois, S. L., Hopkins, D. M., Scheff, S. W., & Pauly, J. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00206-9 · Cited by 56 · see citing works
Self-citationNicotine: Alcohol Reward Interactions
Lajtha, Á., & Sershen, H. W. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0181-8 · Cited by 55 · see citing works
Atomoxetine Reverses Nicotine Withdrawal-Associated Deficits in Contextual Fear Conditioning
Davis, J. A., & Gould, T. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301315 · Cited by 52 · see citing works
Potential therapeutic uses of mecamylamine and its stereoisomers
Nickell, J. R., Grinevich, V. P., Siripurapu, K. B., Smith, A. M., & Dwoskin, L. P. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.04.005 · Cited by 52 · see citing works
Nicotine Administration Induced Changes in the Gonadal Functions in Male Rats
Kavitharaj, N. K., & Vijayammal, P. L. (1998) · Pharmacology · doi:10.1159/000028262 · Cited by 53 · see citing works
Neurophysiology of Nicotine Addiction
Dani, J. A., Jenson, D., & Broussard, J. I. (2012) · Journal of Addiction Research & Therapy · doi:10.4172/2155-6105.s1-001 · Cited by 53 · see citing works
Hellström‐Lindahl, E., Seiger, Å., Kjældgaard, A., & Nordberg, A. K. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00209-3 · Cited by 52 · see citing works
Huang, L. Z., Abbott, L. C., & Winzer‐Serhan, U. H. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.03.008 · Cited by 54 · see citing works
Huang, L. Z., & Winzer‐Serhan, U. H. (2006) · Brain Research · doi:10.1016/j.brainres.2006.06.084 · Cited by 52 · see citing works
Poorthuis, R. B., & Mansvelder, H. D. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.07.003 · Cited by 48 · see citing works
Arthur, D. B., & Levin, E. (2002) · Psychopharmacology · doi:10.1007/s00213-001-0961-6 · Cited by 49 · see citing works
Terry, A. V., Gearhart, D. A., Mahadik, S. P., Warsi, S., Davis, L. W., & Waller, J. L. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.006 · Cited by 49 · see citing works
Christensen, D. Z., Mikkelsen, J. D., Hansen, H. H., & Thomsen, M. S. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06845.x · Cited by 46 · see citing works
Shacka, J. J., & Robinson, S. E. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00564-2 · Cited by 46 · see citing works
Self-citationVerbois, S. L. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(02)00366-0 · Cited by 46 · see citing works
Determinants of nicotine self-administration
Shoaib, M. C. (1996) · Drug Development Research · doi:10.1002/(sici)1098-2299(199607/08)38:3/4 · Cited by 7 · see citing works
Self-citationGarcia‐Ratés, S., Camarasa, J., Escubedo, E., & Pubill, D. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.05.015 · Cited by 43 · see citing works
Involvement of cholinergic mechanisms in the behavioral effects of dietary fat consumption
Morganstern, I., Ye, Z., Liang, S., Fagan, S. E., & LEIBOWITZ, S. F. (2012) · Brain Research · doi:10.1016/j.brainres.2012.06.004 · Cited by 42 · see citing works
Brain Nicotinic Acetylcholine Receptor Availability and Response to Smoking Cessation Treatment
Brody, A. L., Mukhin, A. G., Mamoun, M. S., Luu, T., Neary, M. K., Liang, L., Shieh, J., Sugar, C. A., Rose, J. E., & Mandelkern, M. A. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.138 · Cited by 42 · see citing works
Peripheral involvement in nicotine-induced enhancement of ethanol intake
Ericson, M., Engel, J. A., & Söderpalm, B. (2000) · Alcohol · doi:10.1016/s0741-8329(99)00099-3 · Cited by 41 · see citing works
Sex differences in conditioned nicotine reward are age-specific
Lenoir, M., Starosciak, A. K., Ledon, J., Booth, C., Zakharova, E., Wade, D., Vignoli, B., & Izenwasser, S. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.02.019 · Cited by 40 · see citing works
Neonicotinoids and Derivatives: Effects in Mammalian Cells and Mice
Tomizawa, M. (2004) · Journal of Pesticide Science · doi:10.1584/jpestics.29.177 · Cited by 40 · see citing works
Avila, A. M., Dávila‐García, M. I., Ascarrunz, V. S., Xiao, Y., & Kellar, K. J. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.4.974 · Cited by 40 · see citing works
Quik, M., Polonskaya, Y., Gillespie, A. J., Lloyd, G. K., & Langston, J. W. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00244-x · Cited by 40 · see citing works
Cormier, A., Paas, Y., Zini, R., Tillement, J. P., Lagrue, G., Changeux, J., & Grailhe, R. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.000463 · Cited by 40 · see citing works
Marks, M. J., Pauly, J. R., Grun, E. U., & Collins, A. C. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(96)00027-7 · Cited by 39 · see citing works
Self-citationPerez, X. A., O’Leary, K. T., Parameswaran, N., McIntosh, J. M., & Quik, M. (2009) · Molecular Pharmacology · doi:10.1124/mol.108.053801 · Cited by 38 · see citing works
Hypersensitive knockin mouse strains identify receptors and pathways for nicotine action.
Lester, H. A., Fonck, C., Tapper, A. R., McKinney, S. L., Damaj, M. I., Balogh, S. A., Owens, J. C., Wehner, J. M., Collins, A. C., & Labarca, C. G. (2003) · PubMed · Cited by 34 · see citing works
Self-citationHoft, N. R., Stitzel, J. A., Hutchison, K. E., & Ehringer, M. A. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00650.x · Cited by 33 · see citing works
Moen, J. K., & Lee, A. M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.745783 · Cited by 30 · see citing works
Hosur, V., Leppanen, S., Taha, A. A., & Loring, R. H. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06373.x · Cited by 29 · see citing works
Dávila‐García, M. I., Houghtling, R. A., Qasba, S. S., & Kellar, K. J. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00344-1 · Cited by 28 · see citing works
Fox-Loe, A. M., Moonschi, F. H., & Richards, C. I. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.661827 · Cited by 27 · see citing works
Pharmacological and histological characterisation of nicotine-kindled seizures in mice
Bastlund, J. F., Berry, D. J., & Watson, W. P. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.01.015 · Cited by 27 · see citing works
Lange‐Asschenfeldt, C., Schäble, S., Suvorava, T., Gholamreza-Fahimi, E., Bisha, M., Stermann, T., Henning, U., & Kojda, G. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.03.025 · Cited by 26 · see citing works
Levin, E. D., Tizabi, Y., Rezvani, A. H., Caldwell, D. P., Petro, A. E., & Getachew, B. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.104 · Cited by 26 · see citing works
Demonstration of functional α4-containing nicotinic receptors in the medial habenula
Fonck, C., Nashmi, R., Salas, R., Zhou, C., Huang, Q., Biasi, M. D., Lester, R. A. J., & Lester, H. A. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.021 · Cited by 26 · see citing works
Visanji, N. P., Mitchell, S. N., O'Neill, M. J., & Duty, S. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.07.013 · Cited by 25 · see citing works
Vivekanandarajah, A., Waters, K. A., & Machaalani, R. (2018) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2018.07.007 · Cited by 25 · see citing works
McCallum, S. E., Caggiula, A. R., Epstein, L. H., Saylor, S., Ploskina, T., & Sved, A. F. (1999) · Psychopharmacology · doi:10.1007/s002130050842 · Cited by 24 · see citing works
Nicotine-mecamylamine interactions
Zevin, S. (2000) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2000.108066 · Cited by 24 · see citing works
Ding, Z., Katner, S. N., Rodd, Z. A., Truitt, W. A., Hauser, S. R., Deehan, G. A., Engleman, E. A., & McBride, W. J. (2012) · Alcohol · doi:10.1016/j.alcohol.2011.11.007 · Cited by 22 · see citing works
Involvement of Nicotinic Receptors in Methamphetamine- and Mdma-Induced Neurotoxicity
Escubedo, E., Camarasa, J., Chipana, C., Garcia‐Ratés, S., & Pubill, D. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)88006-9 · Cited by 22 · see citing works
Locker, A. R., Marks, M. J., Kamens, H. M., & Klein, L. C. (2015) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.09.009 · Cited by 22 · see citing works
Self-citationLeonard, S. S. (2003) · Drug Development Research · doi:10.1002/ddr.10292 · Cited by 23 · see citing works
Brody, A. L., Hubert, R., Mamoun, M. S., Enoki, R., Garcia, L. Y., Abraham, P., Young, P., & Mandelkern, M. A. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4367-x · Cited by 21 · see citing works
Kamens, H. M., Miyamoto, J. H., Powers, M. S., Ro, K., Soto, M., Cox, R. J., Stitzel, J. A., & Ehringer, M. A. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.08.035 · Cited by 20 · see citing works
Löf, E., Chau, P., Stomberg, R., & Söderpalm, B. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.10.056 · Cited by 20 · see citing works
Nicotine Acts on Cholinergic Signaling Mechanisms to Directly Modulate Choroid Plexus Function
Lallai, V., Grimes, N. P., Fowler, J. P., Sequeira, P. A., Cartagena, P. M., Limón, A., Coutts, M., Monuki, E. S., Bunney, W. E., Demuro, A., et al. (2019) · eNeuro · doi:10.1523/eneuro.0051-19.2019 · Cited by 19 · see citing works
Varani, A. P., Pedrón, V. T., Moutinho, L. M., Antonelli, M. C., Bettler, B., & Balerio, G. N. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.013 · Cited by 17 · see citing works
Bordia, T., McGregor, M., McIntosh, J. M., Drenan, R. M., & Quik, M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.040 · Cited by 17 · see citing works
Wang, J., Spiegel, N., Bertelsen, S. E., Le, N., McKenna, N. P., Budde, J., Harari, O., Kapoor, M., Brooks, A. I., Hancock, D. B., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080204 · Cited by 17 · see citing works
Gözen, O., Nesil, T., Kanıt, L., Koylu, E. O., & Pöğün, Ş. (2016) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2016.1198799 · Cited by 17 · see citing works
Mahmood, H. M., Aldhalaan, H., Alshammari, T. K., Alqasem, M., Alshammari, M. A., Albekairi, N. A., & AlSharari, S. D. (2020) · Autism Research · doi:10.1002/aur.2342 · Cited by 17 · see citing works
- Authors
- Pauly, J. R., Marks, M. J., Robinson, S. F., van de Kamp, J. L., & Collins, A. C.
- Affiliations
- Augusta University (US)
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1996-07
- Volume
- 278
- Issue
- 1
- Pages
- 361-369
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W1820461132
- Cited by
- 126
- References
- 0
- Citations by year
- 2022: 2 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 9 · 2014: 3 · 2013: 8 · 2012: 7
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Funders
- National Institutes of Health (5k05da000197-07)
- National Institute on Drug Abuse (DA 03194, DA00197, R01DA003194)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotinic acetylcholine receptors, chronic nicotine treatment, mecamylamine, receptor mRNA expression, receptor up-regulation, DBA/2 mice
- MeSH terms
- Animals, Autoradiography, Binding, Competitive, Brain, Female, Mecamylamine, Mice, Inbred DBA, Nicotine, RNA, Messenger, Up-Regulation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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