Synthesis of (+)-artemisinin and (+)-deoxoartemisinin from arteannuin B and arteannuic acid
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The evidence for steps ii)-iv) proposed in Scheme 12 comes solely from in vitro studies conducted with the tertiary allylic hydroperoxide 481.
“The evidence for steps ii)-iv) which are proposed in Scheme 12 comes solely from in vitro studies, conducted with the tertiary allylic hydroperoxide 481 [171,236,237,239,254], which can be obtained in good yield from photosensitized oxygenation of 480 [193,218].”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [239]
Arteannuin B can be converted into artemisinin by chemical transformations.
“It is indeed possible to convert arteannuin B into artemisinin by chemical transformations [239]”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [239]
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Clair, J. J. L. (2006) · Angewandte Chemie · doi:10.1002/ange.200504033 · Cited by 2 · see citing works
Nowak, D. M., & LANSBURY, P. T. (1998) · ChemInform · doi:10.1002/chin.199819188
Self-citationRimada, R. S., Gatti, W. O., Jeandupeux, R., & Cafferata, L. F. R. (2009)
Research on Synthetic Method of Artemisinin
Tu, Y. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811655-5.00013-1
Photochemical routes to artemisinin
Lancel, M., Tambosco, B., & Amara, Z. (2023) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781837672301-00301
Forschung zur Artemisinin-Synthesemethode
Tu, Y. (2024) · Springer eBooks · doi:10.1007/978-3-662-68757-4_13
- Authors
- Nowak, D. M., & Lansbury, P. T.
- Affiliations
- University at Buffalo, State University of New York (US)
- Corresponding author
- Nowak, Deanne M
- Venue
- Tetrahedron
- Publisher
- Elsevier BV
- Published
- 1998-01
- Volume
- 54
- Issue
- 3-4
- Pages
- 319-336
- ISSN
- 0040-4020 (ISSN-L)
- OpenAlex
- W2000228966
- Cited by
- 51
- References
- 65
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 3 · 2017: 4 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 4
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Tetrahedron (publishedVersion)
- Funders
- Merck Sharp and Dohme
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Physical Sciences › Chemistry › Organic Chemistry › Organic Chemistry Synthesis Methods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biological Activity of Diterpenoids and Biflavonoids
- Keywords
- artemisinin, arteannuin B, total synthesis, photooxygenation, cyclization, oxidative lactonization, convergent synthesis, sesquiterpene lactones
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