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Cited by 609Parasitic Diseases Research and TreatmentHelminth infection and controlResearch on Leishmaniasis Studies

The DOI matches its Crossref record; 258 of the 258 references it cites were found in a registry or an index.

Chapter 4 Heartworm Disease in Animals and Humans

McCall, John W., Genchi, Claudio, Kramer, Laura H., Guerrero, Jorge, Venco, Luigi·2008·Advances in Parasitology
DOI 10.1016/s0065-308x(08)00204-2
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Abstract

Heartworm disease due to Dirofilaria immitis continues to cause severe disease and even death in dogs and other animals in many parts of the world, even though safe, highly effective and convenient preventatives have been available for the past two decades. Moreover, the parasite and vector mosquitoes continue to spread into areas where they have not been reported previously. Heartworm societies have been established in the USA and Japan and the First European Dirofilaria Days (FEDD) Conference was held in Zagreb, Croatia, in February of 2007. These organizations promote awareness, encourage research and provide updated guidelines for the diagnosis, treatment and prevention of heartworm disease. The chapter begins with a review of the biology and life cycle of the parasite. It continues with the prevalence and distribution of the disease in domestic and wild animals, with emphasis on more recent data on the spreading of the disease and the use of molecular biology techniques in vector studies. The section on pathogenesis and immunology also includes a discussion of the current knowledge of the potential role of the Wolbachia endosymbiont in inflammatory and immune responses to D. immitis infection, diagnostic use of specific immune responses to the bacteria, immunomodulatory activity and antibiotic treatment of infected animals. Canine, feline and ferret heartworm disease are updated with regard to the clinical presentation, diagnosis, prevention, therapy and management of the disease, with special emphasis on the recently described Heartworm Associated Respiratory Disease (HARD) Syndrome in cats. The section devoted to heartworm infection in humans also includes notes on other epizootic filariae, particularly D. repens in humans in Europe. The chapter concludes with a discussion on emerging strategies in heartworm treatment and control, highlighting the potential role of tetracycline antibiotics in adulticidal therapy.

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Crossref · 10.1016/s0065-308x(08)00204-2

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Citations

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Research works printed but not linked: 27

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  25. Supakorndej, 2004, Early migration and development of Dirofilaria immitis in the ferret, Mustela putorius furo, J. Parasitol., 80, 237, 10.2307/3283753 · DOI
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Metadata

Authors
McCall, J. W., Genchi, C., Kramer, L. H., Guerrero, J., & Venco, L.
Affiliations
  • University of Georgia (US)
  • University of Milan (IT)
  • University of Parma (IT)
  • University of Pennsylvania (US)
ORCID
Venue
Advances in Parasitology
Publisher
Elsevier
Published
2008
Volume
66
Pages
193-285
ISSN
0065-308X (ISSN-L)
DOI
10.1016/s0065-308x(08)00204-2
OpenAlex
W1494995468
Cited by
609
References
258
Citations by year
2026: 31 · 2025: 33 · 2024: 46 · 2023: 51 · 2022: 36 · 2021: 48 · 2020: 51 · 2019: 34 · 2018: 23 · 2017: 30 · 2016: 35 · 2015: 30 · 2014: 46 · 2013: 24 · 2012: 24
FWCI
95.83
Type
book chapter
Language
en
Open access
closed
Locations
  • Advances in Parasitology/Advances in parasitology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
  • Life Sciences › Immunology and Microbiology › Parasitology › Helminth infection and control
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
Keywords
heartworm disease, Dirofilaria immitis, canine heartworm disease, feline heartworm disease, Dirofilaria repens, Wolbachia endosymbiont, mosquito vectors, heartworm prevention, tetracycline antibiotics
MeSH terms
Animals, Cat Diseases, Cats, Dirofilaria immitis, Dirofilariasis, Dog Diseases, Dogs, Female, Ferrets, Filaricides, Host-Parasite Interactions, Humans, Male, Symbiosis, Wolbachia

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