Cited by 262Skin Protection and AgingSirtuins and Resveratrol in MedicinePhytochemicals and Antioxidant Activities

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Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice☆☆Part of this work was conducted at the Department of Dermatology, Case Western Reserve University and the Research Institute of University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106.

Afaq, Farrukh, Adhami, Vaqar Mustafa, Ahmad, Nihal·2003·Toxicology and Applied Pharmacology

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Abstract

Nonmelanoma skin cancer is the most common cancer among humans and solar UV radiation, particularly its UVB component (290-320 nm), is its major cause. One way to reduce the occurrence of the cancer is via the use of substances (often antioxidants) termed "photochemopreventive agents". Resveratrol (trans-3,4',5-trihydroxystilbene), a phytoalexin found in grapes, nuts, fruits, and red wine, is a potent antioxidant with strong anti-inflammatory and antiproliferative properties. This study was designed to examine whether resveratrol possesses the potential to ameliorate the damages caused by short-term UVB exposure to mouse skin. Single topical application of resveratrol (25 micromol/0.2 ml acetone per mouse) to SKH-1 hairless mice was found to result in significant inhibition of UVB (180 mJ/cm(2))-mediated increase in bifold skin thickness and skin edema. The resveratrol treatment to mouse skin was also found to result in significant inhibition of UVB-mediated induction of cyclooxygenase and ornithine decarboxylase (ODC) enzyme activities and protein expression of ODC, which are well-established markers for tumor promotion. We also observed that resveratrol inhibits UVB-mediated increased level of lipid peroxidation, a marker of oxidative stress. Taken together, our results suggest that resveratrol may afford substantial protection against the damages caused by UVB exposure, and these protective effects may be mediated via its antioxidant properties.

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Authors: Afaq, F., Adhami, V. M., & Ahmad, N.
Affiliations: University of Wisconsin–Madison (US)
Corresponding author: Ahmad, Nihal
ORCID: Afaq, Farrukh
Adhami, Vaqar Mustafa
Ahmad, Nihal
Venue: Toxicology and Applied Pharmacology
Publisher: Elsevier BV
Published: 2003-01
Volume: 186
Issue: 1
Pages: 28-37
ISSN: 0041-008X (ISSN-L)
DOI: 10.1016/s0041-008x(02)00014-5
OpenAlex: W1579832894
Cited by: 262
References: 62
Citations by year: 2026: 1 · 2025: 7 · 2024: 7 · 2023: 10 · 2022: 12 · 2021: 14 · 2020: 8 · 2019: 10 · 2018: 16 · 2017: 17 · 2016: 6 · 2015: 18 · 2014: 14 · 2013: 7 · 2012: 18
FWCI: 13.75
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Toxicology and Applied Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords: resveratrol, UV-B radiation, non-melanoma skin cancer, SKH-1 mice, topical application, cyclooxygenase, ornithine decarboxylase, lipid peroxidation, oxidative stress, antioxidants, skin edema, tumor promotion
MeSH terms: Resveratrol, Administration, Topical, Animals, Antioxidants, Female, Hydrogen Peroxide, Mice, Hairless, Prostaglandin-Endoperoxide Synthases, Radiation Injuries, Experimental, Skin, Stilbenes, Ultraviolet Rays, Lipid Peroxidation, Mice

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