Cited by 139Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene RegulationT-cell and B-cell Immunology

WNT Signaling and Lymphocyte Development

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van de Wetering, Marc, de Lau, Wim, Clevers, Hans·2002·Cell

Abstract

Developmental studies in model organisms have revealed that cell fate decisions are governed by only a handful of highly conserved signal transduction cascades. Recent data indicate that at least two of these, the Wnt and the Notch cascades, have been recruited by the vertebrate immune system to control early lymphopoiesis.

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Crossref · 10.1016/s0092-8674(02)00709-2

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66 of 66 references verified0 citation errors · 0 not checkable

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  • The Wnt signalling pathway is an important regulator in all developmental stages of T-cells.

    “Furthermore, with regard to T-cell development, the Wnt signalling pathway has been described as an important regulator in all developmental stages of T-cells [42,43,44].”

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Authors
van de Wetering, M., de Lau, W., & Clevers, H.
Affiliations
University Medical Center Utrecht (NL)
Corresponding author
Clevers, Hans
Venue
Cell
Publisher
Elsevier BV
Published
2002-04
Volume
109
Issue
2
Pages
S13-S19
ISSN
0092-8674 (ISSN-L)
OpenAlex
W1987938190
Cited by
139
References
66
Citations by year
2026: 2 · 2025: 5 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 8
FWCI
1.36
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
Wnt signaling, lymphocyte development, Notch signaling, signaling pathways, cell fate determination, vertebrate immune system
MeSH terms
Animals, Cell Differentiation, DNA-Binding Proteins, Humans, Lymphocytes, Proto-Oncogene Proteins, Thymus Gland, Transcription Factors, Signal Transduction, Mice, Knockout, Cell Lineage, Zebrafish Proteins, Wnt Proteins, Mice, Lymphoid Enhancer-Binding Factor 1

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