Cited by 248Neurotransmitter Receptor Influence on BehaviorEstrogen and related hormone effectsNeural and Behavioral Psychology Studies

Differential subjective effects of D-amphetamine by gender, hormone levels and menstrual cycle phase

White, Tara L, Justice, Angela J.H, de Wit, Harriet·2002·Pharmacology Biochemistry and Behavior

Abstract

Estrogen and progesterone interact with monoamines in ways that suggest the potential modulation of responses to psychoactive drugs by endogenous steroids, both between menstrual phases and between the sexes. The present study assessed the subjective and physiological effects of a single dose of D-amphetamine (AMPH; 15 mg oral) in healthy, normally cycling women (n=13), who received amphetamine and placebo (PL) during both the follicular and luteal phases of a single menstrual cycle, and in healthy men (n=7). Females reported greater amphetamine-induced subjective stimulation [Addiction Research Center Inventory (ARCI)-A, ARCI-MBG; Drug Effects Questionnaire (DEQ) Feel Drug, Feel High, Want More] during the follicular phase than the luteal phase. Within the follicular phase, the magnitude of individuals' AMPH-induced stimulation was positively associated with baseline (predrug) salivary estradiol [r=+.55-.78; Profile of Mood States (POMS) Vigor, Positive Mood, Elation], and negatively associated with salivary progesterone [r=-.66-.68; POMS Friendliness; Subjective States Questionnaire (SSQ) Pleasant Sedation]. Sex differences also emerged. Males reported feeling greater AMPH-induced stimulation (ARCI-A, ARCI-MBG; DEQ Feel Drug, Want More) than females in the luteal phase. Thus, higher levels of estrogen and lower levels of progesterone are associated with greater subjective stimulation after AMPH in women, and these hormonal influences contribute to sex differences in amphetamine responding.

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Crossref · 10.1016/s0091-3057(02)00818-3

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Authors
White, T. L., Justice, A. J. H., & de Wit, H.
Affiliations
University of Chicago (US)
Corresponding author
White, Tara L
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
2002-11
Volume
73
Issue
4
Pages
729-741
ISSN
0091-3057 (ISSN-L)
OpenAlex
W2063675303
Cited by
248
References
52
Citations by year
2026: 3 · 2025: 11 · 2024: 7 · 2023: 5 · 2022: 9 · 2021: 6 · 2020: 30 · 2019: 7 · 2018: 11 · 2017: 11 · 2016: 10 · 2015: 15 · 2014: 16 · 2013: 10 · 2012: 15
FWCI
1.27
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute on Drug Abuse (R01DA002812, T32DA007255)
  • National Center for Research Resources (M01RR000055)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
amphetamine, subjective effects, menstrual cycle, follicular phase, luteal phase, estrogen, progesterone, salivary estradiol, salivary progesterone, sex differences, stimulant effects, mood states, women
MeSH terms
Adolescent, Adult, Affect, Analysis of Variance, Dextroamphetamine, Double-Blind Method, Estradiol, Female, Humans, Male, Menstrual Cycle, Progesterone, Sex Characteristics, Cross-Over Studies

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