Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug

Qinghaosu (Artemisinin): an Antimalarial Drug from China

Klayman, D. L. (1985) · Science · doi:10.1126/science.3887571 · Cited by 2,186 · see citing works

Engineering a mevalonate pathway in Escherichia coli for production of terpenoids

Martin, V. J. J., Pitera, D. J., Withers, S. T., Newman, J. D., & Keasling, J. D. (2003) · Nature Biotechnology · doi:10.1038/nbt833 · Cited by 1,720 · see citing works

Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial.

(2005) · The Lancet · doi:10.1016/s0140-6736(05)67176-0 · Cited by 1,050 · see citing works

Artemisinins target the SERCA of Plasmodium falciparum

Eckstein‐Ludwig, U., Webb, R. J., van Goethem, I. D. A., East, J. M., Lee, A. G., Kimura, M., O’Neill, P. M., Bray, P. G., Ward, S. A., & Krishna, S. (2003) · Nature · doi:10.1038/nature01813 · Cited by 1,029 · see citing works

Identification of an antimalarial synthetic trioxolane drug development candidate

Vennerstrom, J. L., Arbe‐Barnes, S., Brun, R., Charman, S. A., Chiu, F. C. K., Chollet, J., Dong, Y., Dorn, A., Hunziker, D., Matile, H., et al. (2004) · Nature · doi:10.1038/nature02779 · Cited by 622 · see citing works

Untitled work

(1994) · Medical Entomology and Zoology · Cited by 615 · see citing works

T-DNA of Agrobacterium tumefaciens encodes an enzyme of cytokinin biosynthesis.

Akiyoshi, D. E., Klee, H. J., Amasino, R. M., Nester, E. W., & Gordon, M. P. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.19.5994 · Cited by 513 · see citing works

Enzymic formation of sesquiterpenes

Cane, D. E. (1990) · Chemical Reviews · doi:10.1021/cr00105a002 · Cited by 469 · see citing works

<i>Artemisia annua</i> L. (Asteraceae) trichome‐specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin

Teoh, K. H., Polichuk, D. R., Reed, D. W., Nowak, G., & Covello, P. S. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.01.065 · Cited by 409 · see citing works

Automation and environmental control in plant tissue culture

Aitken-Christie, J., Kozai, T., & Smith, M. A. L. (1995) · Springer eBooks · doi:10.1007/978-94-015-8461-6 · Cited by 347 · see citing works

Is the Reaction Catalyzed by 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase a Rate-Limiting Step for Isoprenoid Biosynthesis in Plants?

Chappell, J., Wolf, F., Proulx, J., Cuellar, R., & Saunders, C. (1995) · Plant Physiology · doi:10.1104/pp.109.4.1337 · Cited by 335 · see citing works

The chemistry, pharmacology, and clinical applications of qinghaosu (Artemisinin) and its derivatives

Luo, X., & Shen, C. (1987) · Medicinal Research Reviews · doi:10.1002/med.2610070103 · Cited by 320 · see citing works

Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway inEscherichia coli enhances lycopene production

Kim, S.-W., & Keasling, J. D. (2001) · Biotechnology and Bioengineering · doi:10.1002/1097-0290(20000220)72:4 · Cited by 300 · see citing works

Cytokinin/auxin balance in crown gall tumors is regulated by specific loci in the T-DNA

Akiyoshi, D. E., Morris, R. O., Hinz, R., Mischke, B. S., Kosuge, T., Garfinkel, D. J., Gordon, M. P., & Nester, E. W. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.2.407 · Cited by 298 · see citing works

Secondary metabolism of hairy root cultures in bioreactors

Kim, Y., Wyslouzil, B. E., & Weathers, P. J. (2002) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1079/ivp2001243 · Cited by 290 · see citing works

Molecular Cloning, Expression, and Characterization of Amorpha-4,11-diene Synthase, a Key Enzyme of Artemisinin Biosynthesis in Artemisia annua L.

Mercke, P., Bengtsson, M., Bouwmeester, H. J., Posthumus, M. A., & Brodelius, P. E. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1962 · Cited by 283 · see citing works

Development and Fine Structure of the Glandular Trichomes of Artemisia annua L.

Duke, S. O., & Paul, R. N. (1993) · International Journal of Plant Sciences · doi:10.1086/297096 · Cited by 276 · see citing works

Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis

Bouwmeester, H. J., Wallaart, T. E., Janssen, M. H. A., van Loo, B., Jansen, B. J. M., Posthumus, M. A., Schmidt, C. O., De Kraker, J.-W., König, W. A., & Franssen, M. C. R. (1999) · Phytochemistry · doi:10.1016/s0031-9422(99)00206-x · Cited by 266 · see citing works

Isoprenoid Biosynthesis in Plants: Carbon Partitioning Within the Cytoplasmic Pathway

Newman, J. D., & Chappell, J. (1999) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409239991209228 · Cited by 266 · see citing works

A single amino acid residue can determine the sensitivity of SERCAs to artemisinins

Uhlemann, A., Cameron, A., Eckstein‐Ludwig, U., Fischbarg, J., Iserovich, P., Zuñiga, F. A., Malcolm, E. A. S. T., Lee, A. J., Brady, L., Haynes, R. K., et al. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb947 · Cited by 256 · see citing works

Localization of Artemisinin and Artemisitene in Foliar Tissues of Glanded and Glandless Biotypes of Artemisia annua L.

Duke, M. V., Paul, R. N., Elsohly, H. N., Sturtz, G., & Duke, S. O. (1994) · International Journal of Plant Sciences · doi:10.1086/297173 · Cited by 252 · see citing works

Artemisinin, a Novel Antimalarial Drug: Biochemical and Molecular Approaches for Enhanced Production

Abdin, M. Z., Israr, M., Rehman, R. U., & Jain, S. K. (2003) · Planta Medica · doi:10.1055/s-2003-38871 · Cited by 252 · see citing works

Stereoselective total synthesis of (+)-artemisinin, the antimalarial constituent of Artemisia annua L

Avery, M. A., Chong, W. K. M., & Jennings-White, C. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00029a028 · Cited by 250 · cited 1× · see citing works

Artemisinins: mechanisms of action and potential for resistance

Krishna, S., Uhlemann, A., & Haynes, R. K. (2004) · Drug Resistance Updates · doi:10.1016/j.drup.2004.07.001 · Cited by 243 · see citing works

Amorpha-4,11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin

Wallaart, T. E., Bouwmeester, H. J., Hille, J., Poppinga, L., & Maijers, N. C. A. (2001) · Planta · doi:10.1007/s004250000428 · Cited by 242 · see citing works

Expression of a chimeric farnesyl diphosphate synthase gene in Artemisia annua L. transgenic plants via Agrobacterium tumefaciens-mediated transformation

Chen, D.-H., Ye, H.-C., & Li, G.-F. (2000) · Plant Science · doi:10.1016/s0168-9452(00)00217-x · Cited by 225 · see citing works

Precursor Balancing for Metabolic Engineering of Lycopene Production in Escherichia coli

Farmer, W. R., & Liao, J. C. (2001) · Biotechnology Progress · doi:10.1021/bp000137t · Cited by 213 · see citing works

Expression of an exogenous isopentenyl diphosphate isomerase gene enhances isoprenoid biosynthesis in Escherichia coli

Kajiwara, S., Fraser, P. D., Kondô, K., & Misawa, N. (1997) · Biochemical Journal · doi:10.1042/bj3240421 · Cited by 210 · see citing works

Identification of Intermediates and Enzymes Involved in the Early Steps of Artemisinin Biosynthesis in<i>Artemisia annua</i>

Bertea, C. M., Freije, J. R., van der Woude, H., Verstappen, F. W., Perk, L., Marquez, V., De Kraker, J.-W., Posthumus, M. A., Jansen, B. J., de Groot, A., et al. (2005) · Planta Medica · doi:10.1055/s-2005-837749 · Cited by 205 · see citing works

Efficacy of Artesunate Plus Amodiaquine versus That of Artemether-Lumefantrine for the Treatment of Uncomplicated Childhood Plasmodium falciparum Malaria in Zanzibar, Tanzania

Mårtensson, A., Stromberg, J., Sisowath, C., Msellem, M. I., Gil, J. P., Montgomery, S., Olliaro, P., Ali, A., & Björkman, A. (2005) · Clinical Infectious Diseases · doi:10.1086/444460 · Cited by 203 · see citing works

Cytokinin Accumulation and Action: Biochemical, Genetic, and Molecular Approaches

Binns, A. N. (1994) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.pp.45.060194.001133 · Cited by 203 · see citing works

Effect of light irradiation on hairy root growth and artemisinin biosynthesis of Artemisia annua L

Liu, C., Guo, C., Wang, Y., & Ouyang, F. (2002) · Process Biochemistry · doi:10.1016/s0032-9592(02)00165-6 · Cited by 183 · see citing works

Total synthesis of arteannuin and deoxyarteannuin

Xing-Xiang, X., Jie, Z., Da-Zhong, H., & Wei-Shan, Z. (1986) · Tetrahedron · doi:10.1016/s0040-4020(01)87487-1 · Cited by 181 · see citing works

Controlled Cytokinin Production in Transgenic Tobacco Using a Copper-Inducible Promoter

McKenzie, M. J., Mett, V. L., Reynolds, P. H. S., & Jameson, P. E. (1998) · PLANT PHYSIOLOGY · doi:10.1104/pp.116.3.969 · Cited by 129 · see citing works

Isolation and Identification of Dihydroartemisinic Acid from <i>Artemisia annua</i> and Its Possible Role in the Biosynthesis of Artemisinin

Wallaart, T. E., van Uden, W., Lubberink, H. G. M., Woerdenbag, H. J., Pras, N., & Quax, W. J. (1999) · Journal of Natural Products · doi:10.1021/np980370p · Cited by 129 · see citing works

The effect of phytohormones on growth and artemisinin production in Artemisia annua hairy roots

Weathers, P. J., Bunk, G., & McCoy, M. C. (2005) · In Vitro Cellular &amp; Developmental Biology - Plant · doi:10.1079/ivp2004604 · Cited by 129 · see citing works

Improved growth of Artemisia annua L hairy roots and artemisinin production under red light conditions

Wang, Y., Zhang, H., Zhao, B., & Yuan, X. (2001) · Biotechnology Letters · doi:10.1023/a:1013786332363 · Cited by 126 · see citing works

Production of the new antimalarial drug artemisinin in shoot cultures of Artemisia annua L.

Woerdenbag, H. J., Lüers, J. F. J., van Uden, W., Pras, N., Malingré, T. M., & Alfermann, A. W. (1993) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/bf00029850 · Cited by 120 · see citing works

Artemisinin production by transformed roots of Artemisia annua

Weathers, P. J., Cheetham, R. D., Follansbee, E., & Teoh, K. H. (1994) · Biotechnology Letters · doi:10.1007/bf00149632 · Cited by 117 · see citing works

Spiro and Dispiro-1,2,4-trioxolanes as Antimalarial Peroxides: Charting a Workable Structure−Activity Relationship Using Simple Prototypes

Dong, Y., Chollet, J., Matile, H., Charman, S. A., Chiu, F. C. K., Charman, W. N., Scorneaux, B., Urwyler, H., Tomas, J. S., Scheurer, C., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm049040u · Cited by 117 · see citing works

Traditional antimalarials and the development of novel antimalarial drugs

Wright, C. W. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.05.012 · Cited by 114 · see citing works

Effects of ipt gene expression on the physiological and chemical characteristics of Artemisia annua L.

Geng, S., Ma, M., Ye, H., Liu, B., Li, G., & Chong, K. (2001) · Plant Science · doi:10.1016/s0168-9452(00)00453-2 · Cited by 110 · see citing works

Artemisia judaica L.: micropropagation and antioxidant activity

Chang-jiang, L., Murch, S. J., El-Demerdash, M., & Saxena, P. K. (2004) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2004.01.011 · Cited by 109 · see citing works

Isolation and Identification of Dihydroartemisinic Acid Hydroperoxide from<i>Artemisia annua</i>:  A Novel Biosynthetic Precursor of Artemisinin

Wallaart, T. E., Pras, N., & Quax, W. J. (1999) · Journal of Natural Products · doi:10.1021/np9900122 · Cited by 101 · see citing works

Production of artemisinin in tissue cultures of Artemisia annua

Nair, M. S. R., Acton, N., Klayman, D. L., Kendrick, K., Basile, D. V., & Mante, S. (1986) · Journal of Natural Products · doi:10.1021/np50045a021 · Cited by 98 · cited 1× · see citing works

Reaction of artemisinin with haemoglobin: implications for antimalarial activity

Kannan, R., Kumar, K., Sahal, D., Kukreti, S., & Chauhan, V. S. (2005) · Biochemical Journal · doi:10.1042/bj20041170 · Cited by 97 · see citing works

Cloning and analysis of a cDNA encoding farnesyl diphosphate synthase from Artemisia annua

Matsushita, Y., Kang, W., & Charlwood, B. V. (1996) · Gene · doi:10.1016/0378-1119(96)00054-6 · Cited by 95 · see citing works

Production of artemisinin by hairy root cultures of Artemisia annua L

Liu, C. Z., Wang, Y. C., Ouyang, F., Ye, H. C., & Li, G. F. (1997) · Biotechnology Letters · doi:10.1023/a:1018362309677 · Cited by 94 · see citing works

REVIEW: Metabolic Engineering of Isoprenoids

Barkovich, R. J., & Liao, J. C. (2001) · Metabolic Engineering · doi:10.1006/mben.2000.0168 · Cited by 88 · see citing works

Automation in plant tissue culture — general introduction and overview —

Aitken-Christie, J., Kozai, T., & Takayama, S. (1995) · Springer eBooks · doi:10.1007/978-94-015-8461-6_1 · Cited by 87 · see citing works

Effects of gibberellic acid on hairy root cultures of Artemisia annua: Growth and artemisinin production

Smith, T. C., Weathers, P. J., & Cheetham, R. D. (1997) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/s11627-997-0044-4 · Cited by 87 · see citing works

Germplasm Variation in Artemisinin Content of Artemism annua Using an Alternative Method of Artemisinin Analysis from Crude Plant Extracts

Charles, D. J., Simon, J. E., Wood, K. V., & Heinstein, P. F. (1990) · Journal of Natural Products · doi:10.1021/np50067a021 · Cited by 87 · see citing works

Enzyme-catalyzed synthesis of sugar-containing monomers and linear polymers

Park, O.-J., Kim, D., & Dordick, J. S. (2000) · Biotechnology and Bioengineering · doi:10.1002/1097-0290(20001020)70:2 · Cited by 83 · see citing works

Cloning of an Arabidopsis thaliana cDNA coding for farnesyl diphosphate synthase by functional complementation in yeast

Delourme, D., Lacroute, F., & Karst, F. (1994) · Plant Molecular Biology · doi:10.1007/bf00019499 · Cited by 83 · see citing works

Scale‐up of Artemisia annua L. hairy root cultures produces complex patterns of terpenoid gene expression

Souret, F. F., Kim, Y., Wyslouzil, B. E., Wobbe, K. K., & Weathers, P. J. (2003) · Biotechnology and Bioengineering · doi:10.1002/bit.10711 · Cited by 81 · see citing works

Biosynthesis of artemisinin in Artemisia annua

Akhila, A., Thakur, R. S., & Popli, S. P. (1987) · Phytochemistry · doi:10.1016/s0031-9422(00)81731-8 · Cited by 78 · see citing works

Artemisinin production by Artemisia annua L.-transformed organ cultures

Paniego, N. B., & Giulietti, A. M. (1996) · Enzyme and Microbial Technology · doi:10.1016/0141-0229(95)00216-2 · Cited by 75 · see citing works

A comparative study of mist and bubble column reactors in the in vitro production of artemisinin

Kim, Y., Wyslouzil, B. E., & Weathers, P. J. (2001) · Plant Cell Reports · doi:10.1007/s002990100342 · Cited by 75 · see citing works

Artemisia annua L.: dedifferentiated and differentiated cultures

Paniego, N. B., & Giulietti, A. M. (1994) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/bf00037715 · Cited by 73 · see citing works

Agrobacterium tumefaciens-mediated transformation of Artemisia annua L. and regeneration of transgenic plants

Vergauwe, A., Cammaert, R., Vandenberghe, D., Genetello, C., Inzé, D., Montagu, M. V., & den Eeckhout, E. V. (1996) · Plant Cell Reports · doi:10.1007/bf00231590 · Cited by 72 · see citing works

Antimalarial Multi-Drug Resistance in Asia: Mechanisms and Assessment

Uhlemann, A., & Krishna, S. (2005) · Current topics in microbiology and immunology · doi:10.1007/3-540-29088-5_2 · Cited by 71 · see citing works

Effect of Sterol Inhibitors on the Incorporation of¹⁴<i>C</i>-Isopentenyl Pyrophosphate into Artemisinin by a Cell-Free System from<i>Artemisia annua</i>Tissue Cultures and Plants

Kudakasseril, G., Lam, L., & Staba, E. (1987) · Planta Medica · doi:10.1055/s-2006-962706 · Cited by 70 · see citing works

Biotransformation of arteannuic acid into arteannuin-B and artemisinin in Artemisia annua

Sangwan, R. S., Agarwal, K., Luthra, R., Thakur, R. S., & Sangwan, N. S. (1993) · Phytochemistry · doi:10.1016/0031-9422(91)80019-w · Cited by 68 · see citing works

High efficiency of genetic transformation and regeneration of Artemisia annua L. via Agrobacterium tumefaciens-mediated procedure

Han, J., Wang, H., Ye, H., Liu, Y., Li, Z., Zhang, Y., Zhang, Y., Fang, Y., & Li, G. (2004) · Plant Science · doi:10.1016/j.plantsci.2004.07.020 · Cited by 67 · see citing works

Three-dimensional structure of Plasmodium falciparum Ca2+-ATPase(PfATP6) and docking of artemisinin derivatives to PfATP6

Jung, M., Kim, H., Nam, K. Y., & No, K. T. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.04.041 · Cited by 65 · see citing works

Alteration of biomass and artemisinin production in Artemisia annua hairy roots by media sterilization method and sugars

Weathers, P. J., Jesus-Gonzalez, L. D., Kim, Y. J., Souret, F. F., & Towler, M. J. (2004) · Plant Cell Reports · doi:10.1007/s00299-004-0837-4 · Cited by 65 · see citing works

The Production of Artemisinin in Artemisia annua L. Tissue Cultures

Martinez, B. C., & Staba, E. J. (1988) · Advances in cell culture · doi:10.1016/b978-0-12-007906-3.50009-7 · Cited by 63 · see citing works

Bioconversion of arteannuin B to artemisinin

Nair, M. S. R., & Basile, D. V. (1993) · Journal of Natural Products · doi:10.1021/np50099a015 · Cited by 62 · cited 3× · see citing works

Synergistic cytotoxicity of artemisinin and sodium butyrate on human cancer cells.

Singh, N. P., & Lai, H. C. (2005) · PubMed · Cited by 60 · see citing works

Advances in the Plant Isoprenoid Biosynthesis Pathway and Its Metabolic Engineering

Liu, Y., Wang, H., Ye, H., & Li, G. (2005) · Journal of Integrative Plant Biology · doi:10.1111/j.1744-7909.2005.00111.x · Cited by 60 · see citing works

Factors influencing Agrobacterium tumefaciens-mediated transformation of Artemisia annua L.

Vergauwe, A., Geldre, E. V., Inzé, D., MONTAGU, M. V., & den Eeckhout, E. V. (1998) · Plant Cell Reports · doi:10.1007/s002990050540 · Cited by 58 · see citing works

Antiplasmodial activity of Artemisia annua plant cell cultures

Tawfiq, N. K., Anderson, L. A., ROBERTS, M. F., Phillipson, J. D., Bray, D. H., & Warhurst, D. C. (1989) · Plant Cell Reports · doi:10.1007/bf00270085 · Cited by 56 · see citing works

Artemisinin production in Artemisia annua hairy root cultures with improved growth by altering the nitrogen source in the medium

Wang, J., & Tan, R. X. (2002) · Biotechnology Letters · doi:10.1023/a:1016126917795 · Cited by 55 · see citing works

Production of terpenoid from Artemisia annua L. plantlet cultures in bioreactor

Fulzele, D. P., Heble, M. R., & Rao, P. S. (1995) · Journal of Biotechnology · doi:10.1016/0168-1656(95)00034-n · Cited by 54 · see citing works

Immunoquantitative analysis of artemisinin from Artemisia annua using polyclonal antibodies

Ferreira, J., & Janick, J. (1996) · Phytochemistry · doi:10.1016/0031-9422(95)00542-0 · Cited by 54 · see citing works

Comparison of various bioreactors on growth and artemisinin biosynthesis of Artemisia annua L. shoot cultures

Liu, C., Chen, G., Wang, Y., & Ouyang, F. (2003) · Process Biochemistry · doi:10.1016/s0032-9592(02)00294-7 · Cited by 49 · see citing works

The mevalonate-independent pathway is expressed in transformed roots of Artemisia annua and regulated by light and culture age

Souret, F. F., Weathers, P. J., & Wobbe, K. K. (2002) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1079/ivp2002343 · Cited by 48 · see citing works

A novel ketone derivative of artemisinin biotransformed by Streptomyces griseus ATCC 13273

Liu, J.-H., Chen, Y., Yu, B., & Chen, Y. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.12.076 · Cited by 44 · see citing works

On the possible role of qinghao acid in the biosynthesis of artemisinin

El-Feraly, F. S., Al-Meshal, I. A., Al-Yahya, M. A., & Hifnawy, M. S. (1986) · Phytochemistry · doi:10.1016/s0031-9422(00)83739-5 · Cited by 41 · see citing works

Studies on the Effects of<i>fpf1</i>Gene on<i>Artemisia annua</i>Flowering Time and on the Linkage between Flowering and Artemisinin Biosynthesis

(2004) · Planta Medica · doi:10.1055/s-2004-818947 · Cited by 39 · see citing works

In VitroProduction of Artemisinin fromArtemisia annuaL.

Whipkey, A. L., Simon, J. E., Charles, D. J., & Janick, J. (1992) · Journal of Herbs Spices & Medicinal Plants · doi:10.1300/j044v01n01_03 · Cited by 38 · see citing works

Advances in the plant isoprenoid biosynthesis pathway and its metabolic engineering

Liu, Wang, Ye, Hc, & Li, L. (2007) · 中国生物学文摘 · Cited by 38 · see citing works

In Vitro Micropropagation and Flowering in Artemisia annua

Gulati, A., Bharel, S., Jain, S. K., Abdin, M. Z., & Srivastava, P. S. (1996) · Journal of Plant Biochemistry and Biotechnology · doi:10.1007/bf03262976 · Cited by 37 · see citing works

A cDNA Encoding Farnesyl Pyrophosphate Synthase in White Lupin

Attucci, S., Aitken, S.-M., Ibrahim, R. K., & Gulick, P. J. (1995) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.2.835 · Cited by 34 · see citing works

Induction of Hairy Root from Artemisia annua with Agrobacterium rhizogenes and Its Culture in Vitro

Qin, M., Guo-zhen, L., Yue, Y., Ye, H., & Li, G. (1994) · Journal of Integrative Plant Biology · Cited by 31 · see citing works

Production of artemisinin by hairy rot cultures of Artemisia annua L in bioreactor

Chang-jiang, L., Wang, Y., Ouyang, F., Ye, H., & Li, G. F. (1998) · Biotechnology Letters · doi:10.1023/a:1005382020039 · Cited by 30 · see citing works

Selection of hairy root clones of Artemisia annua L. for artemisinin production

Xie, D., Ye, H., Li, G., Guo, Z., ZOU, Z., & Guo, Z. (2001) · Israel Journal of Plant Sciences · doi:10.1560/n11n-6blg-er7c-xkct · Cited by 29 · see citing works

Computational analysis of the evolution of the structure and function of 1-deoxy-d-xylulose-5-phosphate synthase, a key regulator of the mevalonate-independent pathway in plants

Krushkal, J., Pistilli, M., Ferrell, K. M., Souret, F. F., & Weathers, P. J. (2003) · Gene · doi:10.1016/s0378-1119(03)00668-1 · Cited by 27 · see citing works

Purification and Characterization of an enzyme involved in biochemical transformation of arteannuin B to artemisinin from Artemisia annua

Dhingra, V., & Lakshmi Narasu, M. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4197 · Cited by 27 · see citing works

Molecular Cloning, Escherichia coli Expression and Genomic Organization of Squalene Synthase Gene from Artemisia annua

He, Y. (2003) · Cited by 26 · see citing works

Enhanced production of artemisinin by

Liu, C., Wang, Y., Guo, C., Ouyang, F., Ye, H., & Li, G. (1998) · Bioprocess Engineering · doi:10.1007/pl00009026 · Cited by 25 · see citing works

Oallus Induction and Regeneration of Plantlets from Artemisia annua and Changes of Qinhaosu Contents

Xi-chun, H., Zeng, M.-Y., Li, G., & Zheng, L. (1983) · Journal of Integrative Plant Biology · Cited by 24 · see citing works

The future of antimalarials: Artemisins and synthetic endoperoxides

Begue, J. P., & BONNET‐DELPON, D. (2005) · Drugs of the Future · doi:10.1358/dof.2005.030.05.901987 · Cited by 21 · see citing works

Multiple shoot culture of Dianthus caryophyllus using mist culture system

Woo, S. H., & Park, J. M. (1993) · Biotechnology Techniques · doi:10.1007/bf00152615 · Cited by 13 · see citing works

Ultrastructural changes of parenchyma cells in detached garlic scape during storage

Wang, Y., Chenghou, L., & Shi-jie, Y. (1994) · Europe PMC (PubMed Central) · Cited by 13 · see citing works

Immobilization of rice (Oryza sativa L.) callus in polyurethane foam using a turbine blade reactor

Liu, C., Moon, K., Honda, H., & Kobayashi, T. (2000) · Biochemical Engineering Journal · doi:10.1016/s1369-703x(99)00046-7 · Cited by 10 · see citing works

Studies on dynamics of growth and biosynthesis of artemisinin in hairy roots of Artemisia annua L.

Liu, B., Ye, H., Li, G., Chen, D., Geng, S., Zhang, Y., Chen, J., & Gao, J. (1998) · PubMed · Cited by 10 · see citing works

The London School of Hygiene and Tropical Medicine: a new century of malaria research

Riley, E. M. (2000) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762000000700004 · Cited by 9 · see citing works

Culture of transgenic Artemisia annua hairy root with cotton cadinene synthase gene

Chen, D., Meng, Y., Ye, H., Li, G., & Chen, X. (1998) · Europe PMC (PubMed Central) · Cited by 9 · see citing works

Global fund switches to artemisinin

Shetty, P. (2004) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(04)01087-4 · Cited by 6 · see citing works

Expression of Green Fluorecent Protein Gene in Transgenic Shoots of Artemisia annua

Chen, D. (1999) · Cited by 6 · see citing works

New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics

Pan, S.-Y., Zhou, S.-F., Gao, S.-H., Yu, Z., Zhang, S.-F., Tang, M.-K., Sun, J.-N., Ma, D., Han, Y., Fong, W. F., et al. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/627375 · Cited by 723 · see citing works

Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials

Corson, T. W., & Crews, C. M. (2007) · Cell · doi:10.1016/j.cell.2007.08.021 · Cited by 656 · see citing works

Terpenoids: Opportunities for Biosynthesis of Natural Product Drugs Using Engineered Microorganisms

Ajikumar, P. K., Tyo, K. E. J., Carlsen, S., Mucha, O., Too, H., & Stephanopoulos, G. N. (2008) · Molecular Pharmaceutics · doi:10.1021/mp700151b · Cited by 445 · see citing works

Genome Sequence of Babesia bovis and Comparative Analysis of Apicomplexan Hemoprotozoa

Brayton, K. A., Lau, A. O. T., Herndon, D. R., Hannick, L. I., Kappmeyer, L. S., Berens, S. J., Bidwell, S. L., Brown, W. C., Crabtree, J., Fadrosh, D., et al. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030148 · Cited by 401 · see citing works

Production and engineering of terpenoids in plant cell culture

Roberts, S. C. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.8 · Cited by 372 · see citing works

The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)

Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363 · see citing works

Recent advances towards development and commercialization of plant cell culture processes for the synthesis of biomolecules

Wilson, S., & Roberts, S. C. (2011) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2011.00664.x · Cited by 359 · see citing works

Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis

Zhao, L., Chang, W., Xiao, Y., Liu, H., & Liu, P. (2013) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-052010-100934 · Cited by 356 · see citing works

Pharmaceutically Active Natural Product Synthesis and Supply via Plant Cell Culture Technology

Kolewe, M. E., Gaurav, V., & Roberts, S. C. (2008) · Molecular Pharmaceutics · doi:10.1021/mp7001494 · Cited by 294 · see citing works

21st Century Natural Product Research and Drug Development and Traditional Medicines

Ngo, L., Okogun, J., & Folk, W. (2013) · Natural product reports (Print) · doi:10.1039/c3np20120a · Cited by 229 · see citing works

Development of transgenic <i>Artemisia annua</i> (Chinese wormwood) plants with an enhanced content of artemisinin, an effective anti‐malarial drug, by hairpin‐RNA‐mediated gene silencing

Zhang, L., Jing, F., Li, F., Li, M., Wang, Y., Wang, G., Sun, X., & Tang, K. (2009) · Biotechnology and Applied Biochemistry · doi:10.1042/ba20080068 · Cited by 206 · see citing works

Cloning and characterization of a panel of constitutive promoters for applications in pathway engineering in Saccharomyces cerevisiae

Sun, J., Shao, Z., Zhao, H., Nair, N. U., Wen, F., Xu, J., & Zhao, H. (2012) · Biotechnology and Bioengineering · doi:10.1002/bit.24481 · Cited by 186 · see citing works

Applications of synthetic biology in medical and pharmaceutical fields

Yan, X., Liu, X., Zhao, C., & Chen, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01440-5 · Cited by 184 · see citing works

Artemisia afra: A potential flagship for African medicinal plants?

Liu, N. Q., van der Kooy, F., & Verpoorte, R. (2008) · South African Journal of Botany · doi:10.1016/j.sajb.2008.11.001 · Cited by 145 · see citing works

Artemisia annua as a self-reliant treatment for malaria in developing countries

de Ridder, S., van der Kooy, F., & Verpoorte, R. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.09.017 · Cited by 141 · see citing works

Light-induced biochemical variations in secondary metabolite production and antioxidant activity in callus cultures of Stevia rebaudiana (Bert)

Ahmad, N., Rab, A., & Ahmad, N. (2015) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2015.11.015 · Cited by 140 · see citing works

Current progress in the study on biosynthesis and regulation of ganoderic acids

Shi, L., Ren, A., Mu, D., & Zhao, M. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-2871-1 · Cited by 130 · see citing works

Abscisic acid (ABA) treatment increases artemisinin content in Artemisia annua by enhancing the expression of genes in artemisinin biosynthetic pathway

Jing, F., Zhang, L., Li, M., Tang, Y., Wang, Y., Wang, Y., Wang, Q., Pan, Q., Wang, G., & Tang, K. (2009) · Biologia · doi:10.2478/s11756-009-0040-8 · Cited by 123 · see citing works

Comparative Effects of Different Light Sources on the Production of Key Secondary Metabolites in Plants In Vitro Cultures

Hashim, M., Ahmad, B., Drouet, S., Hano, C., Abbasi, B. H., & Anjum, S. (2021) · Plants · doi:10.3390/plants10081521 · Cited by 123 · see citing works

UV-B and UV-C pre-treatments induce physiological changes and artemisinin biosynthesis in Artemisia annua L. – An antimalarial plant

Rai, R., Meena, R. P., Smita, S. S., Shukla, A., Kumar, S., & Rai, S. P. (2011) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2011.09.004 · Cited by 116 · see citing works

Regulation of cell fate determination by single-repeat R3 MYB transcription factors in Arabidopsis

Wang, S., & Chen, J. (2014) · Frontiers in Plant Science · doi:10.3389/fpls.2014.00133 · Cited by 112 · see citing works

Comparison of the effects of Artemisia vulgaris and Artemisia absinthium growing in western Anatolia against trichinellosis (Trichinella spiralis) in rats

Caner, A., Döşkaya, M., Döşkaya, A. D., Can, H., Baykan, Ş., Üner, A., Başdemir, G., Zeybek, U., & Gürüz, Y. (2008) · Experimental Parasitology · doi:10.1016/j.exppara.2008.01.012 · Cited by 98 · see citing works

Light-induced fluctuations in biomass accumulation, secondary metabolites production and antioxidant activity in cell suspension cultures of Artemisia absinthium L.

Ali, M., & Abbasi, B. H. (2014) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2014.08.008 · Cited by 94 · see citing works

Promoter of a cotton fibre MYB gene functional in trichomes of Arabidopsis and glandular trichomes of tobacco

Shangguan, X., Xu, B., Yu, Z.-X., Wang, L.-J., & Chen, X. (2008) · Journal of Experimental Botany · doi:10.1093/jxb/ern204 · Cited by 93 · see citing works

Metabolic engineering of microorganisms for isoprenoid production

Kirby, J., & Keasling, J. D. (2008) · Natural Product Reports · doi:10.1039/b802939c · Cited by 91 · see citing works

Discovery of New Biocatalysts for the Glycosylation of Terpenoid Scaffolds

Caputi, L., Lim, E., & Bowles, D. J. (2008) · Chemistry - A European Journal · doi:10.1002/chem.200800548 · Cited by 87 · see citing works

In vitro antiplasmodial and phytochemical study of five Artemisia species from Iran and in vivo activity of two species

Ramazani, A., Sardari, S., Zakeri, S., & Vaziri, B. (2010) · Parasitology Research · doi:10.1007/s00436-010-1900-4 · Cited by 78 · see citing works

Modulation of artemisinin biosynthesis by elicitors, inhibitor, and precursor in hairy root cultures of Artemisia annua L.

Ahlawat, S., Saxena, P., Alam, P., Wajid, S., & Abdin, M. Z. (2014) · Journal of Plant Interactions · doi:10.1080/17429145.2014.949885 · Cited by 78 · see citing works

Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches

Wani, K. I., Choudhary, S., Zehra, A., Naeem, M., Weathers, P., & Aftab, T. (2021) · Planta · doi:10.1007/s00425-021-03676-3 · Cited by 74 · see citing works

Implication of artemisinin nematocidal activity on experimental trichinellosis: In vitro and in vivo studies

Rayia, D. M. A., Saad, A. E., Ashour, D. S., & Oreiby, R. M. (2016) · Parasitology International · doi:10.1016/j.parint.2016.11.012 · Cited by 76 · see citing works

Plasmodium sensitivity to artemisinins: magic bullets hit elusive targets

Ding, X. C., Beck, H., & Raso, G. (2010) · Trends in Parasitology · doi:10.1016/j.pt.2010.11.006 · Cited by 71 · see citing works

Asteraceae species as potential environmental factors of allergy

Denisow‐Pietrzyk, M., Pietrzyk, Ł., & Denisow, B. (2019) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-04146-w · Cited by 70 · see citing works

Synthesis and evaluation of dihydroartemisinin and dihydroartemisitene acetal dimers showing anticancer and antiprotozoal activity

Galal, A. M., Gul, W., Slade, D., Ross, S. A., Feng, S., Hollingshead, M. G., Alley, M. C., Kaur, G., & ElSohly, M. A. (2008) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2008.11.050 · Cited by 69 · see citing works

Lights triggered differential accumulation of antioxidant and antidiabetic secondary metabolites in callus culture of Eclipta alba L.

Khurshid, R., Ullah, M. A., Tungmunnithum, D., Drouet, S., Shah, M., Zaeem, A., Hameed, S., Hano, C., & Abbasi, B. H. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233963 · Cited by 69 · see citing works

Antimalarial pharmacodynamics of chalcone derivatives in combination with artemisinin against Plasmodium falciparum in vitro

Bhattacharya, A., Mishra, L. C., Sharma, M., Awasthi, S. K., & Bhasin, V. K. (2009) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2009.02.008 · Cited by 66 · see citing works

The complexity of medicinal plants: The traditional Artemisia annua formulation, current status and future perspectives

van der Kooy, F., & Sullivan, S. E. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.08.021 · Cited by 66 · see citing works

Chinese Medicine in the Battle Against Obesity and Metabolic Diseases

Xu, L., Zhao, W., Wang, D., & Ma, X. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00850 · Cited by 65 · see citing works

Microbial Production of Isoprenoids Enabled by Synthetic Biology

Immethun, C. M., Hoynes-O’Connor, A., Balassy, A., & Moon, T. S. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00075 · Cited by 61 · see citing works

Combinatorial Engineering of 1-Deoxy-D-Xylulose 5-Phosphate Pathway Using Cross-Lapping In Vitro Assembly (CLIVA) Method

Zou, R., Zhou, K., Stephanopoulos, G. N., & Too, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079557 · Cited by 60 · see citing works

Alkylating enzymes

Wessjohann, L. A., Keim, J., Weigel, B., & Dippe, M. (2013) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2013.02.016 · Cited by 60 · see citing works

Exogenous Strigolactone (GR24) Positively Regulates Growth, Photosynthesis, and Improves Glandular Trichome Attributes for Enhanced Artemisinin Production in Artemisia annua

Wani, K. I., Zehra, A., Choudhary, S., Naeem, M., Khan, M. M. A., Khan, R., & Aftab, T. (2022) · Journal of Plant Growth Regulation · doi:10.1007/s00344-022-10654-w · Cited by 60 · see citing works

Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites

Muangphrom, P., Seki, H., Fukushima, E. O., & Muranaka, T. (2016) · Journal of Natural Medicines · doi:10.1007/s11418-016-1008-y · Cited by 59 · see citing works

Artemisinin production by plant hairy root cultures in gas- and liquid-phase bioreactors

Patra, N., & Srivastava, A. K. (2015) · Plant Cell Reports · doi:10.1007/s00299-015-1875-9 · Cited by 58 · see citing works

Synergistic effects of melatonin and distinct spectral lights for enhanced production of anti-cancerous compounds in callus cultures of Fagonia indica

Khan, T., Ullah, M. A., Garros, L., Hano, C., & Abbasi, B. H. (2018) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2018.10.010 · Cited by 58 · see citing works

Strategies on biosynthesis and production of bioactive compounds in medicinal plants

Guo, M., Lv, H., Chen, H., Dong, S., Zhang, J., Liu, W., He, L., Ma, Y., Yu, H., Chen, S., et al. (2023) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2023.01.007 · Cited by 60 · see citing works

Perspectives and limits of engineering the isoprenoid metabolism in heterologous hosts

Muntendam, R., Melillo, E., Rydén, A., & Kayser, O. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2150-1 · Cited by 56 · see citing works

Schisandra lignans production regulated by different bioreactor type

Szopa, A., Kokotkiewicz, A., Łuczkiewicz, M., & Ekiert, H. (2017) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2017.02.007 · Cited by 54 · see citing works

Biotechnological Approaches for Production of Artemisinin, an Anti-Malarial Drug from Artemisia annua L.

Al-Khayri, J. M., Sudheer, W. N., Lakshmaiah, V. V., Mukherjee, E., Nizam, A., Thiruvengadam, M., Nagella, P., Alessa, F. M., Al-Mssallem, M. Q., Adel Abdel-Sabour, R. E. Z. K., et al. (2022) · Molecules · doi:10.3390/molecules27093040 · Cited by 54 · see citing works

β-Cyclodextrins enhance artemisinin production in Artemisia annua suspension cell cultures

Durante, M., Caretto, S., Quarta, A., Paolis, A. D., Nisi, R., & Mita, G. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3232-4 · Cited by 51 · see citing works

Cambial meristematic cells: a platform for the production of plant natural products

Ochoa-Villarreal, M., Howat, S., Jang, M. O., Kim, I. S., Jin, Y.-W., Lee, E.-K., & Loake, G. J. (2015) · New Biotechnology · doi:10.1016/j.nbt.2015.02.003 · Cited by 50 · see citing works

Selection and Clonal Propagation of High Artemisinin Genotypes of Artemisia annua

Wetzstein, H. Y., Porter, J. A., Janick, J., Ferreira, J. F. S., & Mutui, T. M. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.00358 · Cited by 49 · see citing works

Updates on artemisinin: an insight to mode of actions and strategies for enhanced global production

Pandey, N., & Rai, S. P. (2015) · PROTOPLASMA · doi:10.1007/s00709-015-0805-6 · Cited by 48 · see citing works

Medicinal plants for in vitro antiplasmodial activities: A systematic review of literature

Lemma, M. T., Ahmed, A. M., Elhady, M. T., Ngo, H. T., Vu, T. L.-H., Sang, T. K., Campos‐Alberto, E., Sayed, A., Mizukami, S., Na‐Bangchang, K., et al. (2017) · Parasitology International · doi:10.1016/j.parint.2017.09.002 · Cited by 45 · see citing works

Comparison of Artemisia annua Bioactivities between Traditional Medicine and Chemical Extracts

Nageeb, A., Al-Tawashi, A., Emwas, A.-H. M., Al‐Talla, Z. A., & Al-Rifai, N. (2014) · Current Bioactive Compounds · doi:10.2174/157340720904140404151439 · Cited by 43 · see citing works

Bioreactor type affects the accumulation of phenolic acids and flavonoids in microshoot cultures of Schisandra chinensis (Turcz.) Baill.

Szopa, A., Kokotkiewicz, A., Bednarz, M., Jafernik, K., Łuczkiewicz, M., & Ekiert, H. (2019) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-019-01676-6 · Cited by 42 · see citing works

Hairy roots induction and artemisinin analysis in Artemisia dubia and Artemisia indica

Mannan, A., Shaheen, N., Arshad, W., Qureshi, R. A., Zia, M., & Mirza, B. (2008) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.4314/ajb.v7i18.59272 · Cited by 41 · see citing works

Inhibition of tumor cell proliferation and induction of apoptosis in human lung carcinoma 95-D cells by a new sesquiterpene from hairy root cultures of Artemisia annua

Zhai, D. D., Supaibulwatana, K., & Zhong, J. (2010) · Phytomedicine · doi:10.1016/j.phymed.2010.02.008 · Cited by 40 · see citing works

A novel strategy to enhance terpenoids production using cambial meristematic cells of Tripterygium wilfordii Hook. f.

Song, Y., Chen, S., Wang, X., Zhang, R., Tu, L., Hu, T., Liu, X., Zhang, Y., Huang, L., & Gao, W. (2019) · Plant Methods · doi:10.1186/s13007-019-0513-x · Cited by 39 · see citing works

Biotechnological approaches for artemisinin production in Artemisia

Kayani, W. K., Kiani, B. H., Dilshad, E., & Mirza, B. (2018) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-018-2432-9 · Cited by 37 · see citing works

Differentially Expressed Genes during Contrasting Growth Stages of Artemisia annua for Artemisinin Content

Nair, P., Misra, A., Singh, A., Shukla, A. K., Gupta, M. M., Gupta, A. K., Gupta, V., Khanuja, S. P. S., & Shasany, A. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060375 · Cited by 38 · see citing works

Exogenous hydrogen sulphide alleviates copper stress impacts in Artemisia annua L.: Growth, antioxidant metabolism, glandular trichome development and artemisinin biosynthesis

Nomani, L., Zehra, A., Choudhary, S., Wani, K. I., Naeem, M., Siddiqui, M. H., Khan, M. M. A., & Aftab, T. (2021) · Plant Biology · doi:10.1111/plb.13242 · Cited by 33 · see citing works

Antimalarial Effects of Iranian Flora Artemisia sieberi on Plasmodium berghei In Vivo in Mice and Phytochemistry Analysis of Its Herbal Extracts

Nahrevanian, H., Milan, B. S., Kazemi, M., Hajhosseini, R., Mashhadi, S. S., & Nahrevanian, S. (2012) · Malaria Research and Treatment · doi:10.1155/2012/727032 · Cited by 32 · see citing works

Characterization of development and artemisinin biosynthesis in self-pollinated Artemisia annua plants

Alejos-Gonzalez, F., Qu, G., Zhou, L.-L., Saravitz, C. H., Shurtleff, J. L., & Xie, D.-Y. (2011) · Planta · doi:10.1007/s00425-011-1430-z · Cited by 31 · see citing works

Volatile fingerprints of artemisinin‐rich Artemisia annua cultivars by headspace solid‐phase microextraction gas chromatography/mass spectrometry

Reale, S., Fasciani, P., Pace, L. G., Angelis, F. D., & Marcozzi, G. (2011) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.5155 · Cited by 32 · see citing works

Spectral lights trigger biomass accumulation and production of antioxidant secondary metabolites in adventitious root cultures of Stevia rebaudiana (Bert.)

Idrees, M., Sania, B., Hafsa, B., Kumari, S., Khan, H., Fazal, H., Ahmad, I., Akbar, F., Ahmad, N., Ali, S., et al. (2018) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2018.05.003 · Cited by 31 · see citing works

Cloning and characterization of trichome-specific promoter of cpr71av1 gene involved in artemisinin biosynthesis in Artemisia annua L.

Wang, Y., Yang, K., Jing, F., Li, M., Deng, T., Huang, R.-Z., Wang, B., Wang, G., Sun, X., & Tang, K. (2011) · Molecular Biology · doi:10.1134/s0026893311040145 · Cited by 28 · see citing works

In Vitro Evaluation of Achillea Millefolium on the Production and Stimulation of Human Skin Fibroblast Cells (HFS-PI-16)

Ghobadian, Z., Ahmadi, M. R. H., Rezazadeh, L., Hosseini, E., Kokhazadeh, T., & Ghavam, S. (2015) · Medical Archives · doi:10.5455/medarh.2015.69.212-217 · Cited by 26 · see citing works

Three-Dimensional Evaluation on Ecotypic Diversity of Traditional Chinese Medicine: A Case Study of Artemisia annua L.

Li, L., Brinckmann, J. A., Liu, B., Zheng, S., Huang, L., & Chen, S. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01225 · Cited by 26 · see citing works

Genetic engineering of artemisinin biosynthesis: prospects to improve its production

Abdin, M. Z., & Alam, P. (2015) · Acta Physiologiae Plantarum · doi:10.1007/s11738-015-1771-5 · Cited by 25 · see citing works

Patterns and dynamics of genetic diversity in Plasmodium falciparum: What past human migrations tell us about malaria

Mita, T., & Jombart, T. (2014) · Parasitology International · doi:10.1016/j.parint.2014.09.007 · Cited by 25 · see citing works

Artemisinic acid: A promising molecule potentially suitable for the semi-synthesis of artemisinin

Kong, J., Yang, Y., Wang, W., Cheng, K.-D., & Zhu, P. (2013) · RSC Advances · doi:10.1039/c3ra40525g · Cited by 24 · see citing works

Iron oxide nanoparticles (Fe3O4-NPs) elicited Artemisia annua L. in vitro, toward enhancing artemisinin production through overexpression of key genes in the terpenoids biosynthetic pathway and induction of oxidative stress

Ayoobi, A., Saboora, A., Asgarani, E., & Efferth, T. (2024) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-024-02705-9 · Cited by 23 · see citing works

Searching for Artemisinin Production Improvement in Plants and Microorganisms

Barbacka, K., & Baer‐Dubowska, W. (2011) · Current Pharmaceutical Biotechnology · doi:10.2174/138920111798376923 · Cited by 22 · see citing works

Recent advances in plant biotechnology and genetic engineering for production of secondary metabolites

Sheludko, Y. V. (2010) · Cytology and Genetics · doi:10.3103/s009545271001010x · Cited by 22 · see citing works

Comparative artemisinin analysis in Artemisia dubia transformed with two different Agrobacteria harbouring rol ABC genes.

Kiani, B. H., Safdar, N., Mannan, A., & Mirza, B. (2012) · Plant Omics · Cited by 22 · see citing works

Cumulative role of bioinoculants on growth, antioxidant potential and artemisinin content in Artemisia annua L. under organic field conditions

Gupta, R., Singh, A., Gupta, M. M., & Pandey, R. (2016) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-016-2130-4 · Cited by 21 · see citing works

Regeneration and chemical profiling in Hemidesmus indicus (L.) R. Br.

Pathak, A. R., Joshi, A., Shrivastava, N., & Sharma, P. (2017) · South African Journal of Botany · doi:10.1016/j.sajb.2017.09.022 · Cited by 21 · see citing works

A golden phoenix arising from the herbal nest — A review and reflection on the study of antimalarial drug Qinghaosu

Li, Y., & Wu, Y. (2010) · Frontiers of Chemistry in China · doi:10.1007/s11458-010-0214-5 · Cited by 20 · see citing works

Production and Genetic Engineering of Terpenoids Production in Plant Cell and Organ Cultures

Bonfill, M., Malik, S., Mirjalili, M. H., Goleniowski, M. E., Cusido, R. M., & Palazón, J. (2013) · Springer eBooks · doi:10.1007/978-3-642-22144-6_123 · Cited by 19 · see citing works

The rise to prominence of Artemisia annual the transformation of a Chinese plant to a global pharmaceutical

zu Biesen, C. M. (2010) · African Sociological Review / Revue Africaine de Sociologie · doi:10.4314/asr.v14i2.70234 · Cited by 19 · see citing works

Influence of abiotic elicitors on improvement production of artemisinin in cell culture of Artemisia annua L.

Zebarjadi, A., Dianatkhah, S., Pour Mohammadi, P., & Qaderi, A. (2018) · Cellular and Molecular Biology · doi:10.14715/cmb/2018.64.9.1 · Cited by 17 · see citing works

Effects of exogenous methyl jasmonate and 2-isopentenyladenine on artemisinin production and gene expression in Artemisia annua

Mehrjerdi, M. Z., Bihamta, M. R., Omidi, M., Naghavi, M. R., Soltanloo, H., & Ranjbar, M. (2013) · TURKISH JOURNAL OF BOTANY · doi:10.3906/bot-1206-12 · Cited by 17 · see citing works

Production of Pharmaceuticals by Plant Tissue Cultures

Muranaka, T., & Saito, K. (2010) · Elsevier eBooks · doi:10.1016/b978-008045382-8.00065-4 · Cited by 17 · see citing works

In Vivo Antimalarial Effects of Iranian Flora Artemisia khorassanica against Plasmodium berghei and Pharmacochemistry of its Natural Components.

Nahrevanian, H., Esmaeili, B., Kazemi, M., Nazem, H., & Amini, M. (2010) · Europe PMC (PubMed Central) · Cited by 17 · see citing works

Characterization of the Promoter of Artemisia annua Amorpha-4,11-diene Synthase (ADS) Gene Using Homologous and Heterologous Expression as well as Deletion Analysis

Zhu, M., Zhang, F., Lv, Z., Shen, Q., Zhang, L., Lu, X., Jiang, W., Fu, X., Yan, T., Chen, L., et al. (2013) · Plant Molecular Biology Reporter · doi:10.1007/s11105-013-0656-2 · Cited by 16 · see citing works

A Microbial Transformation Model for Simulating Mammal Metabolism of Artemisinin

Ma, Y., Sun, P., Zhao, Y., Wang, K., Chang, X., Bai, Y., Zhang, D., & Yang, L. (2019) · Molecules · doi:10.3390/molecules24020315 · Cited by 16 · see citing works

Characterization of santalene synthases using an inorganic pyrophosphatase coupled colorimetric assay

Hua, G., Hu, Y., Yang, C., Liu, D., Mao, Z., Zhang, L., & Zhang, Y. (2018) · Analytical Biochemistry · doi:10.1016/j.ab.2018.02.002 · Cited by 14 · see citing works

Influence of Agrobacterium rhizogenes on induction of hairy roots for enhanced production of artemisinin in Artemisia annua L. plants

Ahlawat, S. (2012) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb12.057 · Cited by 14 · see citing works

Synthesis of Silver Nanoparticles from Artemisia sieberiand Calotropis procera Medical Plant Extracts and their Characterization using SEM Analysis

Alkammash, N. M. (2017) · Biosciences Biotechnology Research Asia · doi:10.13005/bbra/2474 · Cited by 14 · see citing works

In vitro regeneration of gamma irradiated callus of artemisia annua and evaluation of increase artemisinin content by HPLC analysis

Patil, A. S. (2018) · Journal of Analytical & Pharmaceutical Research · doi:10.15406/japlr.2018.07.00284 · Cited by 14 · see citing works

New perspectives of the Artemisia annua bioactive compounds as an affordable cure in treatment of malaria and cancer

Kumar, S., Apoorva, Rai, K. K., & Rai, S. P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820655-3.00015-x · Cited by 14 · see citing works

Bioconversion of Artemisinin to its Nonperoxidic Derivative Deoxyartemisinin through Suspension Cultures of Withania somnifera Dunal

Sabir, F., Kumar, A., Tiwari, P., Pathak, N., Sangwan, R. S., Bhakuni, R. S., & Sangwan, N. S. (2010) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2010-9-1013 · Cited by 13 · see citing works

Antioxidant properties of extracts from selected plant materials (Caesalpinia spinosa, Perilla frutescens, Artemisia annua and Viola wittrockiana) in vitro and in model food systems

Skowyra, M. (2014) · doi:10.5821/dissertation-2117-95555 · Cited by 13 · see citing works

Developmental variation during seed germination and biochemical responses of Brassica rapa exposed to various colored lights

Nawaz, T., Ahmad, N., Ali, S., Khan, M., Fazal, H., & Khalil, S. A. (2018) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2018.01.008 · Cited by 12 · see citing works

Influence of Plant Growth Regulators and Artificial Light on the Growth and Accumulation of Inulin of Dedifferentiated Chicory (Cichorium intybus L.) Callus Cells

Kirakosyan, R. N., Sumin, A. V., Polupanova, A. A., Pankova, M. G., Degtyareva, I. S., Sleptsov, N. N., & Khuat, Q. V. (2022) · Life · doi:10.3390/life12101524 · Cited by 11 · see citing works

Hairy root mediated functional derivatization of artemisinin and their bioactivity analysis

Pandey, P., Singh, S., Tewari, N., Srinivas, K. V. N. S., Shukla, A., Gupta, N., Vasudev, P. G., Khan, F., Pal, A., Bhakuni, R. S., et al. (2015) · Journal of Molecular Catalysis B Enzymatic · doi:10.1016/j.molcatb.2015.01.007 · Cited by 11 · see citing works

Bioreactor-Grown Shoot Cultures for the Secondary Metabolite Production

Król, A., Kokotkiewicz, A., Szopa, A., Ekiert, H., & Łuczkiewicz, M. (2020) · Reference series in phytochemistry · doi:10.1007/978-3-030-30185-9_34 · Cited by 11 · see citing works

A new sesquiterpene from hairy root culture of Artemisia annua

Zhai, D. D., Jin, H. Z., & Zhong, J. (2010) · Chinese Chemical Letters · doi:10.1016/j.cclet.2010.01.034 · Cited by 11 · see citing works

Anti-toxoplasma, antioxidant and cytotoxic activities of Pleopeltis crassinervata (Fée) T. Moore hexane fraction

Anacleto-Santos, J., López-Camacho, P. Y., Mondragón‐Flores, R., Vega‐Avila, E., Basurto‐Islas, G., Mondragón-Castelán, M. E., Carrasco‐Ramírez, E., & Rivera-Fernández, N. (2019) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2019.12.032 · Cited by 10 · see citing works

Artemisinin and artemisinin-related agents

Rawe, S. L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-101210-9.00004-4 · Cited by 11 · see citing works

Biotechnological Approaches for Production of Artemisinin, an Anti-Malarial Drug from Artemisia annua L.

Al-Khayri, J. M., Sudheer, W. N., Lakshmaiah, V. V., Mukherjee, E., Nizam, A., Thiruvengadam, M., Nagella, P., Alessa, F. M., Al-Mssallem, M. Q., Adel Abdel-Sabour, R. E. Z. K., et al. (2022) · Molecules · doi:10.3390/molecules27093040 · Cited by 54 · see citing works

Artemisinin, a Novel Antimalarial Drug: Biochemical and Molecular Approaches for Enhanced Production

Abdin, M. Z., Israr, M., Rehman, R. U., & Jain, S. K. (2003) · Planta Medica · doi:10.1055/s-2003-38871 · Cited by 252 · see citing works

Searching for Artemisinin Production Improvement in Plants and Microorganisms

Barbacka, K., & Baer‐Dubowska, W. (2011) · Current Pharmaceutical Biotechnology · doi:10.2174/138920111798376923 · Cited by 22 · see citing works

Recent Advances to Enhance Yield of Artemisinin: A Novel Antimalarial Compound, in Artemisia annua L. Plants

Ram, M., Jain, D. C., Mishra, H., Mandal, S., & Abdin, M. Z. (2013) · Springer eBooks · doi:10.1007/978-3-642-41027-7_11 · Cited by 5 · see citing works

Biosynthesis and Production of Artemisinin: A Novel Class of Molecule

Ali, A., Khan, M. A., & Zainul, M. (2013) · Springer eBooks · doi:10.1007/978-3-642-22144-6_133 · Cited by 1 · see citing works