Genetic background influences the effects of withdrawal from chronic nicotine on learning and high-affinity nicotinic acetylcholine receptor binding in the dorsal and ventral hippocampus
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Rationale The effects of nicotine on cognitive processes may play an important role in nicotine addiction. Nicotine withdrawal impairs hippocampus-dependent learning and genetic factors influence this effect. However, the neural changes that contribute to these impairments are unknown. Chronic nicotine upregulates hippocampal nicotinic acetycholine receptors (nAChRs), which may contribute to cognitive deficits when nicotine administration ceases. If nAChR upregulation underlies withdrawal deficits in learning, then strains of mice exhibiting withdrawal deficits in hippocampus-dependent learning should also show upregulation of hippocampal nAChRs.Objectives Here, we examined the effects of nicotine withdrawal on fear conditioning and [(3)H]epibatidine binding in the dorsal and ventral hippocampus in two inbred mouse strains and their F1 hybrids.Methods Male C57BL/6NTac, 129S6/SvEvTac, and B6129SF1/Tac mice were administered chronic nicotine (18 mg/kg/day) for 12 days through osmotic pumps and then were trained and tested in fear conditioning 24 h after cessation of nicotine treatment.Results Nicotine withdrawal impaired hippocampus-dependent contextual conditioning in C57BL/6NTac mice but not 129S6/SvEvTac or B6129SF1/Tac mice; no changes were observed in hippocampus-independent cued fear conditioning. Upregulated [(3)H]epibatidine binding was found in the dorsal, but not ventral, hippocampus of C57BL/6NTac mice and in the ventral hippocampus of B6129SF1/Tac mice after chronic nicotine.Conclusions Upregulation of high-affinity binding sites in the dorsal hippocampus of C57BL/6NTac mice, the only strain that exhibited nAChR upregulation in this region and withdrawal deficits in contextual conditioning, suggests that upregulation of high-affinity binding sites in the dorsal hippocampus mediates, in part, nicotine withdrawal deficits in contextual conditioning and genetic background modulates these effects.
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Previous work has shown that while nicotine withdrawal at the same dose significantly impairs hippocampal-dependent contextual learning in C57/Bl6 mice, the 129SvEv;C57Bl/6J F1 hybrid mice utilized in these studies do not exhibit learning impairments.
“our previous work has shown that while nicotine withdrawal at the same dose significantly impairs hippocampal-dependent contextual learning in C57/Bl6 mice, the 129SvEv;C57Bl/6J F1 hybrid mice utilized in these studies do not exhibit learning impairments (Wilkinson et al, 2013).”
From Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal (2013) · cites this paper as Wilkinson et al, 2013
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Cognitive function during nicotine withdrawal: Implications for nicotine dependence treatment
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- Authors
- Wilkinson, D. S., Turner, J. R., Blendy, J. A., & Gould, T. J.
- Affiliations
- Temple University (US)
- University of Pennsylvania (US)
- Corresponding author
- Gould, Thomas J.
- Venue
- Psychopharmacology
- Published
- 2012-07-27
- Volume
- 225
- Issue
- 1
- Pages
- 201-208
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC3755015
- OpenAlex
- W1991057698
- Cited by
- 32
- References
- 60
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 7 · 2015: 4 · 2014: 9 · 2013: 3
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (F32DA026236, DA017949, R01DA017949, R00DA032681, K99DA032681, DA024787, DA024787-01A1S1, DA026236, R01DA024787)
- National Cancer Institute (CA-143187, P50CA143187)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- nicotine withdrawal, chronic nicotine, nicotinic acetylcholine receptors, hippocampus-dependent learning, fear conditioning, contextual conditioning, dorsal hippocampus, ventral hippocampus, epibatidine binding, inbred mouse strains, genetic background, nicotine dependence
- MeSH terms
- Animals, Binding Sites, Conditioning, Psychological, Fear, Hippocampus, Male, Mice, Inbred C57BL, Nicotine, Pyridines, Receptors, Nicotinic, Species Specificity, Substance Withdrawal Syndrome, Tobacco Use Disorder, Up-Regulation, Nicotinic Agonists, Bridged Bicyclo Compounds, Heterocyclic, Mice, Mice, 129 Strain
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