The motivational valence of nicotine in the rat ventral tegmental area is switched from rewarding to aversive following blockade of the α7-subunit-containing nicotinic acetylcholine receptor

Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions

Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229 · see citing works

The rat brain in stereotaxic coordinates (2nd edn)

Herman, J. P., & Watson, S. J. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90017-8 · Cited by 1,751 · see citing works

Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

Picciotto, M. R., Zoli, M., Rimondini, R., Léna, C., Marubio, L. M., Pich, E. M., Fuxe, K., & Changeux, J.-P. (1998) · Nature · doi:10.1038/34413 · Cited by 1,320 · see citing works

Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors

McGehee, D. S., Heath, M. J. S., Gelber, S., Devay, P., & Role, L. W. (1995) · Science · doi:10.1126/science.7569895 · Cited by 1,070 · see citing works

The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine

Corrigall, W. A., Franklin, K. B. J., Coen, K. M., & Clarke, P. B. S. (1992) · Psychopharmacology · doi:10.1007/bf02245149 · Cited by 829 · see citing works

Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area

Corrigall, W. A., Coen, K. M., & Adamson, K. L. (1994) · Brain Research · doi:10.1016/0006-8993(94)90401-4 · Cited by 740 · see citing works

Molecular and Physiological Diversity of Nicotinic Acetylcholine Receptors in the Midbrain Dopaminergic Nuclei

Klink, R., d'Exaerde, A. D. K., Zoli, M., & Changeux, J.-P. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01452.2001 · Cited by 674 · see citing works

Nicotinic receptors in the brain: correlating physiology with function

Jones, S., Sudweeks, S. N., & Yakel, J. L. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01471-x · Cited by 447 · see citing works

Pharmacological Characterization of Recombinant Human Neuronal Nicotinic Acetylcholine Receptors hα2β2, hα2β4, hα3β2, hα3β4, hα4β2, hα4β4 and hα7 Expressed in Xenopus Oocytes

Chavez-Noriega, L. E., Crona, J. H., Washburn, M. S., Urrutia, A., Elliott, K. J., & Johnson, E. C. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36376-1 · Cited by 405 · see citing works

Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes.

Chavez-Noriega, L. E., Crona, J. H., Washburn, M. S., Urrutia, A., Elliott, K. J., & Johnson, E. C. (1997) · PubMed · Cited by 392 · see citing works

Nicotine self-administration in animals and humans: similarities and differences

Rose, J. E., & Corrigall, W. A. (1997) · Psychopharmacology · doi:10.1007/s002130050209 · Cited by 262 · see citing works

N-methyl-d-aspartate receptor antagonism in the ventral tegmental area diminishes the systemic nicotine-induced dopamine release in the nucleus accumbens

Schilström, B., Nomikos, G. G., Nisell, M., Hertel, P., & Svensson, T. H. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00243-1 · Cited by 206 · see citing works

Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental area

Laviolette, S. R., & van der Kooy, D. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001197 · Cited by 180 · see citing works

The nicotinic antagonist methyllycaconitine has differential effects on nicotine self-administration and nicotine withdrawal in the rat

Markou, A., & Paterson, N. E. (2001) · Nicotine & Tobacco Research · doi:10.1080/14622200110073380 · Cited by 155 · see citing works

Response of nicotine self-administration in the rat to manipulations of mu-opioid and γ-aminobutyric acid receptors in the ventral tegmental area

Corrigall, W., Coen, K. M., Adamson, K. L., Chow, B. L., & Zhang, J. (2000) · Psychopharmacology · doi:10.1007/s002139900355 · Cited by 152 · see citing works

Evidence That Nicotinic α7 Receptors Are Not Involved in the Hyperlocomotor and Rewarding Effects of Nicotine

Grottick, A. J., Trube, G., Corrigall, W. A., Huwyler, J., Malherbe, P., Wyler, R., & Higgins, G. A. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39179-7 · Cited by 143 · see citing works

Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine.

Grottick, A. J., Trube, G., Corrigall, W., Huwyler, J., Malherbe, P., Wyler, R., & Higgins, G. A. (2000) · PubMed · Cited by 142 · see citing works

GABAA receptors in the ventral tegmental area control bidirectional reward signalling between dopaminergic and non‐dopaminergic neural motivational systems

Laviolette, S. R., & van der Kooy, D. (2001) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2001.01458.x · Cited by 140 · see citing works

Deprivation State Switches the Neurobiological Substrates Mediating Opiate Reward in the Ventral Tegmental Area

Nader, K., & van der Kooy, D. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-01-00383.1997 · Cited by 133 · see citing works

Two pharmacologically distinct components of nicotinic receptor-mediated rubidium efflux in mouse brain require the beta2 subunit.

Marks, M. J., Whiteaker, P., Calcaterra, J., Stitzel, J. A., Bullock, A. E., Grady, S. R., Picciotto, M. R., Changeux, J., & Collins, A. C. (1999) · PubMed · Cited by 126 · see citing works

The role of nicotinic receptor beta-2 subunits in nicotine discrimination and conditioned taste aversion

Shoaib, M., Gommans, J., Morley, A., Stolerman, I. P., Grailhe, R., & Changeux, J.-P. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(01)00194-0 · Cited by 110 · see citing works

Aversion instead of preference learning indicated by nicotine place conditioning in rats

Jorenby, D. E., Steinpreis, R. E., Sherman, J. E., & Baker, T. B. (1990) · Psychopharmacology · doi:10.1007/bf02244233 · Cited by 99 · see citing works

A comparison of the effects of nicotine on dopamine and non-dopamine neurons in the rat ventral tegmental area: an in vitro electrophysiological study

Yin, R., & French, E. D. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00237-9 · Cited by 85 · see citing works

Nicotine-Induced Enhancement of Glutamatergic and GABAergic Synaptic Transmission in the Mouse Amygdala

Barazangi, N., & Role, L. W. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.1.463 · Cited by 80 · see citing works

Two Pharmacologically Distinct Components of Nicotinic Receptor-Mediated Rubidium Efflux in Mouse Brain Require the β2 Subunit

Marks, M. J., Whiteaker, P., Calcaterra, J., Stitzel, J. A., Bullock, A. E., Grady, S. R., Picciotto, M. R., Changeux, J.-P., & Collins, A. C. (1999) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38240-0 · Cited by 79 · see citing works

Methyl lycaconitine: A novel nicotinic antagonist

Drasdo, A. L., Caulfield, M. P., Bertrand, D., Bertrand, S., & Wonnacott, S. (1992) · Molecular and Cellular Neuroscience · doi:10.1016/1044-7431(92)90043-2 · Cited by 78 · see citing works

Antagonism of the discriminative and aversive stimulus properties of nicotine in C57BL/6J mice

Gommans, J., Stolerman, I. P., & Shoaib, M. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00130-1 · Cited by 61 · see citing works

Nicotine modifies the activity of ventral tegmental area dopaminergic neurons and hippocampal GABAergic neurons

Fisher, J. L., Pidoplichko, V. I., & Dani, J. A. (1998) · Journal of Physiology-Paris · doi:10.1016/s0928-4257(98)80012-0 · Cited by 55 · see citing works

Mecamylamine Blockade of Both Positive and Negative Effects of IV Nicotine in Human Volunteers

Lundahl, L. H., Henningfield, J. E., & Lukas, S. E. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00252-5 · Cited by 31 · see citing works

Untitled work

(2000) · doi:10.1002/1098-2396(20001215)38:4

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

Tzschentke, T. M. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00070.x · Cited by 1,336 · see citing works

Guidelines on nicotine dose selection for in vivo research

Matta, S. G., Balfour, D. J., Benowitz, N. L., Boyd, R. T., Buccafusco, J. J., Caggiula, A. R., Craig, C. R., Collins, A. C., Damaj, M. I., Donny, E. C., et al. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0441-0 · Cited by 824 · see citing works

Nicotine Activation of α4* Receptors: Sufficient for Reward, Tolerance, and Sensitization

Tapper, A. R., McKinney, S. L., Nashmi, R., Schwarz, J., Deshpande, P., Labarca, C., Whiteaker, P., Marks, M. J., Collins, A. C., & Lester, H. A. (2004) · Science · doi:10.1126/science.1099420 · Cited by 686 · see citing works

The neurobiology of positive emotions

Burgdorf, J., & Panksepp, J. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.06.001 · Cited by 677 · see citing works

The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour

Laviolette, S. R., & van der Kooy, D. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1298 · Cited by 452 · see citing works

It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood

PICCIOTTO, M., ADDY, N., MINEUR, Y., & BRUNZELL, D. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.12.005 · Cited by 451 · see citing works

Nicotine induces conditioned place preferences over a large range of doses in rats

Foll, B. L., & Goldberg, S. R. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2021-5 · Cited by 229 · see citing works

Nicotinic Acetylcholine Receptors in the Mesolimbic Pathway: Primary Role of Ventral Tegmental Area α6β2* Receptors in Mediating Systemic Nicotine Effects on Dopamine Release, Locomotion, and Reinforcement

Gotti, C., Guiducci, S., Tedesco, V., Corbioli, S., Zanetti, L., Moretti, M., Zanardi, A., Rimondini, R., Mugnaini, M., Clementi, F., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5095-09.2010 · Cited by 226 · see citing works

Smoking, nicotine and neuropsychiatric disorders

Döme, P., Lazáry, J., Kalapos, M. P., & Rihmer, Z. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.07.013 · Cited by 215 · see citing works

μ-Opioid Receptor and CREB Activation Are Required for Nicotine Reward

Walters, C. L., Cleck, J. N., Kuo, Y., & Blendy, J. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.005 · Cited by 209 · see citing works

Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental area

Laviolette, S. R., & van der Kooy, D. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001197 · Cited by 180 · see citing works

Nicotine aversion: Neurobiological mechanisms and relevance to tobacco dependence vulnerability

Fowler, C. D., & Kenny, P. J. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.09.008 · Cited by 167 · see citing works

Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats

Kenny, P. J., Boutrel, B., Gasparini, F., Koob, G. F., & Markou, A. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2069-2 · Cited by 151 · see citing works

NMDA Receptors Regulate Nicotine-Enhanced Brain Reward Function and Intravenous Nicotine Self-Administration: Role of the Ventral Tegmental Area and Central Nucleus of the Amygdala

Kenny, P. J., Chartoff, E. H., Roberto, M., Carlezon, W. A., & Markou, A. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.58 · Cited by 148 · see citing works

Conditioned Place Preference

(2008) · Springer eBooks · doi:10.1007/978-3-540-38918-7_5441 · Cited by 146 · see citing works

Neuronal nicotinic acetylcholine receptors: neuroplastic changes underlying alcohol and nicotine addictions

Feduccia, A. A., Chatterjee, S., & Bartlett, S. E. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00083 · Cited by 142 · see citing works

Group II Metabotropic and α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate (AMPA)/Kainate Glutamate Receptors Regulate the Deficit in Brain Reward Function Associated with Nicotine Withdrawal in Rats

Kenny, P. J., Gasparini, F., & Markou, A. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.052027 · Cited by 138 · see citing works

Subtypes of nicotinic acetylcholine receptors in nicotine reward, dependence, and withdrawal: evidence from genetically modified mice

Fowler, C. D., Arends, M. A., & Kenny, P. J. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32830c360e · Cited by 131 · see citing works

Recent advances in understanding nicotinic receptor signaling mechanisms that regulate drug self-administration behavior

Tuesta, L. M., Fowler, C. D., & Kenny, P. J. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.06.026 · Cited by 129 · see citing works

Neurobiological Mechanisms of Nicotine Reward and Aversion

Wills, L. P., Ables, J. L., Braunscheidel, K. M., Caligiuri, S. P. B., Elayouby, K. S., Fillinger, C., Ishikawa, M., Moen, J. K., & Kenny, P. J. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000299 · Cited by 126 · see citing works

Nicotine place preference in the mouse: influences of prior handling, dose and strain and attenuation by nicotinic receptor antagonists

Grabus, S. D., Martin, B. R., Brown, S. E., & Damaj, M. I. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0305-7 · Cited by 118 · see citing works

Advances in pharmacotherapy for tobacco dependence

Foulds, J., Burke, M. V., Steinberg, M. B., Williams, J. M., & Ziedonis, D. M. (2004) · Expert Opinion on Emerging Drugs · doi:10.1517/eoed.9.1.39.32951 · Cited by 107 · see citing works

Lesions of the Tegmental Pedunculopontine Nucleus Block the Rewarding Effects and Reveal the Aversive Effects of Nicotine in the Ventral Tegmental Area

Laviolette, S. R., Alexson, T. O., & van der Kooy, D. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08653.2002 · Cited by 98 · see citing works

Nicotine-Induced Changes in Neurotransmitter Levels in Brain Areas Associated with Cognitive Function

Singer, S., Rossi, S., Verzosa, S., Hashim, A. T., Lonow, R., Cooper, T. B., Sershen, H. W., & Lajtha, Á. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000035814.45494.15 · Cited by 98 · see citing works

Differential modulation of gene expression in the NMDA postsynaptic density of schizophrenic and control smokers

Mexal, S., Frank, M., Berger, R., Adams, C. E., Ross, R. G., Freedman, R., & Leonard, S. S. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.06.006 · Cited by 93 · see citing works

GABAB receptors as a therapeutic strategy in substance use disorders: Focus on positive allosteric modulators

Filip, M., Frankowska, M., Sadakierska−Chudy, A., Suder, A., Szumiec, Ł., Mierzejewski, P., Bieńkowski, P., Przegaliński, E., & Cryan, J. F. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.06.016 · Cited by 91 · see citing works

Reinforcing effects of nicotine microinjections into the ventral tegmental area of mice: dependence on cholinergic nicotinic and dopaminergic D1 receptors

David, V., Besson, M., Changeux, J.-P., Granon, S., & Cazala, P. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.02.003 · Cited by 87 · see citing works

A psychobiological framework of the substrates that mediate nicotine use during adolescence

O'Dell, L. E. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.039 · Cited by 81 · see citing works

Decreased withdrawal symptoms but normal tolerance to nicotine in mice null for the α7 nicotinic acetylcholine receptor subunit

Salas, R., Main, A., Gangitano, D., & De Biasi, M. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.08.017 · Cited by 76 · see citing works

Ecology and neurobiology of toxin avoidance and the paradox of drug reward

Hagen, E. H., Sullivan, R. J., Schmidt, R., Morris, G., Kempter, R., & Hammerstein, P. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.01.077 · Cited by 76 · see citing works

Tobacco dependence, the insular cortex and the hypocretin connection

Kenny, P. J. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.08.015 · Cited by 69 · see citing works

Morphine-induced place preference: Involvement of cholinergic receptors of the ventral tegmental area

Rezayof, A., Nazari-Serenjeh, F., Zarrindast, M., Sepehri, H., & Delphi, L. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.01.081 · Cited by 69 · see citing works

How conditioned stimuli acquire the ability to activate VTA dopamine cells: A proposed neurobiological component of reward-related learning

Zellner, M. R., & Ranaldi, R. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.011 · Cited by 68 · see citing works

Animal Models of Nicotine Exposure: Relevance to Second-Hand Smoking, Electronic Cigarette Use, and Compulsive Smoking

Cohen, A., & George, O. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00041 · Cited by 67 · see citing works

Smoking and alcoholism target genes associated with plasticity and glutamate transmission in the human ventral tegmental area

Flatscher‐Bader, T., Zuvela, N. G., Landis, N., & Wilce, P. A. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm283 · Cited by 66 · see citing works

Elevation of Dopamine Induced by Cigarette Smoking: Novel Insights from a [11C]-(+)-PHNO PET Study in Humans

Foll, B. L., Guranda, M., Wilson, A. A., Houle, S., Rusjan, P., Wing, V. C., Zawertailo, L. A., Busto, U. E., Selby, P. L., Brody, A. L., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.209 · Cited by 63 · see citing works

Age dependent nicotinic influences over dopamine neuron synaptic plasticity

Placzek, A. N., Zhang, T. A., & Dani, J. A. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.05.014 · Cited by 61 · see citing works

Addiction‐related neuroadaptations following chronic nicotine exposure

Wills, L., & Kenny, P. J. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15356 · Cited by 61 · see citing works

Varenicline attenuates nicotine-enhanced brain-stimulation reward by activation of α4β2 nicotinic receptors in rats

Spiller, K., Xi, Z.-X., Li, X., Ashby, C. R., Callahan, P. M., Tehim, A., & Gardner, E. L. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.04.006 · Cited by 58 · see citing works

Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice

Besson, M., David, V., Baudonnat, M., Cazala, P., Guilloux, J., Repérant, C., Cloëz-Tayarani, I., Changeux, J., Gardier, A. M., & Granon, S. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2422-1 · Cited by 57 · see citing works

Inhalation of Alcohol Vapor: Measurement and Implications

MacLean, R. R., Valentine, G. W., Jatlow, P. I., & Sofuoglu, M. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13291 · Cited by 57 · see citing works

An inhibitory brainstem input to dopamine neurons encodes nicotine aversion

Liu, C. J., Tose, A. J., Verharen, J. P. H., Zhu, Y., Tang, L. W., de Jong, J. W., Du, J. X., Beier, K. T., & Lammel, S. (2022) · Neuron · doi:10.1016/j.neuron.2022.07.003 · Cited by 55 · see citing works

Adolescent male Wistar rats are more responsive than adult rats to the conditioned rewarding effects of intravenously administered nicotine in the place conditioning procedure

Shram, M. J., & Lê, A. D. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.09.018 · Cited by 52 · see citing works

Repeated administration of the GABAB receptor positive modulator BHF177 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine seeking in rats

Vlachou, S., Guery, S., Froestl, W., Banerjee, D., Benedict, J., Finn, M. G., & Markou, A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2119-x · Cited by 52 · see citing works

Acute nicotine changes dynorphin and prodynorphin mRNA in the striatum

Isola, R., Zhang, H., Tejwani, G. A., Neff, N. H., & Hadjiconstantinou, M. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1315-4 · Cited by 51 · see citing works

Direct effect of nicotine on mesolimbic dopamine release in rat nucleus accumbens shell

Kleijn, J., Folgering, J. H. A., van der Hart, M. C. G., Rollema, H., Cremers, T. I. F. H., & Westerink, B. H. C. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.02.035 · Cited by 48 · see citing works

The Role of Nicotinic Acetylcholine Receptors in the Primary Reinforcing and Reinforcement-Enhancing Effects of Nicotine

Palmatier, M. I., Liu, X., Caggiula, A. R., Donny, E. C., & Sved, A. F. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301228 · Cited by 48 · see citing works

Monoamine oxidase A knockout mice exhibit impaired nicotine preference but normal responses to novel stimuli

Agatsuma, S., Lee, M.-S., Zhu, H., Chen, K., Shih, J. C., Seif, I., & Hiroi, N. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl206 · Cited by 47 · see citing works

Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes

Gold, A. B., & Lerman, C. E. (2012) · Human Genetics · doi:10.1007/s00439-012-1143-9 · Cited by 40 · see citing works

Nicotine self‐administration remodels perineuronal nets in ventral tegmental area and orbitofrontal cortex in adult male rats

Vazquez‐Sanroman, D. B., Monje, R. D., & Bardo, M. T. (2017) · Addiction Biology · doi:10.1111/adb.12437 · Cited by 40 · see citing works

Pleiotropic impact of constitutive fosB inactivation on nicotine-induced behavioral alterations and stress-related traits in mice

Zhu, H., Lee, M.-S., Agatsuma, S., & Hiroi, N. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm027 · Cited by 39 · see citing works

Acute Nicotine Administration Increases BOLD fMRI Signal in Brain Regions Involved in Reward Signaling and Compulsive Drug Intake in Rats

Bruijnzeel, A. W., Alexander, J. C., Pérez, P. D., Bauzo-Rodriguez, R., Hall, G., Klausner, R., Guerra, V. M. C. D. O., Zeng, H., Igari, M., & Febo, M. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu011 · Cited by 37 · see citing works

Nicotine-induced enhancement of responding for conditioned reinforcement in rats: Role of prior nicotine exposure and α4β2 nicotinic receptors

Guy, E. G., & Fletcher, P. J. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2832-8 · Cited by 34 · see citing works

Contribution of dihydro-beta-erythroidine sensitive nicotinic acetylcholine receptors in the ventral tegmental area to cocaine-induced behavioral sensitization in rats

Champtiaux, N., Kalivas, P. W., & Bardo, M. T. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.10.017 · Cited by 33 · see citing works

Varenicline Dose Dependently Enhances Responding for Nonpharmacological Reinforcers and Attenuates the Reinforcement-Enhancing Effects of Nicotine

Levin, M. E., Weaver, M. T., Palmatier, M. I., Caggiula, A. R., Sved, A. F., & Donny, E. C. (2011) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntr213 · Cited by 31 · see citing works

Involvement of rat dopaminergic system of nucleus accumbens in nicotine-induced anxiogenic-like behaviors

Zarrindast, M., Khalifeh, S., Rezayof, A., Rostami, P., Aghamohammadi‐Sereshki, A., & Zahmatkesh, M. (2012) · Brain Research · doi:10.1016/j.brainres.2012.04.036 · Cited by 31 · see citing works

A Role for Matrix Metalloproteinases in Nicotine-Induced Conditioned Place Preference and Relapse in Adolescent Female Rats

Natarajan, R., Harding, J. W., & Wright, J. W. (2013) · Journal of Experimental Neuroscience · doi:10.4137/jen.s11381 · Cited by 31 · see citing works

Cholinergic tone in ventral tegmental area: Functional organization and behavioral implications

Zhang, C., Liu, X., Zhou, P., Zhang, J., He, W., & Yuan, T. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.02.003 · Cited by 27 · see citing works

Blocking α4β2 and α7 nicotinic acetylcholine receptors inhibits the reinstatement of morphine-induced CPP by drug priming in mice

Feng, B., Xing, J.-H., Jia, D., Liu, S., Guo, H.-J., Li, X., He, X., & Zhao, M. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.01.040 · Cited by 26 · see citing works

Animal Models of Addiction and Neuropsychiatric Disorders and Their Role in Drug Discovery: Honoring the Legacy of Athina Markou

Kenny, P. J., Hoyer, D., & Koob, G. F. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.02.009 · Cited by 26 · see citing works

Methamphetamine-seeking behavior is due to inhibition of nicotinic cholinergic transmission by activation of cannabinoid CB1 receptors

Hiranita, T., Nawata, Y., Sakimura, K., & Yamamoto, T. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.012 · Cited by 26 · see citing works

Nicotine-induced conditioned place preference in adolescent rats

Natarajan, R., Wright, J. W., & Harding, J. W. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.05.004 · Cited by 25 · see citing works

Nicotine‐motivated behavior in C aenorhabditis elegans requires the nicotinic acetylcholine receptor subunits acr‐5 and acr‐15

Sellings, L. H. L., Pereira, S., Qian, C. S., Dixon-McDougall, T., Nowak, C., Zhao, B., Tyndale, R. F., & van der Kooy, D. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12099 · Cited by 23 · see citing works

Molecular Mechanisms Underlying the Motivational Effects of Nicotine

Brunzell, D. H., & Picciotto, M. R. (2008) · Nebraska Symposium on Motivation/The Nebraska symposium on motivation · doi:10.1007/978-0-387-78748-0_3 · Cited by 22 · see citing works

Effects of transdermal nicotine delivery on cognitive outcomes: A meta‐analysis

Majdi, A., Sadigh‐Eteghad, S., & GJEDDE, A. H. (2021) · Acta Neurologica Scandinavica · doi:10.1111/ane.13436 · Cited by 19 · see citing works

Ultrastructural localization of high‐affinity choline transporter in the rat anteroventral thalamus and ventral tegmental area: Differences in axon morphology and transporter distribution

Holmstrand, E. C., Asafu-Adjei, J. K., Sampson, A. R., Blakely, R., & Sesack, S. R. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22310 · Cited by 19 · see citing works

Activation of matrix metalloproteinase in dorsal hippocampus drives improvement in spatial working memory after intra‐ VTA nicotine infusion in rats

Shu, H., Zheng, G., Wang, X., Sun, Y., Liu, Y., Weaver, J. M. R., Shen, X., Liu, W., & Jin, X. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13283 · Cited by 19 · see citing works

Accumbens Cholinergic Interneurons Mediate Cue-Induced Nicotine Seeking and Associated Glutamatergic Plasticity

Leyrer‐Jackson, J. M., Holter, M. C., Overby, P. F., Newbern, J. M., Scofield, M. D., Olive, M. F., & Gipson, C. D. (2020) · eNeuro · doi:10.1523/eneuro.0276-20.2020 · Cited by 18 · see citing works

Dopamine D2 and acetylcholine α7 nicotinic receptors have subcellular distributions favoring mediation of convergent signaling in the mouse ventral tegmental area

Garzón, M., Duffy, Á., Chan, J., Lynch, M., Mackie, K., & Pickel, V. M. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.008 · Cited by 16 · see citing works

Nicotinic Acetylcholine α4β2 Receptor Regulates the Motivational Effect of Intracranial Self Stimulation Behavior in the Runway Method

Sagara, H., Kitamura, Y., Yae, T., Shibata, K., Suemaru, K., Sendo, T., Araki, H., & Gomita, Y. (2008) · Journal of Pharmacological Sciences · doi:10.1254/jphs.08168fp · Cited by 15 · see citing works

Blockade of nicotinic acetylcholine or dopamine D1-like receptors in the central nucleus of the amygdala or the bed nucleus of the stria terminalis does not precipitate nicotine withdrawal in nicotine-dependent rats

Jonkman, S., & Markou, A. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.02.030 · Cited by 13 · see citing works

Withania somnifera Dunal (Indian ginseng) impairs acquisition and expression of ethanol-elicited conditioned place preference and conditioned place aversion

Spina, L., Longoni, R., Rosas, M., Collu, M., Peana, A. T., Espa, E., Kasture, S. B., Cotti, E., & Acquas, E. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115600132 · Cited by 12 · see citing works

Plasticity in Brainstem Mechanisms of Pain Modulation by Nicotinic Acetylcholine Receptors in the Rat

Jareczek, F. J., White, S. R., & Hammond, D. L. (2017) · eNeuro · doi:10.1523/eneuro.0364-16.2017 · Cited by 12 · see citing works

The effects of nicotine on conditioning, extinction, and reinstatement in humans

Palmisano, A. N., Hudd, E. C., McQuade, C., de Wit, H., & Astur, R. S. (2017) · Addictive Behaviors · doi:10.1016/j.addbeh.2017.09.008 · Cited by 12 · see citing works

Translational research in addiction: Toward a framework for the development of novel therapeutics

Paterson, N. E. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.12.017 · Cited by 11 · see citing works

Evaluation of motivational effects induced by intracranial self-stimulation behavior.

Sagara, H., Sendo, T., & Gomita, Y. (2010) · PubMed · doi:10.18926/amo/40501 · Cited by 10 · see citing works

Cotinine Enhances Fear Extinction and Astrocyte Survival by Mechanisms Involving the Nicotinic Acetylcholine Receptors Signaling

Oliveros-Matus, P., Perez-Urrutia, N., Alvarez-Ricartes, N., Echeverria, F., Barreto, G. E., Elliott, J. M., Iarkov, A., & Echeverrı́a, V. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00303 · Cited by 10 · see citing works

Nicotine improves probabilistic reward learning in wildtype but not alpha7 nAChR null mutants, yet alpha7 nAChR agonists do not improve probabilistic learning

Milienne-Petiot, M., Higa, K. K., Grim, A., Deben, D. S., Groenink, L., Twamley, E. W., Geyer, M. A., & Young, J. W. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.08.005 · Cited by 9 · see citing works

The incentive amplifying effects of nicotine: Roles in alcohol seeking and consumption

King, C. P., & Meyer, P. (2022) · Advances in pharmacology · doi:10.1016/bs.apha.2021.10.008 · Cited by 9 · see citing works

Extending Animal Models to Explore Social Rewards Associated With Designated Smoking Areas on College Campuses

Lochbihler, S. L., Miller, D. A., & Etcheverry, P. E. (2013) · Journal of American College Health · doi:10.1080/07448481.2013.865624 · Cited by 8 · see citing works

Iptakalim Preferentially Decreases Nicotine-induced Hyperlocomotion in Phencyclidine-sensitized Rats: A Potential Dual Action against Nicotine Addiction and Psychosis

Volf, N., Hu, G., & Li, M. (2012) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2012.10.3.168 · Cited by 8 · see citing works

Motivational Effects of Methamphetamine as Measured by the Runway Method Using Priming Stimulation of Intracranial Self-stimulation Behavior

Sagara, H., Kitamura, Y., Sendo, T., Araki, H., & Gomita, Y. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.541 · Cited by 7 · see citing works

Nicotine analog inhibition of nicotine self-administration in rats

Rowland, N. E., Robertson, K. L., Soti, F. S., & Kem, W. R. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1186-8 · Cited by 7 · see citing works

Nicotine enhances responding for conditioned reinforcement via α4β2 nicotinic acetylcholine receptors in the ventral tegmental area, but not the nucleus accumbens or the prefrontal cortex

Tabbara, R. I., & Fletcher, P. J. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.12.011 · Cited by 7 · see citing works

Tobacco smoke exposure enhances reward sensitivity in male and female rats

Chellian, R., Wilks, I., Levin, B., Xue, S., Behnood‐Rod, A., Wilson, R., McCarthy, M. J., Ravula, A., Chandasana, H., Derendorf, H., et al. (2021) · Psychopharmacology · doi:10.1007/s00213-020-05736-0 · Cited by 7 · see citing works

Nicotinic Acetylcholine Receptors in the Ventral Tegmental Area are Important Targets for Nicotine and Ethanol Co-dependence

Taylor, D. H. (2013) · Biochemistry & Pharmacology Open Access · doi:10.4172/2167-0501.s1-002 · Cited by 4 · see citing works

Pharmacological activation of kappa opioid receptors in the nucleus accumbens core and ventral tegmental area increases the aversive effects of nicotine

Pham, H. H. N., Seeley, S. L., & D’Souza, M. S. (2022) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000675 · Cited by 3 · see citing works

Intra-ventral tegmental area microinjections of urotensin II modulate the effects of cocaine

Mueller, L. E., Kausch, M. A., Markovic, T., MacLaren, D. A. A., Dietz, D., Park, J., & Clark, S. D. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.09.036 · Cited by 2 · see citing works

Neurochemistry of Nicotine Dependence

Brunzell, D. H. (2007) · CRC Press eBooks · doi:10.1201/9781420054422.ch2 · Cited by 2 · see citing works

β2* nicotinic acetylcholine receptor subtypes mediate nicotine-induced enhancement of Pavlovian conditioned responding to an alcohol cue

Maddux, J.-M. N., Gonzales, L., & Kregar, N. P. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.1004368 · Cited by 2 · see citing works

Nicotinic α7 receptors on cholinergic neurons in the striatum mediate cocaine-reinforcement, but not food reward

Fritz, M., da Rosa, P. B., Wilhelms, D., Jaarola, M., Ruud, J., Engblom, D., & Klawonn, A. M. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1418686 · Cited by 1 · see citing works

Dips in dopamine say “no” to nicotine

Servonnet, A., & Nicola, S. M. (2022) · Neuron · doi:10.1016/j.neuron.2022.08.021 · Cited by 1 · see citing works

Nicotine induces abnormal motor coupling through sensitization of a mechanosensory circuit in Caenorhabditis elegans

Liu, Y., Huang, L., Wang, R., Qi, F., Liu, Y., Chen, Q., Mialon, M., Chen, L., Pinan‐Lucarré, B., & Gao, S. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003423 · Cited by 1 · see citing works

Nicotine and ADHD: Cognitive Association

King, J. A., & Rossi, V. (2007) · Journal of Dual Diagnosis · doi:10.1300/j374v03n02_03 · Cited by 1 · see citing works

Neurochemistry of Drug Abuse

Staley, J. K., & Cosgrove, K. (2006) · CRC Press eBooks · doi:10.1201/9781420003468.ch6 · Cited by 1 · see citing works

SUBTLE HETEROGENEITY OF HIGH-AFFINITY CHOLINE TRANSPORTER EXPRESSION AND LOCALIZATION IN LIMBIC PROJECTIONS OF THE CHOLINERGIC BRAINSTEM TEGMENTUM

Holmstrand, E. C. (2011) · D-Scholarship@Pitt (University of Pittsburgh)

THE NEUROBIOLOGY OF 50-KHZ VOCALIZATIONS IN RATS

Burgdorf, J. S. (2005) · ScholarWorks@BGSU (Bowling Green State University)

Effets motivationnels de la nicotine chez le rat. Implication des endocannabinoïdes et d'autres systèmes de neurotransmission.

Forget, B. (2007) · HAL

A quantitative analysis of the value-enhancing effects of nicotine, bupropion, and varenicline in male and female rats

Barrett, S. T. (2014) · Lincoln (University of Nebraska)

Role of the Ventral Tegmental Area and Ventral Tegmental Area Nicotinic Acetylcholine Receptors in the Incentive Amplifying Effect of Nicotine

Sheppard, A. B. (2014) · Digital Commons - East Tennessee State University (East Tennessee State University)

Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental area

Laviolette, S. R., & van der Kooy, D. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001197 · Cited by 180 · see citing works

Nicotine-Mediated Activation of Dopaminergic Neurons in Distinct Regions of the Ventral Tegmental Area

Zhao-Shea, R., Liu, L., Soll, L. G., Improgo, M. R., Meyers, E. E., McIntosh, J. M., Grady, S. R., Marks, M. J., Gardner, P. D., & Tapper, A. R. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.240 · Cited by 113 · see citing works

Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice

Besson, M., David, V., Baudonnat, M., Cazala, P., Guilloux, J., Repérant, C., Cloëz-Tayarani, I., Changeux, J., Gardier, A. M., & Granon, S. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2422-1 · Cited by 57 · see citing works

α4α6β2* Nicotinic Acetylcholine Receptor Activation on Ventral Tegmental Area Dopamine Neurons Is Sufficient to Stimulate a Depolarizing Conductance and Enhance Surface AMPA Receptor Function

Engle, S. E., Shih, P.-Y., McIntosh, J. M., & Drenan, R. M. (2013) · Molecular Pharmacology · doi:10.1124/mol.113.087346 · Cited by 51 · see citing works

Nicotine persistently activates ventral tegmental area dopaminergic neurons via nicotinic acetylcholine receptors containing alpha4 and alpha6 subunits

Liu, L., Zhao-Shea, R., McIntosh, J. M., Gardner, P. D., & Tapper, A. R. (2012) · eScholarship@UMassChan · Cited by 1 · see citing works