Cited by 595Stress Responses and CortisolNeuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.

Animal models of social stress: effects on behavior and brain neurochemical systems

Blanchard, Robert J, McKittrick, Christina R, Blanchard, D.Caroline·2001·Physiology & Behavior

DOI 10.1016/s0031-9384(01)00449-8

Open this paper in CoChat — free account

Abstract

Social interactions serve as an evolutionarily important source of stress, and one that is virtually ubiquitous among mammalian species. Animal models of social stress are varied, ranging from a focus on acute, intermittent, or chronic exposure involving agonistic behavior, to social isolation. The relative stressfulness of these experiences may depend on the species, sex, and age of the subjects, and subject sex also appears to influence the value of hypothalamic--pituitary--adrenal (HPA) axis activity as a general criterion for stress response: higher glucocorticoid levels are typically found in dominant females in some species. Social stress models often produce victorious and defeated, or dominant and subordinate, animals that may be compared to each other or to controls, but the appropriateness of specific types of comparisons and the interpretations of their differences may vary for the different models. Social stress strongly impacts behavior, generally reducing aggression and enhancing defensiveness, both inside and outside the stress situation. Social and sexual behaviors may be reduced in subordinate animals, as is activity and responsivity to normally rewarding events. However, some components of these changes may be dependent on the presence of a dominant, rather than representing a longer-term and general alteration in behavior. Social stress effects on brain neurotransmitter systems have been most extensively investigated, and most often found in serotonin and noradrenergic systems, with changes also reported for other monoamine and for peptidergic systems. Morphological changes and alterations of neogenesis and of cell survival particularly involving the hippocampus and dentate gyrus have been reported with severe social stress, as have longer-term changes in HPA axis functioning. These findings indicate that social stress models can provide high magnitude and appropriate stressors for research, but additionally suggest a need for caution in interpretation of the findings of these models and care in analysis of their underlying mechanisms.

Integrity signals

Registry

Crossref · 10.1016/s0031-9384(01)00449-8

Cites

126 of 126 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

THE EFFECTS OF STRESSFUL LIFE EVENTS ON DEPRESSION
Kessler, R. C. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.191 · Cited by 2,111
Neurogenesis in the Dentate Gyrus of the Adult Tree Shrew Is Regulated by Psychosocial Stress and NMDA Receptor Activation
Gould, E., McEwen, B. S., Tanapat, P., Galea, L. A. M., & Fuchs, E. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02492.1997 · Cited by 1,496
A Comparison of the Social Postures of Some Common Laboratory Rodents
Grant, E. C., & Mackintosh, J. H. (1963) · Behaviour · doi:10.1163/156853963x00185 · Cited by 1,167
Chronic Psychosocial Stress Causes Apical Dendritic Atrophy of Hippocampal CA3 Pyramidal Neurons in Subordinate Tree Shrews
Magariños, A. M., McEwen, B. S., Flügge, G., & Fuchs, E. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03534.1996 · Cited by 864
Hippocampal damage associated with prolonged and fatal stress in primates
Uno, H., Tarara, R., Else, J., Suleman, M., & Sapolsky, R. (1989) · The Journal of Neuroscience · doi:10.1523/jneurosci.09-05-01705.1989 · Cited by 728
Antipredator defensive behaviors in a visible burrow system
Blanchard, R. J., & Blanchard, D. C. (1989) · Journal of comparative psychology · doi:10.1037/0735-7036.103.1.70 · Cited by 663
Self-citation
Aggressive behavior in the rat
Blanchard, R. J., & Blanchard, D. C. (1977) · Behavioral Biology · doi:10.1016/s0091-6773(77)90308-x · Cited by 560
Self-citation
Reproductive suppression among female mammals: implications for biomedicine and sexual selection theory
Wasser, S. K., & Barash, D. P. (1983) · The Quarterly Review of Biology · doi:10.1086/413545 · Cited by 548
Encyclopedia of stress
Fink, G. (2000) · Cited by 502
Social defeat stress selectively alters mesocorticolimbic dopamine release: an in vivo microdialysis study
Tidey, J. W., & Miczek, K. A. (1996) · Brain Research · doi:10.1016/0006-8993(96)00159-x · Cited by 496

Show all 126 references

Research works printed but not linked: 1

Brady, 1994, Chronic social stress increases mRNA expression of tyrosine hydroxylase in the locus coeruleus and pro-opiomelanocortin in the anterior pituitary in rats, Soc Neurosci Abstr, 20, 646

Sorted by citations

Items 101–200 of 595

Early environmental experience alters baseline and ethanol-induced cognitive impulsivity: relationship to forebrain 5-HT1A receptor binding
Hellemans, K. G. C., Nóbrega, J. N., & Olmstead, M. C. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.10.018 · Cited by 75
Proteomic analysis of rat hippocampus after repeated psychosocial stress
Carboni, L., Piubelli, C., Pozzato, C., Astner, H., Arban, R., Righetti, P. G., Hamdan, M. H., & Domenici, E. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.045 · Cited by 72
Behavioral, transcriptomic and epigenetic responses to social challenge in honey bees
Shpigler, H. Y., Saul, M. C., Murdoch, E. E., Cash-Ahmed, A. C., Seward, C. H., Sloofman, L. G., Chandrasekaran, S., Sinha, S., Stubbs, L. J., & Robinson, G. E. (2017) · Genes Brain & Behavior · doi:10.1111/gbb.12379 · Cited by 76
Ethological concepts enhance the translational value of animal models
Peters, S. M., Pothuizen, H. H. J., & Spruijt, B. M. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.043 · Cited by 70
Social isolation stress induces ATF‐7 phosphorylation and impairs silencing of the 5‐HT 5B receptor gene
Maekawa, T., Kim, S., Nakai, D., Makino, C., Takagi, T., Ogura, H., Yamada, K., Chatton, B., & Ishii, S. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.318 · Cited by 70
Individual differences in cardiovascular response to social challenge
Sgoifo, A., Costoli, T., Meerlo, P., Buwalda, B., Pico-Alfonso, M. A., de Boer, S. F., Musso, E., & Koolhaas, J. M. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.07.001 · Cited by 70
Chronic Subordinate Colony Housing Paradigm: A Mouse Model to Characterize the Consequences of Insufficient Glucocorticoid Signaling
Langgartner, D., Füchsl, A. M., Uschold‐Schmidt, N., Slattery, D. A., & Reber, S. O. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00018 · Cited by 73
Repeated social defeat in female mice induces anxiety-like behavior associated with enhanced myelopoiesis and increased monocyte accumulation in the brain
Yin, W., Gallagher, N. R., Sawicki, C. M., McKim, D. B., Godbout, J. P., & Sheridan, J. F. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.01.015 · Cited by 68
Modeling anxiety in healthy humans: a key intermediate bridge between basic and clinical sciences
Grillon, C., Robinson, O. J., Cornwell, B., & Ernst, M. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0445-1 · Cited by 73
Physiological stress response of young adults exposed to bullying during adolescence
Hamilton, L. D., Newman, M. L., Delville, C. L., & Delville, Y. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.09.001 · Cited by 67
Long-term exposure to unpredictable and uncontrollable aversive events alters fearfulness in sheep
Destrez, A., Deiss, V., Leterrier, C., Boivin, X., & Boissy, A. (2012) · animal · doi:10.1017/s1751731112001796 · Cited by 67
Naringenin attenuates behavioral derangements induced by social defeat stress in mice via inhibition of acetylcholinesterase activity, oxidative stress and release of pro-inflammatory cytokines
Umukoro, S., Kalejaye, H. A., Ben‐Azu, B., & Ajayi, A. M. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.016 · Cited by 67
Photoperiodic responses of depression-like behavior, the brain serotonergic system, and peripheral metabolism in laboratory mice
Otsuka, T., Kawai, M., Togo, Y., Goda, R., Kawase, T., Matsuo, H., Iwamoto, A., Nagasawa, M., Furuse, M., & Yasuo, S. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.10.013 · Cited by 66
Effect of enrichment on variation and results in the light/dark test
Augustsson, H., de Weerd, H. A. V., Kruitwagen, C. L. J. J., & Baumans, V. (2003) · Laboratory Animals · doi:10.1258/002367703322389898 · Cited by 68
Social cues and hormone levels in male Octodon degus (Rodentia): a field test of the Challenge Hypothesis
Soto-Gamboa, M. R., Villalón, M., & Bozinovic, F. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2004.11.010 · Cited by 65
Chronic isolation stress predisposes the frontal cortex but not the hippocampus to the potentially detrimental release of cytochrome c from mitochondria and the activation of caspase‐3
Filipović, D., Zlatković, J., Inta, D., Bjelobaba, I. M., Stojiljković, M., & Gass, P. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22687 · Cited by 65
Relationship between Levels of Testosterone and Cortisol in Saliva and Aggressive Behaviors of Adolescents
Yu, Y., & Jun-Xia, S. H. I. (2009) · Biomedical and Environmental Sciences · doi:10.1016/s0895-3988(09)60021-0 · Cited by 63
Comparative approaches in evolutionary psychology: molecular neuroscience meets the mind.
Panksepp, J., Moskal, J. R., Panksepp, J. B., & Kroes, R. A. (2002) · PubMed · Cited by 64
Social modulation of decision-making: a cross-species review
van den Bos, R., Jolles, J. W., & Homberg, J. R. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00301 · Cited by 74
Intermittent Exposure to Social Defeat and Open-field Test in Rats: Acute and Long-term Effects on ECG, Body Temperature and Physical Activity
Sgoifo, A., Pozzato, C., Meerlo, P., Costoli, T., Manghi, M., Stilli, D., Olivetti, G., & Musso, E. (2002) · Stress · doi:10.1080/102538902900012387 · Cited by 63
Neonatal and juvenile stress induces changes in adult social behavior without affecting cognitive function
Tóth, E., Avital, A., Leshem, M., Richter‐Levin, G., & Braun, K. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.012 · Cited by 61
Gene–environment interactions and construct validity in preclinical models of psychiatric disorders
Burrows, E. L., McOmish, C. E., & Hannan, A. J. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.12.011 · Cited by 63
Time-dependent behavioral, neurochemical, and immune consequences of repeated experiences of social defeat stress in male mice and the ameliorative effects of fluoxetine
Beitia, G., Garmendia, L., Azpiroz, A., Vegas, Ó., Brain, P. F., & Arregi, A. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2004.11.002 · Cited by 61
Social defeat stress produces prolonged alterations in acoustic startle and body weight gain in male Long Evans rats
Pulliam, J. V. K., Dawaghreh, A. M., Alema‐Mensah, E., & Plotsky, P. M. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.05.005 · Cited by 60
Learning to fear and cope with a natural stressor: individually and socially acquired corticosterone and avoidance responses to biting flies
Kavaliers, M., Colwell, D. D., & Choleris, E. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(02)00021-1 · Cited by 61
Loss of hippocampal neuronal nitric oxide synthase contributes to the stress‐related deficit in learning and memory
Palumbo, M. L., Fosser, N. S., Rı́os, H., Zubilete, M. A. Z., Guelman, L. R., Cremaschi, G., & Genaro, A. M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04528.x · Cited by 60
Chronic subordinate colony housing paradigm: a mouse model for mechanisms of PTSD vulnerability, targeted prevention, and treatment-2016 Curt Richter Award Paper
Reber, S. O., Langgartner, D., Foertsch, S., Postolache, T. T., Brenner, L. A., Guendel, H., & Lowry, C. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.08.031 · Cited by 59
The effects of social defeat on behavior and dopaminergic markers in mice
Jin, H.-M., Muna, S. S., Bagalkot, T. R., Cui, Y., Yadav, B. K., & Chung, Y. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.12.043 · Cited by 62
Individual differences in chronically defeated male mice: Behavioral, endocrine, immune, and neurotrophic changes as markers of vulnerability to the effects of stress
Gómez-Lázaro, E., Arregi, A., Beitia, G., Vegas, Ó., Azpiroz, A., & Garmendia, L. (2011) · Stress · doi:10.3109/10253890.2011.562939 · Cited by 68
Differential effects of social defeat in rats with high and low locomotor response to novelty
Calvo, N., Cecchi, M., Kabbaj, M., Watson, S. J., & Akil, H. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.046 · Cited by 58
Single exposure to social defeat increases corticotropin-releasing factor and glucocorticoid receptor mRNA expression in rat hippocampus
Marini, F., Pozzato, C., Andreetta, V., Jansson, B., Arban, R., Domenici, E., & Carboni, L. (2005) · Brain Research · doi:10.1016/j.brainres.2005.10.002 · Cited by 57
Murine model of repeated exposures to conspecific trained aggressors simulates features of post-traumatic stress disorder
Hammamieh, R., Chakraborty, N., de Lima, T. C. M., Meyerhoff, J. L., Gautam, A., Muhie, S. Y., D’Arpa, P., Lumley, L. A., Carroll, E. E., & Jett, M. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.022 · Cited by 57
Leading compounds for the validation of animal models of psychopathology
Micale, V., Kučerová, J., & Šulcová, A. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1692-9 · Cited by 58
The Biopsychology of Maternal Behavior in Nonhuman Mammals
Kristal, M. B. (2009) · ILAR Journal · doi:10.1093/ilar.50.1.51 · Cited by 57
Chronic social stress in the visible burrow system modulates stress-related gene expression in the bed nucleus of the stria terminalis
CHOI, D., Nguyen, M. M. N., Tamashiro, K. L., MA, L., Sakai, R. R., & Herman, J. P. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.05.046 · Cited by 56
Incubation of depression: ECM assembly and parvalbumin interneurons after stress
Spijker, S., Koskinen, M.-K., & Riga, D. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.015 · Cited by 55
Anxious to see you: Neuroendocrine mechanisms of social vigilance and anxiety during adolescence
Wright, E. C., Hostinar, C. E., & Trainor, B. C. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14628 · Cited by 55
Alcohol self-administration in rats: Modulation by temporal parameters related to repeated mild social defeat stress
Caldwell, E. E., & Riccio, D. C. (2010) · Alcohol · doi:10.1016/j.alcohol.2010.02.012 · Cited by 58
Physical stress differs from psychosocial stress in the pattern and time-course of behavioral responses, serum corticosterone and expression of plasticity-related genes in the rat
Kavushansky, A., Ben‐Shachar, D., Richter‐Levin, G., & Klein, E. (2009) · Stress · doi:10.1080/10253890802556081 · Cited by 59
Social defeat protocol and relevant biomarkers, implications for stress response physiology, drug abuse, mood disorders and individual stress vulnerability: a systematic review of the last decade
Vasconcelos, M., Stein, D. J., & de Almeida, R. M. M. (2015) · Trends in Psychiatry and Psychotherapy · doi:10.1590/2237-6089-2014-0034 · Cited by 55
Structural plasticity of the adult brain: how animal models help us understand brain changes in depression and systemic disorders related to depression
McEwen, B. S. (2004) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2004.6.2/bmcewen · Cited by 54
Linking the social environment to illness in farm animals
Proudfoot, K. L., Weary, D. M., & von Keyserlingk, M. A. G. (2012) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2012.02.008 · Cited by 60
Stress, Motivation, and the Gut–Brain Axis: A Focus on the Ghrelin System and Alcohol Use Disorder
Morris, L. S., Voon, V., & Leggio, L. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13781 · Cited by 57
Long-term effects of repeated social stress on the conditioned place preference induced by MDMA in mice
García-Pardo, M. P., Blanco-Gandía, M. C., Valiente-Lluch, M., Rodríguez‐Arias, M., Miñarro, J., & Aguilar, M. A. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.06.006 · Cited by 53
Thinking small: towards microRNA-based therapeutics for anxiety disorders
Scott, K. A., Hoban, A. E., Clarke, G., Moloney, G. M., Dinan, T. G., & Cryan, J. F. (2015) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2014.997873 · Cited by 52
Targeting dynamic interplay among disordered domains or endophenotypes to understand complex neuropsychiatric disorders: Translational lessons from preclinical models
Kalueff, A. V., Stewart, A., Song, C., & Gottesman, I. I. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.03.007 · Cited by 50
Prefrontal neuromodulation by nicotinic receptors for cognitive processes
Coura, R., & Granon, S. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2596-6 · Cited by 57
Social isolation during puberty affects female sexual behavior in mice
Kerčmar, J., Tobet, S. A., & Majdič, G. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00337 · Cited by 50
Recognition of competitors by male golden hamsters
Petrulis, A., Weidner, M. L., & Johnston, R. E. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.03.001 · Cited by 50
Psychosocial stress-induced intestinal permeability in healthy humans: What is the evidence?
Torre, D. L., Oudenhove, L. V., Vanuytsel, T., & Verbeke, K. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100579 · Cited by 52
Contribution of brain dopamine, serotonin and opioid receptors in the mechanisms of neuroimmunomodulation: Evidence from pharmacological analysis
Idova, G. V., Лазаревна, А. Е., & Чейдо, М. А. (2012) · International Immunopharmacology · doi:10.1016/j.intimp.2012.02.010 · Cited by 49
Neurotrophins in the ventral tegmental area: Role in social stress, mood disorders and drug abuse
Nikulina, E. M., Johnston, C. E., Wang, J., & Hammer, R. P. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.028 · Cited by 50
Impact of the Hormonal Milieu on the Neurobiology of Alcohol Dependence and Withdrawal
Devaud, L. L., Risinger, F. O., & Selvage, D. J. (2006) · The Journal of General Psychology · doi:10.3200/genp.133.4.337-356 · Cited by 51
Moderate Stress-Induced Social Bonding and Oxytocin Signaling are Disrupted by Predator Odor in Male Rats
Muroy, S. E., Long, K. L. P., Kaufer, D., & Kirby, E. D. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.16 · Cited by 47
Sodium metavanadate induced cognitive decline, behavioral impairments, oxidative stress and down regulation of myelin basic protein in mice hippocampus: Ameliorative roles of β‐spinasterol, and stigmasterol
Adebiyi, O. E., Olopade, J. O., & Olayemi, F. O. (2018) · Brain and Behavior · doi:10.1002/brb3.1014 · Cited by 48
Changes in endocrine and immune responses of neonatal pigs exposed to a psychosocial stressor
Tuchscherer, M., Kanitz, E., Puppe, B., Tuchscherer, A., & Viergutz, T. (2009) · Research in Veterinary Science · doi:10.1016/j.rvsc.2009.04.010 · Cited by 51
Hormonal Modulation of Perception in Motivation-Based Action Selection Architectures
Avila-García, O., & Cañamero, L. D. (2005) · University of Hertfordshire Research Archive (University of Hertfordshire) · Cited by 47
Differential responses to distinct psychotropic agents of selectively bred dominant and submissive animals
Nesher, E., Gross, M., Lisson, S., Tikhonov, T., Yadid, G., & Pinhasov, A. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.08.040 · Cited by 49
Gonadal hormones modulate the display of submissive behavior in socially defeated female Syrian hamsters
Faruzzi, A. N., Solomon, M. B., Demas, G. E., & Huhman, K. L. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2004.11.023 · Cited by 47
Further validation of the affective bias test for predicting antidepressant and pro-depressant risk: effects of pharmacological and social manipulations in male and female rats
Hinchcliffe, J. K., Stuart, S. A., Mendl, M., & Robinson, E. S. J. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4687-5 · Cited by 48
Stress in Aquaculture Hatcheries: Source, Impact and Mitigation
Rehman, S., Gora, A. H., Ahmad, I., & Rasool, S. I. (2017) · International Journal of Current Microbiology and Applied Sciences · doi:10.20546/ijcmas.2017.610.357 · Cited by 45
Could neonatal testosterone replacement prevent alterations induced by prenatal stress in male rats?
Pereira, O. C. M., Bernardi, M. M., & Gerardin, D. C. C. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.10.035 · Cited by 46
Long-Term Effect of Social Interactions on Behavioral Plasticity and Lifetime Mating Success
Han, C. S., & Brooks, R. C. (2014) · The American Naturalist · doi:10.1086/674935 · Cited by 45
Antidiabetic Drug Metformin Ameliorates Depressive-Like Behavior in Mice with Chronic Restraint Stress via Activation of AMP-Activated Protein Kinase
Ai, H., Fang, W., Hanyi, H., Xupang, H., & Lu, W. (2020) · Aging and Disease · doi:10.14336/ad.2019.0403 · Cited by 44
Interaction effects of corticosterone and experience on aggressive behavior in the green anole lizard
Yang, E.-J., & Wilczynski, W. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(03)00139-9 · Cited by 45
Reduction of dominant or submissive behaviors as models for antimanic or antidepressant drug testing: Technical considerations
Malatyńska, E., Pinhasov, A., Crooke, J. J., Smith‐Swintosky, V. L., & Brenneman, D. E. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.05.035 · Cited by 45
Role of the bed nucleus of the stria terminalis in the acquisition and expression of conditioned defeat in Syrian hamsters
Markham, C. M., Norvelle, A., & Huhman, K. L. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.022 · Cited by 44
The environmental enrichment model revisited: A translatable paradigm to study the stress of our modern lifestyle
Rojas‐Carvajal, M., Sequeira‐Cordero, A., & Brenes, J. C. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15160 · Cited by 51
Differential involvement of amygdaloid CRH system(s) in the salience and valence of the stimuli
Merali, Z., Michaud, D. S., McIntosh, J. F., Kent, P., & Anisman, H. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.09.014 · Cited by 44
Sex differences in effects of mild chronic stress on seizure risk and GABAA receptors in rats
Chadda, R., & Devaud, L. L. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.03.022 · Cited by 44
Social Regulation of Neurogenesis in Teleosts
Sørensen, C., Øverli, Ø., Summers, C. H., & Nilsson, G. (2007) · Brain Behavior and Evolution · doi:10.1159/000105487 · Cited by 44
Effect of group size on the aggression strategy of an extirpating stingless bee, Trigona spinipes
Nieh, J. C., Kruizinga, K., Barreto, L. S., Contrera, F. A. L., & Imperatriz-Fonseca, V. L. (2005) · Insectes Sociaux · doi:10.1007/s00040-004-0785-6 · Cited by 44
Predation and Risk Behaviors of Free-Roaming Owned Cats in Auckland, New Zealand via the Use of Animal-Borne Cameras
Bruce, S. J., Zito, S., Gates, M. C., Aguilar, G. D., Walker, J. K., Goldwater, N., & Dale, A. R. (2019) · Frontiers in Veterinary Science · doi:10.3389/fvets.2019.00205 · Cited by 43
Stress in the social context: a behavioural and eco-evolutionary perspective
MacLeod, K. J., English, S., Ruuskanen, S., & Taborsky, B. (2023) · Journal of Experimental Biology · doi:10.1242/jeb.245829 · Cited by 50
Associations between success and failure in a face-to-face competition and psychobiological parameters in young women
Costa, R., & Salvador, A. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.012 · Cited by 43
Juvenile social subjugation induces a sex-specific pattern of anxiety and depression-like behaviors in adult rats
Weathington, J. M., Arnold, A. R., & Cooke, B. M. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.10.008 · Cited by 43
Host stress hormones alter vector feeding preferences, success, and productivity
Gervasi, S. S., Burkett-Cadena, N. D., Burgan, S. C., Schrey, A. W., Hassan, H. K., Unnasch, T. R., & Martin, L. B. (2016) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2016.1278 · Cited by 43
Effect of different rearing systems and pre-kindling handling on behaviour and performance of rabbit does
Mugnai, C., Bosco, A. D., & Castellini, C. (2009) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2009.02.007 · Cited by 42
Exogenous norepinephrine attenuates the efficacy of sunitinib in a mouse cancer model
Deng, G.-H., Liu, J., Zhang, J., Wang, Y., Peng, X., Wei, Y.-Q., & Jiang, Y. (2014) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-33-21 · Cited by 42
Non-invasive cortisol measurements as indicators of physiological stress responses in guinea pigs
Nemeth, M., Pschernig, E., Wallner, B., & Millesi, E. (2016) · PeerJ · doi:10.7717/peerj.1590 · Cited by 45
Methods for Evaluating the Combined Effects of Chemical and Nonchemical Exposures for Cumulative Environmental Health Risk Assessment
Payne-Sturges, D., Scammell, M. K., Levy, J. I., Cory‐Slechta, D. A., Symanski, E., Shmool, J. L. C., Laumbach, R. J., Linder, S. H., & Clougherty, J. E. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15122797 · Cited by 43
Antidepressant‐like effects of 20(S)‐protopanaxadiol in a mouse model of chronic social defeat stress and the related mechanisms
Jiang, N., Lv, J., Wang, H., Wang, Q., Lü, C., Yang, Y., Huang, H. M., Xia, T., Lv, G., & Liu, X. (2019) · Phytotherapy Research · doi:10.1002/ptr.6446 · Cited by 42
Infrared thermography of agonistic behaviour in pigs
Boileau, A., Farish, M., Turner, S. P., & Camerlink, I. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112637 · Cited by 42
Antidepressant-Like Effects of Erythropoietin: A Focus on Behavioural and Hippocampal Processes
Osborn, M., Rustom, N., Clarke, M., Litteljohn, D., Rudyk, C., Anisman, H., & Hayley, S. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072813 · Cited by 41
Effects of social crowding on emotionality and expression of hippocampal nociceptin/orphanin FQ system transcripts in mice
Reiss, D., Wolter-Sutter, A., Krężel, W., & Ouagazzal, A. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.07.010 · Cited by 41
Enhancement of social isolation-induced aggressive behavior of young mice by zinc deficiency
Takeda, A., Tamano, H., Kan, F., Hanajima, T., Yamada, K., & Oku, N. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.02.005 · Cited by 41
The effects of enriching laboratory cages using various physical structures on multiple measures of welfare in singly-housed rats
Abou-Ismail, U. A., & Mahboub, H. D. H. (2011) · Laboratory Animals · doi:10.1258/la.2011.010149 · Cited by 41
Future social rank: forecasting status in the green anole (Anolis carolinensis)
Korzan, W. J., Øverli, Ø., & Summers, C. H. (2006) · acta ethologica · doi:10.1007/s10211-006-0015-5 · Cited by 41
Sex Differences in Steroid Modulation of Ethanol Withdrawal in Male and Female Rats
Alele, P. E., & Devaud, L. L. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.107896 · Cited by 41
Animal models of social stress: the dark side of social interactions
Masís-Calvo, M., Schmidtner, A. K., Oliveira, V. E. D. M., Grossmann, C. P., A, T. R. D. J., & Neumann, I. D. (2018) · Stress · doi:10.1080/10253890.2018.1462327 · Cited by 45
Effects of long-lasting social isolation and re-socialization on cognitive performance and brain activity: a longitudinal study in Octodon degus
Rivera, D. S., Lindsay, C. B., Oliva, C. A., Codocedo, J. F., Bozinovic, F., & Inestrosa, N. C. (2020) · Scientific Reports · doi:10.1038/s41598-020-75026-4 · Cited by 48
The Integration of Behaviour into Comparative Physiology
Gilmour, K. M., Wilson, R. W., & Sloman, K. A. (2005) · Physiological and Biochemical Zoology · doi:10.1086/432144 · Cited by 40
Winning Isn't Everything: Mood and Testosterone Regulate the Cortisol Response in Competition
Zilioli, S., & Watson, N. V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0052582 · Cited by 39
Behavioural characterization of C57BL/6N and BALB/c female mice in social home cage – Effect of mixed housing in complex environment
Heinla, I., Åhlgren, J., Vasar, E., & Võikar, V. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.01.024 · Cited by 37
Social defeat-induced anhedonia: effects on operant sucrose-seeking behavior
Riga, D., Theijs, J. T., Vries, T. J. D., Smit, A. B., & Spijker, S. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00195 · Cited by 41
Effect of chronic stress on short and long-term plasticity in dentate gyrus; Study of recovery and adaptation
Radahmadi, M., Hosseini, N., & Nasimi, A. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.005 · Cited by 37
Behavioral and physiological responses of female prairie voles (Microtus ochrogaster) to various stressful conditions
Smith, A. S., Lieberwirth, C., & Wang, Z. (2013) · Stress · doi:10.3109/10253890.2013.794449 · Cited by 37
Adolescent social stress increases anxiety-like behavior and ethanol consumption in adult male and female C57BL/6J mice
Caruso, M. J., Seemiller, L. R., Fetherston, T. B., Miller, C. N., Reiss, D. E., Cavigelli, S. A., & Kamens, H. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-28381-2 · Cited by 37
Consequences of different housing conditions on brain morphology in laying hens
Patzke, N., Ocklenburg, S., van der Staay, F. J., Güntürkün, O., & Manns, M. (2008) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2008.12.005 · Cited by 37
Age- and Sex-Dependent Impact of Repeated Social Stress on Intrinsic and Synaptic Excitability of the Rat Prefrontal Cortex
Urban, K. R., & Valentino, R. J. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw388 · Cited by 36

Authors: Blanchard, R. J., McKittrick, C. R., & Blanchard, D. C.
Affiliations: University of Hawaiʻi at Mānoa (US)
Rutgers, The State University of New Jersey (US)
Corresponding author: Blanchard, Robert J
ORCID: Blanchard, D.Caroline
Venue: Physiology & Behavior
Publisher: Elsevier BV
Published: 2001-06
Volume: 73
Issue: 3
Pages: 261-271
ISSN: 0031-9384 (ISSN-L)
DOI: 10.1016/s0031-9384(01)00449-8
OpenAlex: W2074796005
Cited by: 595
References: 126
Citations by year: 2026: 10 · 2025: 14 · 2024: 22 · 2023: 23 · 2022: 17 · 2021: 27 · 2020: 25 · 2019: 26 · 2018: 23 · 2017: 31 · 2016: 34 · 2015: 33 · 2014: 42 · 2013: 26 · 2012: 39
FWCI: 7.65
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Physiology & Behavior (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: social stress, animal models of stress, social isolation, agonistic behavior, dominance hierarchy, hypothalamic-pituitary-adrenal axis, glucocorticoids, serotonin, noradrenergic system, monoamines, peptidergic systems, hippocampus, dentate gyrus, neurogenesis, aggression, defensiveness, sex differences
MeSH terms: Animals, Behavior, Animal, Brain, Brain Chemistry, Models, Psychological, Social Environment, Stress, Psychological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Animal models of social stress: effects on behavior and brain neurochemical systems

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks