Overexpression and RNA interference of Ap-cyclic AMP-response element binding protein-2, a repressor of long-term facilitation, in Aplysia kurodai sensory-to-motor synapses
Abstract
cyclic AMP-response element binding protein-2 (CREB2) is a member of the CREB/transcription factor (CREB/ATF4) family. CREB2 is a transcription factor known to be involved in Aplysia long-term facilitation. To further examine the role of ApCREB2 on long-term synaptic facilitation, we isolated ApCREB2 from Aplysia kurodai in full-length cDNA library, and found that the overexpression of ApCREB2 blocked 5-hydroxytryptamine (5-HT)-induced long-term synaptic facilitation in Aplysia sensory-to-motor synapses. Furthermore, a single pulse of 5-HT, which normally induces only short-term facilitation, in the presence of ApCREB2 inhibition by RNA interference, induced long-term facilitation in Aplysia sensory-to-motor synapses. These results suggest that ApCREB2 is a functional repressor of long-term facilitation in Aplysia sensory-to-motor synapses.
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The induction and consolidation of LTF in vitro depends on the activity of several transcription factors.
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- Authors
- Lee, J.-A., Kim, H., Lee, Y.-S., & Kaang, B.-K.
- Affiliations
- Seoul National University (KR)
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 337
- Issue
- 1
- Pages
- 9-12
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2060974146
- Cited by
- 25
- References
- 11
- Citations by year
- 2021: 1 · 2020: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- Korea Science and Engineering Foundation
- Ministry of Science and Technology, Taiwan (R01-1999-000-00147-0)
- Ministry of Education
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- ATF4, cyclic AMP response element binding protein, Aplysia kurodai, serotonin, RNA interference, overexpression, short-term facilitation
- MeSH terms
- Animals, Aplysia, Cells, Cultured, Motor Neurons, Neurons, Afferent, RNA, Serotonin, Synapses, Cyclic AMP Response Element-Binding Protein, Long-Term Potentiation, Microscopy, Confocal, Excitatory Postsynaptic Potentials
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