The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
Oxytocin and appetite
Abstract
Oxytocin has potent central effects on feeding behaviour, as well as on social and sexual behaviours, and one likely substrate for its anorectic effect is the ventromedial nucleus of the hypothalamus. This nucleus expresses a high density of oxytocin receptors, but contains very few oxytocin-containing fibres, hence it is a likely target of 'neurohormonal' actions of oxytocin, including possibly oxytocin released from the dendrites of magnocellular oxytocin neurones. As oxytocin release from dendrites is regulated independent of electrical activity and of secretion from the neurohypophysis, exactly how this release is regulated by metabolic and reproduction-related signals remains to be established fully. Intriguingly though, it looks as though this central release of oxytocin from magnocellular neurons might be instrumental in a fundamental shift in motivational behaviour - switching behaviour from being driven by the need to find and consume food, to the need to reproduce.
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“Oxytocin regulates feeding and metabolism at multiple sites (34,35).Its receptors are expressed throughout the gastrointestinal tract, and on gastric vagal nerve endings (36).”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [35]
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Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037
“It should be emphasized, as Leng and colleagues discuss (Leng et al., 2008b), that there is not always a match between Oxt Fig.”
InfluentialIntranasal Oxytocin: Myths and Delusions
Leng, G., & Ludwig, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.003 · Cited by 616
Autism, oxytocin and interoception
Quattrocki, E., & Friston, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.012 · Cited by 393
Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems
Koshimizu, T., Nakamura, K., Egashira, N., Hiroyama, M., Nonoguchi, H., & Tanoue, A. (2012) · Physiological Reviews · doi:10.1152/physrev.00035.2011 · Cited by 431
Hypothalamic Oxytocin Mediates Social Buffering of the Stress Response
Smith, A. S., & Wang, Z. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.017 · Cited by 359
Metadata
- Authors
- LENG, G., ONAKA, T., CAQUINEAU, C., SABATIER, N., TOBIN, V, & TAKAYANAGI, Y.
- Affiliations
- Jichi Medical University (JP)
- Corresponding author
- LENG, G
- Venue
- Progress in brain research
- Publisher
- Elsevier
- Published
- 2008
- Volume
- 170
- Pages
- 137-151
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W1884119423
- Cited by
- 112
- References
- 114
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 7 · 2017: 9 · 2016: 9 · 2015: 10 · 2014: 13 · 2013: 9 · 2012: 11
- FWCI
- 13.33
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Royal Society of Edinburgh
- Biotechnology and Biological Sciences Research Council (BB/E015123/1)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin, appetite, feeding behaviour, anorectic effect, ventromedial hypothalamus, oxytocin receptor, magnocellular neurons, neurohumoral regulation, reproduction
- MeSH terms
- Animals, Appetite, Dendrites, Biological Evolution, Feeding Behavior, Female, Fishes, Humans, Hunger, Lactation, Mammals, Marsupialia, Milk, Neurons, Oxytocin, Pituitary Gland, Posterior, Sexual Behavior, Sexual Behavior, Animal, Social Behavior, Signal Transduction
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