CREB1 Encodes a Nuclear Activator, a Repressor, and a Cytoplasmic Modulator that Form a Regulatory Unit Critical for Long-Term Facilitation

A synaptic model of memory: long-term potentiation in the hippocampus

Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

Bourtchuladze, R., Frenguelli, B., Blendy, J., Cioffi, D., Schutz, G., & Silva, A. J. (1994) · Cell · doi:10.1016/0092-8674(94)90400-6 · Cited by 1,800

Current Protocols in Molecular Biology

(2018) · Current Protocols in Molecular Biology · doi:10.1002/(issn)1934-3647 · Cited by 1,395

Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus

Nibuya, M., Nestler, E., & Duman, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02365.1996 · Cited by 1,206

CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

Bito, H., Deisseroth, K. A., & Tsien, R. W. (1996) · Cell · doi:10.1016/s0092-8674(00)81816-4 · Cited by 1,138

Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila

Yin, J. C. P., Wallach, J. S., Del Vecchio, M., Wilder, E. L., Zhou, H., Quinn, W. G., & Tully, T. (1994) · Cell · doi:10.1016/0092-8674(94)90399-9 · Cited by 959

Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP

Nguyen, P. V., Abel, T., & Kandel, E. R. (1994) · Science · doi:10.1126/science.8066450 · Cited by 888

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

Gonzalez, G. A., Yamamoto, K. K., Fischer, W. H., Karr, D., Menzel, P., Biggs, W., Vale, W., & Montminy, M. (1989) · Nature · doi:10.1038/337749a0 · Cited by 875

A Critical Period for Macromolecular Synthesis in Long-Term Heterosynaptic Facilitation in Aplysia

Montarolo, P. G., Goelet, P., Castellucci, V. F., Morgan, J., Kandel, E. R., & Schacher, S. (1986) · Science · doi:10.1126/science.3775383 · Cited by 769

Exploring the early drivers of pain in Parkinson’s disease

Liu, S., Gunzler, D. D., Gunzler, S. A., Crawford, D. C., & Briggs, F. B. S. (2025) · Scientific Reports · doi:10.1038/s41598-025-90678-w · Cited by 2

Exploring the role of stress sensitivity in memory formation: why do some animals learn while others do not? Lessons from Lymnaea stagnalis

Rivi, V., Yakubets, K., Pelé, G., Batabyal, A., Blom, J. M. C., Tascedda, F., Benatti, C., & Lukowiak, K. D. (2026) · Open Biology · doi:10.1098/rsob.250283 · Cited by 2

How Memory Works, Including Some Comments on the Implicit Memory (Cerebellum/Basal Ganglia) System: The Highest-Level Discriminative System of Mind/Brain

Levin, F. M. (2012) · The Psychoanalytic Review · doi:10.1521/prev.2012.99.4.549 · Cited by 2

Transgenic Mice with Enhanced Cognition

Lee, Y. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-417042-1.00005-x · Cited by 1

Donepezil and galanin interactions in an animal model of Alzheimer’s disease

Sabbagh, J. J. (2020) · Digital Scholarship - UNLV (University of Nevada Reno) · doi:10.34917/2044134 · Cited by 2

Biology of Learning and Memory Genes

Stanl y Pradeep, F., Pradeep, B. V., & Palaniswamy, M. (2011) · Journal of Neurology & Neurophysiology · doi:10.4172/2155-9562.1000118 · Cited by 2

Effects of Axotomy on Cultured Sensory Neurons ofAplysia: Long-Term Injury-Induced Changes in Excitability and Morphology Are Mediated by Different Signaling Pathways

Bedi, S. S., Cai, D., & Glanzman, D. L. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90539.2008 · Cited by 2

Expression of one group of genes maintains one unit of long-term memory in a brain model.

Wong, C. W. (2000) · Medical Hypotheses · doi:10.1054/mehy.1999.1033 · Cited by 2

Plant Prionome maps reveal specific roles of prion-like proteins in stress and memoryPreprint

Garai, S., Citu, Pandey, J., Singla-Pareek, S. L., Sopory, S. K., Kaur, C., & Yadav, G. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.25.311993 · Cited by 2

Epigenetic Alterations of Cognition Functions in Parkinson's DiseasePreprint

Hasani, F., Ahmadi, P., Masrour, M., Khamaki, S., Rahmati, R., & Surguchov, A. P. (2024) · Preprints.org · doi:10.20944/preprints202406.0981.v1 · Cited by 1

Role of insulin-like growth factor-2 in Alzheimer’s disease induced memory impairment and underlying mechanisms

Chen, R., Lu, X., Xiao, A., & Ma, J. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1520253 · Cited by 4

Analysis of interactions of lipid metabolism alleles in dyslipidemia

Nikolaev, I. V., Mulyukova, R. V., Раилевна, К. Л., Vorobieva, E. V., & Gorbunova, V. Y. (2015) · Russian Journal of Genetics Applied Research · doi:10.1134/s2079059715040103 · Cited by 1

Creating the unforgettable: the short story of mapping long-term memory. Bicentennial Symposium.

Wang, S. X. Y. (2011) · PubMed Central · Cited by 1

Presynaptic Mechanisms of Plasticity and Memory in Aplysia and Other Learning-Related Experimental Systems

Hawkins, R. D., Bailey, C. H., & Kandel, E. R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21111-5 · Cited by 1

Promoting the Multidimensional Character of Scientific Reasoning

Bradshaw, W. S., Nelson, J., Adams, B. J., & Bell, J. D. (2017) · Journal of Microbiology and Biology Education · doi:10.1128/jmbe.v18i1.1272 · Cited by 1

La fantástica historia de la increíble prion

Walter Ledermann, D. (2020) · Revista chilena de infectología · doi:10.4067/s0716-10182020000200163 · Cited by 1

The multiple realization of human color vision revisited

Aizawa, K. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.985267 · Cited by 1

Heterosynaptic plasticity: one name for several phenomena

Смирнов, И. В., & Malyshev, A. Y. (2024) · Журнал высшей нервной деятельности им И П Павлова · doi:10.31857/s0044467724060019 · Cited by 1

CREB-Mediated Memory Enhancement

Tanenhaus, A. K., Zhang, J., & Yin, J. C. P. (2015) · Springer eBooks · doi:10.1007/978-3-319-24364-1_7 · Cited by 1

Signal Transduction Pathways in Well-Defined Models of Learning and Memory

Müller, U. (2000) · doi:10.1007/978-1-59259-019-3_3 · Cited by 1

Transcription Factors CREB and NF-KB: Involvement in Synaptic Plasticity and Memory Formation

Albensi, B. C., Barger, S. W., Carrión, Á. M., Fontán‐Lozano, Á., Grilli, M., Josselyn, S. A., Mao, X. R., Meneghini, V., Murphy, K. J., Odero, G. L., et al. (2018) · Cited by 1

Prion-like proteins reveal crosstalk between Stress and Memory pathways in PlantsPreprint

Garai, S., Citu, Singla-Pareek, S. L., Sopory, S. K., Kaur, C., & Yadav, G. (2021) · Research Square · doi:10.21203/rs.3.rs-201763/v1 · Cited by 1

Defective synaptic plasticity in a model of Coffin–Lowry syndrome is rescued by simultaneously targeting PKA and MAPK pathwaysPreprint

Liu, R.-Y., Zhang, Y., Smolen, P. D., Cleary, L. J., & Byrne, J. H. (2022) · Learning & Memory · doi:10.1101/lm.053625.122 · Cited by 2

Transcriptional Regulation Underlying Long-Term Sensitization in Aplysia

Calin-Jageman, R. J., Wilsterman, T., & Calin‐Jageman, I. E. (2024) · Oxford University Press eBooks · doi:10.1093/acrefore/9780190264086.013.499 · Cited by 2

Extracellular vesicles aid in the transfer of long-term associative memory between Caenorhabditis elegansPreprint

Bhar, M., Nandi, T., Narayanan, H., Kishore, K., & Babu, K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.26.640282 · Cited by 1

The effects of chronic calcium dysregulation on behavioral and pathological features of Alzheimer's disease

Sabbagh, J. J. (2020) · Digital Scholarship - UNLV (University of Nevada Reno) · doi:10.34917/4478299

Neural plasticity: cellular and molecular mechanisms of neural plasticity

Selzer, M. A., Clarke, S., Cohen, L. G., Kwakkel, G., & Miller, R. H. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9780511995583.003

ROLE OF SYNAPSIN IN LONG-TERM SYNAPTIC FACILITATION IN APLYSIA

Hart, A. K. (2011) · Digital Commons-TMC (Texas Medical Center)

Mecanismos neurobiológicos involucrados en la persistencia de la memoria de largo término: rol de C-fos en hipocampo y corteza retrosplenial

Katche, C. (2011) · Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)

The evolution of aging-related brain change

Victoroff, J. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00080-9

The role of AMPK and CREB-1 in the regulation of mitochondrial biogenesis during muscle differentiation

Frankó, A. (2007) · Kölner Universitäts PublikationsServer (Universität zu Köln)

Report Postsynaptic Regulation of Long-Term Facilitation in Aplysia

Cai, D., Chen, S., & Glanzman, D. L. (2008)

Brain-TargetedProanthocyanidinMetabolitesfor Alzheimer'sDiseaseTreatment

NaganaGowda, G. A. (2012)

Role of D1 receptor antagonism in contextual fear learning and memory

Heath, F. (2015) · Nottingham ePrints (University of Nottingham)

Synaptic structure and function at the Drosophila larval neuromuscular junction : a molecular analysis of complexin and radish

Buhl, L. K. (2011)

Effects of Natural Genetic Variation in the foraging Gene on Learning and Memory Phenotypes in the Fruit Fly Drosophila melanogaster

Reaume, C. J. (2012) · TSpace (University of Toronto)

Molecular mechanisms regulating developmental axon pruning.

Singh, K. K. (2008) · TSpace (University of Toronto)

IX. SYNAPSES, CYTOKINES (CK) AND LONG-TERM MEMORY (LTM): AN INTERDISCIPLINARY LOOK AT HOW PSYCHOANALYSIS MIGHT ACTIVATE LEARNING VIA ITS EFFECTS ON EMOTIONAL ATTENTION1

Levin, F. M. (2005) · Austrian Academy of Sciences Press eBooks · doi:10.1553/3-7001-3386-3s211

Between the Genes

(2012) · Chapman & Hall/CRC mathematical and computational biology series · doi:10.1201/b12682-4

A transcriptional program remodels GABAergic synapses in C. elegans

Petersen, S. C. (2011)

Mechanisms of Olfactory Plasticity in Caenorhabditis Elegans

Cho, C. (2025) · Digital Commons - RU (Rockefeller University) · doi:10.48496/7j5q-dk02

CREB-mediated Enhancement of Hippocampus-dependent Memory Consolidation and Reconsolidation

Sekeres, M. J. (2012) · TSpace (University of Toronto)

Targeted knockdown of CREB1 in brain nuclei critically involved in drug-seeking behaviour

McPherson, C. S. (2009) · Minerva Access (University of Melbourne)

CREB Responsive Transcription and Memory Formation

Tubon, T. C., & Yin, J. C. P. (2007) · Springer eBooks · doi:10.1007/978-0-387-73609-9_18

A conserved nuclear export complex coordinates transcripts for dopaminergic synaptogenesis and neuronal survivaPreprint

Maeder, C. I., Kim, J., Kaganovsky, K., Shen, A., Li, Q., Li, Z., Xu, X. Z. S., Li, J. B., Xiang, Y. K., Ding, J., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/282137

Neuronal Activity-Dependent Development of the Nociceptive Circuit in Drosophila

Kaneko, T. (2018) · Deep Blue (University of Michigan)

A loss-of-function study of CRTC1 in hippocampal neurons at basal state and during long-term synaptic plasticity

Lim, A. F. Y. (2019) · doi:10.32657/10220/49191

The role of serotonin in learning and memory: a rich pallet of experimental studies

Cassel, J. (2020) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-444-64125-0.00032-3 · Cited by 3

The Dissociation of Sensory Integration and Associative Learning in Caenorhabditis elegans and the Molecular Mechanisms Leading to Memory Acquisition

Wolfe, G. S. (2020) · TSpace (University of Toronto)

Consciousness

Bickle, J. (2003) · Springer eBooks · doi:10.1007/978-94-010-0237-0_4

References

Crawley, J. N. (2006) · Wiley eBooks · doi:10.1002/9780470119051.refs

Potential Mechanism of Qinggong Shoutao Pill Alleviates Age-associated Memory Decline in D-Galactose-Injured Mice Based on Network Pharmacology, Molecular Docking, and Experimental Verification Integration StrategyPreprint

Pan, G., Chai, L., Chen, R., Yuan, Q., Song, Z., Feng, W., Wei, J., Yang, Z., Zhang, Y., Xie, G., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2028233/v1

Dynamics and mechanisms of ERK activation after different protocols that induce long-term facilitation in AplysiaPreprint

Zhang, Y., Liu, R.-Y., Smolen, P. D., Cleary, L. J., & Byrne, J. H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.05.502983

Effect of Recombinant Insulin-like Growth Factor-2 Injected into the Hippocampus on Memory Impairment Following Hippocampal Intracerebral Hemorrhage in Rats

Vafaee, F., Zarifkar, A., Emamghoreishi, M., Namavar, M. R., Shahpari, M., & Zarifkar, A. H. (2018) · Galen Medical Journal · doi:10.31661/gmj.v7i.1353 · Cited by 11

Structural characterization of a polymorphic repeat at the CACNA1C schizophrenia locusPreprint

Moya, R., Wang, X., Tsien, R. W., & Maurano, M. T. (2024) · medRxiv · doi:10.1101/2024.03.05.24303780

From Molecules to Computational Modeling

Zhang, Y., Smolen, P. D., & Byrne, J. H. (2024) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190069162.013.11

The role of circular RNA targeting IGF2BPs in cancer—a potential target for cancer therapy

Luo, X., Shi, J., Wang, S., & Jin, X. (2024) · Journal of Molecular Medicine · doi:10.1007/s00109-024-02488-8

Distinct Proteomic Brain States Underlying Long-Term Memory Formation in Aversive Operant Conditioning

Bandura, J., Chan, C. C. H., Sun, H., Wheeler, A. R., & Feng, Z. (2024) · Journal of Proteome Research · doi:10.1021/acs.jproteome.4c00055

OsHV-1 Promoter-driven Transgene Expression in Bivalve Cells: An In Vitro Study with an EGFP-tagged Oncogenic H-RasV12

Balakrishnan, S., Sajeevan, A. K. M., Namitha, R., Sunitha, M. R., Muneer, A., Singh, I. S. B., & Puthumana, J. (2025) · Environmental Management · doi:10.1007/s00267-025-02159-5

Sequential transcriptional gates in the thalamo-cortical circuit coordinate memory stabilizationPreprint

Terceros, A. A., Chen, C. Y., Harada, Y., Eilers, T., Gebremedhin, M., Koche, R. P., Hamard, P.-J., Sharma, R., & Rajasethupathy, P. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.28.656415

The role of IGF-II in memory enhancement : implications for autism spectrum disorders

Kohtz, A. S. (2014) · Scholars Archive - University at Albany (University at Albany, State University of New York) · doi:10.54014/0vca-4kf0

CgCREM regulates haemocyte proliferation and inflammatory factor expression in the Pacific oyster Crassostrea gigas

Fan, J., Luo, P., Shen, L., Zuo, J., Wang, W., Zhou, X., Wang, L., & Song, L. (2025) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2025.110871 · Cited by 1

Molecular and Genetic Analysis of Synaptic Signaling in Drosophila

Jackson, T. (2005) · UA Campus Repository (The University of Arizona)

Additional file 1 of LncRNA TDRKH-AS1 promotes breast cancer progression via the miR-134-5p/CREB1 axis

Ding, Y., Huang, Y., Zhang, F., Gong, L., Liang, C., Ding, K., He, X., Ding, X., & Chen, Y. (2023) · Figshare · doi:10.6084/m9.figshare.24636479

Regulation of stress tolerance by CREB1 sustains multiple myeloma cell survival

Kudalkar, R., Altom, J., Galloway, J., Manning, V., Taranto, S., & Cottini, F. (2026) · Cell Death and Disease · doi:10.1038/s41419-025-08246-z

Distinct molecular mechanisms regulate feeding-state-dependent CO2 chemotaxis plasticity during different life stages in Caenorhabditis elegans

Sahu, A. R., Mallick, S., Vats, A., & Bhattacharya, A. (2026) · Genetics · doi:10.1093/genetics/iyag259

Dynamic thresholds and spatial boundaries coordinate memory association and discrimination across scales

Luo, Y., Yang, L., Zhao, S., Nan, X., Yang, J., Zhang, T., & Li, H. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.107059

BindingDB Entry 50009209: Histone deacetylase 3 inhibitors in learning and memory processes with special emphasis on benzamides.

BindingDB (2021) · UC San Diego · doi:10.7270/q2k93bzt

BindingDB Entry 50020539: The evolution of small molecule enzyme activators.

BindingDB (2024) · UC San Diego · doi:10.7270/q2b56q63

Cellular and molecular mechanisms of associative and nonassociative learning

Byrne, J. H., Fioravante, D., & Antzoulatos, E. G. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9780511995583.007

Analysis of the C/EBP family of transcription factors in neuronal repair

Heredia, L. (2009) · Queen Mary Research Online (Queen Mary University of London)

Untitled work

Mattson, M. (1999) · doi:10.1002/(sici)1097-4547(19991001)58:1

Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change

Bartsch, D., Ghirardi, M., Skehel, P. A., Karl, K. A., Herder, S. P., Chen, M., Bailey, C. H., & Kandel, E. R. (1995) · Cell · doi:10.1016/0092-8674(95)90213-9 · Cited by 572

The Requirement for Enhanced CREB1 Expression in Consolidation of Long-Term Synaptic Facilitation and Long-Term Excitability in Sensory Neurons of Aplysia

Liu, R.-Y., Cleary, L. J., & Byrne, J. H. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5071-10.2011 · Cited by 60

Enhancement of Memory-Related Long-Term Facilitation by ApAF, a Novel Transcription Factor that Acts Downstream from Both CREB1 and CREB2

Bartsch, D., Ghirardi, M., Casadio, A., Giustetto, M., Karl, K. A., Zhu, H., & Kandel, E. R. (2000) · Cell · doi:10.1016/s0092-8674(00)00163-x · Cited by 76

Roles of transcription factor CREB in short and long-term memory formation

Kida, S. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.09.1673

Overexpression and RNA interference of Ap-cyclic AMP-response element binding protein-2, a repressor of long-term facilitation, in Aplysia kurodai sensory-to-motor synapses

Lee, J.-A., Kim, H., Lee, Y.-S., & Kaang, B.-K. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01285-5 · Cited by 25