The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
CREB1 Encodes a Nuclear Activator, a Repressor, and a Cytoplasmic Modulator that Form a Regulatory Unit Critical for Long-Term Facilitation
Open accessAbstract
Although CREB seems to be important for memory formation, it is not known which of the isoforms of CREB, CREM, or ATF1 are expressed in the neurons that undergo long-term synaptic changes and what roles they have in memory formation. We have found a single Aplysia CREB1 gene homologous to both mammalian CREB and CREM and have characterized in the sensory neurons that mediate gill-withdrawal reflex the expression and function of the three proteins that it encodes: CREB1a, CREB1b, and CREB1c. CREB1a is a transcriptional activator that is both necessary and, upon phosphorylation, sufficient for long-term facilitation. CREB1b is a repressor of long-term facilitation. Cytoplasmic CREB1c modulates both the short- and long-term facilitation. Thus, in the sensory neurons, CREB1 encodes a critical regulatory unit converting short- to long-term synaptic changes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“and both rely on cooperative gene induction by pCREB and CBP53,96,99,100.”
From The right time to learn: Mechanisms and optimization of spaced learning (2016) · cites this paper as [99]
In the citing paper
“For example, increased levels of CREB1 phosphorylation are associated with the induction and consolidation of LTF at sensorimotor synapses2,25,28.”
From Computational design of enhanced learning protocols (2012) · cites this paper as [28]
Citations
Cites
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
Bourtchuladze, R., Frenguelli, B., Blendy, J., Cioffi, D., Schutz, G., & Silva, A. J. (1994) · Cell · doi:10.1016/0092-8674(94)90400-6 · Cited by 1,800
Current Protocols in Molecular Biology
(2018) · Current Protocols in Molecular Biology · doi:10.1002/(issn)1934-3647 · Cited by 1,395
Nibuya, M., Nestler, E., & Duman, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02365.1996 · Cited by 1,206
Bito, H., Deisseroth, K. A., & Tsien, R. W. (1996) · Cell · doi:10.1016/s0092-8674(00)81816-4 · Cited by 1,138
Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila
Yin, J. C. P., Wallach, J. S., Del Vecchio, M., Wilder, E. L., Zhou, H., Quinn, W. G., & Tully, T. (1994) · Cell · doi:10.1016/0092-8674(94)90399-9 · Cited by 959
Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP
Nguyen, P. V., Abel, T., & Kandel, E. R. (1994) · Science · doi:10.1126/science.8066450 · Cited by 888
Self-citationGonzalez, G. A., Yamamoto, K. K., Fischer, W. H., Karr, D., Menzel, P., Biggs, W., Vale, W., & Montminy, M. (1989) · Nature · doi:10.1038/337749a0 · Cited by 875
A Critical Period for Macromolecular Synthesis in Long-Term Heterosynaptic Facilitation in Aplysia
Montarolo, P. G., Goelet, P., Castellucci, V. F., Morgan, J., Kandel, E. R., & Schacher, S. (1986) · Science · doi:10.1126/science.3775383 · Cited by 769
Self-citation
Cited by
Sorted by citations
The molecular biology of memory storage: a dialogue between genes and synapses
Kandel, E. R. (2001) · Science · doi:10.1126/science.1067020 · Cited by 3,917
Self-citationTranscriptional regulation by the phosphorylation-dependent factor CREB
Mayr, B., & Montminy, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085068 · Cited by 2,587
Function and regulation of CREB family transcription factors in the nervous system
Lonze, B. E., & Ginty, D. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00828-0 · Cited by 2,127
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms
Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795
Regulation of histone acetylation during memory formation in the hippocampus
Levenson, J. M., O'Riordan, K. J., Brown, K. D., Trinh, M. A., Molfese, D. L., & Sweatt, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402229200 · Cited by 1,131
Transcription Factors in Long-Term Memory and Synaptic Plasticity
Alberini, C. M. (2009) · Physiological Reviews · doi:10.1152/physrev.00017.2008 · Cited by 991
The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB
Kandel, E. R. (2012) · Molecular Brain · doi:10.1186/1756-6606-5-14 · Cited by 931
Self-citationNeuronal competition and selection during memory formation
Han, J.-H., Kushner, S. A., Yiu, A. P., Cole, C. J., Matynia, A., Brown, R. A., Neve, R. L., Guzowski, J. F., Silva, A. J., & Josselyn, S. A. (2007) · Science · doi:10.1126/science.1139438 · Cited by 682
Barco, A., Alarcon, J. M., & Kandel, E. (2002) · Cell · doi:10.1016/s0092-8674(02)00657-8 · Cited by 595
Self-citationAn activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP
Wayman, G. A., Davare, M., Ando, H., Fortin, D., Varlamova, O., Cheng, H.-Y. M., Marks, D., Obrietan, K., Soderling, T. R., Goodman, R. H., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803072105 · Cited by 559
Casadio, A., Martin, K. C., Giustetto, M., Zhu, H., Chen, M., Bartsch, D., Bailey, C. H., & Kandel, E. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81653-0 · Cited by 503
Self-citationGuan, Z., Giustetto, M., Lomvardas, S., Kim, J.-H., Miniaci, M. C., Schwartz, J. H., Thanos, D., & Kandel, E. R. (2002) · Cell · doi:10.1016/s0092-8674(02)01074-7 · Cited by 497
Self-citationWong, S. T., Athos, J., Figueroa, X. A., Pineda, V. V., Schaefer, M. L., Chavkin, C. C., Muglia, L. J., & Storm, D. R. (1999) · Neuron · doi:10.1016/s0896-6273(01)80036-2 · Cited by 486
Pittenger, C., Huang, Y. Y., Paletzki, R. F., Bourtchouladze, R., Scanlin, H., Vronskaya, S., & Kandel, E. R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00684-0 · Cited by 464
Self-citationMathematical modeling of gene networks.
Smolen, P., Baxter, D., & Byrne, J. (2000) · Neuron · doi:10.1016/s0896-6273(00)81194-0 · Cited by 466
Josselyn, S. A., Shi, C., Carlezon, W. A., Neve, R. L., Nestler, E. J., & Davis, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02404.2001 · Cited by 451
Rajasethupathy, P., Fiumara, F., Sheridan, R., Betel, D., Puthanveettil, S. V., Russo, J. J., Sander, C., Tuschl, T., & Kandel, E. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.029 · Cited by 406
Self-citationIs Heterosynaptic modulation essential for stabilizing hebbian plasiticity and memory
Bailey, C. H., Giustetto, M., Huang, Y.-Y., Hawkins, R. D., & Kandel, E. R. (2000) · Nature Reviews Neuroscience · doi:10.1038/35036191 · Cited by 382
Self-citationThe molecular and cellular biology of enhanced cognition
Lee, Y.-S., & Silva, A. J. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2572 · Cited by 361
Calcium signaling in neurodegeneration
Marambaud, P., Dreses‐Werringloer, U., & Vingtdeux, V. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-20 · Cited by 363
Modeling transcriptional control in gene networks—methods, recent results, and future directions
Smolen, P., Baxter, D., & Byrne, J. (2000) · Bulletin of Mathematical Biology · doi:10.1006/bulm.1999.0155 · Cited by 386
Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV
Impey, S., Fong, A. L., Wang, Y., Cardinaux, J.-R., Fass, D. M., Obrietan, K., Wayman, G. A., Storm, D. R., Soderling, T. R., & Goodman, R. H. (2002) · Neuron · doi:10.1016/s0896-6273(02)00654-2 · Cited by 335
The right time to learn: Mechanisms and optimization of spaced learning
Smolen, P., Zhang, Y., & Byrne, J. H. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.18 · Cited by 326
The role of CREB signaling in Alzheimer’s disease and other cognitive disorders
Saura, C. A., & Valero, J. (2011) · revneuro · doi:10.1515/rns.2011.018 · Cited by 312
Signaling routes to CREM and CREB: plasticity in transcriptional activation
Cesare, D. D., Fimia, G. M., & Sassone‐Corsi, P. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01414-0 · Cited by 310
Regulation of Nuclear Localization: A Key to a Door
Kaffman, A., & O’Shea, E. K. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.291 · Cited by 299
The Molecular Biology of Memory Storage: A Dialog Between Genes and Synapses
Kandel, E. R. (2004) · Bioscience Reports · doi:10.1007/s10540-005-2742-7 · Cited by 283
Self-citationNOBEL LECTURE: The Molecular Biology of Memory Storage: A Dialog Between Genes and Synapses
Kandel, E. R. (2001) · Bioscience Reports · doi:10.1023/a:1014775008533 · Cited by 292
Self-citationγCaMKII Shuttles Ca2+/CaM to the Nucleus to Trigger CREB Phosphorylation and Gene Expression
Ma, H., Groth, R. D., Cohen, S. M., Emery, J. F., Li, B., Hoedt, E., Zhang, G., Neubert, T. A., & Tsien, R. W. (2014) · Cell · doi:10.1016/j.cell.2014.09.019 · Cited by 283
Chen, A. Y.-C., Muzzio, I. A., Malleret, G., Bartsch, D., Verbitsky, M., Pavlidis, P., Yonan, A. L., Vronskaya, S., Grody, M. B., Cepeda, I. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00501-4 · Cited by 279
Self-citationGenetic approaches to memory storage
Mayford, M. R. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(99)01846-6 · Cited by 257
Striatal dopamine- and glutamate-mediated dysregulation in experimental parkinsonism
Chase, T. N., & Oh, J. D. (2000) · Trends in Neurosciences · doi:10.1016/s1471-1931(00)00018-5 · Cited by 250
Müller, U. (2000) · Neuron · doi:10.1016/s0896-6273(00)00017-9 · Cited by 249
Levine, A. A., Guan, Z., Barco, Á., Xu, S., Kandel, E. R., & Schwartz, J. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509735102 · Cited by 255
Self-citationOverexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP
Wang, H., Ferguson, G. D., Pineda, V. V., Cundiff, P. E., & Storm, D. R. (2004) · Nature Neuroscience · doi:10.1038/nn1248 · Cited by 244
Barrett, R. M., & Wood, M. A. (2008) · Learning & Memory · doi:10.1101/lm.917508 · Cited by 247
Molecular Mechanisms of Memory Storage inAplysia
Hawkins, R. D., Kandel, E. R., & Bailey, C. H. (2006) · Biological Bulletin · doi:10.2307/4134556 · Cited by 231
Self-citationThe roles of protein kinases in learning and memoryPreprint
Giese, K.-P., & Mizuno, K. (2013) · Learning & Memory · doi:10.1101/lm.028449.112 · Cited by 238
Transcriptional regulation by cyclic AMP-responsive factors
Cesare, D. D., & Sassone‐Corsi, P. (2000) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(00)64009-6 · Cited by 237
An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling
Impey, S., Davare, M., Lasiek, A., Fortin, D., Ando, H., Varlamova, O., Obrietan, K., Soderling, T. R., Goodman, R. H., & Wayman, G. A. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.10.005 · Cited by 270
Common molecular mechanisms in explicit and implicit memory
Barco, Á., Bailey, C. H., & Kandel, E. R. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03870.x · Cited by 228
Self-citationBrain-Targeted Proanthocyanidin Metabolites for Alzheimer's Disease Treatment
Wang, J., Ferruzzi, M. G., Ho, L., Blount, J. W., Janle, E. M., Gong, B., Pan, Y., Gowda, G. A. N., Raftery, D., Arrieta‐Cruz, I., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6437-11.2012 · Cited by 210
Ho, L., Ferruzzi, M. G., Janle, E. M., Wang, J., Gong, B., Chen, T., Lobo, J., Cooper, B. R., Wu, Q. L., Talcott, S. T., et al. (2012) · The FASEB Journal · doi:10.1096/fj.12-212118 · Cited by 206
CREB, memory enhancement and the treatment of memory disorders: promises, pitfalls and prospects
Barco, Á., Pittenger, C., & Kandel, E. R. (2003) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.7.1.101 · Cited by 202
Self-citationDynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation
Rexach, J. E., Clark, P. M., Mason, D. E., Neve, R. L., Peters, E. C., & Hsieh‐Wilson, L. C. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.770 · Cited by 202
Chain, D. G., Casadio, A., Schacher, S., Hegde, A. N., Valbrun, M., Yamamoto, N., Goldberg, A. L., Bartsch, D., Kandel, E. R., & Schwartz, J. H. (1999) · Neuron · doi:10.1016/s0896-6273(00)80686-8 · Cited by 186
Self-citationTaubenfeld, S. M., Wiig, K. A., Monti, B., Dolan, B., Pollonini, G., & Alberini, C. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-01-00084.2001 · Cited by 178
Molecular Mechanisms Underlying a Unique Intermediate Phase of Memory in Aplysia
Sutton, M. A., Masters, S. E., Bagnall, M. W., & Carew, T. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00342-7 · Cited by 177
The role of protein synthesis during the labile phases of memory: Revisiting the skepticism
Alberini, C. M. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.007 · Cited by 185
In search of general mechanisms for long-lasting plasticity: Aplysia and the hippocampus
Pittenger, C., & Kandel, E. R. (2003) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2002.1247 · Cited by 180
Self-citationMoccia, R., Chen, D., Lyles, V., Kapuya, E., Yaping, E., Kalachikov, S. M., Spahn, C. M. T., Frank, J., Kandel, E. R., Barad, M., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09409.2003 · Cited by 172
Self-citationA Late Phase of Cerebellar Long-Term Depression Requires Activation of CaMKIV and CREB
Ahn, S., Ginty, D. D., & Linden, D. J. (1999) · Neuron · doi:10.1016/s0896-6273(00)80808-9 · Cited by 173
Bitner, R. S. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.11.009 · Cited by 163
Yao, B., Zhang, Q., Yang, Z., An, F., Nie, H., Wang, H., Cheng, Y., Sun, J., Chen, K., Zhou, J., et al. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01608-7 · Cited by 162
Schulz, S., Siemer, H., Krug, M., & Höllt, V. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05683.1999 · Cited by 153
Ubiquitin-proteasome-mediated local protein degradation and synaptic plasticity
Hegde, A. N. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.005 · Cited by 143
Hoedjes, K. M., Kruidhof, H. M., Huigens, M. E., Dicke, M., Vet, L. E. M., & Smid, H. M. (2010) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2010.2199 · Cited by 142
Cyclic GMP pathway is critical for inducing long–term sensitization of nociceptive sensory neurons
Lewin, M. R., & Walters, E. T. (1999) · Nature Neuroscience · doi:10.1038/4520 · Cited by 138
The Ubiquitin Proteasome System Functions as an Inhibitory Constraint on Synaptic Strengthening
Zhao, Y., Hegde, A. N., & Martin, K. C. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00332-4 · Cited by 136
The past, the future and the biology of memory storage
Kandel, E. R., & Pittenger, C. (1999) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1999.0542 · Cited by 135
Self-citationMemory enhancement: consolidation, reconsolidation and insulin-like growth factor 2
Alberini, C. M., & Chen, D. Y. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.12.007 · Cited by 130
Chapter 10 Synaptic remodeling, synaptic growth and the storage of long-term memory in Aplysia
Bailey, C. H., & Kandel, E. R. (2008) · Progress in brain research · doi:10.1016/s0079-6123(07)00010-6 · Cited by 134
Self-citationAlberini (2006) · doi:10.1007/s00018-006-6025-7 · Cited by 158
Klemke, M., Kehlenbach, R. H., & Huttner, W. B. (2001) · The EMBO Journal · doi:10.1093/emboj/20.14.3849 · Cited by 123
Spaced Training Forms Complementary Long-Term Memories of Opposite Valence in Drosophila
Jacob, P. F., & Waddell, S. (2020) · Neuron · doi:10.1016/j.neuron.2020.03.013 · Cited by 112
Purcell, A. L., Sharma, S. K., Bagnall, M. W., Sutton, M. A., & Carew, T. J. (2003) · Neuron · doi:10.1016/s0896-6273(03)00030-8 · Cited by 117
Continuing the search for the engram: examining the mechanism of fear memories
Josselyn, S. A. (2010) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100015 · Cited by 116
Spieler, D., Kaffe, M., Knauf, F., Bessa, J., Tena, J. J., Giesert, F., Schormair, B., Tilch, E., Lee, H., Horsch, M., et al. (2014) · Genome Research · doi:10.1101/gr.166751.113 · Cited by 112
Behavioral analysis of CREB αΔ mutation on a B6/129 F1 hybrid background
Graves, L. A., Dalvi, A., Lucki, I., Blendy, J. A., & Abel, T. G. (2002) · Hippocampus · doi:10.1002/hipo.10003 · Cited by 108
Rahn, E. J., Karlsson, M. G., & Sweatt, J. D. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.06.008 · Cited by 113
Steiger, J. L., Bandyopadhyay, S., Farb, D. H., & Russek, S. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1200-04.2004 · Cited by 104
Pinto, S., Quintana, D. G., Smith, P., Mihalek, R., Hou, Z.-H., Boynton, S., Jones, C. J., Hendricks, M., Velinzon, K., Wohlschlegel, J. A., et al. (1999) · Neuron · doi:10.1016/s0896-6273(00)80752-7 · Cited by 105
Dorsal hippocampal CREB is both necessary and sufficient for spatial memoryPreprint
Sekeres, M. J., Neve, R. L., Frankland, P. W., & Josselyn, S. A. (2010) · Learning & Memory · doi:10.1101/lm.1785510 · Cited by 104
Acute and long-term synaptic modulation by neurotrophins
Lu, B. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)46010-x · Cited by 102
Alberini, C. M. (1999) · Journal of Experimental Biology · doi:10.1242/jeb.202.21.2887 · Cited by 102
Disorders of memory and plasticity in psychiatric disease
Pittenger, C. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.4/cpittenger · Cited by 92
Sekeres, M. J., Mercaldo, V., Richards, B. A., Sargin, D., Mahadevan, V., Woodin, M. A., Frankland, P. W., & Josselyn, S. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1419-12.2012 · Cited by 103
Albright, T. D., Jessell, T. M., Kandel, E. R., & Posner, M. I. (2000) · Cell · doi:10.1016/s0092-8674(00)00251-8 · Cited by 98
Self-citationSharma, S. K., & Carew, T. J. (2004) · Learning & Memory · doi:10.1101/lm.81104 · Cited by 95
Role of ubiquitin–proteasome-mediated proteolysis in nervous system disease
Hegde, A. N., & Upadhya, S. C. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.07.006 · Cited by 96
Bengtson, C. P., & Bading, H. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-3-7091-0932-8_17 · Cited by 101
Sadamoto, H., Sato, H., Kobayashi, S., Murakami, J., Aonuma, H., Ando, H., Fujito, Y., Hamano, K., Awaji, M., Lukowiak, K., et al. (2003) · Journal of Neurobiology · doi:10.1002/neu.10296 · Cited by 94
Butcher, L. M., Meaburn, E. L., Knight, J., Sham, P. C., Schalkwyk, L. C., Craig, I., & Plomin, R. J. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi142 · Cited by 93
Yiu, A. P., Rashid, A. J., & Josselyn, S. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.107 · Cited by 99
Pham, T. A., Rubenstein, J. L. R., Silva, A. J., Storm, D. R., & Stryker, M. P. (2001) · Neuron · doi:10.1016/s0896-6273(01)00381-6 · Cited by 88
McLean, J. H., Harley, C. W., Darby‐King, A., & Yuan, Q. (1999) · Learning & Memory · doi:10.1101/lm.6.6.608 · Cited by 90
Roles for the Endoplasmic Reticulum in Regulation of Neuronal Calcium Homeostasis
Karagas, N. E., & Venkatachalam, K. (2019) · Cells · doi:10.3390/cells8101232 · Cited by 95
Transcriptional regulation of long-term memory in the marine snail Aplysia
Lee, Y., Bailey, C. H., Kandel, E. R., & Kaang, B. (2008) · Molecular Brain · doi:10.1186/1756-6606-1-3 · Cited by 85
Self-citationMolecular and cellular mechanisms of memory allocation in neuronetworks
Won, J., & Silva, A. J. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.017 · Cited by 82
Computational design of enhanced learning protocols
Zhang, Y., Liu, R.-Y., Heberton, G. A., Smolen, P., Baxter, D. A., Cleary, L. J., & Byrne, J. H. (2012) · Nature Neuroscience · doi:10.1038/nn.2990 · Cited by 80
Lee, J. A., Kim, H. K., Kim, K., Han, J., Lee, Y., Lim, C., Chang, D., Kubo, T., & Kaang, B. (2001) · Learning & Memory · doi:10.1101/lm.40201 · Cited by 78
Striatal glutamatergic mechanisms and extrapyramidal movement disorders
Chase, T. N., Bibbiani, F., & Oh, J. D. (2003) · Neurotoxicity Research · doi:10.1007/bf03033378 · Cited by 77
Bartsch, D., Ghirardi, M., Casadio, A., Giustetto, M., Karl, K. A., Zhu, H., & Kandel, E. R. (2000) · Cell · doi:10.1016/s0092-8674(00)00163-x · Cited by 76
Self-citationGarcía-Gimeno, M. A., & Struhl, K. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.12.4340-4349.2000 · Cited by 77
Nagakura, A., Niimura, M., & Takeo, S. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704629 · Cited by 76
Manseau, F., Fan, X., Hueftlein, T., Sossin, W. S., & Castellucci, V. F. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01247.2001 · Cited by 76
Liu, R.-Y., Fioravante, D., Shah, S., & Byrne, J. H. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3848-07.2008 · Cited by 73
cAMP-response Elements in Aplysia creb1, creb2, and Ap-uch Promoters
Mohamed, H. A., Yao, W., Fioravante, D., Smolen, P. D., & Byrne, J. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502541200 · Cited by 73
Hebert, M. A., Serova, L. I., & Sabban, E. L. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03386.x · Cited by 77
The genetic basis of cognition
Flint, J. (1999) · Brain · doi:10.1093/brain/122.11.2015 · Cited by 77
Metadata
- Authors
- Bartsch, D., Casadio, A., Karl, K. A., Serodio, P., & Kandel, E. R.
- Affiliations
- New York State Psychiatric Institute (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Kandel, Eric R
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-10
- Volume
- 95
- Issue
- 2
- Pages
- 211-223
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2072387005
- Cited by
- 373
- References
- 34
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 14 · 2023: 6 · 2022: 7 · 2021: 9 · 2020: 11 · 2019: 15 · 2018: 10 · 2017: 12 · 2016: 5 · 2015: 13 · 2014: 13 · 2013: 13 · 2012: 16
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (MH45923-09)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- CREB1, CREM, ATF1, long-term facilitation, short-term facilitation, synaptic plasticity, memory formation, gill-withdrawal reflex, sensory neurons, transcriptional activator, transcriptional repressor, CREB phosphorylation, Aplysia
- MeSH terms
- Amino Acid Sequence, Animals, Aplysia, Base Sequence, Cytoplasm, DNA-Binding Proteins, Mammals, Memory, Molecular Sequence Data, Neurons, Nuclear Proteins, Phosphorylation, Repressor Proteins, RNA, Messenger, Synapses, Transcription Factors, Cyclic AMP Response Element-Binding Protein, Calcium-Calmodulin-Dependent Protein Kinases, Cyclic AMP Response Element Modulator, Calcium-Calmodulin-Dependent Protein Kinase Type 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review