Differential subjective effects of D-amphetamine by gender, hormone levels and menstrual cycle phase
Abstract
Estrogen and progesterone interact with monoamines in ways that suggest the potential modulation of responses to psychoactive drugs by endogenous steroids, both between menstrual phases and between the sexes. The present study assessed the subjective and physiological effects of a single dose of D-amphetamine (AMPH; 15 mg oral) in healthy, normally cycling women (n=13), who received amphetamine and placebo (PL) during both the follicular and luteal phases of a single menstrual cycle, and in healthy men (n=7). Females reported greater amphetamine-induced subjective stimulation [Addiction Research Center Inventory (ARCI)-A, ARCI-MBG; Drug Effects Questionnaire (DEQ) Feel Drug, Feel High, Want More] during the follicular phase than the luteal phase. Within the follicular phase, the magnitude of individuals' AMPH-induced stimulation was positively associated with baseline (predrug) salivary estradiol [r=+.55-.78; Profile of Mood States (POMS) Vigor, Positive Mood, Elation], and negatively associated with salivary progesterone [r=-.66-.68; POMS Friendliness; Subjective States Questionnaire (SSQ) Pleasant Sedation]. Sex differences also emerged. Males reported feeling greater AMPH-induced stimulation (ARCI-A, ARCI-MBG; DEQ Feel Drug, Want More) than females in the luteal phase. Thus, higher levels of estrogen and lower levels of progesterone are associated with greater subjective stimulation after AMPH in women, and these hormonal influences contribute to sex differences in amphetamine responding.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
During periods of low oestrogen, increased ADHD symptoms and decreased response to psychostimulant medication have been described.
“Additionally, during periods of low oestrogen, increased ADHD symptoms [30,41,91,92] and decreased response to psychostimulant medication [25,42,93,94,95] have been described.”
From A Female-Specific Treatment Group for ADHD—Description of the Programme and Qualitative Analysis of First Experiences (2024) · cites this paper as [95]
Cites
McNair, D. M. (1992) · Medical Entomology and Zoology · Cited by 2,527 · see citing works
Majewska, M. D. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90025-a · Cited by 1,087 · see citing works
Martin, W. R., Sloan, J. W., SAPIRA, J. D., & Jasinski, D. R. (1971) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1971122part1245 · Cited by 945 · see citing works
Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria
Drevets, W. C., Gautier, C., Price, J. C., Kupfer, D. J., Kinahan, P. E., Grace, A. A., Price, J. L., & Mathis, C. A. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01038-6 · Cited by 706 · cited 1× · see citing works
“Neuroimaging data indicate that the intensity of the subjective ‘‘high’’ induced by dopamine agonists (e.g., AMPH, methylphenidate) is significantly correlated with the levels of drug-induced dopamine release in human PET experiments ( r >|.9|, Drevets et al., 2001; r =.78, Volkow et al., 1999).”
Stimulants : neurochemical, behavioral, and clinical perspectives
Creese, I. (1983) · Raven Press eBooks · Cited by 698 · see citing works
Gender Differences in Dopaminergic Function in Striatum and Nucleus Accumbens
Becker, J. B. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00168-9 · Cited by 696 · see citing works
Volkow, N. D., Wang, G.-J., Fowler, J., Logan, J., Gatley, S., Wong, C., Hitzemann, R., & Pappas, N. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35115-8 · Cited by 434 · see citing works
Shirtcliff, E. A. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(00)00042-1 · Cited by 412 · see citing works
Hormones in saliva: mode of entry and consequent implications for clinical interpretation
Vining, R. F., McGinley, R. A., & Symons, R. G. (1983) · Clinical Chemistry · doi:10.1093/clinchem/29.10.1752 · Cited by 341 · see citing works
Textbook of endocrine physiology
(1989) · General and Comparative Endocrinology · doi:10.1016/0016-6480(89)90187-1 · Cited by 291 · see citing works
Sex difference and estrous cycle variations in amphetamine-elicited rotational behavior
Becker, J. B., Robinson, T. E., & Lorenz, K. A. (1982) · European Journal of Pharmacology · doi:10.1016/0014-2999(82)90178-9 · Cited by 268 · see citing works
Utility of subjective‐effects measurements in assessing abuse liability of drugs in humans
Fischman, M. W., & Foltin, R. W. (1991) · British Journal of Addiction · doi:10.1111/j.1360-0443.1991.tb01749.x · Cited by 267 · see citing works
Sex and menstrual cycle differences in the subjective effects from smoked cocaine in humans.
Sofuoglu, M., Dudish-Poulsen, S., Nelson, D. B., Pentel, P. R., & Hatsukami, D. K. (1999) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.7.3.274 · Cited by 263 · see citing works
Becker, J. B., & Cha, J.-H. (1989) · Behavioural Brain Research · doi:10.1016/s0166-4328(89)80112-3 · Cited by 227 · see citing works
Increased Dopamine Receptor Sensitivity After Estrogen Treatment Using the Rat Rotation Model
Hruska, R. E., & Silbergeld, E. K. (1980) · Science · doi:10.1126/science.7189902 · Cited by 225 · see citing works
Lukas, S. E., Sholar, M. B., Lundahl, L. H., Lamas, X., Kouri, E. M., Wines, J. D., Kragie, L., & Mendelson, J. H. (1996) · Psychopharmacology · doi:10.1007/bf02246017 · Cited by 224 · see citing works
Li, X., & Becker, J. B. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90510-x · Cited by 214 · see citing works
Acute Stimulatory Effect of Estradiol on Striatal Dopamine Synthesis
Pasqualini, C., Olivier, V., Guibert, B., Frain, O., & Leviel, V. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65041651.x · Cited by 201 · see citing works
Justice, A. J. H., & de Wit, H. (1999) · Psychopharmacology · doi:10.1007/s002130051033 · Cited by 199 · see citing works
Self-citationBecker, J. B., & Rudick, C. N. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00091-x · Cited by 190 · see citing works
Influence of Ovarian Hormones and Estrous Cycle on the Behavioral Response to Cocaine in Female Rats
Sell, S. L., Scalzitti, J. M., Thomas, M. L., & Cunningham, K. A. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39310-3 · Cited by 190 · see citing works
The influence of estrogen on nigrostriatal dopamine activity
Becker, J. B., & Beer, M. E. (1986) · Behavioural Brain Research · doi:10.1016/0166-4328(86)90044-6 · Cited by 177 · see citing works
Freeman, E. W., Purdy, R. H., Coutifaris, C., Rickels, K., & Paul, S. M. (2008) · Neuroendocrinology · doi:10.1159/000126579 · Cited by 160 · see citing works
Lu, Y.-C., Bentley, G. R., Gann, P. H., Hodges, K. R., & Chatterton, R. T. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00093-x · Cited by 159 · see citing works
Shirtcliff, E. A., Granger, D. A., Schwartz, E. B., Curran, M. J., Booth, A., & Overman, W. H. (2000) · Hormones and Behavior · doi:10.1006/hbeh.2000.1614 · Cited by 149 · see citing works
Textbook of Endocrine Physiology
Hegde, B. M. (1994) · Postgraduate Medical Journal · doi:10.1136/pgmj.70.819.57-a · Cited by 138 · see citing works
Premenstrual changes and changes in gonadal hormones
Halbreich, U. M., Endicott, J., Goldstein, S., & Nee, J. (1986) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1986.tb06287.x · Cited by 111 · see citing works
Acute Effects of Estradiol Pretreatment on the Response to d-Amphetamine in Women
Justice, A., & de Wit, H. (2000) · Neuroendocrinology · doi:10.1159/000054520 · Cited by 99 · see citing works
Self-citationMood changes and physical complaints during the normal menstrual cycle in healthy young women
Laessle, R. G., Tuschi, R. J., Schweiger, U., & Pirke, K. M. (1990) · Psychoneuroendocrinology · doi:10.1016/0306-4530(90)90021-z · Cited by 97 · see citing works
Sofuoglu, M., Babb, D. A., & Hatsukami, D. K. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00527-5 · Cited by 95 · see citing works
Justice, A., & de Wit, H. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00218-5 · Cited by 85 · see citing works
Self-citationShimizu, H., & Bray, G. A. (1993) · Brain Research · doi:10.1016/0006-8993(93)90107-x · Cited by 80 · see citing works
Effects of estrogen on striatal dopamine receptor function in male and female rats
Hruska, R. E., Ludmer, L. M., Pitman, K. T., Ryck, M. D., & Silbergeld, E. K. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90162-9 · Cited by 74 · see citing works
A PET study of D2 dopamine receptor density at different phases of the menstrual cycle
Nordström, A., Olsson, H., & Halldin, C. (1998) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(98)00021-3 · Cited by 72 · see citing works
Abplanalp, J. M., Rose, R. M., Donnelly, A. F., & Livingston-Vaughan, L. (1979) · Psychosomatic Medicine · doi:10.1097/00006842-197912000-00002 · Cited by 72 · see citing works
de Wit, H., Schmitt, L., Purdy, R. H., & Hauger, R. L. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00024-5 · Cited by 63 · see citing works
Dluzen, D. E., & Ramirez, V. D. (1987) · Brain Research · doi:10.1016/0006-8993(87)90762-1 · Cited by 63 · see citing works
Ovarian Hormones Modulate Cocaine‐Induced Locomotor and Stereotypic Activity
Perrotti, L. I., Russo, S. J., FLETCHER, H., CHIN, J., Webb, T. R., Jenab, S., & Quiñones-Jenab, V. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03566.x · Cited by 59 · see citing works
Measurements of Salivary Progesteronea
Ellison, P. T. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb18350.x · Cited by 58 · see citing works
Cerebrospinal Fluid Levels of Monoamine Metabolites
Eriksson, E., Alling, C., Andersch, B., Andersson, K., & Berggren, U. (1994) · Neuropsychopharmacology · doi:10.1038/sj.npp.1380107 · Cited by 54 · see citing works
Salivary progesterone as an index of the luteal function
Zorn, J. R., McDonough, P. G., Nessman, C., Janssens, Y., & Cedard, L. (1984) · Fertility and Sterility · doi:10.1016/s0015-0282(16)47599-0 · Cited by 48 · see citing works
Dluzen, D. E., & Ramirez, V. D. (1990) · Brain Research · doi:10.1016/0006-8993(90)91016-a · Cited by 43 · see citing works
Ovarian hormone replacement affects cocaine-induced behaviors in ovariectomized female rats
Quiñones-Jenab, V., Perrotti, L. I., Monagle, J. M., Ho, A., & Kreek, M. J. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00381-6 · Cited by 42 · see citing works
Fernández‐Ruíz, J., de Miguel, R., Hernández, M., & Ramos, J. A. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90262-g · Cited by 41 · see citing works
Dluzen, D. E., & Ramirez, V. D. (2008) · Neuroendocrinology · doi:10.1159/000124160 · Cited by 39 · see citing works
Rapid stimulation of striatal dopamine synthesis by estradiol
Pasqualini, C., Olivier, V., Guibert, B., Frain, O., & Leviel, V. (1996) · Cellular and Molecular Neurobiology · doi:10.1007/bf02088105 · Cited by 29 · see citing works
Bourque, J., Sulon, J., Demey-Ponsart, E., Sodoyez, J. C., & Gaspard, U. J. (1986) · Clinical Chemistry · doi:10.1093/clinchem/32.6.948 · Cited by 20 · see citing works
Sero‐salivary progesterone correlation
Bolaji, I. I. (1994) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(94)90119-8 · Cited by 20 · see citing works
Radioimmunoassay of plasma and salivary progesterone during the menstrual cycle
Cedard, L., Janssens, Y., Tanguy, G., & Zorn, J. R. (1984) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(84)90258-9 · Cited by 19 · see citing works
Estradiol Modulation of Central Monoamine Activity in Female Mountain Spiny Lizards
Woodley, S. K., Matt, K. S., & Moore, M. C. (2000) · Brain Behavior and Evolution · doi:10.1159/000047202 · Cited by 11 · see citing works
Plasma homovanillic acid profile at different phases of the ovulatory cycle in healthy women
Abel, K. M., O’Keane, V., Sherwood, R. A., & Murray, R. M. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00308-8 · Cited by 7 · see citing works
Flagged first, then by citations
1 of the 52 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Young, S., Adamo, N., Ásgeirsdóttir, B. B., Branney, P., Beckett, M., Colley, W., Cubbin, S., Deeley, Q., Farrag, E., Gudjonsson, G., et al. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02707-9 · Cited by 610 · see citing works
Gender differences in drug responses
Franconi, F., Brunelleschi, S., Steardo, L., & Cuomo, V. (2006) · Pharmacological Research · doi:10.1016/j.phrs.2006.11.001 · Cited by 464 · see citing works
Sex differences in striatal dopamine release in healthy adults.
Munro, C. A., Mccaul, M., Wong, D., Oswald, L., Zhou, Y., Brašić, J. R., Kuwabara, H., Kumar, A., Alexander, M., Ye, W., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.01.008 · Cited by 364 · see citing works
Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis
Becker, J. B., Perry, A. N., & Westenbroek, C. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-14 · Cited by 315 · see citing works
Sex Differences and Hormonal Influences on Acquisition of Cocaine Self-Administration in Rats
Jackson, L. R., Robinson, T. E., & Becker, J. B. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300778 · Cited by 304 · see citing works
Anker, J. J., & Carroll, M. E. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_93 · Cited by 302 · see citing works
Quinn, P. O., & Madhoo, M. (2014) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.13r01596 · Cited by 264 · see citing works
Amping Up Effort: Effects ofd-Amphetamine on Human Effort-Based Decision-Making
Wardle, M. C., Treadway, M. T., Mayo, L. M., Zald, D. H., & de Wit, H. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4387-11.2011 · Cited by 258 · see citing works
The drug effects questionnaire: psychometric support across three drug types
Morean, M. E., de Wit, H., King, A. C., Sofuoglu, M., Rueger, S. Y., & O’Malley, S. S. (2013) · Psychopharmacology · doi:10.1007/s00213-012-2954-z · Cited by 252 · see citing works
Exogenous Progesterone Attenuates the Subjective Effects of Smoked Cocaine in Women, but not in Men
Evans, S. M., & Foltin, R. W. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300887 · Cited by 204 · see citing works
Sex differences in vulnerability to drug self-administration.
Lynch, W. J. (2006) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.14.1.34 · Cited by 199 · see citing works
Menstrual cycle phase and responses to drugs of abuse in humans
Terner, J. M., & de Wit, H. (2006) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2005.12.007 · Cited by 190 · see citing works
Sex Differences in Drug Addiction: A Review of Animal and Human Studies
Fattore, L., Altea, S., & Fratta, W. (2008) · Women s Health · doi:10.2217/17455057.4.1.51 · Cited by 191 · see citing works
Sex differences in a rat model of risky decision making.
Orsini, C. A., Willis, M. L., Gilbert, R. J., Bizon, J. L., & Setlow, B. (2015) · Behavioral Neuroscience · doi:10.1037/bne0000111 · Cited by 172 · see citing works
Differential effects of MDMA and methylphenidate on social cognition
Schmid, Y., Hysek, C. M., Simmler, L. D., Crockett, M. J., Quednow, B. B., & Liechti, M. E. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114542454 · Cited by 155 · see citing works
Ilieva, I. P., Hook, C. J., & Farah, M. J. (2015) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00776 · Cited by 154 · see citing works
Lynch, W. J. (2008) · Psychopharmacology · doi:10.1007/s00213-007-1028-0 · Cited by 152 · see citing works
Towers, E. B., Williams, I. L., Qillawala, E. I., Rissman, E. F., & Lynch, W. J. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000361 · Cited by 149 · see citing works
Sex Differences in Drug-Related Stress-System Changes
Fox, H. C., & Sinha, R. (2009) · Harvard Review of Psychiatry · doi:10.1080/10673220902899680 · Cited by 152 · see citing works
MDMA enhances “mind reading” of positive emotions and impairs “mind reading” of negative emotions
Hysek, C. M., Domes, G., & Liechti, M. E. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2645-9 · Cited by 144 · see citing works
Effects of MDMA and intranasal oxytocin on social and emotional processing
Kirkpatrick, M. G., Lee, R., Wardle, M. C., Jacob, S., & de Wit, H. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.12 · Cited by 143 · see citing works
Feltenstein, M. W., Henderson, A. R., & See, R. E. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2187-6 · Cited by 141 · see citing works
Stimulant Use in Pregnancy: An Under-recognized Epidemic Among Pregnant Women
Smid, M. C., Metz, T. D., & Gordon, A. J. (2019) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000418 · Cited by 141 · see citing works
Dopamine Transporter Gene Associated with Diminished Subjective Response to Amphetamine
Lott, D. C., Kim, S., Cook, E. H., & de Wit, H. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300637 · Cited by 138 · see citing works
Larson, E. B., Anker, J. J., Gliddon, L. A., Fons, K. S., & Carroll, M. E. (2007) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.15.5.461 · Cited by 135 · see citing works
Colzato, L. S., Hertsig, G., van den Wildenberg, W. P. M., & Hommel, B. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.02.029 · Cited by 131 · see citing works
Evans, S. M., & Foltin, R. W. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.08.010 · Cited by 127 · see citing works
O’Leary, M. M., Loney, B. R., & Eckel, L. A. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.12.004 · Cited by 127 · see citing works
Dolder, P. C., Müller, F., Schmid, Y., Borgwardt, S. J., & Liechti, M. E. (2018) · Psychopharmacology · doi:10.1007/s00213-017-4650-5 · Cited by 117 · see citing works
Oswald, L. M., Wand, G. S., Kuwabara, H., Wong, D. F., Zhu, S., & Brasic, J. R. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3407-z · Cited by 114 · see citing works
Sex-dependent regulation of social reward by oxytocin: an inverted U hypothesis
Borland, J. M., Rilling, J. K., Frantz, K. J., & Albers, H. E. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0129-2 · Cited by 116 · see citing works
Krolick, K. N., Zhu, Q., & Shi, H. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.07.008 · Cited by 121 · see citing works
Transdermal nicotine alters some of marihuana's effects in male and female volunteers
Penetar, D. M., Kouri, E. M., Gross, M. M., McCarthy, E. M., Rhee, C. K., Peters, E. N., & Lukas, S. E. (2005) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2005.01.008 · Cited by 114 · see citing works
Effect of Menstrual Cycle Phase on Dopamine D2 Receptor Availability in Female Cynomolgus Monkeys
Czoty, P. W., Riddick, N. V., Gage, H. D., Sandridge, M., Nader, S. H., Garg, S., Bounds, M. C., Garg, P., & Nader, M. A. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.3 · Cited by 109 · see citing works
Willeit, M., Ginovart, N., Graff, A., Rusjan, P., Vitcu, I., Houle, S., Seeman, P., Wilson, A. A., & Kapur, S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301400 · Cited by 107 · see citing works
Hamidovic, A., Dlugos, A., Skol, A., Palmer, A. A., & de Wit, H. (2009) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0017840 · Cited by 108 · see citing works
Sex differences in the subjective effects of oral Δ9-THC in cannabis users
Fogel, J. S., Kelly, T. H., Westgate, P. M., & Lile, J. A. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.01.007 · Cited by 107 · see citing works
Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans
Kirkpatrick, M. G., Francis, S. M., Lee, R., de Wit, H., & Jacob, S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.04.006 · Cited by 106 · see citing works
Lacy, R. T., Strickland, J. C., Feinstein, M. A., Robinson, A. M., & Smith, M. A. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4368-9 · Cited by 106 · see citing works
Effects of progesterone on the reinstatement of cocaine-seeking behavior in female rats.
Anker, J. J., Larson, E. B., Gliddon, L. A., & Carroll, M. E. (2007) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.15.5.472 · Cited by 107 · see citing works
Estradiol Modulates Effort-Based Decision Making in Female Rats
Uban, K. A., Rummel, J., Floresco, S., & Galea, L. A. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.176 · Cited by 101 · see citing works
Russell, S. E., Rachlin, A. B., Smith, K. L., Muschamp, J. W., Berry, L., Zhao, Z., & Chartoff, E. H. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.07.042 · Cited by 101 · see citing works
MDMA alters emotional processing and facilitates positive social interaction
Wardle, M. C., & de Wit, H. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3570-x · Cited by 96 · see citing works
“Women not on hormonal contraceptives were scheduled only during the follicular phase (White et al. 2002).”
Marijuana, the Endocannabinoid System and the Female Reproductive System.
Brents, L. K. (2016) · PubMed Central · Cited by 96 · see citing works
Drug-drug interactions between psychiatric medications and MDMA or psilocybin: a systematic review
Sarparast, A., Thomas, K., Malcolm, B., & Stauffer, C. S. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06083-y · Cited by 88 · see citing works
Sex Differences in the Effects of MDMA (Ecstasy) on Plasma Copeptin in Healthy Subjects
Simmler, L. D., Hysek, C. M., & Liechti, M. E. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1143 · Cited by 89 · see citing works
Attenuation of cocaine-seeking by progesterone treatment in female rats
Feltenstein, M. W., Byrd, E. A., Henderson, A. R., & See, R. E. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.09.014 · Cited by 88 · see citing works
Sex differences in the glutamate system: Implications for addiction
Giacometti, L. L., & Barker, J. M. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.03.010 · Cited by 87 · see citing works
Kučerová, J., Amchová, P., Babinská, Z., Dušek, L., Micale, V., & Šulcová, A. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00091 · Cited by 87 · see citing works
MDMA decreases the effects of simulated social rejection
Frye, C. G., Wardle, M. C., Norman, G. J., & de Wit, H. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.030 · Cited by 85 · see citing works
Prosocial effects of MDMA: A measure of generosity
Kirkpatrick, M. G., Delton, A. W., Robertson, T. E., & de Wit, H. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115573806 · Cited by 85 · see citing works
Carvedilol inhibits the cardiostimulant and thermogenic effects of MDMA in humans
Hysek, C. M., Schmid, Y., Rickli, A., Simmler, L. D., Donzelli, M., Grouzmann, E., & Liechti, M. E. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01936.x · Cited by 82 · see citing works
How Reward and Emotional Stimuli Induce Different Reactions Across the Menstrual Cycle
Sakaki, M., & Mather, M. (2012) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2011.00415.x · Cited by 82 · see citing works
Ovarian Hormones and Drug Abuse
Maria, M. M. M., Flanagan, J. C., & Brady, K. T. (2014) · Current Psychiatry Reports · doi:10.1007/s11920-014-0511-7 · Cited by 81 · see citing works
Personality and the Subjective Effects of Acute Amphetamine in Healthy Volunteers
White, T. L., Lott, D. C., & de Wit, H. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300939 · Cited by 76 · see citing works
Self-citationMDMA effects consistent across laboratories
Kirkpatrick, M. G., Baggott, M. J., Mendelson, J. E., Galloway, G. P., Liechti, M. E., Hysek, C. M., & de Wit, H. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3528-z · Cited by 75 · see citing works
Effects of allopregnanolone on the reinstatement of cocaine-seeking behavior in male and female rats
Anker, J. J., Holtz, N. A., Zlebnik, N. E., & Carroll, M. E. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1371-9 · Cited by 77 · see citing works
Pharmacogenetic Treatments for Drug Addiction: Cocaine, Amphetamine and Methamphetamine
Haile, C. N., Kosten, T. R., & Kosten, T. A. (2009) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990902825447 · Cited by 73 · see citing works
MDMA Impairs Both the Encoding and Retrieval of Emotional Recollections
Doss, M. K., Weafer, J. J., Gallo, D. A., & de Wit, H. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.171 · Cited by 72 · see citing works
Anker, J. J., & Carroll, M. E. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.04.003 · Cited by 72 · see citing works
Candidate Gene Studies of a Promising Intermediate Phenotype: Failure to Replicate
Hart, A. B., de Wit, H., & Palmer, A. A. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.245 · Cited by 70 · see citing works
Hysek, C. M., Brugger, R., Simmler, L. D., Bruggisser, M., Donzelli, M., Grouzmann, E., Hoener, M. C., & Liechti, M. E. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.188425 · Cited by 69 · see citing works
Sex Differences in the Response of Children With ADHD to Once-Daily Formulations of Methylphenidate
Sonuga-Barke, E. J. S., Coghill, D., Markowitz, J. S., Swanson, J. M., Vandenberghe, M., & HATCH, S. J. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31804659f1 · Cited by 66 · see citing works
Intimate insight: MDMA changes how people talk about significant others
Baggott, M. J., Kirkpatrick, M. G., Bedi, G., & de Wit, H. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115581962 · Cited by 65 · see citing works
Diekhof, E. K., & Ratnayake, M. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.10.016 · Cited by 65 · see citing works
Gender differences in the behavioral and subjective effects of methamphetamine in healthy humans
Mayo, L. M., Paul, E. R., DeArcangelis, J., Hedger, K. V., & de Wit, H. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05276-2 · Cited by 64 · see citing works
Dose-response effects of d-amphetamine on effort-based decision-making and reinforcement learning
Soder, H. E., Cooper, J. A., Lopez-Gamundi, P., Hoots, J. K., Nunez, C., Lawlor, V. M., Lane, S. D., Treadway, M. T., & Wardle, M. C. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-020-0779-8 · Cited by 61 · see citing works
Comer, S. D., Bickel, W. K., Yi, R., de Wit, H., Higgins, S. T., Wenger, G. R., Johanson, C., & Kreek, M. J. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833bb9f8 · Cited by 60 · see citing works
Stress-induced changes in mood and cortisol release predict mood effects of amphetamine
Hamidovic, A., Childs, E., Conrad, M., King, A. C., & de Wit, H. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.12.029 · Cited by 60 · see citing works
Childs, E., & de Wit, H. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00416.x · Cited by 60 · see citing works
Kirkpatrick, M. G., Goldenson, N. I., Kapadia, N., Kahler, C. W., de Wit, H., Swift, R. M., McGeary, J. E., Sussman, S. Y., & Leventhal, A. M. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4091-y · Cited by 59 · see citing works
Mello, N. K., Knudson, I. M., & Mendelson, J. H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301314 · Cited by 59 · see citing works
Alyea, R. A., & Watson, C. S. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0800026 · Cited by 59 · see citing works
Silverman, J. L., & Koenig, J. I. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.03.017 · Cited by 58 · see citing works
Bisagno, V., & Cadet, J. L. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000049 · Cited by 60 · see citing works
Hysek, C. M., & Liechti, M. E. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2761-6 · Cited by 58 · see citing works
Wardle, M. C., Marcus, B. A., & de Wit, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140501 · Cited by 57 · see citing works
Dolder, P. C., Strajhar, P., Vizeli, P., Hammann, F., Odermatt, A., & Liechti, M. E. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00617 · Cited by 57 · see citing works
Hysek, C. M., Fink, A. E., Simmler, L. D., Donzelli, M., Grouzmann, E., & Liechti, M. E. (2013) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3182979d32 · Cited by 56 · see citing works
Allott, K., & Redman, J. R. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.09.009 · Cited by 56 · see citing works
Bailer, U., Narendran, R., Frankle, W., Himes, M. L., Duvvuri, V., Mathis, C., & Kaye, W. (2011) · International Journal of Eating Disorders · doi:10.1002/eat.20937 · Cited by 54 · see citing works
Personality and gender differences in effects of d-amphetamine on risk taking.
White, T. L., Lejuez, C. W., & de Wit, H. (2007) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.15.6.599 · Cited by 54 · see citing works
Self-citationAssociation between the Casein Kinase 1 Epsilon Gene Region and Subjective Response to D-Amphetamine
Veenstra-VanderWeele, J. M., Qaadir, A., Palmer, A. A., Cook, E. H., & de Wit, H. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300936 · Cited by 55 · see citing works
Dopaminergic activity in depressed smokers: A positron emission tomography study
Busto, U. E., Redden, L., Mayberg, H. S., Kapur, S., Houle, S., & Zawertailo, L. A. (2009) · Synapse · doi:10.1002/syn.20646 · Cited by 54 · see citing works
Hamidovic, A., Dlugos, A. M., Palmer, A. A., & de Wit, H. (2010) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32833a1f3c · Cited by 52 · see citing works
Wardle, M. C., Kirkpatrick, M. G., & de Wit, H. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu035 · Cited by 52 · see citing works
Interactions between Bupropion and 3,4-Methylenedioxymethamphetamine in Healthy Subjects
Schmid, Y., Rickli, A., Schaffner, A., Duthaler, U., Grouzmann, E., Hysek, C. M., & Liechti, M. E. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.222356 · Cited by 51 · see citing works
Amphetamine as a social drug: effects of d-amphetamine on social processing and behavior
Wardle, M. C., Garner, M. J., Munafo, M. R., & de Wit, H. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2708-y · Cited by 50 · see citing works
Estrogens of multiple classes and their role in mental health disease mechanisms
Watson, C. S. (2010) · International Journal of Women s Health · doi:10.2147/ijwh.s6907 · Cited by 52 · see citing works
Further evidence of association between amphetamine response and SLC6A2 gene variants
Dlugos, A. M., Hamidovic, A., Palmer, A. A., & de Wit, H. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1628-y · Cited by 49 · see citing works
Commonly used stimulants: Sleep problems, dependence and psychological distress
Ogeil, R. P., & Phillips, J. G. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.05.036 · Cited by 49 · see citing works
OPRM1 gene variants modulate amphetamine-induced euphoria in humans
Dlugos, A. M., Hamidovic, A., Hodgkinson, C. A., Shen, P., Goldman, D. A., Palmer, A. A., & de Wit, H. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00655.x · Cited by 49 · see citing works
Effects of amphetamine on reactivity to emotional stimuli
Wardle, M. C., & de Wit, H. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2498-7 · Cited by 48 · see citing works
The Impact of Gender on Antidepressants
Sramek, J. J., & Cutler, N. R. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_118 · Cited by 47 · see citing works
Urinary and plasma oxytocin changes in response to MDMA or intranasal oxytocin administration
Francis, S. M., Kirkpatrick, M. G., de Wit, H., & Jacob, S. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.08.011 · Cited by 46 · see citing works
Neurocognitive, Autonomic, and Mood Effects of Adderall: A Pilot Study of Healthy College Students
Weyandt, L. L., White, T. L., Gudmundsdottir, B. G., Nitenson, A. Z., Rathkey, E. S., De Leon, K. A., & Bjorn, S. A. (2018) · Pharmacy · doi:10.3390/pharmacy6030058 · Cited by 43 · see citing works
Self-citationThe therapeutic potential of exercise for neuropsychiatric diseases: A review
Swenson, S., Blum, K., McLaughlin, T., Gold, M. S., & Thanos, P. K. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.116763 · Cited by 42 · see citing works
Acute Effects of the Novel Psychoactive Drug 2C-B on Emotions
González, D., Torrens, M., & Farré, M. (2015) · BioMed Research International · doi:10.1155/2015/643878 · Cited by 43 · see citing works
Cornforth, C., Sonuga-Barke, E., & Coghill, D. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210791959827 · Cited by 41 · see citing works
Peltier, M. R., & Sofuoglu, M. (2018) · CNS Drugs · doi:10.1007/s40263-018-0525-5 · Cited by 42 · see citing works
- Authors
- White, T. L., Justice, A. J. H., & de Wit, H.
- Affiliations
- University of Chicago (US)
- Corresponding author
- White, Tara L
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 73
- Issue
- 4
- Pages
- 729-741
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2063675303
- Cited by
- 248
- References
- 52
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 7 · 2023: 5 · 2022: 9 · 2021: 6 · 2020: 30 · 2019: 7 · 2018: 11 · 2017: 11 · 2016: 10 · 2015: 15 · 2014: 16 · 2013: 10 · 2012: 15
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (R01DA002812, T32DA007255)
- National Center for Research Resources (M01RR000055)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- amphetamine, subjective effects, menstrual cycle, follicular phase, luteal phase, estrogen, progesterone, salivary estradiol, salivary progesterone, sex differences, stimulant effects, mood states, women
- MeSH terms
- Adolescent, Adult, Affect, Analysis of Variance, Dextroamphetamine, Double-Blind Method, Estradiol, Female, Humans, Male, Menstrual Cycle, Progesterone, Sex Characteristics, Cross-Over Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review