Cited by 112Neuroendocrine regulation and behaviorRegulation of Appetite and ObesityHypothalamic control of reproductive hormones

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Oxytocin and appetite

LENG, G, ONAKA, T, CAQUINEAU, C, SABATIER, N, TOBIN, V, TAKAYANAGI, Y·2008·Progress in brain research

DOI 10.1016/s0079-6123(08)00413-5

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Abstract

Oxytocin has potent central effects on feeding behaviour, as well as on social and sexual behaviours, and one likely substrate for its anorectic effect is the ventromedial nucleus of the hypothalamus. This nucleus expresses a high density of oxytocin receptors, but contains very few oxytocin-containing fibres, hence it is a likely target of 'neurohormonal' actions of oxytocin, including possibly oxytocin released from the dendrites of magnocellular oxytocin neurones. As oxytocin release from dendrites is regulated independent of electrical activity and of secretion from the neurohypophysis, exactly how this release is regulated by metabolic and reproduction-related signals remains to be established fully. Intriguingly though, it looks as though this central release of oxytocin from magnocellular neurons might be instrumental in a fundamental shift in motivational behaviour - switching behaviour from being driven by the need to find and consume food, to the need to reproduce.

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Anatomy and regulation of the central melanocortin system
Cone, R. D. (2005) · Nature Neuroscience · doi:10.1038/nn1455 · Cited by 1,583
Atlas of estradiol‐concentrating cells in the central nervous system of the female rat
Pfaff, D. W., & Keiner, M. (1973) · The Journal of Comparative Neurology · doi:10.1002/cne.901510204 · Cited by 1,494
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
Mountjoy, K. G., Mortrud, M. T., Low, M. J., Simerly, R. B., & Cone, R. D. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.10.7854347 · Cited by 1,157
Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
Lu, D., Willard, D. H., Patel, I. R., Kadwell, S. H., Overton, L. K., Kost, T., Luther, M., Chen, W., Woychik, R. P., Wilkison, W. O., et al. (1994) · Nature · doi:10.1038/371799a0 · Cited by 1,075
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791
Oxytocin induces maternal behavior in virgin female rats
Pedersen, C. A., Ascher, J. A., Monroe, Y. L., & Prange, A. J. (1982) · Science · doi:10.1126/science.7071605 · Cited by 770
Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene.
Lim, M. M., Wang, Z., Olazábal, D. E., Ren, X., Terwilliger, E. F., & Young, L. J. (2004) · Nature · doi:10.1038/nature02539 · Cited by 628
The neuroendocrine basis of social recognition
Ferguson, J. N., Young, L. J., & Insel, T. R. (2002) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2002.0229 · Cited by 494
Facilitation of the lordosis reflex of female rats from the ventromedial nucleus of the hypothalamus.
Pfaff, D. W., & Sakuma, Y. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012690 · Cited by 461
CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior
Bale, T. L., Davis, A. M., Auger, A. P., Dorsa, D. M., & McCarthy, M. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02546.2001 · Cited by 446
Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis
Pow, D. V., & Morris, J. F. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90091-2 · Cited by 446
Localization and pharmacological characterization of high affinity binding sites for vasopressin and oxytocin in the rat brain by light microscopic autoradiography
Tribollet, E., Barberis, C., Jard, S., Dubois-Dauphin, M., & Dreifuss, J. J. (1988) · Brain Research · doi:10.1016/0006-8993(88)91437-0 · Cited by 442
Developmental consequences of oxytocin
Carter, C. S. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00151-3 · Cited by 367
Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size
Blevins, J. E., Schwartz, M. W., & Baskin, D. G. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00604.2003 · Cited by 332
Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus
Michaud, J. L. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.14.1465 · Cited by 328
Extracellular dopamine in the medial preoptic area: implications for sexual motivation and hormonal control of copulation
Hull, E. M., Du, J., Lorrain, D., & Matuszewich, L. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07465.1995 · Cited by 321
The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat
Oldfield, B. J., Giles, M., Watson, A. M. D., Anderson, C. R., Colvill, L. M., & McKinley, M. J. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00555-3 · Cited by 317
The oxytocin receptor
Zingg, H. H., & Laporte, S. A. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(03)00080-8 · Cited by 316
Topographic mapping of VMH → arcuate nucleus microcircuits and their reorganization by fasting
Sternson, S. M., Shepherd, G. M., & Friedman, J. M. (2005) · Nature Neuroscience · doi:10.1038/nn1550 · Cited by 307
Convergence of Pre- and Postsynaptic Influences on Glucosensing Neurons in the Ventromedial Hypothalamic Nucleus
Song, Z., Levin, B. E., McArdle, J. J., Bakhos, N., & Routh, V. H. (2001) · Diabetes · doi:10.2337/diabetes.50.12.2673 · Cited by 303
The magnocellular oxytocin system, the fount of maternity: Adaptations in pregnancy
Russell, J. A., Leng, G., & Douglas, A. J. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/s0091-3022(02)00104-8 · Cited by 295
Self-citation
Oxytocin receptor-deficient mice developed late-onset obesity
Takayanagi, Y., Kasahara, Y., Onaka, T., Takahashi, N., Kawada, T., & Nishimori, K. (2008) · Neuroreport · doi:10.1097/wnr.0b013e3283021ca9 · Cited by 294
Knockout Mice Lacking Steroidogenic Factor 1 Are a Novel Genetic Model of Hypothalamic Obesity
Majdič, G., Young, M. J., Gómez-Sánchez, E. P., Anderson, P., Szczepaniak, L. S., Dobbins, R. L., McGarry, J., & Parker, K. L. (2002) · Endocrinology · doi:10.1210/endo.143.2.8652 · Cited by 289
The role of dopamine in motivation for food in humans: implications for obesity
Wang, G.-J., Volkow, N. D., & Fowler, J. S. (2002) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.6.5.601 · Cited by 285
Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats
Olson, B. R., Drutarosky, M. D., Chow, M.-S., Hruby, V. J., Stricker, E. M., & Verbalis, J. G. (1991) · Peptides · doi:10.1016/0196-9781(91)90176-p · Cited by 283
Centrally released oxytocin mediates mating-induced anxiolysis in male rats
Waldherr, M., & Neumann, I. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705860104 · Cited by 261
Oxytocin inhibits food and fluid intake in rats
Arletti, R., Benelli, A., & Bertolini, A. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90234-u · Cited by 254
Oxytocin Deficiency Mediates Hyperphagic Obesity of Sim1 Haploinsufficient Mice
Kublaoui, B. M., Gemelli, T., Tolson, K. P., Wang, Y., & Zinn, A. R. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0067 · Cited by 239
Mate Searching in Caenorhabditis elegans : A Genetic Model for Sex Drive in a Simple Invertebrate
Lipton, J. A., Kleemann, G. A., Ghosh, R., Lints, R., & Emmons, S. W. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1746-04.2004 · Cited by 211
Estradiol Modulates Density of Putative Oxytocin Receptors’ in Discrete Rat Brain Regions
de Kloet, R., Voorhuis, D. A. M., Boschma, Y., & Elands, J. (2008) · Neuroendocrinology · doi:10.1159/000124680 · Cited by 198
Pharmacological characteristics and anatomical distribution of [3H]oxytocin-binding sites in the wistar rat brain studied by autoradiography
Freund-Mercier, M. J., Stoeckel, M. E., Palacios, J. M., Pazos, A., Reichhart, J. M., Porte, A., & Richard, P. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90113-8 · Cited by 192
α-Melanocyte-Stimulating Hormone Stimulates Oxytocin Release from the Dendrites of Hypothalamic Neurons While Inhibiting Oxytocin Release from Their Terminals in the Neurohypophysis
Sabatier, N., Caquineau, C., Dayanithi, G., Bull, P., Douglas, A. J., Guan, X. M. M., Jiang, M., Van der Ploeg, L., & Leng, G. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-32-10351.2003 · Cited by 190
Oxytocin Facilitation of Maternal Behavior in Sheepa
Keverne, E. B., & Kendrick, K. M. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34348.x · Cited by 183
Brain oxytocin receptor antagonism blunts the effects of anorexigenic treatments in rats: evidence for central oxytocin inhibition of food intake
OLSON, B. R., DRUTAROSKY, M. D., STRICKER, E. M., & VERBALIS, J. G. (1991) · Endocrinology · doi:10.1210/endo-129-2-785 · Cited by 180
Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin
Blevins, J. E., Eakin, T. J., Murphy, J. A., Schwartz, M. W., & Baskin, D. G. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.036 · Cited by 164
Anatomy and neurochemistry of the pair bond
Young, L. J., Murphy Young, A. Z., & Hammock, E. A. D. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20771 · Cited by 163
Localization of oxytocin receptor messenger ribonucleic acid in the rat brain.
Yoshimura, R., Kiyama, H., Kimura, T., Araki, T., Maeno, H., Tanizawa, O., & Tohyama, M. (1993) · Endocrinology · doi:10.1210/endo.133.3.8396014 · Cited by 161
Neuronal activation in the hypothalamus and brainstem during feeding in rats
Johnstone, L. E., Fong, T. M., & Leng, G. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.08.003 · Cited by 154
Sex, parturition and motherhood without oxytocin?
Russell, J., & Leng, G. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1570343 · Cited by 150
Development of the ventromedial nucleus of the hypothalamus
McClellan, K., Parker, K. L., & Tobet, S. A. (2006) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2006.02.002 · Cited by 139
Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction
Wessells, H., Gralnek, D. R., Dorr, R. T., Hruby, V. J., Hadley, M. E., & Levine, N. (2000) · Urology · doi:10.1016/s0090-4295(00)00680-4 · Cited by 137
Oxytocin knockout mice demonstrate enhanced intake of sweet and nonsweet carbohydrate solutions
Sclafani, A. J., Rinaman, L., Vollmer, R. R., & Amico, J. A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00826.2006 · Cited by 131
Neural Pathways Controlling Central and Peripheral Oxytocin Release During Stress
Onaka, T. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.0953-8194.2004.01186.x · Cited by 130
Localized actions of progesterone in hypothalamus involve oxytocin.
Schumacher, M., Coirini, H., Frankfurt, M., & McEwen, B. S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.17.6798 · Cited by 130
Effects of leptin and orexin-A on food intake and feeding related hypothalamic neurons
Shiraishi, T., Oomura, Y., Sasaki, K., & Wayner, M. J. (2000) · Physiology & Behavior · doi:10.1016/s0031-9384(00)00341-3 · Cited by 125
The role of RFamide peptides in feeding
Bechtold, D. A., & Luckman, S. M. (2007) · Journal of Endocrinology · doi:10.1677/joe-06-0069 · Cited by 124
Atrial natriuretic peptide in brain and pituitary gland
Gutkowska, J., Antunes‐Rodrigues, J., & McCann, S. M. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.2.465 · Cited by 118
Differential Roles for Cholecystokinin A Receptors in Energy Balance in Rats and Mice
Bi, S., Scott, K. A., Kopin, A. S., & Moran, T. H. (2004) · Endocrinology · doi:10.1210/en.2004-0284 · Cited by 114
Novel Leptin-Regulated Genes Revealed by Transcriptional Profiling of the Hypothalamic Paraventricular Nucleus
Tung, Y. L., Ma, M. K. L., Piper, S., Coll, A. P., O’Rahilly, S., & Yeo, G. S. H. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3412-08.2008 · Cited by 111
Estradiol influences oxytocin-immunoreactive brain systems
Jirikowski, G. F., Caldwell, J. D., Pedersen, C. A., & Stumpf, W. E. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90022-x · Cited by 111
Species differences in central oxytocin receptor gene expression: Comparative analysis of promoter sequences
Young, L. J., Huot, B., Nilsen, R., Wang, Z., & Insel, T. R. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.05188.x · Cited by 110
Neuroendocrine mechanisms of change in food intake during pregnancy: A potential role for brain oxytocin
Douglas, A. J., Johnstone, L. E., & Leng, G. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.012 · Cited by 108
Increased Fos Expression in Oxytocin Neurons Following Masculine Sexual Behavior
Witt, D. M., & Insel, T. R. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00549.x · Cited by 102
Sex differences in and effects of estrogen on oxytocin receptor messenger ribonucleic acid expression in the ventromedial hypothalamus
Bale, T. L. (1995) · Endocrinology · doi:10.1210/en.136.1.27 · Cited by 102
Oxytocin receptor mRNA expression in the ventromedial hypothalamus during the estrous cycle
Bale, T., Dorsa, D. M., & Johnston, C. I. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-07-05058.1995 · Cited by 98
Oxytocin receptors: ligand binding, signalling and cholesterol dependence
Gimpl, G., Reitz, J., Brauer, S., & TROSSEN, C. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00417-2 · Cited by 96
Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice
Holder, J. L., Zhang, L., Kublaoui, B. M., Dileone, R., Öz, O. K., Bair, C.-H., Lee, Y.-H., & Zinn, A. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00446.2003 · Cited by 95
The hypothalamus, hormones, and hunger: alterations in human obesity and illness
Goldstone, A. P. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)53003-1 · Cited by 87
Orexin A (hypocretin-1) application at the medial preoptic area potentiates male sexual behavior in rats
Gulia, K. K., Mallick, H. N., & Kumar, V. M. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00877-1 · Cited by 85
Activation of melanocortin MC4 receptors increases erectile activity in rats ex copula
Martin, W. J., McGowan, E., Cashen, D. E., Gantert, L. T., Drisko, J. E., Hom, G. J., Nargund, R. P., Sebhat, I. K., Howard, A. D., der Ploeg, L. H. T. V., et al. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02479-2 · Cited by 83
Oxytocin gene deletion mice overconsume palatable sucrose solution but not palatable lipid emulsions
Miedlar, J. A., Rinaman, L., Vollmer, R. R., & Amico, J. A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00228.2007 · Cited by 82
Prolactin-Releasing Peptide Mediates Cholecystokinin-Induced Satiety in Mice
Bechtold, D. A., & Luckman, S. M. (2006) · Endocrinology · doi:10.1210/en.2006-0753 · Cited by 81
Evidence for Conservation of the Vasopressin/Oxytocin Superfamily in Annelida
Satake, H., Takuwa, K., Minakata, H., & Matsushima, O. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.9.5605 · Cited by 79
Ovarian steroids and sexual interaction alter oxytocinergic content and distribution in the basal forebrain
Caldwell, J. D., Jirikowski, G. F., Greer, E. R., Stumpf, W. E., & Pedersen, C. A. (1988) · Brain Research · doi:10.1016/0006-8993(88)90882-7 · Cited by 76
Octopus, which owns the most advanced brain in invertebrates, has two members of vasopressin/oxytocin superfamily as in vertebrates
Takuwa‐Kuroda, K., Ukena, K., Kanda, A., & Minakata, H. (2003) · Regulatory Peptides · doi:10.1016/s0167-0115(03)00151-4 · Cited by 75
Electrophysiological Actions of Oxytocin on Hypothalamic Neurons in vitro: Neuropharmacological Characterization and Effects of Ovarian Steroids
Kow, L., Johnson, A. E., Ogawa, S., & Pfaff, D. W. (2008) · Neuroendocrinology · doi:10.1159/000125948 · Cited by 73
Estradiol Modulation of Oxytocin Binding in the Ventromedial Hypothalamic Nucleus of Male and Female Rats
Coirini, H., Johnson, A. E., & McEwen, B. S. (2008) · Neuroendocrinology · doi:10.1159/000125221 · Cited by 71
Regulation of Oxytocin Secretion
Leng, G., Caquineau, C., & Sabatier, N. (2005) · Vitamins and hormones · doi:10.1016/s0083-6729(05)71002-5 · Cited by 68
The skinny on neurotrophins
Wisse, B. E., & Schwartz, M. W. (2003) · Nature Neuroscience · doi:10.1038/nn0703-655 · Cited by 63
Oxytocin and vasopressin binding sites in the hypothalamus of the rat: Histoautoradiographic detection
Krémarik, P., Freund‐Mercier, M. J., & Stoeckel, M. E. (1995) · Brain Research Bulletin · doi:10.1016/0361-9230(94)00196-8 · Cited by 63
HORMONE STORAGE IN INDIVIDUAL NEUROSECRETORY GRANULES OF THE PITUITARY GLAND: A QUANTITATIVE ULTRASTRUCTURAL APPROACH TO HORMONE STORAGE IN THE NEURAL LOBE
Morris, J. F. (1976) · Journal of Endocrinology · doi:10.1677/joe.0.0680209 · Cited by 61
Regulation of the milk ejection reflex in the rat.
Dyball, R. E. J., & Leng, G. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016283 · Cited by 60
Enhanced Salt Intake in Oxytocin Deficient Mice
Puryear, R., Rigatto, K., Amico, J. A., & Morris, M. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7776 · Cited by 58
Caenorhabditis elegansUNC-103 ERG-Like Potassium Channel Regulates Contractile Behaviors of Sex Muscles in Males before and during Mating
Garcia, L. R., & Sternberg, P. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02696.2003 · Cited by 58
Effects of α‐Melanocyte‐Stimulating Hormone on Magnocellular Oxytocin Neurones and their Activation at Intromission in Male Rats
Caquineau, C., Leng, G., Guan, X.-M., Jiang, M., der Ploeg, L. H. T. V., & Douglas, A. J. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01465.x · Cited by 58
Socially induced sex change regulates forebrain isotocin in Lythrypnus dalli
Black, M. P., Reavis, R. H., & Grober, M. S. (2003) · Neuroreport · doi:10.1097/00001756-200401190-00036 · Cited by 57
Effects of Central Oxytocin Administration on Intraoral Intake of Glucose in Deprived and Nondeprived Rats
Lokrantz, C.-M., Uvnäs‐Moberg, K., & Kaplan, J. M. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00021-8 · Cited by 57
DISTRIBUTION OF NEUROSECRETORY GRANULES AMONG THE ANATOMICAL COMPARTMENTS OF THE NEUROSECRETORY PROCESSES OF THE PITUITARY GLAND: A QUANTITATIVE ULTRASTRUCTURAL APPROACH TO HORMONE STORAGE IN THE NEURAL LOBE
Morris, J. F. (1976) · Journal of Endocrinology · doi:10.1677/joe.0.0680225 · Cited by 55
Vasopressin excites ventromedial hypothalamic glucose-responsive neurons In vitro
Kow, L.-W., & Pfaff, D. W. (1986) · Physiology & Behavior · doi:10.1016/0031-9384(86)90398-7 · Cited by 54
α‐Melanocyte‐Stimulating Hormone and Oxytocin: A Peptide Signalling Cascade in the Hypothalamus
Sabatier, N. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01464.x · Cited by 54
Self-citation
Presynaptic actions of endocannabinoids mediate α-MSH-induced inhibition of oxytocin cells
Sabatier, N., & Leng, G. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00667.2005 · Cited by 52
Studies of the SIM1 gene in relation to human obesity and obesity-related traits
Hung, C.-C. C., Luan, J., Sims, M., Keogh, J. M., Hall, C., Wareham, N. J., O’Rahilly, S., & Farooqi, I. S. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803443 · Cited by 51
Method for quantitating the molecular content of a subcellular organelle: hormone and neurophysin content of newly formed and aged neurosecretory granules.
Nordmann, J. J., & Morris, J. F. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.1.180 · Cited by 49
Dehydration anorexia is attenuated in oxytocin-deficient mice
Rinaman, L., Vollmer, R. R., Karam, J. R., Phillips, D., Li, X., & Amico, J. A. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00860.2004 · Cited by 48
Effects of leptin on fasting-induced inhibition of neuronal nitric oxide synthase mRNA in the paraventricular and supraoptic nuclei of rats
Isse, T., Ueta, Y., Serino, R., Noguchi, J., Yamamoto, Y., Nomura, M. J., Shibuya, I., Lightman, S. L., & Yamashita, H. (1999) · Brain Research · doi:10.1016/s0006-8993(99)02065-x · Cited by 45
Functional Role of Peptidergic Anterior Lobe Neurons in Male Sexual Behavior of the SnailLymnaea stagnalis
de Boer, P. A. C. M., Maat, A. T., Pieneman, A. W., Croll, R. P., Kurokawa, M., & Jansen, R. F. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.6.2823 · Cited by 44
Immunocytochemical localization of somatostatin and vasotocin in the brain of the Pacific hagfish, Eptatretus stouti
Nozaki, M., & Gorbman, A. (1983) · Cell and Tissue Research · doi:10.1007/bf00207697 · Cited by 43
Sexual Motivation Promotes Oxytocin Secretion in Male Rats
Hillegaart, V., Alster, P., Uvnäs‐Moberg, K., & Ahlénius, S. (1998) · Peptides · doi:10.1016/s0196-9781(97)00250-7 · Cited by 43
Functionally-defined compartments of the lordosis neural circuit in the ventromedial hypothalamus in female rats
Daniels, D., & Flanagan‐Cato, L. M. (2000) · Journal of Neurobiology · doi:10.1002/1097-4695(200010)45:1 · Cited by 42
The oxytocin/vasopressin receptor antagonist atosiban delays the gastric emptying of a semisolid meal compared to saline in human
Ohlsson, B., Björgell, O., Ekberg, O., & Darwiche, G. (2006) · BMC Gastroenterology · doi:10.1186/1471-230x-6-11 · Cited by 41
Effect of feeding on Fos protein expression in sheep hypothalamus with special reference to the supraoptic and paraventricular nuclei: an immunohistochemical study
Chaillou, É., Baumont, R., Tramu, G., & Tillet, Y. (2000) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2000.01338.x · Cited by 38
Inhibition of Luteinizing Hormone Secretion and Expression of c‐fos and Corticotrophin‐Releasing Factor Genes in the Paraventricular Nucleus During Insulin‐Induced Hypoglycaemia in Sheep
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NPY-induced inhibition of male copulatory activity is a direct behavioural effect
Poggioli, R., Vergoni, A. V., Marrama, D., Giuliani, D., & Bertolini, A. (1990) · Neuropeptides · doi:10.1016/0143-4179(90)90130-q · Cited by 35
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Effects of food deprivation upon behavioral patterns and time budgeting of Aplysia fasciata
Susswein, A. J. (1984) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(84)90968-3 · Cited by 28
Effects of annetocin, an oxytocin‐related peptide isolated from the earthworm Eisenia foetida, and some putative neurotransmitters on gut motility of the earthworm
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Authors: LENG, G., ONAKA, T., CAQUINEAU, C., SABATIER, N., TOBIN, V, & TAKAYANAGI, Y.
Affiliations: Jichi Medical University (JP)
Corresponding author: LENG, G
ORCID: LENG, G
ONAKA, T
TOBIN, V
TAKAYANAGI, Y
Venue: Progress in brain research
Publisher: Elsevier
Published: 2008
Volume: 170
Pages: 137-151
ISSN: 0079-6123 (ISSN-L)
DOI: 10.1016/s0079-6123(08)00413-5
OpenAlex: W1884119423
Cited by: 112
References: 114
Citations by year: 2026: 4 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 7 · 2017: 9 · 2016: 9 · 2015: 10 · 2014: 13 · 2013: 9 · 2012: 11
FWCI: 13.33
Type: book chapter
Language: en
Open access: closed
Locations: Progress in brain research (publishedVersion)
PubMed (publishedVersion)
Funders: Royal Society of Edinburgh
Biotechnology and Biological Sciences Research Council (BB/E015123/1)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: oxytocin, appetite, feeding behaviour, anorectic effect, ventromedial hypothalamus, oxytocin receptor, magnocellular neurons, neurohumoral regulation, reproduction
MeSH terms: Animals, Appetite, Dendrites, Biological Evolution, Feeding Behavior, Female, Fishes, Humans, Hunger, Lactation, Mammals, Marsupialia, Milk, Neurons, Oxytocin, Pituitary Gland, Posterior, Sexual Behavior, Sexual Behavior, Animal, Social Behavior, Signal Transduction

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