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Cited by 93Sleep and Wakefulness ResearchVagus Nerve Stimulation ResearchNeuroscience of respiration and sleep

Somnogenic and pyrogenic effects of interleukin-1β and lipopolysaccharide in intact and vagotomized rats

Opp, Mark R., Toth, Linda A.·1998·Life Sciences
DOI 10.1016/s0024-3205(98)00010-1
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Abstract

The vagus nerve appears to serve a role in mediating peripheral immunologic influences on CNS processes. Previous work demonstrates that subdiaphragmatic vagotomy prevents or attenuates many of the behavioral and physiological responses to exogenous interleukin-1 (IL-1) or lipopolysaccharide (LPS). We determined whether the somnogenic effects of IL-1 and LPS were altered in vagotomized rats, and whether the effects of vagotomy on IL-1- and LPS-induced alterations in sleep would vary as a function of circadian phase. The data indicate that vagotomy does not influence the normal circadian patterns of sleep and wakefulness in untreated rats, or modify the pyrogenic or somnogenic effects of intracerebroventricular administration of IL-1. However, in unchallenged animals vagotomy reduces basal brain temperatures, increases delta wave amplitudes during slow-wave sleep (SWS), and induces a reduced rate of weight gain, gastric distension, and adrenal hypoplasia. Vagotomy attenuates the febrile effects of IL-1 during both light and dark phases, attenuated IL-1-induced sleep enhancement during the dark phase, and attenuated IL-1-induced increases in delta wave amplitudes within SWS during the light period. In LPS-treated rats, vagotomy attenuates the febrile and SWS responses to LPS after administration at light onset, but not after administration at dark onset. These results indicate that subdiaphragmatic vagotomy attenuates several of the somnogenic and pyrogenic effects of IL-1beta and LPS, although the effectiveness of the vagal transection in modulating these responses is influenced by circadian factors.

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  • Depending on dose and/or timing, IL1- or LPS-induced alterations in sleep are blocked or attenuated in animals subjected to vagotomy.

    “Depending on factors such as dose and/or timing, IL1or LPS-induced alterations in sleep are blocked or attenuated in animals subjected to vagotomy”

    From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Opp and Toth, 1998

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Authors
Opp, M. R., & Toth, L. A.
Affiliations
  • The University of Texas Medical Branch at Galveston (US)
  • St. Jude Children's Research Hospital (US)
Corresponding author
Opp, Mark R.
ORCID
Opp, Mark R.
Venue
Life Sciences
Publisher
Elsevier BV
Published
1998-01
Volume
62
Issue
10
Pages
923-936
ISSN
0024-3205 (ISSN-L)
DOI
10.1016/s0024-3205(98)00010-1
OpenAlex
W1994715351
Cited by
93
References
33
Citations by year
2025: 1 · 2024: 2 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 6 · 2012: 3
FWCI
4.69
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Life Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (7r01mh054976-06, 5r01ns026429-10, 7r29mh052275-06)
  • National Institute of Mental Health (MH52275, MH 54976)
  • National Institute of Neurological Disorders and Stroke (NS-26429)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords
vagotomy, vagus nerve, IL-1β, lipopolysaccharide, sleep, fever, circadian rhythm, slow-wave sleep, delta oscillations, brain temperature, adrenal hypoplasia, intracerebroventricular administration
MeSH terms
Animals, Brain, Electroencephalography, Fever, Injections, Intraventricular, Interleukin-1, Lipopolysaccharides, Male, Sleep, Vagotomy, Rats, Sprague-Dawley, Rats

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