Effect of subtype selective nicotinic compounds on attention as assessed by the five-choice serial reaction time task
Abstract
Nicotine can improve attentional functioning in humans, and a number of studies have recently demonstrated that under specific task conditions, nicotine can also improve attention in the rat. Neuronal nicotinic receptors comprise combinations of alpha(2-9) and beta(2-4) subunits, arranged to form a pentameric receptor, with the principal CNS subtypes currently believed to be alpha(4)beta(2) and a homomeric alpha(7) receptor. In the present studies, we attempted to delineate the particular nicotinic receptor subtype(s) contributing to the effects of nicotine on attention by assessing various nicotinic ligands on performance in the five-choice serial reaction time task (5-CSRTT). In rats performing below criterion (<80% correct, >20% omissions to a 1-s visual stimulus), subchronic dosing with nicotine (0.2 mg/kg sc) and the alpha(4)beta(2) agonist SIB 1765F (5 mg/kg sc) increased correct responding and decreased response latencies across the treatment week; whereas the alpha(7) agonist AR-R 17779 (20 mg/kg sc) was without effect. In subjects meeting the criterion, the competitive high affinity (including alpha(4)beta(2)) nicotine receptor antagonist DHbetaE (1-10 mg/kg sc) and the alpha(7) antagonist methyllycaconitine (MLA: 5-10 mg/kg i.p.) did not disrupt performance, whereas at the highest dose, the non-competitive antagonist mecamylamine (0.3-3 mg/kg sc) decreased accuracy and increased response latencies. These changes bore some similarities to those of pre-feeding and the non-competitive NMDA antagonist dizocilpine (0.03-0.06 mg/kg sc), suggesting that mecamylamine-induced performance disruption may relate to non-nicotinic receptor effects. In subjects chronically treated with nicotine, acute nicotine challenge (0.4 mg/kg sc) significantly increased accuracy whilst having no effect on any other performance measures. Finally, in these same nicotine pre-treated rats, the decrease in latency and increase in premature responses induced by nicotine (0.2 mg/kg sc) to a target stimulus of 150 ms was fully antagonised by DHbetaE (3 mg/kg sc) but not MLA (5 mg/kg i.p.). These results suggest that alpha(7) receptors do not play a role in any of the behavioural effects of nicotine observed in the 5-CSRTT, whereas a high affinity site, perhaps alpha(4)beta(2), is more likely involved.
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The 5-CSRTT is a visual attention task that can reliably detect cognitive aspects of nicotine withdrawal.
“The five-choice serial reaction time task (5-CSRTT) is a visual attention task [205] that can reliably detect cognitive aspects of nicotine withdrawal [206, 207].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [205]
Pharmacological studies failed to implicate the α7 nAChR in attention.
“Pharmacological studies failed to implicate this receptor in attention (Grottick and Higgins, 2000; Hahn et al, 2003).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Grottick and Higgins, 2000
Cites
CENTRAL CHOLINERGIC SYSTEMS AND COGNITION
Everitt, B. J., & Robbins, T. W. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.649 · Cited by 1,348 · see citing works
Neuronal nicotinic receptors in the human brain
Paterson, D., & Nordberg, A. K. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00045-3 · Cited by 782 · see citing works
Nicotinic Receptors in the Development and Modulation of CNS Synapses
Role, L. W., & Berg, D. K. (1996) · Neuron · doi:10.1016/s0896-6273(00)80134-8 · Cited by 762 · see citing works
Carli, M., Robbins, T. W., Evenden, J. L., & Everitt, B. J. (1983) · Behavioural Brain Research · doi:10.1016/0166-4328(83)90138-9 · Cited by 736 · see citing works
Nicotinic acetylcholine involvement in cognitive function in animals
Levin, E. D., & Simon, B. B. (1998) · Psychopharmacology · doi:10.1007/s002130050667 · Cited by 675 · see citing works
Lukas, R. J., Changeux, J., Novère, N. G. L., Albuquerque, E. X., Balfour, D. J. K., Berg, D. K., Bertrand, D., Chiappinelli, V. A., Clarke, P. B. S., Collins, A. C., et al. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01406-6 · Cited by 536 · see citing works
Clarke, P. B. S., & Pert, A. (1985) · Brain Research · doi:10.1016/0006-8993(85)90456-1 · Cited by 527 · see citing works
Muir, J. L., Everitt, B. J., & Robbins, T. W. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.3.470 · Cited by 503 · see citing works
Clineschmidt, B. V., Martin, G. E., & Bunting, P. R. (1982) · Drug Development Research · doi:10.1002/ddr.430020203 · Cited by 499 · see citing works
Sahakian, B. J., Jones, G., Levy, R., Gray, J. A., & Warburton, D. M. (1989) · The British Journal of Psychiatry · doi:10.1192/bjp.154.6.797 · Cited by 494 · see citing works
Jones, G., Sahakian, B. J., Levy, R., Warburton, D. M., & Gray, J. A. (1992) · Psychopharmacology · doi:10.1007/bf02247426 · Cited by 476 · see citing works
The effects of nicotine on locomotor activity in non‐tolerant and tolerant rats
Clarke, P. B. S., & Kumar, R. (1983) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1983.tb09398.x · Cited by 457 · see citing works
Harrison, A. A., Everitt, B. J., & Robbins, T. W. (1997) · Psychopharmacology · doi:10.1007/s002130050410 · Cited by 452 · see citing works
Benwell, M. E. M., & Balfour, D. J. K. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb09067.x · Cited by 426 · see citing works
Muir, J. L., Everitt, B. J., & Robbins, T. W. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02313.1994 · Cited by 421 · see citing works
Chavez-Noriega, L. E., Crona, J. H., Washburn, M. S., Urrutia, A., Elliott, K. J., & Johnson, E. C. (1997) · PubMed · Cited by 392 · see citing works
Nicotine-Haloperidol Interactions and Cognitive Performance in Schizophrenics
Levin, E. D. (1996) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00018-8 · Cited by 342 · see citing works
Transdermal nicotine effects on attention
Levin, E. D., Conners, C. K., Silva, D., Hinton, S. C., Meck, W. H., March, J. S., & Rose, J. E. (1998) · Psychopharmacology · doi:10.1007/s002130050750 · Cited by 331 · see citing works
Robbins, T. W., Everitt, B. J., Marston, H. M., Wilkinson, J., Jones, G. H., & Page, K. J. (1989) · Behavioural Brain Research · doi:10.1016/s0166-4328(89)80143-3 · Cited by 321 · see citing works
Cole, B. J., & Robbins, T. W. (1989) · Behavioural Brain Research · doi:10.1016/s0166-4328(89)80048-8 · Cited by 316 · see citing works
Muir, J. L., Dunnett, S. B., Robbins, T. W., & Everitt, B. J. (1992) · Experimental Brain Research · doi:10.1007/bf00229886 · Cited by 280 · see citing works
Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer's disease
White, H. K., & Levin, E. D. (1999) · Psychopharmacology · doi:10.1007/s002130050931 · Cited by 273 · see citing works
Nicotinic System Involvement in Alzheimer??s and Parkinson??s Diseases
NEWHOUSE, P. A., Potter, A., & Levin, E. D. (1997) · Drugs & Aging · doi:10.2165/00002512-199711030-00005 · Cited by 266 · see citing works
Day, J. C., Damsma, G., & Fibiger, H. C. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90233-r · Cited by 263 · see citing works
Davies, A. R. L., HARDICK, D. J., Blagbrough, I. S., Potter, B. V. L., Wolstenholme, A. J., & Wonnacott, S. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(98)00221-4 · Cited by 246 · see citing works
Cole, B. J., & Robbins, T. W. (1987) · Psychopharmacology · doi:10.1007/bf00216011 · Cited by 240 · see citing works
Clineschmidt, B. V., Martin, G. E., Bunting, P. R., et al. (1982) · Drug Development Research · doi:10.1002/ddr.430020204 · Cited by 230 · see citing works
Characterization of the locomotor stimulant action of nicotine in tolerant rats
Clarke, P. B. S., & Kumar, R. C. (1983) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1983.tb10733.x · Cited by 222 · see citing works
Nicotine and attention in adult attention deficit hyperactivity disorder (ADHD).
Conners, C. K., Levin, E. D., Sparrow, E. P., Hinton, S. C., Erhardt, D., Meck, W. H., Rose, J. E., & March, J. S. (1996) · PubMed · Cited by 218 · see citing works
Watkins, S. S., Stinus, L., Koob, G. F., & Markou, A. (2000) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35389-3 · Cited by 214 · see citing works
Everitt, B. J., Robbins, T. W., & Muir, J. L. (1995) · Psychopharmacology · doi:10.1007/bf02245253 · Cited by 214 · see citing works
α-Conotoxin MII Blocks Nicotine-Stimulated Dopamine Release in Rat Striatal Synaptosomes
Kulak, J. M., Nguyen, T. A., Olivera, B. M., & McIntosh, J. M. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-14-05263.1997 · Cited by 198 · see citing works
Nicotine patches in Alzheimer's disease: Pilot study on learning, memory, and safety
Wilson, A. L., Langley, L. K., Monley, J., Bauer, T., Rottunda, S. J., McFalls, E. O., Kovera, C. A., & McCarten, J. R. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)00043-v · Cited by 196 · see citing works
AR-R 17779, an α7 nicotinic agonist, improves learning and memory in rats
Levin, E. D., Bettegowda, C., Blosser, J. C., & Gordon, J. C. (1999) · Behavioural Pharmacology · doi:10.1097/00008877-199911000-00014 · Cited by 193 · see citing works
Thi�bot, M.-H., Kloczko, J., Chermat, R., et al. (1982) · Drug Development Research · doi:10.1002/ddr.430010718 · Cited by 193 · see citing works
Nicotine enhances sustained attention in the rat under specific task conditions
Mirza, N. R., & Stolerman, I. P. (1998) · Psychopharmacology · doi:10.1007/s002130050671 · Cited by 181 · see citing works
Humby, T., Laird, F. M., Davies, W., & Wilkinson, L. S. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00701.x · Cited by 180 · see citing works
Inglis, F. M., & Fibiger, H. C. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00578-s · Cited by 176 · see citing works
Noradrenaline and attention lapses
Smith, A. P., & Nutt, D. (1996) · Nature · doi:10.1038/380291a0 · Cited by 170 · see citing works
Sharples, C. G. V., Kaiser, S., Soliakov, L. S., Marks, M. J., Collins, A. C., Washburn, M. S., Wright, E., Spencer, J. A., Gallagher, T., Whiteaker, P., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-08-02783.2000 · Cited by 164 · see citing works
A reappraisal of the functions of the nucleus basalis of Meynert
Richardson, R. T., & DeLong, M. R. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90107-5 · Cited by 154 · see citing works
Determinants of Competitive Antagonist Sensitivity on Neuronal Nicotinic Receptor β Subunits
Harvey, S. C., & Luetje, C. W. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-12-03798.1996 · Cited by 153 · see citing works
Neural Systems Underlying Arousal and Attention: Implications for Drug Abusea
Robbins, T. W., Granon, S., Muir, J. L., Durantou, F., Harrison, A. A., & Everitt, B. J. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09740.x · Cited by 149 · see citing works
Nicotine in an animal model of attention
Stolerman, I. P., Mirza, N. R., Hahn, B., & Shoaib, M. C. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00886-9 · Cited by 144 · see citing works
Grottick, A. J., Trube, G., Corrigall, W., Huwyler, J., Malherbe, P., Wyler, R., & Higgins, G. A. (2000) · PubMed · Cited by 142 · see citing works
Self-citationBlondel, A., Sanger, D. J., & Moser, P. C. (2000) · Psychopharmacology · doi:10.1007/s002130000378 · Cited by 138 · see citing works
Inglis, F. M., Day, J. C., & Fibiger, H. C. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90342-5 · Cited by 136 · see citing works
Neuronal responses related to reinforcement in the primate basal forebrain
Wilson, F. A. W., & Rolls, E. T. (1990) · Brain Research · doi:10.1016/0006-8993(90)90546-n · Cited by 130 · see citing works
O’Dell, T. J., & Christensen, B. N. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90276-5 · Cited by 111 · see citing works
The role of nicotinic and muscarinic acetylcholine receptors in attention
Mirza, N. R., & Stolerman, I. P. (2000) · Psychopharmacology · doi:10.1007/s002130050048 · Cited by 108 · see citing works
Selective effects of nicotine on attentional processes
Mancuso, G., Sherwood, N., Tirelli, E., Warburton, D. M., & M�len, M. (1999) · Psychopharmacology · doi:10.1007/s002130051107 · Cited by 106 · see citing works
Nicotine for the treatment of Tourette's syndrome
Sanberg, P. R., Silver, A. A., Shytle, R. D., Philipp, M. K., Cahill, D. W., Fogelson, H. M., & McConville, B. J. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(96)00199-4 · Cited by 106 · see citing works
Effects of dopamine D1 and D2 receptor blockade on MK-801-induced hyperlocomotion in rats
Ouagazzal, A., Nieoullon, A., & Amalric, M. (1993) · Psychopharmacology · doi:10.1007/bf02253532 · Cited by 104 · see citing works
Harrison, A. A., Everitt, B. J., & Robbins, T. W. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00053-3 · Cited by 103 · see citing works
Pathological mutations of nicotinic receptors and nicotine-based therapies for brain disorders
Léna, C., & Changeux, J. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80088-8 · Cited by 100 · see citing works
Age-associated impairments in a test of attention: evidence for involvement of cholinergic systems
Jones, D., Barnes, J., Kirkby, D. L., & Higgins, G. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07282.1995 · Cited by 98 · see citing works
Self-citationWhat aspects of hum an enhanced by nicotine? performance are truly
Heishman, S. J. (1998) · Addiction · doi:10.1080/09652149835864 · Cited by 95 · see citing works
O‘Neill, M. F., Dourish, C. T., & Iversen, S. D. (1991) · Psychopharmacology · doi:10.1007/bf02246034 · Cited by 95 · see citing works
Carli, M., & SAMANIN, R. (1992) · Psychopharmacology · doi:10.1007/bf02801977 · Cited by 94 · see citing works
Selective antagonism of behavioural effects of nicotine by dihydro-?-erythroidine in rats
Stolerman, I. P., Chandler, C. J., Garcha, H. S., et al. (1997) · Psychopharmacology · doi:10.1007/s002130050205 · Cited by 93 · see citing works
Evaluation of the information processing and mood effects of a transdermal nicotine patch
Warburton, D. M., & Mancuso, G. (1998) · Psychopharmacology · doi:10.1007/s002130050514 · Cited by 91 · see citing works
Cholinergic Control of Cognitive Resources
Warburton, D. M., & Rusted, J. M. (2008) · Neuropsychobiology · doi:10.1159/000118998 · Cited by 86 · see citing works
Effortful processing is a requirement for nicotine-induced improvements in memory
Rusted, J. M., Tennant, A., Warburton, D. M., & Graupner, L. (1998) · Psychopharmacology · doi:10.1007/s002130050682 · Cited by 58 · see citing works
Nicotinic acetylcholine receptor knockout mice as animal models for studying receptor function
Marubio, L. M., & Changeux, J. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00007-8 · Cited by 55 · see citing works
Pharmacological Characterization of SIB-1765F: A Novel Cholinergic Ion Channel Agonist
Sacaan, A. I., Reid, R. T., Santori, E. M., Adams, P., Correa, L. D., Mahaffy, L. S., Bleicher, L. S., Cosford, N. D. P., Stauderman, K. A., McDonald, I. A., et al. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36402-x · Cited by 55 · see citing works
Ruotsalainen, S., Miettinen, R., MacDonald, E., Koivisto, E., & Sirviö, J. (2000) · Psychopharmacology · doi:10.1007/s002130050032 · Cited by 49 · see citing works
Effects of a Novel Cholinergic Ion Channel Agonist SIB-1765F on Locomotor Activity in Rats
Menzaghi, F., Whelan, K. T., Risbrough, V. B., Rao, T. S., & Lloyd, G. K. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36403-1 · Cited by 45 · see citing works
Inter-species consistency in the behavioural pharmacology of nicotine dependence
Stolerman, I. P. (1999) · Behavioural Pharmacology · doi:10.1097/00008877-199911000-00002 · Cited by 44 · see citing works
Conditioned tolerance to the heart rate effects of smoking
Epstein, L. H., Caggiula, A. R., Perkins, K. A., et al. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90390-n · Cited by 35 · see citing works
Blondel, A., Simon, H., Sanger, D. J., & Moser, P. C. (1999) · Behavioural Pharmacology · doi:10.1097/00008877-199911000-00013 · Cited by 34 · see citing works
Grottick, A. J., Wyler, R., & Higgins, G. A. (2000) · Psychopharmacology · doi:10.1007/s002130000444 · Cited by 28 · see citing works
Self-citationNicotine Receptors in the Central Nervous System
Martin, B. R. (1986) · Elsevier eBooks · doi:10.1016/b978-0-12-185203-0.50018-5 · Cited by 25 · see citing works
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Levin, E. D., McClernon, F. J., & Rezvani, A. H. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0164-7 · Cited by 820 · see citing works
Modes and models of forebrain cholinergic neuromodulation of cognition
Hasselmo, M. E., & Sarter, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.104 · Cited by 733 · see citing works
Reward, addiction, withdrawal to nicotine
De Biasi, M., & Dani, J. A. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113734 · Cited by 366 · see citing works
“…−/− mice (Pons et al. 2008), consistent with the pharmacological evidence indicating that the α7 subunit does not influence chronic nicotine self-administration in trained rats (Grottick & Higgins 2000) nor nicotine-induced conditioned place preference (Stolerman et al. 2004, Walters et al. 2006).”
BackgroundLecourtier, L., & Kelly, P. H. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.01.004 · Cited by 283 · see citing works
Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice
Young, J. W., Crawford, N., Kelly, J. S., Kerr, L. E., Marston, H. M., Spratt, C., Finlayson, K., & Sharkey, J. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.03.008 · Cited by 233 · see citing works
Modulators in concert for cognition: Modulator interactions in the prefrontal cortex
Briand, L. A., Gritton, H., Howe, W. M., Young, D. A., & Sarter, M. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.06.007 · Cited by 216 · see citing works
Higgins, G. A., Enderlin, M., Haman, M., & Fletcher, P. J. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1549-0 · Cited by 179 · see citing works
Self-citationLong-Lasting Cognitive Deficits Resulting from Adolescent Nicotine Exposure in Rats
Counotte, D. S., Spijker, S., Van de Burgwal, L. H., Hogenboom, F., Schoffelmeer, A. N. M., De Vries, T. J., Smit, A. B., & Pattij, T. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.96 · Cited by 163 · see citing works
Hoyle, E., Genn, R. F., Fernandes, C., & Stolerman, I. P. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0549-2 · Cited by 161 · see citing works
Howe, W. M., Ji, J., Parikh, V., Williams, S., Mocaër, E., Trocmé-Thibierge, C., & Sarter, M. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.9 · Cited by 150 · see citing works
Nicotinic–serotonergic interactions in brain and behaviour
Seth, P., Cheeta, S., Tucci, S., & File, S. E. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00715-8 · Cited by 145 · see citing works
Dose-Related Enhancement of Mood and Cognition in Smokers Administered Nicotine Nasal Spray
Myers, C. S., Taylor, R. C., Moolchan, E. T., & Heishman, S. J. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301425 · Cited by 143 · see citing works
Parikh, V., Ji, J., Decker, M. W., & Sarter, M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5712-09.2010 · Cited by 133 · see citing works
Attentional effects of nicotinic agonists in rats
Hahn, B., Sharples, C. G. V., Wonnacott, S., Shoaib, M., & Stolerman, I. P. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00099-6 · Cited by 135 · see citing works
Levin, E. D., & Rezvani, A. H. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.019 · Cited by 129 · see citing works
Parikh, V., Man, K., Decker, M. W., & Sarter, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5251-07.2008 · Cited by 127 · see citing works
Nicotine enhances contextual fear conditioning in C57BL/6J mice at 1 and 7 days post-training
Gould, T. J., & Stephen Higgins, J. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(03)00057-1 · Cited by 123 · see citing works
Semenova, S., Stolerman, I. P., & Markou, A. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.05.009 · Cited by 104 · see citing works
Age and sex differences in impulsive action in rats: the role of dopamine and glutamate
Burton, C. L., & Fletcher, P. J. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.01.046 · Cited by 87 · see citing works
Phencyclidine exacerbates attentional deficits in a neurodevelopmental rat model of schizophrenia
Le Pen, G., Grottick, A. J., Higgins, G. A., & Moreau, J.-L. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300208 · Cited by 82 · see citing works
Self-citationCounotte, D. S., Smit, A. B., Pattij, T., & Spijker, S. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.05.010 · Cited by 77 · see citing works
Leveraging the cortical cholinergic system to enhance attention
Demeter, E., & Sarter, M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.060 · Cited by 75 · see citing works
Hernan, A. E., Alexander, A., Jenks, K. R., Barry, J., Lenck-Santini, P.-P., Isaeva, E., Holmes, G. L., & Scott, R. C. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.11.012 · Cited by 73 · see citing works
Young, J. W., Meves, J. M., & Geyer, M. A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.11.028 · Cited by 69 · see citing works
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Nicotine and Hippocampus-Dependent Learning: Implications for Addiction
Gould, T. J. (2006) · Molecular Neurobiology · doi:10.1385/mn:34:2:93 · Cited by 61 · see citing works
Rezvani, A. H., Cauley, M., Sexton, H., Xiao, Y., Brown, M. L., Paige, M. A., McDowell, B. E., Kellar, K. J., & Levin, E. D. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2161-8 · Cited by 50 · see citing works
Chen, G.-J., Xiong, Z., & Yan, Z. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-3 · Cited by 30 · see citing works
Heightened Nicotinic Regulation of Auditory Cortex during Adolescence
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- Authors
- Grottick, A. J., & Higgins, G. A.
- Affiliations
- F. Hoffmann-La Roche AG (CH)
- Corresponding author
- Higgins, G.A
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 117
- Issue
- 1-2
- Pages
- 197-208
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2044831514
- Cited by
- 240
- References
- 72
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2018: 5 · 2017: 6 · 2016: 9 · 2015: 14 · 2014: 10 · 2013: 16 · 2012: 17
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotine, nicotinic acetylcholine receptors, alpha7 nicotinic acetylcholine receptor, alpha4beta2 nicotinic receptor, attention, 5-choice serial reaction time task, methyllycaconitine, mecamylamine, MK-801
- MeSH terms
- Animals, Attention, Conditioning, Operant, Ligands, Male, Nicotine, Receptors, Nicotinic, Serial Learning, Nicotinic Agonists, Nicotinic Antagonists, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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