Photostability evaluation of five UV-filters, trans-resveratrol and beta-carotene in sunscreens
Abstract
Trans-resveratrol (RES) is used in cosmetic formulations and beta-carotene (BTC) is a classical sunscreen antioxidant, but their photostability in sunscreens, a property directly correlated to performance and safety has not been addressed in the literature. This paper reports the assessment of RES and/or BTC influence on the photostability of five UV-filters (octyl methoxycinnamate - OMC, avobenzone -AVO, octocrylene - OCT, bemotrizinole - BMZ, octyltriazone - OTZ) in three different combinations after UVA exposure followed by the identification of degradation products and the assessment of photoreactivity. The evaluation of sunscreen photostability was performed by HPLC and spectrophotometric analysis, and degradation products were identified by GC-MS analysis. Components RES, BTC, OMC and AVO were significantly degraded after UV exposure (reduction of around 16% in recovery). According to HPLC analysis, all formulations presented similar photostability profiles. Eleven degradation products were identified in GC-MS analysis, among them products of RES, BTC, OMC and AVO photodegradation. All evaluated formulations were considered photoreactive, as well as the isolated compounds RES and AVO. Considering HPLC, spectrophotometric and GC-MS results, it is suggested that formulations containing BMZ were considered the most photostable. The combination RES+BTC in a sunscreen improved the photostability of AVO. The benefits of using a combination of antioxidants in sunscreens was demonstrated by showing that using RES+BTC+studied UV-filters led to more photostable formulations, which in turn implies in better safety and efficacy.
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trans-Resveratrol combined with β-carotene ameliorates the photostability of UV filters, particularly avobenzone.
“In addition, it was also noticed that trans-resveratrol combined with β-carotene ameliorates the photostability of the UV filters, in particular of avobenzone (11) [37].”
From UV Filters: Challenges and Prospects (2022) · cites this paper as [37]
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- Authors
- Freitas, J. V., Lopes, N. P., & Gaspar, L. R.
- Affiliations
- Universidade de São Paulo (BR)
- Corresponding author
- Gaspar, Lorena Rigo
- Venue
- European Journal of Pharmaceutical Sciences
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 78
- Pages
- 79-89
- ISSN
- 0928-0987 (ISSN-L)
- OpenAlex
- W2190993508
- Cited by
- 66
- References
- 51
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 12 · 2020: 8 · 2019: 10 · 2018: 2 · 2017: 5 · 2016: 7
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmaceutical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Physical Sciences › Materials Science › Polymers and Plastics › Polymer Science and PVC
- Keywords
- photostability, UV filters, trans-resveratrol, beta-carotene, sunscreen, avobenzone, octyl methoxycinnamate, octocrylene, photodegradation products, photoreactivity, antioxidants, UVA exposure, degradation products
- MeSH terms
- Resveratrol, Acrylates, Benzoates, Chromatography, High Pressure Liquid, Cinnamates, Drug Stability, Gas Chromatography-Mass Spectrometry, Phenols, Photolysis, Propiophenones, Spectrophotometry, Ultraviolet, Stilbenes, Sunscreening Agents, Superoxides, Triazines, Ultraviolet Rays, beta Carotene, Singlet Oxygen
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