The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
CREB1 Encodes a Nuclear Activator, a Repressor, and a Cytoplasmic Modulator that Form a Regulatory Unit Critical for Long-Term Facilitation
Open accessAbstract
Although CREB seems to be important for memory formation, it is not known which of the isoforms of CREB, CREM, or ATF1 are expressed in the neurons that undergo long-term synaptic changes and what roles they have in memory formation. We have found a single Aplysia CREB1 gene homologous to both mammalian CREB and CREM and have characterized in the sensory neurons that mediate gill-withdrawal reflex the expression and function of the three proteins that it encodes: CREB1a, CREB1b, and CREB1c. CREB1a is a transcriptional activator that is both necessary and, upon phosphorylation, sufficient for long-term facilitation. CREB1b is a repressor of long-term facilitation. Cytoplasmic CREB1c modulates both the short- and long-term facilitation. Thus, in the sensory neurons, CREB1 encodes a critical regulatory unit converting short- to long-term synaptic changes.
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In the citing paper
“and both rely on cooperative gene induction by pCREB and CBP53,96,99,100.”
From The right time to learn: Mechanisms and optimization of spaced learning (2016) · cites this paper as [99]
In the citing paper
“For example, increased levels of CREB1 phosphorylation are associated with the induction and consolidation of LTF at sensorimotor synapses2,25,28.”
From Computational design of enhanced learning protocols (2012) · cites this paper as [28]
Citations
Cites
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A Critical Period for Macromolecular Synthesis in Long-Term Heterosynaptic Facilitation in Aplysia
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Metadata
- Authors
- Bartsch, D., Casadio, A., Karl, K. A., Serodio, P., & Kandel, E. R.
- Affiliations
- New York State Psychiatric Institute (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Kandel, Eric R
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-10
- Volume
- 95
- Issue
- 2
- Pages
- 211-223
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2072387005
- Cited by
- 373
- References
- 34
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 14 · 2023: 6 · 2022: 7 · 2021: 9 · 2020: 11 · 2019: 15 · 2018: 10 · 2017: 12 · 2016: 5 · 2015: 13 · 2014: 13 · 2013: 13 · 2012: 16
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (MH45923-09)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- CREB1, CREM, ATF1, long-term facilitation, short-term facilitation, synaptic plasticity, memory formation, gill-withdrawal reflex, sensory neurons, transcriptional activator, transcriptional repressor, CREB phosphorylation, Aplysia
- MeSH terms
- Amino Acid Sequence, Animals, Aplysia, Base Sequence, Cytoplasm, DNA-Binding Proteins, Mammals, Memory, Molecular Sequence Data, Neurons, Nuclear Proteins, Phosphorylation, Repressor Proteins, RNA, Messenger, Synapses, Transcription Factors, Cyclic AMP Response Element-Binding Protein, Calcium-Calmodulin-Dependent Protein Kinases, Cyclic AMP Response Element Modulator, Calcium-Calmodulin-Dependent Protein Kinase Type 2
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