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Long-term memory in mental retardation: evidence for a specific impairment in subjects with down’s syndrome.
Abstract
This study aimed at investigating long-term memory functioning in Down's syndrome subjects (DS) as compared to individuals with mental retardation of different etiology (MR) and mental-age matched normal children (MA). For this purpose, tests of verbal and visuo-perceptual explicit memory and a verbal repetition priming task were administered to 15 DS, 15 MR and 30 MA subjects. Our results document comparable verbal priming in the three groups. As for explicit memory, normal children performed better than MR individuals, and these, in turn, better than DS subjects. Compared to MR subjects, DS subjects were particularly deficient in organizing verbal material according to its categorical structure and in actively retrieving stored information. These results support a view positing heterogeneity of neuropsychological deficits across distinct etiology MR groups.
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“The memory impairment includes deficits in both short-term and long-term declarative memory, with procedural memory comparable to typically developing peers (Carlesimo et al., 1997; Pennington et al., 2003; Vicari et al., 2005, 2000; Godfrey and Lee, 2018).”
From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Carlesimo et al., 1997
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Stavroussi, P., Ανδρέου, Γ., & Karagiannopoulou, D. (2015) · International Journal of Disability Development and Education · doi:10.1080/1034912x.2015.1111307 · Cited by 23
Basten, I. A., Boada, R., Taylor, H. G., Koenig, K. A., Barrionuevo, V. L., Brandão, A. C., & Costa, A. C. S. (2018) · Brain Sciences · doi:10.3390/brainsci8120205 · Cited by 24
A quantitative transcriptome reference map of the normal human hippocampus
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Subicular hypotrophy in fetuses with Down syndrome and in the Ts65Dn model of Down syndrome
Stagni, F., Giacomini, A., Emili, M., Uguagliati, B., Bonasoni, M. P., Bartesaghi, R., & Guidi, S. (2019) · Brain Pathology · doi:10.1111/bpa.12663 · Cited by 21
Metadata
- Authors
- Carlesimo, G. A., Marotta, L., & Vicari, S.
- Affiliations
- University of Rome Tor Vergata (IT)
- Bambino Gesù Children's Hospital (IT)
- Corresponding author
- Carlesimo, Giovanni A
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 1997-01
- Volume
- 35
- Issue
- 1
- Pages
- 71-79
- ISSN
- 0028-3932 (ISSN-L)
- OpenAlex
- W2063948502
- Cited by
- 211
- References
- 54
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 8 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 8 · 2017: 17 · 2016: 11 · 2015: 14 · 2014: 12 · 2013: 13 · 2012: 15
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- Down syndrome, intellectual disability, long-term memory, declarative memory, verbal memory, repetition priming, memory retrieval, neuropsychological deficits, etiology of intellectual disability
- MeSH terms
- Adolescent, Cues, Down Syndrome, Female, Humans, Male, Memory, Memory, Short-Term, Intellectual Disability, Neuropsychological Tests, Pilot Projects, Verbal Learning, Wechsler Scales
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