The acute response of plasma brain-derived neurotrophic factor as a result of exercise in major depressive disorder.
Abstract
Brain-derived neurotrophic factor (BDNF) and other neurotrophins are believed to play an important role in affective disorders. In this study we investigated plasma-BDNF response during an incremental exercise test in 18 patients suffering from moderate major depressive disorder (MDD) and 18 controls. The patients were not treated with antidepressants or neuroleptics. Possible associations between plasma plasma-BDNF levels, dexamethasone suppression test cortisol levels and Montgomery-Asberg Depression Rating Scale (MADRS) scores were also tested. No difference in basal BDNF levels between patients and controls was found. BDNF increased significantly during exercise in both male and female patients as well as in male controls, with no significant differences between the groups. BDNF levels declined after exercise, but after 60 min of rest BDNF levels showed tendencies to increase again in male patients. No correlation between BDNF and cortisol or MADRS scores was found. We conclude that unmedicated patients with moderate depression and normal activity of the hypothalamic-pituitary-adrenal axis do not have a disturbed peripheral BDNF release during exercise. The BDNF increase 60 min after interruption of exercise in male patients might indicate up-regulated BDNF synthesis, but this needs to be further investigated in future studies.
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Peripheral BDNF concentration returns to baseline within about minutes to one hour after exercise cessation.
“In a period of about minutes to one hour after cessation of exercise, the level of peripheral BDNF concentration returns to the baseline [174,176,177,178].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [176]
In studies of human patients with MDD, AE has been associated with increased BDNF serum concentration.
“In studies of human patients with MDD, AE has been associated with increased BDNF serum concentration (Gustafsson et al., 2009; Laske et al., 2010).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Gustafsson et al., 2009
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- Authors
- Gustafsson, G., Lira, C. M., Johansson, J., Wisén, A., Wohlfart, B., Ekman, R., & Westrin, Å.
- Affiliations
- Skåne University Hospital (SE)
- Lund University (SE)
- University of Gothenburg (SE)
- Corresponding author
- Gustafsson, Gunnar
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 169
- Issue
- 3
- Pages
- 244-248
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2067350830
- Cited by
- 118
- References
- 27
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 7 · 2018: 10 · 2017: 11 · 2016: 4 · 2015: 13 · 2014: 10 · 2013: 11 · 2012: 9
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- brain-derived neurotrophic factor, major depressive disorder, acute exercise, incremental exercise test, plasma BDNF, neurotrophins, hypothalamic-pituitary-adrenal axis, cortisol, dexamethasone suppression test, mood disorders
- MeSH terms
- Adult, Major Depressive Disorder, Dexamethasone, Enzyme-Linked Immunosorbent Assay, Exercise Therapy, Female, Humans, Hydrocortisone, Male, Middle Aged, Psychiatric Status Rating Scales, Sex Factors, Time Factors, Case-Control Studies, Brain-Derived Neurotrophic Factor, Young Adult
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