The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Postural Orthostatic Tachycardia Syndrome: The Mayo Clinic Experience
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In the citing paper
“and more than 75% are female.7–9,11–14,16”
In the citing paper
“The symptoms associated with POTS are those that occur with standing, such as lightheadedness and palpitations; not associated with particular postures, such as bloating, nausea, diarrhea, and abdominal pain; and systemic, such as fatigue, sleep disturbance, and migraine headaches.7”
In the citing paper
“Most patients present with POTS between the ages of 15 and 25 years,7”
In the citing paper
“It is a useful biomarker in that it identifies patients who respond better to beta blockers.11”
From Hyperadrenergic Postural Tachycardia Syndrome: Clinical Biomarkers and Response to Guanfacine (2024) · cites this paper as [11]
In the citing paper
“The typical demographic is young women (mean age 30.2 Æ 10.3 years, 86% women)”
From Postural Orthostatic Tachycardia Syndrome (2019) · cites this paper as [6]
In the citing paper
“with an average HR increment of 44.2 Æ 13.2 beats/min from supine to upright (6)”
From Postural Orthostatic Tachycardia Syndrome (2019) · cites this paper as [6]
In the citing paper
“It is frequently preceded by symptoms of a viral illness (in 42%) or may occur post-operatively (in 9.5%) (6).”
From Postural Orthostatic Tachycardia Syndrome (2019) · cites this paper as [6]
In the citing paper
“The onset of POTS can be subacute (13.8%), insidious (5.9%), or acute (12.5%).”
From Postural Orthostatic Tachycardia Syndrome (2019) · cites this paper as [6]
In the citing paper
“In one study, >50% of POTS patients (6) were noted to have loss of sweat function in distal lower extremities (32), measured as impaired sweat volume on quantitative sudomotor axon reflex testing (32) or reduced intraepidermal C-fiber density on skin biopsy (33).”
From Postural Orthostatic Tachycardia Syndrome (2019) · cites this paper as [6]
In the citing paper
“When sodium intake is controlled, urine sodium excretion can be used as a surrogate for hypovolemia, and approximately 30% of POTS patients have evidence of hypovolemia based on <100 mEq of urinary sodium excretion in 24 h (6).”
From Postural Orthostatic Tachycardia Syndrome (2019) · cites this paper as [6]
In the citing paper
“Another large subgroup within the POTS population is the so-called hyperadrenergic subtype, with features that may correspond to 30% to 60% of POTS patients (6,36,37).”
From Postural Orthostatic Tachycardia Syndrome (2019) · cites this paper as [6]
In the citing paper
“These patients have elevated standing plasma norepinephrine (NE) levels (>600 pg/ml), reflecting an exaggerated sympathetic response (6,36),”
From Postural Orthostatic Tachycardia Syndrome (2019) · cites this paper as [6]
In the citing paper
“Women with POTS often report fluctuations in the severity of POTS symptoms throughout their menstrual cycle, with worsening during either the pre-menstrual or early follicular phase when both estrogen and progesterone levels are dropping or low (6,9,45,51).”
From Postural Orthostatic Tachycardia Syndrome (2019) · cites this paper as [6]
In the citing paper
“A frequently described comorbidity in POTS patients is migraine, as well as other chronic headache types (6,65,72,73).”
From Postural Orthostatic Tachycardia Syndrome (2019) · cites this paper as [6]
In the citing paper
“Chronic fatigue has been cited in up to 48% of POTS patients (6), and patients with CFS often have POTS as well (81).”
From Postural Orthostatic Tachycardia Syndrome (2019) · cites this paper as [6]
In the citing paper
“The presentation seems to have two patterns – acute onset after one of the above triggers or with slowly progressive symptoms over a longer period of time (Thieben et al., 2007).”
From Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1 (2021) · cites this paper as Thieben et al., 2007
In the citing paper
“A low titer of an antibody to the ganglionic acetylcholine receptor (nAChR) was reported in 15% of adult POTS patients evaluated at the Mayo Clinic between 1993 and 2003 [26].”
From Postural tachycardia syndrome: beyond orthostatic intolerance (2015) · cites this paper as [26]
In the citing paper
“Patients frequently report symptom onset following acute stressors (e.g., pregnancy, a traumatic event, surgery, or a viral illness) [2;26].”
From Postural tachycardia syndrome: beyond orthostatic intolerance (2015) · cites this paper as [26]
In the citing paper
“Symptoms can be exacerbated by simple activities of daily life like standing still, exercise, food or alcohol ingestion, or heat exposure [26].”
From Postural tachycardia syndrome: beyond orthostatic intolerance (2015) · cites this paper as [26]
In the citing paper
“Although the successful off-label use of different medications might be expected to be influenced by the POTS subtype, Thieben et al. did not find this to be true with a variety of medications [26].”
From Postural tachycardia syndrome: beyond orthostatic intolerance (2015) · cites this paper as [26]
In the citing paper
“Autonomic problems in POTS might include gastrointestinal complaints, such as abdominal pain, nausea and irritable bowel syndrome, as well as bladder symptoms and abnormal sudomotor regulation [19;26].”
From Postural tachycardia syndrome: beyond orthostatic intolerance (2015) · cites this paper as [26]
In the citing paper
“The prevalence of anti-gAChR antibodies in this study was higher than that in previous study.17”
From Autoimmune postural orthostatic tachycardia syndrome (2018) · cites this paper as [17]
In the citing paper
“approximately 50% of POTS patients evaluated at tertiary care centers exhibit a neuropathic phenotype associated with partial sympathetic denervation, usually due to a distal small fiber neuropathy producing sympathetic denervation of the lower limbs”
From Postural tachycardia syndrome – Diagnosis, physiology, and prognosis (2018) · cites this paper as Thieben et al., 2007
In the citing paper
“An initial study reported a low titer of ganglionic acetylcholine receptor (AChR) antibodies in the serum of approximately 15% of POTS patients (Thieben et al., 2007).”
From Postural tachycardia syndrome – Diagnosis, physiology, and prognosis (2018) · cites this paper as Thieben et al., 2007
In the citing paper
“In support of the hypothesis that this is one mechanism in hEDS, a study by Thieben et al. [2007] identified a hyperadrenergic state in 29% of cases of POTS from a general cohort though cases of hEDS were not specifically identified.”
From Cardiovascular autonomic dysfunction in Ehlers–Danlos syndrome—Hypermobile type (2017) · cites this paper as Thieben et al. [2007]
In the citing paper
“These confirm prior findings, but now establish them in a cohort that is many times larger than prior studies that have detailed the clinical characteristics of POTS patients 17, 18, 22, 36.”
From The face of postural tachycardia syndrome – insights from a large cross‐sectional online community‐based survey (2019) · cites this paper as [17]
In the citing paper
“Other studies have reported similar findings 17, 18.”
From The face of postural tachycardia syndrome – insights from a large cross‐sectional online community‐based survey (2019) · cites this paper as [17]
In the citing paper
“A characteristic patient with POTS is a young woman about 25 years old, reporting first symptoms at age around 15 years, although the range of disease onset may extend until fifth decade of life and one-fifth are men [21,22].”
From Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management (2019) · cites this paper as [21]
In the citing paper
“However, a substantial number of POTS patients do not report any triggering event and experience rather slowly progressing or even stationary symptoms over a long period of time [21].”
From Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management (2019) · cites this paper as [21]
In the citing paper
“POTS has been shown to have a prevalence of 0.2% in cohort studies31–33 and predominately affects females at a 5:1 ratio.31,34–36”
From Sinus Tachycardia: a Multidisciplinary Expert Focused Review (2022) · cites this paper as [34]
In the citing paper
“The vast majority are young, with a mean age of presentation between 15–3034,36.”
From Sinus Tachycardia: a Multidisciplinary Expert Focused Review (2022) · cites this paper as [34]
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Metadata
- Authors
- Thieben, M. J., Sandroni, P., Sletten, D. M., Benrud-Larson, L. M., Fealey, R. D., Vernino, S., Low, P. A., Lennon, V. A., & Shen, W.-K.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Low, Phillip A.
- Venue
- Mayo Clinic Proceedings
- Publisher
- Elsevier BV
- Published
- 2007-03
- Volume
- 82
- Issue
- 3
- Pages
- 308-313
- ISSN
- 0025-6196 (ISSN-L)
- OpenAlex
- W2113993848
- Cited by
- 516
- References
- 23
- Citations by year
- 2026: 16 · 2025: 28 · 2024: 31 · 2023: 33 · 2022: 36 · 2021: 34 · 2020: 41 · 2019: 29 · 2018: 38 · 2017: 34 · 2016: 26 · 2015: 27 · 2014: 29 · 2013: 30 · 2012: 17
- FWCI
- 16.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mayo Clinic Proceedings (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK068055, P01DK068055)
- National Institute of Neurological Disorders and Stroke (NS3 2352, P01NS044233, P50NS032352, NS-44233, NS4 3364, S11NS043364)
- National Center for Research Resources (M01-RR00858)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- postural orthostatic tachycardia syndrome, autonomic dysfunction, autoimmune etiology, hyperadrenergic state, norepinephrine, hypovolemia, urinary sodium, quantitative sudomotor axon reflex test, thermoregulatory sweat test, pathogenesis
- MeSH terms
- Adult, Autonomic Nervous System Diseases, Female, Humans, Hypotension, Orthostatic, Male, Minnesota, Retrospective Studies, Syndrome, Chi-Square Distribution
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