The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8
Open accessAbstract
We isolated a Xenopus homolog of Frzb, a newly described protein containing an amino-terminal Frizzled motif. It dorsalized Xenopus embryos and was expressed in the Spemann organizer during early gastrulation. Unlike Frizzled proteins, endogenous Frzb was soluble. Frzb was secretable and could act across cell boundaries. In several functional assays, Frzb antagonized Xwnt-8, a proposed ventralizing factor with an expression pattern complementary to that of Frzb. Furthermore, Frzb blocked induction of MyoD, an action reported recently for a dominant-negative Xwnt-8. Frzb coimmunoprecipitated with Wnt proteins, providing direct biochemical evidence for Frzb-Wnt interactions. These observations implicate Frzb in axial patterning and support the concept that Frzb binds and inactivates Xwnt-8 during gastrulation, preventing inappropriate ventral signaling in developing dorsal tissues.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In the extra-cellular matrix, a number of secreted proteins that bind to Wnts and prevent their interaction with either Fz or LRP5/6 to antagonize Wnt signaling have been identified. These include Dickkopf (Dkk) proteins,16 Wnt-inhibitor protein (WIF),17 soluble Frizzled-related proteins (SFRP),18 Cerebrus,19 Frzb20 and the context dependent Wnt inhibitor Wise.21”
From Wnt signal transduction pathways (2008) · cites this paper as [20]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Antibodies, a laboratory manual
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,318
Bone: Formation by Autoinduction
Urist, M. R. (1965) · Science · doi:10.1126/science.150.3698.893 · Cited by 5,529
Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
Nielsen, H., Engelbrecht, J., Brunak, S., & von HEIJNE, G. (1997) · Protein Engineering Design and Selection · doi:10.1093/protein/10.1.1 · Cited by 5,343
Normal Table of Xenopus Laevis (Daudin)
Nieuwkoop, P. D., & Faber, J. (1958) · Copeia · doi:10.2307/1439568 · Cited by 4,542
Wessel, D., & Flügge, U. (1984) · Analytical Biochemistry · doi:10.1016/0003-2697(84)90782-6 · Cited by 3,997
Normal table of Xenopus laevis (Daudin)
Gurdon, J. B. (1995) · Trends in Genetics · doi:10.1016/s0168-9525(00)89129-5 · Cited by 2,888
Appendix G: In Situ Hybridization: An Improved Whole-Mount Method for Xenopus Embryos
Harland, R. M. (1991) · Methods in cell biology · doi:10.1016/s0091-679x(08)60307-6 · Cited by 2,048
Bone morphogenetic proteins: multifunctional regulators of vertebrate development.Preprint
Hogan, B. L. M. (1996) · Genes & Development · doi:10.1101/gad.10.13.1580 · Cited by 1,964
Structural features in eukaryotic mRNAs that modulate the initiation of translation.
Kozak, M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54860-2 · Cited by 1,826
The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4
Zimmerman, L. B., Jesús-Escobar, J. M. D., & Harland, R. M. (1996) · Cell · doi:10.1016/s0092-8674(00)80133-6 · Cited by 1,639
Research works printed but not linked: 3
- Evans, 1991, Biochemical fractionation of oocytes, Meth. Cell Biol., 36, 117
- Kay, 1991, Injection of oocytes and embryos, Meth. Cell Biol., 36, 657
- Saunders, 1968
Cited by
Sorted by citations
Items 401–500 of 518
Kong, W., Yang, Y., Zhang, T., Shi, D., & Zhang, Y. (2012) · Evolution & Development · doi:10.1111/j.1525-142x.2012.00533.x · Cited by 11
“2C), consistent with previous observation (Leyns et al. 1997; Wang et al. 1997).”
BackgroundFujita, M., Urano, T., Shiraki, M., Momoeda, M., Tsutsumi, O., Hosoi, T., Orimo, H., Ouchi, Y., & Inoue, S. (2004) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2004.00249.x · Cited by 11
Translation of Regenerative Medicine Products Into the Clinic in the United States
Lee, M. H., Au, P., Hyde, J., Johnson, C. G., Heidaran, M. A., Karandish, S., Boxer, L., Mendicino, M., Yoon, D. M., Tull, L., et al. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-410396-2.00005-0 · Cited by 10
Dehydrated human amniotic membrane modulates canonical Wnt signaling in multiple cell types in vitro
Moreno, S. E., Massee, M., Bara, H., & Koob, T. J. (2021) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2021.151168 · Cited by 10
Novel gene ashwin functions in Xenopus cell survival and anteroposterior patterning
Patil, S., Alexander, T. B., Uzman, J. A., Lou, C., Gohil, H., & Sater, A. K. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20834 · Cited by 10
“…include the multifunctional BMP4/Wnt/Nodal antagonist cerberus (Piccolo et al., 1999), the Wnt antagonists dickkopf (Glinka et al., 1998) and frzb (Wang et al., 1997; Leyns et al., 1997), as well as transcriptional regulators such as Hex (Jones et al., 1999; Brickman et al., 2000), Lim1 (Taira et…”
BackgroundWnt/ -Catenin Signaling in Vertebrate Posterior Neural Development
Elkouby, Y. M., & Frank, D. (2010) · Cited by 10
Bernascone, I., González, T., Barea, M. D., Carabaña, C., Hachimi, M., Bosch‐Fortea, M., Santamaría, S. S., Martin, R., Tarnick, J., García‐Sanz, J. A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10509-1 · Cited by 10
Signalling architectures can prevent cancer evolution
Oña, L., & Lachmann, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-57494-w · Cited by 10
Gain-of-Function and Loss-of-Function Strategies in Xenopus
Lavery, D. L., & Hoppler, S. (2008) · Methods in molecular biology · doi:10.1007/978-1-60327-469-25 · Cited by 10
Murato, Y., Yamaguti, M., Katamura, M., Cho, K. W. Y., & Hashimoto, C. (2006) · The International Journal of Developmental Biology · doi:10.1387/ijdb.052106ym · Cited by 10
Reis, A. H., & Sokol, S. (2020) · Scientific Reports · doi:10.1038/s41598-021-92824-6 · Cited by 6
“Rspo2 is a Wnt antagonist The anteriorized phenotype caused by Rspo2 is similar to the ones generated by Wnt antagonists (Glinka et al., 1998; Heasman et al., 2000; Itoh et al., 2000; Itoh et al., 1995; Wang et al., 1997; Zhang et al., 2012).”
Houston, D. W., Elliott, K. L., Coppenrath, K., Wlizla, M., & Horb, M. E. (2022) · Development · doi:10.1242/dev.200552 · Cited by 11
Zhao, X., Huang, H., Chen, Y., Liu, Y., Zhang, Z., Ma, Q., & Qiu, M. S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.06.044 · Cited by 9
“, 1997), but not Wnt-3A or -5A signaling (Wang et al., 1997).”
BackgroundInfluentialOsteoarthritis, a disease bridging development and regeneration
Lories, R. J. U., & Luyten, F. P. (2012) · BoneKEy Reports · doi:10.1038/bonekey.2012.136 · Cited by 10
Self-citationHayata, T., Tanegashima, K., Takahashi, S., Sogame, A., & Asashima, M. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00638-4 · Cited by 9
Shen, Y., Zhang, F., Lan, H., Chen, K., Zhang, Q., Xie, G., Teng, L., & Jin, K. (2015) · Europe PMC (PubMed Central) · Cited by 9
FRZB up-regulated in hepatocellular carcinoma bone metastasis.
Huang, J. M., Hu, W., Lin, X., Wang, X., & Jin, K. (2015) · PubMed Central · Cited by 9
Studying Wnt Signaling in Xenopus
Hoppler, S. (2008) · Methods in molecular biology · doi:10.1007/978-1-60327-469-2_21 · Cited by 9
Molecular Control of Pronephric Development
Jones, E. A. (2003) · Elsevier eBooks · doi:10.1016/b978-012722441-1/50010-5 · Cited by 9
Maéno, M., Komiyama, K., Matsuzaki, Y., Hosoya, J., Kurihara, S., Sakata, H., & Izutsu, Y. (2012) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2011.01321.x · Cited by 8
“It has been shown that Wnt inhibitors, such as dkk1, frzb-1, crescent and Cerberus, are expressed in the anterior edge of the involuting mesoderm and endoderm at the gastrulation stage, and play a physiological role for the development of heart formation (Glinka et al. 1998; Leyns et al. 1997; Wang et al. 1997; Pera &…”
BackgroundXu, R., Zhang, F., Lu, J., Wang, K., Pan, P., Sun, Y., & Zhang, Y. (2021) · Aging · doi:10.18632/aging.202815 · Cited by 8
Estrogen‐inducible sFRP5 inhibits early B‐lymphopoiesis in vivo, but not during pregnancy
Yokota, T., Oritani, K., Sudo, T., Ishibashi, T., Doi, Y., Habuchi, Y., Ichii, M., Fukushima, K., Okuzaki, D., Tomizuka, K., et al. (2015) · European Journal of Immunology · doi:10.1002/eji.201444939 · Cited by 8
Transcriptional Activity of the Promoter Region of Rat Frizzled-Related Protein Gene
Yam, J. W. P., Chan, K. W., Wong, V. K. W., & Hsiao, W. L. W. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5349 · Cited by 7
Asashima, M., Yokota, C., Takahashi, S., Lau, C. L., & Malacinski, G. M. (1999) · The International Journal of Developmental Biology · doi:10.1387/ijdb.10213077 · Cited by 7
A mathematical modelling portrait of Wnt signalling in early vertebrate embryogenesis
Giuraniuc, C. V., Zain, S., Ghafoor, S., & Hoppler, S. (2022) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2022.111239 · Cited by 6
“…products of this second class of maternal Wnt/𝛽-catenin target genes are known to negatively regulate zygotic wnt8/𝛽-catenin signalling (e.g. FRZB (Wang et al., 1997)) or BMP signalling (e.g. CHD, chordin Piccolo et al. (1996)), which will have consequences for the expression of Wnt target…”
BackgroundZhang, Z., Yaryhin, O., Koyabu, D. B., & Werneburg, I. (2022) · Journal of Morphology · doi:10.1002/jmor.21474 · Cited by 6
“The antagonistic inhibition of Wnt proteins, for example, is reported as an important factor in head formation in Xenopus laevis (Wang et al., 1997).”
Background[Effects of FRZB on growth and metastasis of gastric cancer cell line SGC-7901].
Qu, Y., Li, J., Cai, Q., Liu, B., & Zhu, Z. (2008) · PubMed · Cited by 6
Sakai, M. (2007) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2007.00975.x · Cited by 6
“Co-injection of dkk-1 or Frzb with tBR also results in the formation of complete secondary axis.”
BackgroundThe Molecular Basis of the Gastrula Organizer in Amphibians and Cnidarians
Yasuoka, Y., & Taira, M. (2018) · Diversity and commonality in animals · doi:10.1007/978-4-431-56609-0_31 · Cited by 6
Overview of the FDA Regulatory Process
Whittlesey, K. J., Lee, M. H., Dang, J. M., Colehour, M. B., Arcidiacono, J. A., Lazarus, E. F., Kaplan, D. S., Fink, D. W., Durfor, C. N., Batra, A., et al. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-381422-7.10063-x · Cited by 5
The Molecular Nature of Spemann’s Organizer
Robertis, E. M. D., & Wessely, O. (2004) · Springer eBooks · doi:10.1007/978-3-662-10416-3_5 · Cited by 5
L’inducteur céphalique Cerberus est un inhibiteur multivalent extracellulaire
Agius, E., Piccolo, S., & Robertis, E. M. D. (1999) · Journal de la Société de Biologie · doi:10.1051/jbio/1999193040347 · Cited by 5
“…sécrétés comme Noggin (Lamb et al., 1993 ; Smith et al., 1993 ; Zimmerman et al., 1996), Chordin (Piccolo et al., 1996 ; Sasai et al., 1994), Frzb-1 (Leyns et al., 1997; Wang et al., 1997), Dickkopf-1 (Glinka et al., 1998) et Cerbe rus (Bouwmeester et al., 1996; Piccolo et al., 1999).”
Myogenic Cell Specification during Somitogenesis
BUCKINGHAM, M. E., & Tajbakhsh, S. (1999) · Elsevier eBooks · doi:10.1016/b978-012505255-9/50042-0 · Cited by 5
Pattern formation and developmental mechanisms
Anderson, K. V., & Beddington, R. S. P. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80070-6 · Cited by 5
Understanding and manipulating extracellular behaviors of Wnt ligands
Mii, Y. (2024) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-024-00856-9 · Cited by 4
“1996; Wang et al .”
Nanista, E. M., Poythress, L. E., Skipper, I. R., Haskins, T., Cora, M. F., & Rozario, T. (2025) · Development · doi:10.1242/dev.204781 · Cited by 5
“Since SFRP can inhibit Wnt signaling (Leyns et al., 1997; Rattner et al., 1997; Wang et al., 1997), we pursued its potential role in regeneration.”
Cell‐autonomous signal transduction in the Xenopus egg Wnt/β‐catenin pathway
Motomura, E., Narita, T., Nasu, Y., Kato, H., Sedohara, A., Nishimatsu, S., & Sakai, M. (2014) · Development Growth & Differentiation · doi:10.1111/dgd.12181 · Cited by 4
“Co-injection of Frzb mRNA and Wnt8 or Wnt8-KDEL mRNA displayed distinct distributions We co-injected Frzb mRNA, which is an inhibitor of Wnt8 (Leyns et al. 1997; Wang et al. 1997) and examined whether Frzb changes the distribution of Wnt8HA, using our methanol method (Fig.”
MethodOverview of the FDA Regulatory Process
Lee, M. H., Whittlesey, K. J., Dang, J. M., Colehour, M. B., Arcidiacono, J. A., Lazarus, E. F., Kaplan, D. S., Fink, D. W., Durfor, C. N., Batra, A., et al. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-385942-6.00083-4 · Cited by 4
Zhang, J., Xu, M., Chen, T., & Zhou, Y. (2022) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd9100353 · Cited by 4
Insights into the Wnt Signaling Pathway Evolution
Rismani, E., Haghighi-Najafabadi, N., Far, B. E., Shahbazi, B., & Mafakher, L. (2022) · Physiology · doi:10.5772/intechopen.108012 · Cited by 4
Weihe, U., Milán, M., & Cohen, S. M. (2005) · Elsevier eBooks · doi:10.1016/b0-44-451924-6/00017-x · Cited by 4
Paradigm shifts in neural induction / Changements de paradigme dans l'induction neurale
Gilbert, S. F. (2000) · Revue d histoire des sciences · doi:10.3406/rhs.2000.2098 · Cited by 4
Secreted Wnt Inhibitors or Modulators
Bovolenta, P., Gorny, A., Esteve, P., & Steinbeißer, H. (2014) · Wiley eBooks · doi:10.1002/9781118444122.ch13 · Cited by 4
Transcriptional regulation of the promoter of the rat frizzled related protein gene by CREB
Yam, J. W. P., Chan, K. W., & Hsiao, W. L. W. (2003) · Oncogene · doi:10.1038/sj.onc.1206489 · Cited by 4
“…WL Wendy Hsiao; E-mail: bowhsiao@ust.hk Oncogene (2003) 22, 3901–3910 & 2003 Nature Publishing Group All rights reserved 0950-9232/03 $25.00 www.nature.com/onc Rattner et al., 1997; Wang et al., 1997; Wolf et al., 1997; Zhou et al., 1998; Chang et al., 1999; Yam et al., 1999; Katoh, 2001).”
BackgroundInfluentialWnt Signals and Antagonists: The Molecular Nature of Spemann’s Head Organizer
Niehrs, C. (2004) · Springer eBooks · doi:10.1007/978-3-662-10416-3_9 · Cited by 4
Mayfield, J. E., Rajic, A. J., Aguilar‐Calvo, P., Soldau, K., Flores, S., Lawrence, R., Choudhury, B., Ghassemian, M., Pizzo, D. P., Wagner, S. L., et al. (2025) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlaf018 · Cited by 5
“41,49 Ontological analysis of differentially abundant proteins revealed that top ranked biological process ontologies (by P - value) included wound healing and blood coagulation, consistent with CAA-associated vascular lesions.”
Evolutionary and Structural Assessment of the Human Secreted Frizzled-Related Protein (SFRP) Family
Mafakher, L., Rismani, E., & Teimoori‐Toolabi, L. (2025) · Journal of Molecular Evolution · doi:10.1007/s00239-025-10249-5 · Cited by 3
“Numerous studies have demonstrated that the NTR domain of SFRPs forms a strong attachment with the heparin, thereby regulating Wnt binding (Finch et al. 1997; Leyns et al. 1997; Üren et al. 2000; Wang et al. 1997; Zhong et al. 2007).”
Chromatin deactivation in pregranulosa cells contributes to primordial follicle formation
Wang, X., Qiu, X., Ma, Y., Guo, X., Wei, J., Wang, F., Wang, H., & Zhu, G. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110598 · Cited by 3
“5, 0.5 days after hatching; D4, 4 days after hatching; H3K27ac, acetylation of lysine 27 on histone H3; IGV, Integrative Genomics Viewer; qPCR, quantitative PCR. FAM65B (17), and FRZB (18), encode membrane-associated proteins implicated in blocking cell–cell communications.”
InfluentialSmall Peptide Derived from SFRP5 Suppresses Melanogenesis by Inhibiting Wnt Activity
Choi, Y.-S., Hong, J.-G., Lim, D., Kim, M., Park, S., Kang, H.-C., Seo, W.-S., & Lee, J. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46060324 · Cited by 3
“The founding member Frzb was initially identified through its sequence similarity with the Fz receptors [24,25], and immediately associated with Wnt signaling because of its ability to bind to Wnt8 and block its signaling in Xenopus, strongly supporting its role as a Wnt antagonist [25,26].”
BackgroundBouldin, C. M., & Kimelman, D. (2012) · Cell Research · doi:10.1038/cr.2012.104 · Cited by 3
Heparan Sulfate Clusters Regulate Distribution and Signaling of Wnt Morphogens
Mii, Y. (2020) · Trends in Glycoscience and Glycotechnology · doi:10.4052/tigg.2006.7e · Cited by 3
Davidson, G. R., & Niehrs, C. (2014) · Wiley eBooks · doi:10.1002/9781118444122.ch2 · Cited by 3
Apoptosis in the overloaded myocardium: potential stimuli and modifying signals
Schumann, H., Heinrich, H., Bartling, B., Darmer, D., & Holtz, J. (2000) · Steinkopff eBooks · doi:10.1007/978-3-642-57724-6_4 · Cited by 3
Molecular mechanisms of ectodermal dysplasia syndromes
Laurikkala, J. (2004) · Työväentutkimus Vuosikirja · Cited by 3
Transmembrane protein 150b attenuates BMP signaling in the Xenopus organizer
Keum, B., Yeo, I., Koo, Y., Han, W., Choi, S., Kim, G., & Han, J. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.31059 · Cited by 2
Identification of potential biomarkers for hypertension based on transcriptomic analysis in rats
Gu, W., Liu, J., Liu, Y., & Wang, Z. (2025) · Hypertension Research · doi:10.1038/s41440-025-02200-4 · Cited by 2
Early Head Specification in Xenopus laevis
Lake, B. B., & Kao, K. R. (2003) · The Scientific World JOURNAL · doi:10.1100/tsw.2003.54 · Cited by 2
“Nodals, Wnts, and ADMP in the trunk organizer may inhibit head marker expression and promote trunk development while the head organizer secretes anti-Wnts (Cerberus, Dkk-1, Frzb-1, WIF-1, sFRP-1,2) and anti-nodal (Cerberus) to inhibit trunk while promoting head development[47].”
BackgroundInfluentialAxis Formation and Its Evolution in Ray-Finned Fish
Hibi, M., Takeuchi, M., Hashimoto, H., & Shimizu, T. (2018) · Diversity and commonality in animals · doi:10.1007/978-4-431-56609-0_32 · Cited by 2
Adipokines, Inflammation, and Insulin Resistance in Obesity
Kwon, H., & Pessin, J. E. (2018) · Springer eBooks · doi:10.1007/978-3-319-89506-2_9 · Cited by 3
Overview of the US Food and Drug Administration Regulatory Process
Yong, C., Kaplan, D. S., Gray, A., Ricles, L. M., Kwilas, A. R., Brubaker, S. A., Arcidiacono, J. A., Xu, L., Chang, C., Robinson, R., et al. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809880-6.00077-1 · Cited by 2
Towards the Unification of Quantum Dynamics, Relativity and Living OrganismsPreprint
Tozzi, A., Peters, J. F., & Torday, J. S. (2018) · Preprints.org · doi:10.20944/preprints201809.0570.v1 · Cited by 2
“…the history of the organism through cell-cell interactions (Torday, 2014), embryonic differentiation being due to the effects of soluble growth factors on pattern formation, target cells ‘observing’ the secretions of their neighboring cells of differing germ line origins (Wang et al, 1997).”
BackgroundFenner, J. L., Wang, B., Ka, C., Gautam, S., & Range, R. (2025) · Journal of Developmental Biology · doi:10.3390/jdb13040036 · Cited by 1
Gan, Q., Li, W., Lex, R. K., Ying, Z., & Beronja, S. (2026) · Science · doi:10.1126/science.aed3065 · Cited by 1
Maternal mRNAs and the Making of Cell Lineages in the Early Xenopus Embryo
Houston, D. W. (2022) · CRC Press eBooks · doi:10.1201/9781003050230-4 · Cited by 1
Characterization of a novel corticosterone response gene in Xenopus tropicalis tadpole tails
Paul, B., Dockery, R., Valverde, V. M., & Buchholz, D. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1121002 · Cited by 1
“In embryos, frzb is expressed in the anterior endoderm or in the prechordal mesoderm and plays a crucial role in anteroposterior patterning in Xenopus laevis by binding and inactivating Xwnt-8 during gastrulation (39).”
BackgroundSelf-organization from organs to embryoids by activin in early amphibian development
Asashima, M., Satou-Kobayashi, Y., Haramoto, Y., & Ariizumi, T. (2025) · Cells and Development · doi:10.1016/j.cdev.2025.203996 · Cited by 1
Recent Advances in Homeostasis
Zaman, G. S. (2022) · Physiology · doi:10.5772/intechopen.100954 · Cited by 1
Development of Neural Tissues inXenopus laevis
Muñoz, W. A., Sater, A. K., & McCrea, P. D. (2014) · Wiley eBooks · doi:10.1002/9781118492833.ch13 · Cited by 1
Function of the CHD4/Mi-2ß chromatin remodelling ATPase during neural development of Xenopus laevis
Nieberler, M. (2012) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.13954 · Cited by 1
The Wnt Signal Transduction Pathway
Barish, G. D., & Williams, B. O. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-218-0_4 · Cited by 1
Pattern formation and developmental mechanisms
Makałowska, I., Makałowski, W., & Wolfsberg, T. G. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00204-5 · Cited by 1
Åberg, T. (2006) · Työväentutkimus Vuosikirja · Cited by 1
Identification and functional characterization of PTK7 ligands in Xenopus laevis
Peradziryi, H. (2011) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3158 · Cited by 1
Dorsal activity of maternal squint is mediated by a non-coding function of the RNA
Lim, S. M. (2013) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/58582 · Cited by 1
Ontogeny of Skeletal Muscle Cells
Cossu, G. (2002) · Springer eBooks · doi:10.1007/978-88-470-2097-9_6
Musculature and Growth Factors
Neuhaus, P., Neuhaus, H., & Braun, T. W. (2005) · doi:10.1002/9783527619689.ch17
Matsuda, Y. (2009) · edoc (University of Basel) · doi:10.5451/unibas-004811226
Short-Versus Long-Range Effects of Spemann’s Organizer
Blitz, I. L., & Cho, K. W. Y. (2004) · Springer eBooks · doi:10.1007/978-3-662-10416-3_2
A Novel Gene in the Armadillo Family Interacts with Presenilin 1
Kosik, K. S., Ho, C., Liyange, U., Lemere, C. A., Medina, M., & Zhou, J. (1998) · Elsevier eBooks · doi:10.1016/b978-012734610-6/50013-0
Wnts in development : Focus on midbrain
Andersson, E. R. (2009) · Figshare
Down-regulation of Wnt antagonist, SFRP1 in colorectal tumorigenesis
Xin, Z., Sun, L., Zhan, Z., Sun, B., & Yang, Y. (2008) · Chinese Journal of Clinical Oncology · doi:10.1007/s11805-008-0035-1
McCutcheon, L. J. G. (2009) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)
NEW EMBO MEMBER’S REVIEW Wnt signaling and the activation of myogenesis in mammals
Cossu, G., & Borello, U. (2016)
Early Development and Neoplasia
Carraway, K. L., Carraway, C. A. C., & Carraway, K. L. (1998) · Springer eBooks · doi:10.1007/978-3-662-12993-7_7
Review Role of WNT signaling in normal and malignant hematopoiesis
Bendall, L. J. (2006)
Xmc, a novel Xenopus laevis organiser : gene regulating gastrulation movements.
Frazzetto, G. (2002) · OpenGrey (Institut de l'Information Scientifique et Technique)
Johnson, M. L., & Recker, R. R. (2008) · Elsevier eBooks · doi:10.1016/b978-012370544-0.50019-7
Wnt/Frizzled receptor signaling in osteoporosis
Rawadi, G. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511760334.019
Wardle, F. C., & Sive, H. L. (2004) · Springer eBooks · doi:10.1007/978-3-662-10416-3_20
The role of CD44 in Wnt/β-catenin signaling
Schmitt, M. (2014) · Repository KITopen (Karlsruhe Institute of Technology) · doi:10.5445/ir/1000043638
“…proteins of the Wnt inhibitory factor (WIF) family, which compete with transmembrane Wnt-receptors for ligand binding and therefore act as Wnt 9 inhibitors (Bafico et al., 1999; Dennis et al., 1999; Hsieh et al., 1999; Leyns et al., 1997; Salic et al., 1997; Uren et al., 2000; Wang et al., 1997).”
BackgroundIntegrating regulatory mechanisms of Wnt signaling in development and tissue homeostasis
Hall, E. T. (2017) · Summit (Simon Fraser University)
Kiecker, C. M. (2005) · Wiley eBooks · doi:10.1002/9783527619689.ch5
Hoffman, J. M., & Pothoulakis, C. (2017) · Wiley-VCH eBooks · doi:10.1002/9783527692156.ch18
Kennison, J. A. (2002) · Encyclopedia of Molecular Biology · doi:10.1002/047120918x.emb1054
Wnt Signaling in Tissue Differentiation and Morphogenesis
Hoppler, S., & Kühl, M. (2022) · CRC Press eBooks · doi:10.1201/9781003050230-7 · Cited by 1
Heparan Sulfate Clusters Regulate Distribution and Signaling of Wnt Morphogens
Mii, Y. (2020) · Trends in Glycoscience and Glycotechnology · doi:10.4052/tigg.2006.7j
Johnson, M. L., & Recker, R. R. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-375098-3.50018-4
Metadata
- Authors
- Wang, S., Krinks, M., Lin, K., Luyten, F. P., & Moos, M.
- Affiliations
- United States Food and Drug Administration (US)
- Center for Biologics Evaluation and Research (US)
- National Institutes of Health (US)
- Corresponding author
- Moos, Malcolm
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-03
- Volume
- 88
- Issue
- 6
- Pages
- 757-766
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1988350691
- Cited by
- 518
- References
- 70
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 6 · 2020: 12 · 2019: 3 · 2018: 13 · 2017: 17 · 2016: 6 · 2015: 12 · 2014: 15 · 2013: 9 · 2012: 14
- FWCI
- 17.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- George Washington University
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Oncology › Renal and related cancers
- Keywords
- FRZB, Spemann organizer, dorsalization, ventralization, gastrulation, axial patterning, MyoD, Wnt signaling inhibition, secreted proteins, Xenopus embryo
- MeSH terms
- Frizzled-Related Proteins, Animals, Biological Transport, Cell Communication, Dogs, Embryonic Induction, Female, Glycoproteins, Male, Mesoderm, Microsomes, Protein Binding, Proteins, Rabbits, RNA, Messenger, Solubility, Transcription, Genetic, Xenopus, Zygote, MyoD Protein, Gene Expression Regulation, Developmental, COS Cells, Zebrafish Proteins, Intracellular Signaling Peptides and Proteins, Wnt Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
