Cited by 119Treatment of Major DepressionTryptophan and brain disordersNerve injury and regeneration

Inverse Correlation of Brain and Blood BDNF Levels in a Genetic Rat Model of Depression

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Elfving, Betina, Plougmann, Pia Høgh, Müller, Heidi Kaastrup, Mathé, Aleksander A., Rosenberg, Raben, Wegener, Gregers·2010·The International Journal of Neuropsychopharmacology

Abstract

There is accumulating evidence that brain-derived neurotrophic factor (BDNF) plays a critical role in the pathophysiology of depression. Decreased serum levels have been reported in major depression, and a correlation between BDNF reduction and the severity of the disease was found. Moreover, in post-mortem hippocampal tissue, increased levels of BDNF immunoreactivity have been reported in subjects treated with antidepressants compared to untreated subjects. These findings indicate parallel changes in brain and serum BDNF levels during depression. BDNF has been measured in selected brain areas in several animal models. In investigations between Flinders Sensitive Line (FSL) and Flinders Resistant Line (FRL) rats, a genetic rat model of depression, no differences were found in BDNF levels in the frontal cortex and hippocampus, areas believed to be core brain regions in depression. However, to our knowledge brain and serum BDNF levels have never been reported in parallel for any psychiatric disease model. Therefore, we examined the levels of BDNF in whole blood, serum, cerebrospinal fluid (CSF), hippocampus, and frontal cortex in male FSL and FRL rats. BDNF levels in serum and whole blood of FSL rats were significantly increased compared to FRL rats. In contrast, in the hippocampus the BDNF level was significantly decreased in FSL compared to FRL rats while no differences were found in the frontal cortex and CSF. The differential regulation of the BDNF levels in hippocampus, serum, and whole blood in FSL/FRL rats adds to the hypothesis that neurotrophic factors are related to the pathophysiology of depression.

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Authors
Elfving, B., Plougmann, P. H., Müller, H. K., Mathé, A. A., Rosenberg, R., & Wegener, G.
Affiliations
  • Aarhus University Hospital (DK)
  • Karolinska University Hospital (SE)
Corresponding author
Elfving, Betina
Venue
The International Journal of Neuropsychopharmacology
Published
2009-10-02
Volume
13
Issue
05
Pages
563-572
ISSN
  • 1461-1457 (ISSN-L)
  • 1469-5111
OpenAlex
W2091064703
Cited by
119
References
33
Citations by year
2026: 3 · 2025: 3 · 2024: 12 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 9 · 2018: 8 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 5 · 2013: 8 · 2012: 8
FWCI
10.06
Type
journal article
Language
en
Open access
Locations
  • The International Journal of Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministério da Ciência, Tecnologia e Inovação
  • Augustinus Fonden
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
brain-derived neurotrophic factor, depression, Flinders Sensitive Line rats, serum BDNF, cerebrospinal fluid, hippocampus, frontal cortex, neurotrophic factors, depression pathophysiology
MeSH terms
Animals, Brain, Brain Chemistry, Depression, Disease Models, Animal, Genetic Markers, Male, Brain-Derived Neurotrophic Factor, Rats

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