Sepsis-induced alterations in sleep of rats
Open accessAbstract
Sepsis is a systemic immune response to infection that may result in multiple organ failure and death. Polymicrobial infections remain a serious clinical problem, and in the hospital, sepsis is the number-one noncardiac killer. Although the central nervous system may be one of the first systems affected, relatively little effort has been made to determine the impact of sepsis on the brain. In this study, we used the cecal ligation and puncture (CLP) model to determine the extent to which sepsis alters sleep, the EEG, and brain temperature (Tbr) of rats. Sepsis increases the amount of time rats spend in non-rapid eye movement sleep (NREMS) during the dark period, but not during the light period. Rapid eye movements sleep (REMS) of septic rats is suppressed for about 24 h following CLP surgery, after which REMS increases during dark periods for at least three nights. The EEG is dramatically altered shortly after sepsis induction, as evidenced by reductions in slow-frequency components. Furthermore, sleep is fragmented, indicating that the quality of sleep is diminished. Effects on sleep, the EEG, and Tbr persist for at least 84 h after sepsis induction, the duration of our recording period. Immunohistochemical assays focused on brain stem mechanisms responsible for alterations in REMS, as little information is available concerning infection-induced suppression of this sleep stage. Our immunohistochemical data suggest that REMS suppression after sepsis onset may be mediated, in part, by the brain stem GABAergic system. This study demonstrates for the first time that sleep and EEG patterns are altered during CLP-induced sepsis. These data suggest that the EEG may serve as a biomarker for sepsis onset. These data also contribute to our knowledge of potential mechanisms, whereby infections alter sleep and other central nervous system functions.
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Sleep is altered during the acute phase of CLP sepsis, which occurs from 1 to 4 days after sepsis induction.
“Sleep is altered during the acute phase of CLP sepsis, which occurs from 1 to 4 days after sepsis induction (Baracchi et al, 2011).”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Baracchi et al, 2011
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Sepsis-Induced Brain State InstabilityPreprint
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Sleep Deterioration in Survivors of Community-Acquired Pediatric Septic Shock at 3-Month Follow-up
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Impact of prenatal LPS on sepsis-related neurobiological outcomes
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- Authors
- Baracchi, F., Ingiosi, A. M., Raymond, R. M., & Opp, M. R.
- Affiliations
- Department of Anesthesiology,
- Neuroscience Graduate Program, and
- University of Michigan (US)
- Corresponding author
- Opp, Mark R.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2011-11
- Volume
- 301
- Issue
- 5
- Pages
- R1467-R1478
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- PMC
- PMC3213944
- OpenAlex
- W2104211593
- Cited by
- 42
- References
- 63
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 6 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL080972, HL080972)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Keywords
- sepsis, sleep, REM sleep suppression, NREM sleep, EEG changes, brain temperature, cecal ligation and puncture, GABAergic system, brainstem, sleep fragmentation, sepsis biomarkers
- MeSH terms
- Animals, Behavior, Animal, Body Temperature, Brain, Cecum, Circadian Rhythm, Disease Models, Animal, Electroencephalography, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Immunohistochemistry, Ligation, Male, Punctures, Sleep Wake Disorders, Sleep Stages, Sleep, REM, Time Factors, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Photoperiod, Sepsis, Rats
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