Neurochemical alterations produced by daily nicotine exposure in periadolescent vs. adult male rats

Collins, Stephanie L.; Wade, Dean; Ledon, Jennifer; Izenwasser, Sari

doi:10.1016/j.ejphar.2004.08.039

Cited by 62Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationNeurotransmitter Receptor Influence on Behavior

Neurochemical alterations produced by daily nicotine exposure in periadolescent vs. adult male rats

Collins, Stephanie L., Wade, Dean, Ledon, Jennifer, Izenwasser, Sari·2004·European Journal of Pharmacology

DOI 10.1016/j.ejphar.2004.08.039

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Abstract

Chronic treatment with nicotine differentially alters behavior in adolescent rats compared to adult rats. It is not known, however, whether the effects of nicotine on the neurochemical pathways with which it interacts differ in adolescents vs. adults. In the current study, the effects of a 7-day treatment with nicotine on nicotinic, dopaminergic, and serotonergic neurochemistry were examined in the caudate putamen and nucleus accumbens in periadolescent vs. adult male rats. Nicotine treatment increased dopamine transporter densities and decreased serotonin transporter densities in periadolescent rats. There was no change in nicotinic acetylcholine receptor densities or dopamine D1 or D2 receptor densities in nicotine-pretreated periadolescent rats. In adult rats pretreated with nicotine, there was an increase in nicotinic acetylcholine densities, but no change in dopamine transporter, dopamine D1 or D2 receptor, or serotonin transporter densities. Overall, these findings show that periadolescent rats have neurochemical adaptations to nicotine different from adult rats. These alterations may explain, at least in part, the differential behavioral effects of chronic nicotine in adult and adolescent male rats.

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Very few age differences have been reported in the effect of chronic nicotine on presynaptic markers of dopaminergic function.
“Although striatal dopamine transporters have been reported to be upregulated by nicotine in adolescents but not adults, very few age differences have been reported in the effect of chronic nicotine on presynaptic markers of dopaminergic function (Collins et al. 2004; Dao et al. 2011).”
From <scp>N</scp> icotine and the adolescent brain (2015) · cites this paper as Collins et al. 2004
Striatal dopamine transporters are upregulated by nicotine in adolescents but not adults.
“Although striatal dopamine transporters have been reported to be upregulated by nicotine in adolescents but not adults, very few age differences have been reported in the effect of chronic nicotine on presynaptic markers of dopaminergic function (Collins et al. 2004; Dao et al. 2011).”
From <scp>N</scp> icotine and the adolescent brain (2015) · cites this paper as Collins et al. 2004

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Authors: Collins, S. L., Wade, D., Ledon, J., & Izenwasser, S.
Affiliations: University of Miami (US)
Corresponding author: Izenwasser, Sari
ORCID: Collins, Stephanie L.
Izenwasser, Sari
Venue: European Journal of Pharmacology
Publisher: Elsevier BV
Published: 2004-10
Volume: 502
Issue: 1-2
Pages: 75-85
ISSN: 0014-2999 (ISSN-L)
DOI: 10.1016/j.ejphar.2004.08.039
OpenAlex: W1992022133
Cited by: 62
References: 71
Citations by year: 2025: 2 · 2022: 2 · 2020: 4 · 2019: 5 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 2
FWCI: 1.89
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Pharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Drug Abuse (DA 15947, R21DA013936, DA13936, F32DA015947, DA 15119, R01DA015119)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: nicotine, adolescent nicotine exposure, caudate-putamen, nucleus accumbens, nicotinic acetylcholine receptors, dopamine transporter, dopamine D1 receptor, dopamine D2 receptor, serotonin transporter
MeSH terms: Aging, Animals, Caudate Nucleus, Drug Administration Schedule, Male, Membrane Glycoproteins, Nerve Tissue Proteins, Nicotine, Nucleus Accumbens, Protein Binding, Putamen, Receptors, Dopamine, Rats, Sprague-Dawley, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins, Rats

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Neurochemical alterations produced by daily nicotine exposure in periadolescent vs. adult male rats

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