Cited by 134Neural and Behavioral Psychology StudiesMotor Control and AdaptationMemory and Neural Mechanisms

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Chapter 33 The greater limbic system, the emotional motor system and the brain

Nieuwenhuys, Rudolf·1996·Progress in brain research

DOI 10.1016/s0079-6123(08)61887-7

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Handbook of Chemical Neuroanatomy
Stern, C. D. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90021-5 · Cited by 4,160
A PROPOSED MECHANISM OF EMOTION
PAPEZ, J. W. (1937) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1937.02260220069003 · Cited by 3,563
From motivation to action: Functional interface between the limbic system and the motor system
MOGENSON, G., JONES, D., & YIM, C. (1980) · Progress in Neurobiology · doi:10.1016/0301-0082(80)90018-0 · Cited by 2,331
AN ANATOMICAL STUDY OF CONVERGING SENSORY PATHWAYS WITHIN THE CEREBRAL CORTEX OF THE MONKEY
Jones, E. G., & Powell, T. P. S. (1970) · Brain · doi:10.1093/brain/93.4.793 · Cited by 1,717
Preliminary analysis of functions of the temporal lobes in monkeys
KLÜVER, H. (1939) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1939.02270240017001 · Cited by 1,696
The amygdala: Neurobiological aspects of emotion, memory, and mental dysfunction.
Aggleton, J. P. (1992) · Wiley-Liss eBooks · Cited by 1,536
Anatomical evidence of direct projections from the nucleus of the solitary tract to the hypothalamus, amygdala, and other forebrain structures in the rat
Ricardo, J. A., & Koh, E. T. (1978) · Brain Research · doi:10.1016/0006-8993(78)91125-3 · Cited by 1,362
Encyclopedia of Neuroscience
(2009) · Elsevier eBooks · doi:10.1016/c2009-1-03742-3 · Cited by 1,335
Neurological Anatomy. In Relation to Clinical Medicine.
(1970) · Annals of Internal Medicine · doi:10.7326/0003-4819-72-3-449_1 · Cited by 1,264
Efferent connections of the parabrachial nucleus in the rat
Saper, C. B., & Loewy, A. D. (1980) · Brain Research · doi:10.1016/0006-8993(80)91117-8 · Cited by 1,217

Show all 126 references

Research works printed but not linked: 2

Cuvier, 1812, Sur un nouveau rapprochement à établir entre les classes qui composent le Règne animal., Ann. Mus. Hist. Nat., 19, 73
Pow, 1988, Exocytosis of dense-cored vesicles from synaptic and non-synaptic release sites in the hypothalamus of the rat., J. Anat., 158, 214

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Method
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“Among the different brain structures involved in both pathologies, the amygdala is particularly interesting since it is a key component involved in emotion as well as in homeostatic regulation [2, 3].”
Background
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“The possible dismission of the OT from primary olfactory transmission in the microsmatic primate would point to a withdrawal of olfactory signals from ventral striatal functionality, that is, the processing of motivational and goalorientated behaviour [see Pennartz et al., 1994; Nieuwenhuys, 1996].”
Background
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ten Donkelaar, H. J., Lammens, M. M. Y., Cruysberg, J. R. M., Ulzen, K. K.-V., Hori, A., & Shiota, K. (2014) · Springer eBooks · doi:10.1007/978-3-642-54687-7_9 · Cited by 16
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Self-citation
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“Nieuwenhuys (1996) was the first to describe limbic system, and among the brain regions composing it, are frontal cortex, hippocampus, striatum, and amygdala.”
Background
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“Defined as the expanded limbic system (Nauta, 1979; Nieuwenhuys, 1996) they further provide a mediating system between evaluating allocortical (Stephan, 1975) and storing neocortical portions of the nervous system (Fig.”
Background
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“The limbic lobe and the more extensive paralimbic belt form part of a large functional entity, designated as the greater limbic system [510].”
Background
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“This type of structural organization, however, would not preclude other influences from adding variability or nuance to facial behavior across different contexts (Nieuwenhuys 1996, Cattaneo and Pavesi 2014).”
Background
Emotions: The Shared Heritage of Animals and Humans
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Authors: Nieuwenhuys, R.
Affiliations: Radboud University Nijmegen (NL)
Corresponding author: Nieuwenhuys, Rudolf
ORCID: Nieuwenhuys, Rudolf
Venue: Progress in brain research
Publisher: Elsevier
Published: 1996
Volume: 107
Pages: 551-580
ISSN: 0079-6123 (ISSN-L)
DOI: 10.1016/s0079-6123(08)61887-7
OpenAlex: W225598057
Cited by: 134
References: 126
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2021: 2 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 5 · 2013: 6 · 2012: 5
FWCI: 5.59
Type: book chapter
Language: en
Open access: closed
Locations: Progress in brain research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: cerebral cortex, premotor cortex, motor cortex, corticospinal tract, extrapyramidal system, cerebellum
MeSH terms: Animals, Brain Mapping, Emotions, Limbic System, Motor Neurons, Neurons, Afferent

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