Age‐related alterations of gene expression patterns in human CD8+ T cells
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Summary: Aging is associated with progressive T‐cell deficiency and increased incidence of infections, cancer and autoimmunity. In this comprehensive study, we have compared the gene expression profiles in CD8+ T cells from aged and young healthy subjects using Affymetrix microarray Human Genome U133A‐2 GeneChips. A total of 5.2% (754) of the genes analyzed had known functions and displayed statistically significant age‐associated expression changes. These genes were involved in a broad array of complex biological processes, mainly in nucleic acid and protein metabolism. Functional groups, in which down‐regulated genes were overrepresented, were the following: RNA transcription regulation, RNA and DNA metabolism, intracellular (Golgi, endoplasmic reticulum and nuclear) transportation, signaling transduction pathways (T‐cell receptor, Ras/MAPK, JNK/Stat, PI3/AKT, Wnt, TGFβ, insulin‐like growth factor and insulin), and the ubiquitin cycle. In contrast, the following functional groups contained more up‐regulated genes than expected: response to oxidative stress and cytokines, apoptosis, and the MAPKK signaling cascade. These age‐associated gene expression changes may be responsible for impaired DNA replication, RNA transcription, and signal transduction, possibly resulting in instability of cellular and genomic integrity, and alterations of growth, differentiation, apoptosis and anergy in human aged CD8+ T cells.
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Changes in CD8+ T cell transcriptomes are largely due to increased frequencies of effector CD8+ T cells.
“Changes in CD8+ T cell transcriptomes are largely due to increased frequencies of effector CD8+ T cells”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Cao et al., 2010
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Immune Modulation and Its Role in Antiaging
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- Authors
- Cao, J., Gollapudi, S., Sharman, E. H., Jia, Z., & Gupta, S.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Gupta, Sudhir
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2010-01-11
- Volume
- 9
- Issue
- 1
- Pages
- 19-31
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- OpenAlex
- W1995871497
- Cited by
- 71
- References
- 71
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 8 · 2016: 8 · 2015: 6 · 2014: 4 · 2013: 6 · 2012: 3
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Aging Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- CD8+ T cells, aging, gene expression profiling, T cell anergy, T cell receptor signaling, MAPK signaling, PI3K/Akt signaling, Wnt signaling, TGF-beta signaling, oxidative stress response, apoptosis, DNA replication, genomic instability, immunosenescence
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Female, Humans, Male, Signal Transduction, Gene Expression, CD8-Positive T-Lymphocytes, Oligonucleotide Array Sequence Analysis, Young Adult
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