Higher BDNF serum levels predict slower cognitive decline in Alzheimer's disease patients
Open accessAbstract
The neurotrophin brain-derived neurotrophic factor (BDNF) plays a critical role in neuronal survival, synaptic plasticity, and memory. Several recent studies have demonstrated altered BDNF serum levels in Alzheimer's disease (AD) patients. However, the association of BDNF serum levels with the rate of cognitive decline in AD patients is still unclear. We demonstrate that BDNF serum levels are significantly decreased in AD patients with fast cognitive decline [decrease of Mini-Mental State Examination (MMSE) score >4/yr; n=12] compared to AD patients with slow cognitive decline (decrease of MMSE score ≤4/yr, n=28) and show a significant correlation with the rate of cognitive decline during 1 yr follow-up. These results suggest that higher BDNF serum levels are associated with a slower rate of cognitive decline in AD patients. Further longitudinal studies are necessary to elucidate the kinetics and the potential role of serum BDNF as a surrogate marker of disease progression in AD patients.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In Alzheimer's disease patients, higher serum BDNF concentrations are associated with less cognitive decline after 1 year, and this effect is more pronounced in more severe disease stages.
“AD patients with higher serum concentrations of BDNF showed less cognitive decline after 1 year; this effect was more pronounced in the more severe stages of the disease [142, 143].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [142]
BDNF might be a predictor for the rate of disease progression in Alzheimer's disease.
“These studies suggest that BDNF might be a predictor for the rate of disease progression in AD.”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [142]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Transport of brain-derived neurotrophic factor across the blood–brain barrier
Pan, W., Banks, W. A., Fasold, M. B., Bluth, J., & Kastin, A. J. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00141-5 · Cited by 1,354 · see citing works
Nagahara, A. H., Merrill, D. A., Coppola, G., Tsukada, S., Schroeder, B. E., Shaked, G. M., Wang, L., Blesch, A., Kim, A., Conner, J. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1912 · Cited by 1,034 · see citing works
BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders
Mattson, M. P., Maudsley, S., & Martin, B. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.08.001 · Cited by 942 · see citing works
Brain-derived Neurotrophic Factor Is Stored in Human Platelets and Released by Agonist Stimulation
Fujimura, H., Chen, R., Nakamura, T., Nakahashi, T., Kambayashi, J.-I., Sun, B., Altar, C., & Tandon, N. (2002) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613072 · Cited by 777 · see citing works
BDNF is essential to promote persistence of long-term memory storage
Bekinschtein, P., Cammarota, M., Katche, C., Slipczuk, L. N., Rossato, J. I., Goldin, A. P., Izquierdo, I., & Medina, J. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711863105 · Cited by 658 · see citing works
Poduslo, J. F., & Curran, G. L. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00250-v · Cited by 614 · see citing works
BDNF is a novel marker of cognitive function in ageing women: The DR’s EXTRA Study
Komulainen, P., Pedersen, M., Hänninen, T., Brüünsgaard, H., Lakka, T. A., Kivipelto, M., Hassinen, M., Rauramaa, T. H., Pedersen, B. K., & Rauramaa, R. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.07.014 · Cited by 347 · see citing works
Stage-dependent BDNF serum concentrations in Alzheimer’s disease
Laske, C., Stransky, E., Leyhe, T., Eschweiler, G. W., Wittorf, A., Richartz, E., Bartels, M., Buchkremer, G., & Schott, K. J. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-005-0397-y · Cited by 325 · see citing works
Self-citationProtective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats
Arancibia, S., Silhol, M., Mouliere, F. C., Meffre, J., Höllinger, I., Maurice, T., & Tapia‐Arancibia, L. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.05.012 · Cited by 318 · see citing works
Laske, C., Stransky, E., Leyhe, T., Eschweiler, G. W., Maetzler, W., Wittorf, A., Soekadar, S., Richartz, E., Koehler, N., Bartels, M., et al. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.01.014 · Cited by 272 · see citing works
Self-citationA Method for Estimating Progression Rates in Alzheimer Disease
Doody, R. S., Massman, P. J., & Dunn, J. K. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.449 · Cited by 194 · see citing works
Angelucci, F., Spalletta, G., Iulio, F. D., Ciaramella, A., Salani, F., Varsi, A. E., Gianni, W., Sancesario, G., Caltagirone, C., & Bossù, P. (2010) · Current Alzheimer Research · doi:10.2174/156720510790274473 · Cited by 187 · see citing works
Boutajangout, A., Leroy, K., Authelet, M., Anderton, B. H., Brion, J., & Woodgett, J. R. (2002) · Acta Neuropathologica · doi:10.1007/s004010100435 · Cited by 186 · see citing works
Serum BDNF, TNF-α and IL-1β levels in dementia patients
Yasutake, C., Kuroda, K., Yanagawa, T., Okamura, T., & Yoneda, H. (2006) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-006-0652-8 · Cited by 177 · see citing works
Teri, L. L., McCurry, S. M., Edland, S. D., Kukull, W. A., & Larson, E. B. (1995) · The Journals of Gerontology Series A · doi:10.1093/gerona/50a.1.m49 · Cited by 176 · see citing works
Increase of BDNF Serum Concentration in Lithium Treated Patients with Early Alzheimer's Disease
Leyhe, T., Eschweiler, G. W., Stransky, E., Gasser, T., Annas, P., Basun, H., & Laske, C. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1004 · Cited by 158 · see citing works
Self-citationLi, G., Peskind, E. R., Millard, S. P., Chi, P., Sokal, I., Yu, C., Bekris, L. M., Raskind, M. A., Galasko, D. R., & Montine, T. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005424 · Cited by 144 · see citing works
Gunstad, J., Benitez, A. M., Smith, J. L., Glickman, E., Spitznagel, M. B., Alexander, T. S., Juvancic-Heltzel, J. A., & Murray, L. K. (2008) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988708316860 · Cited by 144 · see citing works
Leyhe, T., Stransky, E., Eschweiler, G. W., Buchkremer, G., & Laske, C. (2007) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-007-0764-9 · Cited by 140 · see citing works
Self-citationNoh, M., Koh, S., Kim, Y., Kim, H. Y., Cho, G. W., & Kim, S. H. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05837.x · Cited by 131 · see citing works
Yu, H., Zhang, Z., Shi, Y., Bai, F., Xie, C., Quian, Y., Yuan, Y., & Deng, L. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0710 · Cited by 119 · see citing works
Brain-Derived Neurotrophic Factor Levels in Alzheimer's Disease
O’Bryant, S. E., Hobson, V. L., Hall, J. R., Waring, S. C., Chan, W., Massman, P. J., Lacritz, L. H., Cullum, C. M., & Diaz-Arrastia, R. R. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1051 · Cited by 101 · see citing works
'How Far' vs 'How Fast' in Alzheimer's Disease
KRAEMER, H. C. (1994) · Archives of Neurology · doi:10.1001/archneur.1994.00540150069019 · Cited by 67 · see citing works
Chuang, D., & Manji, H. K. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.04.008 · Cited by 59 · see citing works
Soto, M. E., Andrieu, S., Cantet, C., Reynish, E. L., Ousset, P., Arbus, C., Guyonnet, S., Nourhashémi, F., & Vellas, B. J. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000144073 · Cited by 56 · see citing works
Foulstone, E. J., Tavaré, J. M., & Gunn‐Moore, F. J. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00166-4 · Cited by 54 · see citing works
Marmigère, F., Choby, C., Rage, F., Richard, S., & Tapia‐Arancibia, L. (2001) · Neuroendocrinology · doi:10.1159/000054669 · Cited by 36 · see citing works
Villuendas, G., Sánchez‐Franco, F., Palacios, N., Fernández, M., & Cacicedo, L. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00177-2 · Cited by 28 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Miranda, M., Morici, J. F., Zanoni, M. B., & Bekinschtein, P. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00363 · Cited by 1,416 · see citing works
Physical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging
Ahlskog, J. E., Geda, Y. E., Graff-Radford, N. R., & Petersen, R. C. (2011) · Mayo Clinic Proceedings · doi:10.4065/mcp.2011.0252 · Cited by 885 · see citing works
Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750 · see citing works
Brain-Derived Neurotrophic Factor in Alzheimer’s Disease and Its Pharmaceutical Potential
Gao, L., Zhang, Y., Sterling, K., & Song, W. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00279-0 · Cited by 606 · see citing works
Brosseron, F., Krauthausen, M., Kummer, M., & Heneka, M. T. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8657-1 · Cited by 447 · see citing works
Higher brain <i>BDNF</i> gene expression is associated with slower cognitive decline in older adults
Buchman, A. S., Yu, L., Boyle, P. A., Schneider, J. A., De Jager, P. L., & Bennett, D. A. (2016) · Neurology · doi:10.1212/wnl.0000000000002387 · Cited by 239 · see citing works
Involvement of long noncoding RNAs in diseases affecting the central nervous system
Pastori, C., & Wahlestedt, C. (2012) · RNA Biology · doi:10.4161/rna.20482 · Cited by 100 · see citing works
Vedovelli, K., Silveira, E., Velho, E., Stertz, L., Kapczinski, F., Schröder, N., & Bromberg, E. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.012 · Cited by 26 · see citing works
Mikoteit, T., Hemmeter, U., Eckert, A., Brand, S., Bischof, R., Delini-Stula, A., Holsboer-Trachsler, E., & Beck, J. (2015) · Neuropsychobiology · doi:10.1159/000437439 · Cited by 25 · see citing works
Li, H., Initiative, F. T. A. D. N., Liu, H., Lutz, M. W., & Luo, S. (2023) · Journal of Alzheimer's Disease · doi:10.3233/jad-220680 · Cited by 17 · see citing works
Positive Allosteric Modulators of Trk Receptors for the Treatment of Alzheimer’s Disease
Forsell, P., Parrado Fernández, C., Nilsson, B., Sandin, J., Nordvall, G., & Segerdahl, M. (2024) · Pharmaceuticals · doi:10.3390/ph17080997 · Cited by 14 · see citing works
- Authors
- Laske, C., Stellos, K., Hoffmann, N., Stransky, E., Straten, G., Eschweiler, G. W., & Leyhe, T.
- Affiliations
- University of Tübingen (DE)
- Corresponding author
- Laske, Christoph
- Venue
- The International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-09-22
- Volume
- 14
- Issue
- 03
- Pages
- 399-404
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- OpenAlex
- W2103119955
- Cited by
- 180
- References
- 30
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 7 · 2023: 13 · 2022: 10 · 2021: 13 · 2020: 17 · 2019: 12 · 2018: 10 · 2017: 9 · 2016: 13 · 2015: 11 · 2014: 15 · 2013: 10 · 2012: 11
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- brain-derived neurotrophic factor, serum BDNF, Alzheimer's disease, cognitive decline, Mini-Mental State Examination, biomarkers, disease progression, neurotrophins
- MeSH terms
- Alzheimer Disease, Cognition, Cognition Disorders, Female, Humans, Male, Neuropsychological Tests, Time Factors, Biomarkers, Disease Progression, Brain-Derived Neurotrophic Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review