Cited by 66Diabetes Treatment and ManagementDiabetes Management and ResearchPancreatic function and diabetes

Gliclazide modified release: a critical review of pharmacodynamic, metabolic, and vasoprotective effects

Schernthaner, Guntram·2003·Metabolism

Abstract

Gliclazide modified release (MR) is a new formulation of the drug gliclazide and is given once daily. The specifically designed hydrophilic matrix of gliclazide MR leads to a progressive drug release that parallels the 24-hour glycemic profile in type 2 diabetic patients. Development studies showed a sustained efficacy over 2 years coupled with a very good acceptability. Gliclazide MR acts selectively on adenosine triphosphate-dependent potassium (K(ATP)) channels of the pancreatic beta cell. No interaction with cardiovascular K(ATP) channels has been shown, indicating that the drug can be safely used in patients with ischemic heart disease. In addition, gliclazide MR shows the ability to inhibit key mechanisms in diabetic angiopathy, independently of glycemic control.

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Crossref · 10.1016/s0026-0495(03)00215-4

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49 of 49 references verified0 citation errors · 0 not checkable

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  • The risk of hypoglycemia of each sulfonylurea relates to its pharmacokinetic properties and is highest with long-acting sulfonylureas such as chlorpropamide, glyburide (glibenclamide), and long-acting glipizide.

    “The risk of hypoglycemia of each sulfonylurea relates to its pharmacokinetic properties (104 -108) and is highest with long-acting sulfonylureas such as chlorpropamide, glyburide (glibenclamide), and long-acting glipizide (101,109 -111).”

    From Hypoglycemia in Type 2 Diabetes (2005) · cites this paper as [108]

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Authors
Schernthaner, G.
Affiliations
Krankenanstalt Rudolfstiftung der Stadt Wien (AT)
Corresponding author
Schernthaner, Guntram
Venue
Metabolism
Publisher
Elsevier BV
Published
2003-08
Volume
52
Issue
8 Suppl 1
Pages
29-34
ISSN
0026-0495 (ISSN-L)
OpenAlex
W2108941037
Cited by
66
References
49
Citations by year
2026: 1 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 9 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 3
FWCI
0.32
Type
journal article
Language
en
Open access
closed
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Keywords
gliclazide modified release, type 2 diabetes, sustained drug release, ATP-sensitive potassium channels, pancreatic beta cells, glycemic control, diabetic vascular disease, vascular protection, ischemic heart disease, drug metabolism, pharmacodynamics
MeSH terms
Delayed-Action Preparations, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Drug Administration Schedule, Gliclazide, Humans, Hypoglycemic Agents

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