Cited by 146Nicotinic Acetylcholine Receptors StudyNeurotransmitter Receptor Influence on BehaviorSmoking Behavior and Cessation

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Nicotinic–serotonergic interactions in brain and behaviour

Seth, Pallab, Cheeta, Survjit, Tucci, Sonia, File, Sandra E.·2002·Pharmacology Biochemistry and Behavior

DOI 10.1016/s0091-3057(01)00715-8

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Abstract

This review focuses on nicotinic--serotonergic interactions in the central nervous system (CNS). Nicotine increases 5-hydroxytryptamine (5-HT) release in the cortex, striatum, hippocampus, dorsal raphé nucleus (DRN), hypothalamus, and spinal cord. As yet, there is little firm evidence for nicotinic receptors on serotonergic terminals and thus nicotine's effects on 5-HT may not necessarily be directly mediated, but there is strong evidence that the 5-HT tone plays a permissive role in nicotine's effects. The effects in the cortex, hippocampus, and DRN involve stimulation of 5-HT(1A) receptors, and in the striatum, 5-HT(3) receptors. The 5-HT(1A) receptors in the DRN play a role in mediating the anxiolytic effects of nicotine and the 5-HT(1A) receptors in the dorsal hippocampus and lateral septum mediate its anxiogenic effects. The increased startle and anxiety during nicotine withdrawal is mediated by 5-HT(1A) and 5-HT(3) receptors. The locomotor stimulant effect of acute nicotine is mediated by 5-HT(1A) receptors and 5-HT(2) receptors may play a role in the expression of a sensitised response after chronic nicotine treatment. Unfortunately, the role of 5-HT(1A) receptors in mediating nicotine seeking has not yet been investigated and would seem an important area for future research. There is also evidence for nicotinic--serotonergic interactions in the acquisition of the water maze, passive avoidance, and impulsivity in the five-choice serial reaction task.

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Authors: Seth, P., Cheeta, S., Tucci, S., & File, S. E.
Affiliations: King's College London (GB)
Corresponding author: File, Sandra E.
ORCID: Cheeta, Survjit
Venue: Pharmacology Biochemistry and Behavior
Publisher: Elsevier BV
Published: 2002-04
Volume: 71
Issue: 4
Pages: 795-805
ISSN: 0091-3057 (ISSN-L)
DOI: 10.1016/s0091-3057(01)00715-8
OpenAlex: W2033178939
Cited by: 145
References: 124
Citations by year: 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 8 · 2015: 3 · 2014: 7 · 2013: 8 · 2012: 5
FWCI: 0.87
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology Biochemistry and Behavior (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Keywords: nicotine, serotonin, 5-HT1A receptor, 5-HT3 receptor, 5-HT2 receptor, dorsal raphe nucleus, dorsal hippocampus, striatum, anxiolytic effects, anxiogenic effects, nicotine withdrawal, startle response, locomotor stimulant effects, sensitization, nicotine seeking, impulsivity, water maze, passive avoidance
MeSH terms: Central Nervous System Stimulants, Animals, Anxiety, Behavior, Behavior, Animal, Brain, Humans, Synaptic Transmission, Receptors, Nicotinic, Receptors, Serotonin, Reward

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Nicotinic–serotonergic interactions in brain and behaviour

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