Cited by 959Retinal Diseases and TreatmentsRetinal Development and DisordersRetinal Imaging and Analysis

The DOI matches its Crossref record; 531 of the 550 references it cites were found in a registry or an index.

Age-Related Macular Degeneration: Etiology, Pathogenesis, and Therapeutic Strategies

Ambati, Jayakrishna, Ambati, Balamurali K, Yoo, Sonia H, Ianchulev, Sean, Adamis, Anthony P·2003·Survey of Ophthalmology

DOI 10.1016/s0039-6257(03)00030-4

Open this paper in CoChat — free account

Abstract

Age-related macular degeneration is the principal cause of registered legal blindness among those aged over 65 in the United States, western Europe, Australia, and Japan. Despite intensive research, the precise etiology of molecular events that underlie age-related macular degeneration is poorly understood. However, investigations on parallel fronts are addressing this prevalent public health problem. Sophisticated biochemical and biophysical techniques have refined our understanding of the pathobiology of drusen, geographic atrophy, and retinal pigment epithelial detachments. Epidemiological identification of risk factors has facilitated an intelligent search for underlying mechanisms and fueled clinical investigation of behavior modification. Gene searches have not only brought us to the cusp of identifying the culpable gene loci in age-related macular degeneration, but also localized genes responsible for other macular dystrophies. Recent and ongoing investigations, often cued by tumor biology, have revealed an important role for various growth factors, particularly in the neovascular form of the condition. Transgenic and knockout studies have provided important mechanistic insights into the development of choroidal neovascularization, the principal cause of vision loss in age-related macular degeneration. This in turn has culminated in preclinical and clinical trials of directed molecular interventions.

Integrity signals

Registry

Crossref · 10.1016/s0039-6257(03)00030-4

Cites

531 of 531 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Items 401–531 of 531

17 Beta-estradiol increases VEGF receptor-2 and promotes DNA synthesis in retinal microvascular endothelial cells.
Suzuma, I., Mandai, M., Takagi, H., Suzuma, K., Otani, A., Oh, H., Kobayashi, K., & Honda, Y. (1999) · PubMed · Cited by 69
Inhibition of experimental choroidal neovascularization by overexpression of tissue inhibitor of metalloproteinases-3 in retinal pigment epithelium cells
Takahashi, T., Nakamura, T., Hayashi, A., Kamei, M., Nakabayashi, M., Okada, A. A., Tomita, N., Kaneda, Y., & Tano, Y. (2000) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(00)00772-8 · Cited by 69
Hematogenous photosensitization. A mechanism for the development of age-related macular degeneration.
Gottsch, J. D., Pou, S., Bynoe, L. A., & Rosen, G. M. (1990) · PubMed · Cited by 68
Hypoxia and vascular endothelial growth factor selectively upregulate angiopoietin-2 in bovine microvascular endothelial cells.
王, 英. (2001) · Kyoto University Research Information Repository (Kyoto University) · Cited by 68
RETINAL SENSITIZED PHOTODYNAMIC DAMAGE TO LIPOSOMES
Delmelle, M. (1978) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1978.tb07718.x · Cited by 67
Expression of Thrombospondin-1 in Ischemia-Induced Retinal Neovascularization
Suzuma, K., Takagi, H., Otani, A., Oh, H., & Honda, Y. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65281-9 · Cited by 67
A primate model for age related macular drusen.
Hope, G., Dawson, W. W., Engel, H., Ulshafer, R., Kessler, M., & Sherwood, M. (1992) · British Journal of Ophthalmology · doi:10.1136/bjo.76.1.11 · Cited by 67
ABCR gene analysis in familial exudative age-related macular degeneration.
Souied, E. H., Ducroq, D., Rozet, J., Gerber, S., Perrault, I., Münnich, A., COSCAS, G. J., Soubrane, G., & Kaplan, J. (2000) · PubMed · Cited by 66
Production and accumulation of thrombospondin-1 in human retinal pigment epithelial cells.
Miyajima–Uchida, H., Hayashi, H., Beppu, R., Kuroki, M., Fukami, M., Arakawa, F., Tomita, Y., Kuroki, M., & Oshima, K. (2000) · PubMed · Cited by 66
Modulation of cathepsin D activity in retinal pigment epithelial cells
RAKOCZY, P. E., LAI, C. M., BAINES, M., GRANDI, S. D., FITTON, J. H., & CONSTABLE, I. J. (1997) · Biochemical Journal · doi:10.1042/bj3240935 · Cited by 64
Alu DNA polymorphism in ACE gene is protective for age-related macular degeneration
Hamdi, H., Reznik, J., Castellon, R., Atilano, S. R., Ong, J. M., Udar, N., Tavis, J. H., Aoki, A. M., Nesburn, A. B., Boyer, D. S., et al. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00728-3 · Cited by 62
Expression of transforming growth factor-ß mRNA in experimental choroidal neovascularization
Ogata, N., Yamamoto, C., Miyashiro, M., Yamada, H., Matsushima, M., & Uyama, M. (1997) · Current Eye Research · doi:10.1076/ceyr.16.1.9.5121 · Cited by 62
Lipofuscin-formation in cultured retinal pigment epithelial cells is related to their melanin content
Sundelin, S. P., NILSSON, S. E. G., & Brunk, U. T. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00444-5 · Cited by 62
Proteolytic activity directed toward pigment epithelium-derived factor in vitreous of bovine eyes. Implications of proteolytic processing.
Wu, Y. Q., & Becerra, S. P. (1996) · PubMed · Cited by 60
Hyperoxia/normoxia-driven retinal angiogenesis in mice: a role for angiotensin II.
Lonchampt, M., Pennel, L., & Duhault, J. (2001) · PubMed · Cited by 60
MACULAR TRANSLOCATION WITH RETINOTOMY AND RETINAL ROTATION FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION
Akduman, L., KARAVELLAS, M. P., MACDONALD, J. C., Olk, R. J., & Freeman, W. R. (1999) · Retina · doi:10.1097/00006982-199909000-00009 · Cited by 60
Angiopoietin-1 upregulation by vascular endothelial growth factor in human retinal pigment epithelial cells.
Hangai, M., Murata, T., Miyawaki, N., Spee, C. K., Lim, J. I., He, S., Hinton, D. R., & Ryan, S. J. (2001) · PubMed · Cited by 59
Mitogenesis and retinal pigment epithelial cell antigen expression in the rat after krypton laser photocoagulation.
Zhang, N. L., Samadani, E., & Frank, R. N. (1993) · PubMed · Cited by 58
CD18 and ICAM-1-Dependent Corneal Neovascularization and Inflammation after Limbal Injury
Moromizato, Y., Stechschulte, S., Miyamoto, K., Murata, T., Tsujikawa, A., Joussen, A. M., & Adamis, A. P. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64643-3 · Cited by 58
Self-citation
Pigment epithelium-derived factor exerts opposite effects on endothelial cells of different phenotypes
Hutchings, H., Maitre-Boube, M., Tombran‐Tink, J., & Plouët, J. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00548-x · Cited by 57
Degenerative Retinal Diseases
(1997) · Springer eBooks · doi:10.1007/978-1-4615-5933-7 · Cited by 57
Inhibition of retinal angiogenesis by peptides derived from thrombospondin-1.
Shafiee, A., Penn, J. S., Krutzsch, H. C., Inman, J. K., Roberts, D. D., & Blake, D. A. (2000) · PubMed · Cited by 56
Contrast Sensitivity Evaluation in Eyes Predisposed to Age-Related Macular Degeneration and Presenting Normal Visual Acuity
STANGOS, N. T., Voutas, S., Topouzis, F., & Karampatakis, V. E. (2010) · Ophthalmologica · doi:10.1159/000310612 · Cited by 56
Systemic Hyperoxia Decreases Vascular Endothelial Growth Factor Gene Expression in Ischemic Primate Retina
Pournaras, C. J. (1997) · Archives of Ophthalmology · doi:10.1001/archopht.1997.01100160723009 · Cited by 56
Laser-induced drusen reduction improves visual function at 1 year
Ho, A. C., Maguire, M. G., Yoken, J., Lee, M. S., Shin, D. S., Javornik, N. B., & Fine, S. L. (1999) · Ophthalmology · doi:10.1016/s0161-6420(99)00735-6 · Cited by 55
A prospective study of cigarette smoking and age-related macular degeneration in women
Seddon, J. M. (1996) · JAMA · doi:10.1001/jama.276.14.1141 · Cited by 55
Translocation of the macula for management of subfoveal choroidal neovascularization: comparison of results in age-related macular degeneration and degenerative myopia
Glacet-Bernard, A., Simon, P., Hamelin, N., COSCAS, G. J., & Soubrane, G. (2001) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(00)00733-9 · Cited by 54
Direct Measurement of VEGF-Induced Nitric Oxide Production by Choroidal Endothelial Cells
Uhlmann, S., Friedrichs, U., Eichler, W., Hoffmann, S., & Wiedemann, P. (2001) · Microvascular Research · doi:10.1006/mvre.2001.2334 · Cited by 54
Adaptation to monocular torsion after macular translocation
Seaber, J. H., & Machemer, R. (1997) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/bf00941733 · Cited by 54
IMPROVEMENT OF VISUAL ACUITY OVER TIME IN PATIENTS WITH BILATERAL GEOGRAPHIC ATROPHY FROM AGE-RELATED MACULAR DEGENERATION
Sunness, J. S., Applegate, C. A., & González-Barón, J. (2000) · Retina · doi:10.1097/00006982-200002000-00009 · Cited by 54
Reactive oxygen species mediate angiotensin II-induced leukocyte-endothelial cell interactionsin vivo
Álvarez, Á., & Sanz, M. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.2.199 · Cited by 54
Light-Induced Deposits in Bruch's Membrane of Protoporphyric Mice
Gottsch, J. D. (1993) · Archives of Ophthalmology · doi:10.1001/archopht.1993.01090010130039 · Cited by 53
LONG-TERM DRUSEN STUDY
Sarraf, D., Gin, T., YU, F., BRANNON, A., Owens, S. L., & Bird, A. C. (1999) · Retina · doi:10.1097/00006982-199911000-00006 · Cited by 52
Age-related retinal pigment epithelium and Bruch's membrane degeneration in senescence-accelerated mouse.
Majji, A. B., Cao, J. M., Chang, K. Y., Hayashi, A., Aggarwal, S., Grebe, R. R., & de Juan, E. (2000) · PubMed · Cited by 51
Monoclonal antibody-mediated drug targeting to choroidal neovascularization in the rat.
Kamizuru, H., Kimura, H., Yasukawa, T., Tabata, Y., Honda, Y., & Ogura, Y. (2001) · PubMed · Cited by 51
Basic fibroblast growth factor experimentally induced choroidal angiogenesis in the minipig
Soubrane, G., Cohen, S. Y., Delayre, T., Tassin, J., Ollier-Hartmann, M. P., COSCAS, G. J., Courtois, Y., & Jeanny, J. (1994) · Current Eye Research · doi:10.3109/02713689408995776 · Cited by 50
TREATMENT OF ANGIOMATOUS LESIONS OF THE RETINA WITH PHOTODYNAMIC THERAPY
Rodriguez-Coleman, H., Spaide, R. F., & Yannuzzi, L. A. (2002) · Retina · doi:10.1097/00006982-200204000-00019 · Cited by 50
LASER PHOTOCOAGULATION FOR MACULAR SOFT DRUSEN
FIGUEROA, M. S., REGUERAS, A., BERTRAND, J., Aparicio, M., & MANRIQUE, M. G. (1997) · Retina · doi:10.1097/00006982-199709000-00004 · Cited by 49
Safety and Pharmacokinetics of Intravitreal 2-Methoxyestradiol Implants in Normal Rabbit and Pharmacodynamics in a Rat Model of Choroidal Neovascularization
Robinson, M. R., Baffi, J., Yuan, P., Sung, C., Byrnes, G., Cox, T. A., & Csaky, K. G. (2002) · Experimental Eye Research · doi:10.1006/exer.2001.1132 · Cited by 49
Visual field deficits in early age-related macular degeneration
Tolentino, M. J., Miller, S., Gaudio, A. R., & Sandberg, M. A. (1994) · Vision Research · doi:10.1016/0042-6989(94)90099-x · Cited by 48
The Risk of Fellow Eye Visual Loss with Unilateral Retinal Pigment Epithelial Tears
Schoeppner, G., Chuang, E. L., & Bird, A. C. (1989) · American Journal of Ophthalmology · doi:10.1016/0002-9394(89)90861-1 · Cited by 48
Colour contrast sensitivity in patients with soft drusen, an early stage of ARM
Frennesson, C. I., Nilsson, U., & NILSSON, S. E. G. (1995) · Documenta Ophthalmologica · doi:10.1007/bf01268123 · Cited by 48
Advanced Glycation End Products Induce Angiogenesis in Vivo
Okamoto, T., Tanaka, S., Stan, A. C., Koike, T., Kase, M., Makita, Z., Sawa, H., & Nagashima, K. (2002) · Microvascular Research · doi:10.1006/mvre.2001.2371 · Cited by 47
Macular drusen and the sensitivity of the central visual field
Midena, E., Segato, T., Blarzino, M. C., & Angeli, C. D. (1994) · Documenta Ophthalmologica · doi:10.1007/bf01204616 · Cited by 46
Inferior limited macular translocation for subfoveal choroidal neovascularization secondary to age-related macular degeneration: 1-year visual outcome and recurrence report
Fujii, G. Y., de Juan, E., Pieramici, D. J., Humayun, M. S., Phillips, S., Reynolds, S. M., Melia, M., & SCHACHAT, A. P. (2002) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(02)01511-8 · Cited by 44
Rapid and selective uptake, metabolism, and cellular distribution of docosahexaenoic acid among rod and cone photoreceptor cells in the frog retina.
Rodriguez de Turco, E., Gordon, W., & Bazan, N. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-11-03667.1991 · Cited by 44
Dark adaptation in age-related macular degeneration: relationship to the fellow eye
Haimovici, R., Owens, S. L., Fitzke, F. W., & Bird, A. C. (2002) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-001-0417-z · Cited by 44
Predictors of drusen reduction after subthreshold infrared (810 nm) diode laser macular grid photocoagulation for nonexudative age-related macular degeneration
Rodanant, N., Friberg, T. R., Cheng, L., Aurora, A., Bartsch, D., Toyoguchi, M., Corbin, P. S., El-Bradey, M. H., & Freeman, W. R. (2002) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(02)01691-4 · Cited by 44
Ultrastructure of Bruch's Membrane After Krypton Laser Photocoagulation
Pollack, A. (1986) · Archives of Ophthalmology · doi:10.1001/archopht.1986.01050210131040 · Cited by 43
In vivo use of oligonucleotides to inhibit choroidal neovascularisation in the eye
Garrett, K. L., Shen, W., & Rakoczy, P. E. (2001) · The Journal of Gene Medicine · doi:10.1002/jgm.197 · Cited by 43
Region-and Age-dependent Variation in Susceptibility of the Human Retina to Lipid Peroxidation
Paz, M., & Anderson, R. E. (1993) · Retina · doi:10.1097/00006982-199313020-00022 · Cited by 41
Chorioretinal Juncture
Lewis, H., Straatsma, B. R., & Foos, R. Y. (1986) · Ophthalmology · doi:10.1016/s0161-6420(86)33615-7 · Cited by 39
Induction of an aging mRNA retinal pigment epithelial cell phenotype by matrix-containing advanced glycation end products in vitro.
Honda, S., Farboud, B., Hjelmeland, L. M., & Handa, J. T. (2001) · PubMed · Cited by 39
A donor-age-dependent change in the activity of alpha-mannosidase in human cultured RPE cells.
Wyszynski, R. E., Bruner, W. E., Cano, D. B., Morgan, K. M., Davis, C.-S., & Sternberg, P. (1989) · PubMed · Cited by 35
Nitric oxide synthase-II is expressed in severe corneal alkali burns and inhibits neovascularization.
Sennlaub, F., Courtois, Y., & Goureau, O. (1999) · PubMed · Cited by 35
Radiotherapy and the Treatment of Age-related Macular Degeneration ExternalBeam Radiation Therapy Is Effective in the Treatment of Age-related Macular Degeneration
Finger, P. T. (1998) · Archives of Ophthalmology · doi:10.1001/archopht.116.11.1507 · Cited by 35
Trace Element Status and Free Radical Defense in Elderly Rhesus Macaques (Macaca mulatta) with Macular Drusen
Olin, K., Morse, L., Murphy, C., Paul-Murphy, J., Line, S., Bellhorn, R., Hjelmeland, L., & Keen, C. (1995) · Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine · doi:10.3181/00379727-208-43864 · Cited by 35
The influence of zinc on caspase-3 and DNA breakdown in cultured human retinal pigment epithelial cells.
Wood, J. P. M., & Osborne, N. N. (2001) · PubMed · Cited by 34
Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4
Carron, J. A., Hiscott, P. S., Hagan, S., Sheridan, C., Magee, R. M., & Gallagher, J. A. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(00)00065-0 · Cited by 34
Correlation of Choroidal Subretinal Neovascularization With Fluorescein Angiography
Miller, H., Miller, B. T., & Ryan, S. J. (1985) · American Journal of Ophthalmology · doi:10.1016/0002-9394(85)90354-x · Cited by 34
Activated Macrophages in Experimental Subretinal Neovascularization (With 1 color plate)
Nishimura, T., Goodnight, R., Prendergast, R. A., & Ryan, S. J. (2010) · Ophthalmologica · doi:10.1159/000310075 · Cited by 34
Heat shock cognate-70 gene expression declines during normal aging of the primate retina.
Bernstein, S. L., Liu, A. M., HANSEN, B. C., & Somiari, R. I. (2000) · PubMed · Cited by 33
Active drug targeting with immunoconjugates to choroidal neovascularization
Yasukawa, T., Kimura, H., Tabata, Y., Miyamoto, H., Honda, Y., Ikada, Y., & Ogura, Y. (2000) · Current Eye Research · doi:10.1076/ceyr.21.6.952.6992 · Cited by 33
Studies on the Mechanism of Early Onset Macular Degeneration in Cynomolgus (Macaca fascicularis) Monkeys. I. Abnormal Concentrations of Two Proteins in the Retina
Nicolas, M. G., Fujiki, K., Murayama, K., SUZUKI, M. T., Mineki, R., Hayakawa, M., Yoshikawa, Y., Cho, F., & Kanai, A. (1996) · Experimental Eye Research · doi:10.1006/exer.1996.0026 · Cited by 32
Detection of Inducible Nitric Oxide Synthase and Vascular Endothelial Growth Factor in Choroidal Neovascular Membranes
Kuhli-Hattenbach, C., Falk, B., Nürnberger, F., Koch, F., & Ohrloff, C. (2002) · Ophthalmologica · doi:10.1159/000059634 · Cited by 32
Submacular surgery trials randomized pilot trial of laser photocoagulation versus surgery for recurrent choroidal neovascularization secondary to age-related macular degeneration: ii. quality of life outcomes submacular surgery trials pilot study report number 2
(2000) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(00)00730-3 · Cited by 32
In vivo significance of ICAM-1--dependent leukocyte adhesion in early corneal angiogenesis.
Becker, Kruse, F., Azzam, L., Nobiling, R., Reichling, J., & Völcker, H. E. (1999) · PubMed · Cited by 30
Newly-formed subretinal vessels. Fine structure and fluorescein leakage.
Miller, H., Miller, B. T., & Ryan, S. J. (1986) · PubMed · Cited by 29
Choroidal Neovascularization in Black Patients
Pieramici, D. J. (1994) · Archives of Ophthalmology · doi:10.1001/archopht.1994.01090200049020 · Cited by 29
Inhibitory effect of losartan on laser-induced choroidal neovascularization in rats
Hikichi, T., Mori, F., Takamiya, A., Sasaki, M., Horikawa, Y., Takeda, M., & Yoshida, A. (2001) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(01)01139-4 · Cited by 29
Aging Macular Degeneration
Folk, J. C. (1985) · Ophthalmology · doi:10.1016/s0161-6420(85)33996-9 · Cited by 29
AREDS investigators distort findings.
Seigel, D. (2002) · A M A Archives of Ophthalmology · doi:10.1001/archopht.120.1.100 · Cited by 29
Age-related changes of glycosidases in human retinal pigment epithelium
Cingle, K. A., Kalski, R. S., Bruner, W. E., O'brien, C. M., Erhard, P., & Wyszynski, R. E. (1996) · Current Eye Research · doi:10.3109/02713689608995834 · Cited by 29
Expression of matrix metalloproteinase-7 in choroidal neovascular membranes in age-related macular degeneration
Kadonosono, K., Yazama, F., Itoh, N., Sawada, H., & Ohno, S. (1999) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(99)00135-x · Cited by 28
The Rhesus Monkey as an Animal Model for Age-Related Maculopathy
Monaco, W. A., & Wormington, C. M. (1990) · Optometry and Vision Science · doi:10.1002/j.1538-9235.1990.tb02558.x · Cited by 28
SUBMACULAR SURGERY TRIALS RANDOMIZED PILOT TRIAL OF LASER PHOTOCOAGULATION VERSUS SURGERY FOR RECURRENT CHOROIDAL NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION
Berssler, N. M., Berssler, S. B., & Hawkins, B. (2000) · Cited by 28
The influence of zinc supplementation on glucose homeostasis in NIDDM.
Raz, I., Karsai, D., & Katz, M. (1989) · PubMed · Cited by 27
The mRNA phenotype of a human RPE cell line at replicative senescence.
Matsunaga, H., Handa, J. T., Gelfman, C. M., & Hjelmeland, L. M. (1999) · PubMed · Cited by 27
Preclinical Evaluation of a Phosphorothioate Oligonucleotide in the Retina of Rhesus Monkey
Shen, W., Garrett, K. L., Wang, C., Zhang, K., Ma, Z., Constable, I. J., & Rakoczy, P. E. (2002) · Laboratory Investigation · doi:10.1038/labinvest.3780409 · Cited by 27
The relation of coffee and caffeine to the 5-year incidence of early age-related maculopathy: the beaver dam eye study
Tomany, S. C., Klein, R., & Klein, R. (2001) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(01)00895-9 · Cited by 27
Angiographic findings in patients with exudative age-related macular degeneration
Bermig, J., Tylla, H., Jochmann, C., Nestler, A., & Wolf, S. (2002) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-001-0378-2 · Cited by 27
An immunologic study on age-related macular degeneration.
Chen, H., Wu, L., Pan, S., & Dz, W. (1993) · PubMed · Cited by 27
Intravitreal triamcinolone in subfoveal recurrence of choroidal neovascularisation after laser treatment in macular degeneration. Ranson NT, Danis RP, Ciulla TA, Pratt L. Br J Ophthalmol 2002;86:527–529
Grossniklaus, H. E. (2002) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(02)01779-8 · Cited by 26
Atlas Der Pathologischen Anatomie Des Augapfels
Pagenstecher, H., Genth, C. P., & Gowers, W. R. (2011) · Bayerische Staatsbibliothek · Cited by 26
Limited Macular Translocation for Atrophic Maculopathy
Benner, J. D. (2002) · Archives of Ophthalmology · doi:10.1001/archopht.120.5.586 · Cited by 25
Inhibition of choriocapillaris regeneration with genistein.
Majji, A. B., Hayashi, A., Kim, H. C., Grebe, R. R., & de Juan, E. (1999) · PubMed · Cited by 24
MACULAR DEGENERATION IN A COMMUNITY OF RHESUS MONKEYS
Ulshafer, R. J., Engel, H. M., Dawson, W. W., Allen, C. B., & Kessler, M. J. (1987) · Retina · doi:10.1097/00006982-198700730-00011 · Cited by 24
Evaluation of the Peripherin/RDS Gene as a Candidate Gene in Families with Age-Related Macular Degeneration
Shastry, B. S., & Trese, M. T. (1999) · Ophthalmologica · doi:10.1159/000027413 · Cited by 24
Monocyte synthesis of thrombospondin
Schwartz, B. S. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83264-1 · Cited by 23
Zinc, total protein, and albumin in CSF of patients with cerebrovascular diseases
Palm, R., STRAND, T., & Hallmans, G. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1986.tb03520.x · Cited by 23
Influence of laser photocoagulation on choroidal capillary cytoarchitecture
Guymer, R. H. (2001) · British Journal of Ophthalmology · doi:10.1136/bjo.85.1.40 · Cited by 23
Risk of macular degeneration with statin use should be interpreted with caution
van Leeuwen, R., Vingerling, J. R., & de Jong, P. T. V. M. (2001) · BMJ · doi:10.1136/bmj.323.7324.1308a · Cited by 22
Thalidomide and Prednisolone Inhibit Growth Factor-Induced Human Retinal Pigment Epithelium Cell Proliferation in vitro
Kaven, C., Spraul, C. W., Zavazava, N., Lang, G. K., & Lang, G. E. (2001) · Ophthalmologica · doi:10.1159/000050875 · Cited by 22
Laser Photocoagulation of Soft Drusen in Early Age-Related Maculopathy (Arm). the One-Year Results of a Prospective, Randomised Trial
Frennesson, I. C., & Nilsson, S. (1996) · European Journal of Ophthalmology · doi:10.1177/112067219600600315 · Cited by 22
Molecular Genetic Analysis of ABCR Gene in Japanese Dry Form Age-Related Macular Degeneration
Fuse, N. (2000) · Japanese Journal of Ophthalmology · doi:10.1016/s0021-5155(00)00150-7 · Cited by 21
Role of NF?B in the regulation of macrophage colony stimulating factor by tumor necrosis factor-? in ST2 bone stromal cells
Isaacs, S. D., Fan, X., Fan, D., Gewant, H. D., Murphy, T. C., FARMER, P. K., Taylor, W. R., Nanes, M. S., & Rubin, J. E. (1999) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199905)179:2 · Cited by 21
Vectorial accumulation of cathepsin D in retinal pigmented epithelium: effects of age.
Wilcox, D. K. (1988) · PubMed · Cited by 20
[Surgical extraction of subretinal pseudotumors in age related macular degeneration. Clinical, morphologic and immunohistochemical results].
Heidenkummer, H.-P., & Kampik, A. (1995) · PubMed · Cited by 18
Geographic atrophy of the retinal pigment epithelium: diagnosis and vision rehabilitation.
Potter, J. W., & Thallemer, J. M. (1981) · PubMed · Cited by 17
Age-Related Eye Disease Study Caveats
Ambati, J., & Ambati, B. K. (2002) · Archives of Ophthalmology · doi:10.1001/archopht.120.7.997 · Cited by 17
Self-citation
External Beam Radiation Therapy Is Not Effective in the Treatment of Age-related Macular Degeneration
Augsburger, J. J. (1998) · Archives of Ophthalmology · doi:10.1001/archopht.116.11.1509 · Cited by 17
PHOTOCOAGULATION OF WELL-DEFINED CHOROIDAL NEOVASCULARIZATION IN AGE-RELATED MACULAR DEGENERATION:Clinicopathologic Correlation
Schneider, S., Greven, C. M., & GREEN, R. W. (1998) · Retina · doi:10.1097/00006982-199803000-00009 · Cited by 17
Macular pigment density in monozygotic twins
Hammond, B. R., Fuld, K., & Curran-Celentano, J. (1996) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)70604-x · Cited by 17
External beam radiation in patients suffering from exudative age-related macular degeneration
Krott, R., Staar, S., Müller, R., Bartz‐Schmidt, K. U., Esser, P., & Heimann, K. (1998) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s004170050180 · Cited by 17
Histochemical Comparison of Ocular “Drusen” in Monkey and Human
Mullins, R. F., & Hageman, G. S. (1997) · Springer eBooks · doi:10.1007/978-1-4615-5933-7_1 · Cited by 15
Autoradiographic studies of aged primate macular retinal pigment epithelium.
Hirata, A., & Feeney-Burns, L. (1992) · PubMed · Cited by 15
Exclusion of TIMP3 as a Candidate Locus in Age-related Macular Degeneration
Paz, M. A. D. L., Pericak‐Vance, M. A., Lennon, F., Haines, J. L., & Seddon, J. M. (1998) · Retina · doi:10.1097/00006982-199818020-00025 · Cited by 15
Inhibition of testosterone secretion by digitoxin in rat testicular interstitial cells
Wang, S., Lin, H., Hwang, J.-J., & Wang, P. S. (1999) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19990701)74:1 · Cited by 14
The kinetics of senescence in retinal pigmented epithelial cells: a test for the telomere hypothesis of ageing?
Rawes, V., Kipling, D., Kill, I. R., & Faragher, R. (1997) · PubMed · Cited by 14
Risk Factors for Age-Related Maculopathy: The Visual Impairment Project
McCarty, C. A. (2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.10.1455 · Cited by 12
Artificial senescence of bovine retinal pigment epithelial cells induced by near-ultraviolet in vitro
Li, W., Yanoff, M., Li, Y., & He, Z. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(99)00047-0 · Cited by 12
III. Zur Anatomie der scheibenförmigen Degeneration der Netzhautmitte
Hanssen, R. (1930) · Ophthalmologica · doi:10.1159/000297076 · Cited by 12
Perturbation of EGF-activated MEK1 and PKB signal pathways by TGF-?1 correlates with perturbation of EGF-induced cyclin D1 and DNA synthesis by TGF-?1 in C3H 10T1/2 cells
Yan, S., Krebs, S. J., Leister, K. J., & Wenner, C. E. (2000) · Journal of Cellular Physiology · doi:10.1002/1097-4652(200010)185:1 · Cited by 11
Long-Term Outcome After Radiation Therapy for Subfoveal Choroidal Neovascularization Associated with Age-Related Macular Degeneration
Mandai, M. (2000) · Japanese Journal of Ophthalmology · doi:10.1016/s0021-5155(00)00217-3 · Cited by 11
Cyclic AMP elevating agents and nitric oxide modulate angiotensin II‐induced leukocyte‐endothelial cell interactions in vivo
Álvarez, Á., Piqueras, L., Blázquez, M. A., & Sanz, M. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704096 · Cited by 10
A 5-year follow-up study for distance visual acuity after low dose radiation on subfoveal choroidal neovascularization in age-related macular degeneration
Valmaggia, C., Ries, G., & Ballinari, P. (2001) · Documenta Ophthalmologica · doi:10.1023/a:1013047722865 · Cited by 8
Morphologic characteristics of disciform scarring after radiation treatment for age-related macular degeneration
Haas, A. (2000) · Ophthalmology · doi:10.1016/s0161-6420(00)00154-8 · Cited by 8
Drusen and disciform macular detachment and degeneration. 1972.
Gass, J. D. M. (2003) · PubMed · Cited by 7
High-Dose Supplements for Age-Related Macular Degeneration: Did You Leave Out Centrum?
Abramson, D. H., & Abramson, H. S. (2002) · Archives of Ophthalmology · doi:10.1001/archopht.120.11.1602 · Cited by 5
I. Chorioiditis exsudativa unter dem Bilde der scheibenförmigen Entartung der Netzhautmitte
Paul, L. (1927) · Ophthalmologica · doi:10.1159/000296402 · Cited by 5
Choroidal hypoperfusion after surgical excision of subfoveal neovascular membranes in age-related macular degeneration
Thach, A. B., Marx, J. L., Frambach, D. A., LaBree, L., & Lopez, P. F. (1997) · International Ophthalmology · doi:10.1007/bf00175261 · Cited by 5
A FLUORESCEIN AND INDOCYANINE GREEN ANGIOGRAPHIC STUDY OF CHORIOCAPILLARIS IN AGE-RELATED MACULAR DEGENERATION
Pauleikhoff, D., Spital, G., Radermacker, M., Brumm, G., Lommatzsch, A. P., & Bird, A. C. (2000) · Evidence-Based Eye Care · doi:10.1097/00132578-200001000-00015 · Cited by 5
rhuFabV2 (an Anti-VEGF Antibody Fragment) in Neovascular AMD: Safety and Tolerability of Multiple Intravitreal Injections
Heier, J. (2002) · Investigative Ophthalmology & Visual Science · Cited by 4
Structural determinations and spectroscopic studies of carotenoids reveal the factors important in controlling their function in biological systems.
Frank, H. A. (1996) · PubMed · Cited by 4
Nicotine Increases Severity of Choroidal Neovascularization
Suñer, I. J., Tafur, C., Espinosa–Heidmann, D. G., Legra, J. M., Arango, K., Hernandez, E., Monroy, D. C., Csaky, K. G., & Cousins, S. W. (2002) · Investigative Ophthalmology & Visual Science · Cited by 3
Medication Use and the 5-Year Incidence of Early Age-Related Maculopathy: The Beaver Dam Eye Study
Klein, R. (2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.9.1354 · Cited by 3
Sub-Tenon’s Administration of the Angiostatic Agent Anecortave Acetate in AMD Patients with Subfoveal Choroidal Neovascularization (CNV) - the Clinical Outcome
Slakter, J. S., Singerman, L. J., Yannuzzi, L. A., Russell, S., Hudson, H., Jerdan, J. A., & Zilliox, P. (2002) · Investigative Ophthalmology & Visual Science · Cited by 2
Periocular Injection of an Adenoviral Vector Expressing the Extracellular Portion of Aascular Endothelial Growth Factor Receptor-1 (Adsflt.10) Inhibits Choroidal Neovascularization (CNV)
Demetriades, A.-M., Gehlbach, P. L., Yamamoto, S., Deering, T. G., Ng, E. M., Kovesdi, I., McVey, D., Wei, L. L., & Campochiaro, P. A. (2002) · Investigative Ophthalmology & Visual Science · Cited by 2
Augmentation of Choroidal Neovascularization in a Laser Induced Mouse Model by PEDF
Ferguson, T. A., Kaplan, H. J., Tezel, T. H., Volpert, O. V., Barriero, R., & Schadlu, R. (2002) · Investigative Ophthalmology & Visual Science · Cited by 2
Efficacy of SnET2 Photodynamic Therapy for Choroidal Neovascularization in Age-related Macular Degeneration: Phase III Pivotal Trial Results
Thomas, E. L., Tressler, C. S., & Murphy, R. (2002) · Investigative Ophthalmology & Visual Science · Cited by 2
A new drug-based strategy for intervention in age-related macular degeneration (AMD).
Hussain, A. A., Starita, C., & Marshall, J. S. (2001) · Research Portal (King's College London) · Cited by 1

Flagged first, then by citations

19 of the 550 references couldn’t be matched to a known paper.

Research works printed but not linked: 16

Age-Related Eye Disease Study Research Group, 2000, Risk factors associated with age-related macular degeneration. A case-control study in the age-related eye disease study: age-related eye disease study report number 3, Ophthalmology, 107, 2224
Applegate, 2001, A treatment trial for geographic atrophy from AMD: The GAARD Study, Invest Ophthalmol Vis Sci, 42, S230
Baffi, 2001, The recruitment of inflammatory cells into vascular endothelial growth factor (VEGF) induced choroidal neovascularization (CNV) in rat, Invest Ophthalmol Vis Sci, 42, S227
Becerra, 2001, Pigment epithelium-derived factor (PEDF) in the monkey eye: apical secretion from the retinal pigment epithelium, Invest Ophthalmol Vis Sci, 42, S772
Blodi, 2001, Effects of prinomastat (AG3340), an angiogenesis inhibitor, in patients with subfoveal choroidal neovascularization associated with age-related macular degeneration, Invest Ophthalmol Vis Sci, 41, S311
Hanssen, 1930, Zur anatomie der scheibenformigen degeneration der netzhaumitte, Z Augenh, 72, 360
Hegner, 1916, Retinitis exsudativa bei Lymphogranulomatosis, Klin Monatsbl Augenheil, 57, 27
Holz, 1994, Bilateral macular drusen in age-related macular degeneration. Prognosis and risk factors, Ophthalmology, 101, 1522, 10.1016/S0161-6420(94)31139-0 · DOI
Luna, 1996, Antagonists of integrin αvβ3 inhibit retinal neovascularization in a murine model, Lab Invest, 75, 563
Maguire, 2001, Results of the age-related macular degeneration and thalidomide study (AMDATS), Invest Ophthalmol Vis Sci, 42, S233
McFarlane, 2001, Advanced glycation endproducts (AGEs) modulate cathepsin D expression in retinal pigment epithelium (RPE): implications for age-related dysfunction, Invest Ophthalmol Vis Sci, 42, S414
Nozaki, 2001, Immunolocalization of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in choroidal neovascularization of human, Invest Ophthalmol Vis Sci, 42, S228
Paul, 1927, Choroiditis exsudativa under dem bilde der scheibenformigen entartung der netzhautmitte, Z Augenh, 63, 205
Razavi, 2001, Expression of integrins avb3 and avb5 in human choroidal neovascular membranes, Invest Ophthalmol Vis Sci, 42, S773
Spandau, 2000, High expression of angiogenic chemokines in choroidal neovascularization membranes, Invest Ophthalmol Vis Sci, 41, S836
Tanemura, 2001, Estrogen may enhance VEGFR-2 expression in the process of laser-induced CNV formation, Invest Ophthalmol Vis Sci, 42, S96

Sorted by citations

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
The Retinal Pigment Epithelium in Visual Function
Strauss, O. (2005) · Physiological Reviews · doi:10.1152/physrev.00021.2004 · Cited by 2,828
Complement factor H variant increases the risk of age-related macular degeneration
Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., et al. (2005) · Science · doi:10.1126/science.1110359 · Cited by 2,424
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease
Ng, E. W. M., Shima, D. T., Calias, P., Cunningham, E. T., Guyer, D. R., & Adamis, A. P. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1955 · Cited by 1,629
Self-citation
Genomewide Association Studies and Assessment of the Risk of Disease
Manolio, T. A. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0905980 · Cited by 1,512

See all 959

Authors: Ambati, J., Ambati, B. K., Yoo, S. H., Ianchulev, S., & Adamis, A. P.
Affiliations: Massachusetts Eye and Ear Infirmary (US)
ORCID: Ambati, Jayakrishna
Ambati, Balamurali K
Yoo, Sonia H
Venue: Survey of Ophthalmology
Publisher: Elsevier BV
Published: 2003-05
Volume: 48
Issue: 3
Pages: 257-293
ISSN: 0039-6257 (ISSN-L)
DOI: 10.1016/s0039-6257(03)00030-4
OpenAlex: W2016584341
Semantic Scholar: 966a19179595c3864062c4154d58b52e09b9a723
Cited by: 959
References: 550
Citations by year: 2026: 15 · 2025: 21 · 2024: 22 · 2023: 37 · 2022: 31 · 2021: 42 · 2020: 35 · 2019: 38 · 2018: 42 · 2017: 56 · 2016: 46 · 2015: 57 · 2014: 49 · 2013: 46 · 2012: 48
FWCI: 9.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Survey of Ophthalmology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
Keywords: age-related macular degeneration, drusen, geographic atrophy, retinal pigment epithelium, choroidal neovascularization, genetic risk factors, macular dystrophy, growth factors, gene therapy, treatment options, legal blindness, risk factors
MeSH terms: Animals, Disease Models, Animal, Humans, Macular Degeneration, Mice, Transgenic, Risk Factors, Mice, Knockout, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Age-Related Macular Degeneration: Etiology, Pathogenesis, and Therapeutic Strategies

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks