Cited by 112Neuroendocrine regulation and behaviorRegulation of Appetite and ObesityHypothalamic control of reproductive hormones

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Oxytocin and appetite

LENG, G, ONAKA, T, CAQUINEAU, C, SABATIER, N, TOBIN, V, TAKAYANAGI, Y·2008·Progress in brain research

DOI 10.1016/s0079-6123(08)00413-5

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Abstract

Oxytocin has potent central effects on feeding behaviour, as well as on social and sexual behaviours, and one likely substrate for its anorectic effect is the ventromedial nucleus of the hypothalamus. This nucleus expresses a high density of oxytocin receptors, but contains very few oxytocin-containing fibres, hence it is a likely target of 'neurohormonal' actions of oxytocin, including possibly oxytocin released from the dendrites of magnocellular oxytocin neurones. As oxytocin release from dendrites is regulated independent of electrical activity and of secretion from the neurohypophysis, exactly how this release is regulated by metabolic and reproduction-related signals remains to be established fully. Intriguingly though, it looks as though this central release of oxytocin from magnocellular neurons might be instrumental in a fundamental shift in motivational behaviour - switching behaviour from being driven by the need to find and consume food, to the need to reproduce.

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Brain Arginine Vasotocin Immunoreactivity Differs between Urban and Desert Curve-Billed Thrashers, Toxostoma curvirostre: Relationships with Territoriality and Stress Physiology
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“CCK is secreted from the duodenum in response to a meal and acts at CCK1 receptors on gastric vagal afferents; these project to neurons in the nucleus tractus solitarii, which in turn project directly to magnocellular oxytocin neurons (17, 18).”
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Oxytocin: An Old Hormone, a Novel Psychotropic Drug and its Possible Use in Treating Psychiatric Disorders
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Oral Supplementation with L-Carnosine Attenuates Social Recognition Deficits in CD157KO Mice via Oxytocin Release
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Background
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Quantitative elucidation of the transfer of the neonicotinoid pesticide clothianidin to the breast milk in mice
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Social isolation modulates appetite and defensive behavior via a common oxytocinergic circuit in larval zebrafishPreprint
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Background
Dietary macronutrient composition and central neuropeptide Y injection affect dietary preference and hypothalamic gene expression in chicks
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“In addition, oxytocin has potent central effects on feeding behavior [64].”
Background
Lactation and appetite-regulating hormones: increased maternal plasma peptide YY concentrations 3–6 months postpartum
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“Oxytocin reduces insulin resistance, increases lipolysis and exerts anti-orexigenic effects (10 – 12) .”
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Stojiljković, A. S., Čupić, Ž., Maćešić, S., Ivanović-Šašić, A., & Kolar-Anić, L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.976323 · Cited by 9
“3) and (R12), associated with AVP effects were derived from (39, 54, 59, 60) unless otherwise specified.”
Peptide Signaling in Taste Transduction
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Augmentation of morphine-conditioned place preference by food restriction is associated with alterations in the oxytocin/oxytocin receptor in rat models
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“Importantly, centrally administeredOXT affects feeding behavior and promotes the cessation of food intake (28).”
Background
Convergent evolution of a conserved molecular network underlies parenting and sociality
Kay, T., Piekarski, P., & Kronauer, D. J. C. (2025) · Nature Reviews Genetics · doi:10.1038/s41576-025-00903-5 · Cited by 8
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“…of AVP secretion and for spike propagation failure, we used our model to estimate which hypothetical value of mean AVP release per spike (mAVP/spike; see method) would be quantitatively realistic to simulate [AVP] (Leng et al. 2008a; Leng and Ludwig 2008; Leng et al. 2008b; Morris 1976).”
Method
Vasopressin V1a and V1b receptor modulators: a patent review (2012 – 2014)
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Intranasal oxytocin reduces attentional bias to food stimuli
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“Given the distinct pathways in the medial prefrontal cortex for feeding and bonding that oxytocin regulates, and the transfer from food-related incentives to reproductive ones via oxytocin receptors in the ventromedial nucleus of the hypothalamus (Leng et al., 2008; McCarthy et al., 1994), attentional bias procedures…”
BackgroundInfluential
Stimulating oxytocin receptors in the basolateral amygdala enhances stimulus processing: Differential and consistent effects for stimuli paired with fear versus sucrose in extinction and reversal learning
Fam, J. P., Holmes, N. M., & Westbrook, R. F. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106917 · Cited by 4
“Although several studies have shown reduced intake of food following OTR stimulation across various brain regions (Arletti et al., 1990; Leng et al., 2008; Mullis et al., 2013; Olszewski et al., 2010), few studies have examined whether OT is involved in the learning mechanisms underlying food…”
Background
Effect of oxytocin injection to milching buffaloes on its content & stability in milk.
Pullakhandam, R., Palika, R., Vemula, S. R., Polasa, K., & Sesikeran, B. (2014) · Europe PMC (PubMed Central) · Cited by 4
Significance of neuroendocrine systems and the gut-brain axis (GBA) in the regulation of obesity
Zhao, H., Li, Y., Cheng, R., Wang, Y., Ma, L., & Chen, W. (2026) · PeerJ · doi:10.7717/peerj.20400 · Cited by 3
Body weight modulates the impact of oxytocin on chronic cold-immobilization stress response
Önal, D., Korkmaz, H., Önal, G., & Pehli̇vanoğlu, B. (2024) · Peptides · doi:10.1016/j.peptides.2024.171202 · Cited by 2
Impact of virtual adjunctive cognitive remediation therapy on cognitive flexibility and treatment outcomes in comorbid anorexia nervosa and exercise dependence as quantified using novel biomarkers: A stage 1 registered report
Miller, M. L., Sanzari, C. M., Timko, C. A., & Hormes, J. M. (2023) · International Journal of Eating Disorders · doi:10.1002/eat.23942 · Cited by 1

Authors: LENG, G., ONAKA, T., CAQUINEAU, C., SABATIER, N., TOBIN, V, & TAKAYANAGI, Y.
Affiliations: Jichi Medical University (JP)
Corresponding author: LENG, G
ORCID: LENG, G
ONAKA, T
TOBIN, V
TAKAYANAGI, Y
Venue: Progress in brain research
Publisher: Elsevier
Published: 2008
Volume: 170
Pages: 137-151
ISSN: 0079-6123 (ISSN-L)
DOI: 10.1016/s0079-6123(08)00413-5
OpenAlex: W1884119423
Cited by: 112
References: 114
Citations by year: 2026: 4 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 7 · 2017: 9 · 2016: 9 · 2015: 10 · 2014: 13 · 2013: 9 · 2012: 11
FWCI: 13.33
Type: book chapter
Language: en
Open access: closed
Locations: Progress in brain research (publishedVersion)
PubMed (publishedVersion)
Funders: Royal Society of Edinburgh
Biotechnology and Biological Sciences Research Council (BB/E015123/1)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: oxytocin, appetite, feeding behaviour, anorectic effect, ventromedial hypothalamus, oxytocin receptor, magnocellular neurons, neurohumoral regulation, reproduction
MeSH terms: Animals, Appetite, Dendrites, Biological Evolution, Feeding Behavior, Female, Fishes, Humans, Hunger, Lactation, Mammals, Marsupialia, Milk, Neurons, Oxytocin, Pituitary Gland, Posterior, Sexual Behavior, Sexual Behavior, Animal, Social Behavior, Signal Transduction

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