The efficacy of self-monitoring of blood glucose in the management of patients with type 2 diabetes treated with a gliclazide modified release-based regimen. A multicentre, randomized, parallel-group, 6-month evaluation (DINAMIC 1 study)

Barnett, A. H.; Krentz, A. J.; Strojek, K.; Sieradzki, J.; Azizi, F.; Embong, M.; Imamoglu, S.; Perušičová, J.; Uličiansky, V.; Winkler, G.

doi:10.1111/j.1463-1326.2008.00894.x

Cited by 106Diabetes Management and ResearchDiabetes Treatment and ManagementDiabetes Management and Education

The efficacy of self-monitoring of blood glucose in the management of patients with type 2 diabetes treated with a gliclazide modified release-based regimen. A multicentre, randomized, parallel-group, 6-month evaluation (DINAMIC 1 study)

Barnett, A. H., Krentz, A. J., Strojek, K., Sieradzki, J., Azizi, F., Embong, M., Imamoglu, S., Perušičová, J. +2 more·2008·Diabetes, Obesity and Metabolism

DOI 10.1111/j.1463-1326.2008.00894.x

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Abstract

AIM: To determine if therapeutic management programmes for type 2 diabetes that include self-monitoring of blood glucose (SMBG) result in greater reductions in glycated haemoglobin (HbA1c) compared with programmes without SMBG in non-insulin requiring patients. METHODS: Multicentre, randomized, parallel-group trial. A total of 610 patients were randomized to SMBG or non-SMBG groups. Patients in both groups received the same oral antidiabetic therapy using a gliclazide modified release (MR)-based regimen for 27 weeks. The primary efficacy end-point was the difference between groups in HbA1c at the end of observation. RESULTS: A total of 610 patients were randomized: 311 to the SMBG group and 299 to the non-SMBG group. HbA1c decreased from 8.12 to 6.95% in the SMBG group and from 8.12 to 7.20% in the non-SMBG group; between-group difference was 0.25% (95% CI: 0.06, 1.03; p = 0.0097). Symptoms suggestive of mild to moderate hypoglycaemia was the most commonly reported adverse event, reported by 27 (8.7%) and 21 (7.0%) patients in the SMBG and non-SMBG groups, respectively; the incidence of symptomatic hypoglycaemia was lower in the SMBG group. CONCLUSION: In patients with type 2 diabetes, the application of SMBG as an adjunct to oral antidiabetic agent therapy results in further reductions in HbA1c.

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Current evidence on SMBG in insulin-naïve type 2 diabetic patients is mixed, with some studies showing significant glycemic benefits and others showing no significant benefits.
“Current evidence in this latter population is mixed, with some studies pointing to significant glycemic benefits resulting from SMBG use (8–10), while others have shown no significant benefits (11–13).”
From Structured Self-Monitoring of Blood Glucose Significantly Reduces A1C Levels in Poorly Controlled, Noninsulin-Treated Type 2 Diabetes (2011) · cites this paper as [10]

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Authors: Barnett, A. H., Krentz, A. J., Strojek, K., Sieradzki, J., Azizi, F., Embong, M., Imamoglu, S., Perušičová, J., Uličiansky, V., & Winkler, G.
Affiliations: National Health Service (GB)
University of Southampton (GB)
Medical University of Silesia (PL)
Jagiellonian University (PL)
Shahid Beheshti University (IR)
Universiti Sains Malaysia (MY)
Charles University (CZ)
University of Pavol Jozef Šafárik (SK)
Szent János Kórház (HU)
Corresponding author: Barnett, A. H.
ORCID: Krentz, A. J.
Strojek, K.
Azizi, F.
Venue: Diabetes, Obesity and Metabolism
Publisher: Wiley
Published: 2008-10-29
Volume: 10
Issue: 12
Pages: 1239-1247
ISSN: 1462-8902 (ISSN-L)
1463-1326
DOI: 10.1111/j.1463-1326.2008.00894.x
OpenAlex: W2171310746
Cited by: 106
References: 40
Citations by year: 2025: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 7 · 2015: 2 · 2014: 9 · 2013: 9 · 2012: 10
FWCI: 9.68
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Diabetes Obesity and Metabolism (publishedVersion)
PubMed (publishedVersion)
Bursa Uludag University - AVESIS (submittedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders: Servier
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
Keywords: self-monitoring of blood glucose, type 2 diabetes, gliclazide modified release, HbA1c, glycemic control, oral antidiabetic drugs, hypoglycemia
MeSH terms: Adult, Aged, Aged, 80 and over, Blood Glucose, Diabetes Mellitus, Type 2, Female, Gliclazide, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Insulin, Male, Middle Aged, Blood Glucose Self-Monitoring

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The efficacy of self-monitoring of blood glucose in the management of patients with type 2 diabetes treated with a gliclazide modified release-based regimen. A multicentre, randomized, parallel-group, 6-month evaluation (DINAMIC 1 study)

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