CoChat
Sign Up
Cited by 119

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Boca, an Endoplasmic Reticulum Protein Required for Wingless Signaling and Trafficking of LDL Receptor Family Members in Drosophila

Culi, Joaquim, Mann, Richard S.·2003·Cell
DOI 10.1016/s0092-8674(02)01279-5
Open this paper in CoChat — free account

Abstract

The maturation of cell surface receptors through the secretory pathway often requires chaperones that aid in protein folding and trafficking from one organelle to another. Here we describe boca, an evolutionarily conserved gene in Drosophila melanogaster, which encodes an endoplasmic reticulum protein that is specifically required for the intracellular trafficking of members of the low-density lipoprotein family of receptors (LDLRs). Two LDLRs in flies, Arrow, which is required for Wingless signal transduction, and Yolkless, which is required for yolk protein uptake during oogenesis, both require boca function. Consequently, boca is an essential component of the Wingless pathway but is more generally required for the activities of multiple LDL receptor family members.

Overview

Integrity signals

Registry

Crossref · 10.1016/s0092-8674(02)01279-5

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 56

  1. Adams, 2000, The genome sequence of Drosophila melanogaster, Science, 287, 2185, 10.1126/science.287.5461.2185 · DOI
  2. Baker, 1988, Transcription of the segment-polarity gene wingless in the imaginal discs of Drosophila, and the phenotype of a pupal-lethal wg mutation, Development, 102, 489, 10.1242/dev.102.3.489 · DOI
  3. Baker, 1994, The cyclophilin homolog NinaA functions as a chaperone, forming a stable complex in vivo with its protein target rhodopsin, EMBO J., 13, 4886, 10.1002/j.1460-2075.1994.tb06816.x · DOI
  4. Bhanot, 1999, Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development, Development, 126, 4175, 10.1242/dev.126.18.4175 · DOI
  5. Bhat, 1998, frizzled and frizzled 2 play a partially redundant role in wingless signaling and have similar requirements to wingless in neurogenesis, Cell, 95, 1027, 10.1016/S0092-8674(00)81726-2 · DOI
  6. Brand, 1993, Targeted gene expression as a means of altering cell fates and generating dominant phenotypes, Development, 118, 401, 10.1242/dev.118.2.401 · DOI
  7. Brunner, 1997, Pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila, Nature, 385, 829, 10.1038/385829a0 · DOI · Paper page
  8. Bu, 2001, The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family, Int. Rev. Cytol., 209, 79, 10.1016/S0074-7696(01)09011-8 · DOI
  9. Casares, 1998, Control of antennal versus leg development in Drosophila, Nature, 392, 723, 10.1038/33706 · DOI
  10. Chen, 1999, Wingless transduction by the frizzled and frizzled2 proteins of Drosophila, Development, 126, 5441, 10.1242/dev.126.23.5441 · DOI
  11. Cheon, 2001, Molecular characterization of the VLDL receptor homolog mediating binding of lipophorin in oocyte of the mosquito Aedes aegypti, Insect Biochem. Mol. Biol., 31, 753, 10.1016/S0965-1748(01)00068-6 · DOI
  12. Chou, 1996, The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster, Genetics, 144, 1673, 10.1093/genetics/144.4.1673 · DOI
  13. Chou, 1993, Autosomal P[ovoD1] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras, Development, 119, 1359, 10.1242/dev.119.4.1359 · DOI
  14. Ciccarese, 2000, A new locus for autosomal recessive hypercholesterolemia maps to human chromosome 15q25-q26, Am. J. Hum. Genet., 66, 453, 10.1086/302753 · DOI
  15. Clemens, 2000, Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways, Proc. Natl. Acad. Sci. USA, 97, 6499, 10.1073/pnas.110149597 · DOI · Paper page
  16. Couso, 1994, The wingless signalling pathway and the patterning of the wing margin in Drosophila, Development, 120, 621, 10.1242/dev.120.3.621 · DOI
  17. Dantuma, 1999, An insect homolog of the vertebrate very low density lipoprotein receptor mediates endocytosis of lipophorins, J. Lipid Res., 40, 973, 10.1016/S0022-2275(20)32134-9 · DOI
  18. Deak, 1978, Thoracic duplications in the mutant wingless of Drosophila and their effect on muscles and nerves, Dev. Biol., 66, 422, 10.1016/0012-1606(78)90249-X · DOI
  19. Ellgaard, 1999, Setting the standards, Science, 286, 1882, 10.1126/science.286.5446.1882 · DOI
  20. Fortini, 2002, Signalling, Nat. Rev. Mol. Cell Biol., 3, 673, 10.1038/nrm910 · DOI
  21. Garcia, 2001, Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein, Science, 292, 1394, 10.1126/science.1060458 · DOI · Paper page
  22. Grandea, 2001, Tapasin, Trends Immunol., 22, 194, 10.1016/S1471-4906(01)01861-0 · DOI
  23. Heitzler, 1993, Genetic and cytogenetic analysis of the 43A-E region containing the segment polarity gene costa and the cellular polarity genes prickle and spiny-legs in Drosophila melanogaster, Genetics, 135, 105, 10.1093/genetics/135.1.105 · DOI
  24. Holdener, 1994, msd is required for mesoderm induction in mice, Development, 120, 1335, 10.1242/dev.120.5.1335 · DOI
  25. Howell, 2001, The LDL receptor gene family, Curr. Opin. Neurobiol., 11, 74, 10.1016/S0959-4388(00)00176-8 · DOI
  26. Kim, 1996, Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene, Nature, 382, 133, 10.1038/382133a0 · DOI
  27. Konsolaki, 1998, windbeutel, a gene required for dorsoventral patterning in Drosophila, encodes a protein that has homologies to vertebrate proteins of the endoplasmic reticulum, Genes Dev., 12, 120, 10.1101/gad.12.1.120 · DOI
  28. Kramps, 2002, Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear β-catenin-TCF complex, Cell, 109, 47, 10.1016/S0092-8674(02)00679-7 · DOI
  29. Lecuit, 1997, Proximal-distal axis formation in the Drosophila leg, Nature, 388, 139, 10.1038/40563 · DOI
  30. Lee, 1999, Mosaic analysis with a repressible neurotechnique cell marker for studies of gene function in neuronal morphogenesis, Neuron, 22, 451, 10.1016/S0896-6273(00)80701-1 · DOI
  31. Lee, 2001, Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila, Cell, 107, 161, 10.1016/S0092-8674(01)00526-8 · DOI
  32. Milanesi, 1999, GeneBuilder, Bioinformatics, 15, 612, 10.1093/bioinformatics/15.7.612 · DOI
  33. Neumann, 1997, Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing, Development, 124, 871, 10.1242/dev.124.4.871 · DOI
  34. Nielsen, 1997, Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites, Protein Eng., 10, 1, 10.1093/protein/10.1.1 · DOI
  35. Nusslein-Volhard, 1980, Mutations affecting segment number and polarity in Drosophila, Nature, 287, 795, 10.1038/287795a0 · DOI
  36. Ostrom, 2002, New determinants of receptor-effector coupling, Mol. Pharmacol., 61, 473, 10.1124/mol.61.3.473 · DOI
  37. Panganiban, 1995, The development of crustacean limbs and the evolution of arthropods, Science, 270, 1363, 10.1126/science.270.5240.1363 · DOI
  38. Peifer, 1991, The segment polarity gene armadillo interacts with the wingless signaling pathway in both embryonic and adult pattern formation, Development, 111, 1029, 10.1242/dev.111.4.1029 · DOI
  39. Pelham, 1990, The retention signal for soluble proteins of the endoplasmic reticulum, Trends Biochem. Sci., 15, 483, 10.1016/0968-0004(90)90303-S · DOI
  40. Phillips, 1993, wingless expression mediates determination of peripheral nervous system elements in late stages of Drosophila wing disc development, Development, 118, 427, 10.1242/dev.118.2.427 · DOI
  41. Pinson, 2000, An LDL-receptor-related protein mediates Wnt signalling in mice, Nature, 407, 535, 10.1038/35035124 · DOI
  42. Rorth, 1998, Gal4 in the Drosophila female germline, Mech. Dev., 78, 113, 10.1016/S0925-4773(98)00157-9 · DOI
  43. Rulifson, 1996, wingless refines its own expression domain on the Drosophila wing margin, Nature, 384, 72, 10.1038/384072a0 · DOI
  44. Schonbaum, 1995, The Drosophila yolkless gene encodes a vitellogenin receptor belonging to the low density lipoprotein receptor superfamily, Proc. Natl. Acad. Sci. USA, 92, 1485, 10.1073/pnas.92.5.1485 · DOI
  45. Schonbaum, 2000, Regulation of the vitellogenin receptor during Drosophila melanogaster oogenesis, Mol. Biol. Cell, 11, 511, 10.1091/mbc.11.2.511 · DOI
  46. Sen, 2000, Windbeutel is required for function and correct subcellular localization of the Drosophila patterning protein Pipe, Development, 127, 5541, 10.1242/dev.127.24.5541 · DOI
  47. Shulman, 1998, Frizzled signaling and the developmental control of cell polarity, Trends Genet., 14, 452, 10.1016/S0168-9525(98)01584-4 · DOI
  48. Sorkin, 2002, Signal transduction and endocytosis, Nat. Rev. Mol. Cell Biol., 3, 600, 10.1038/nrm883 · DOI
  49. Tamai, 2000, LDL-receptor-related proteins in Wnt signal transduction, Nature, 407, 530, 10.1038/35035117 · DOI · Paper page
  50. Thompson, 1994, Clustal w, Nucleic Acids Res., 22, 4673, 10.1093/nar/22.22.4673 · DOI · Paper page
  51. Van Uden, 1999, A novel role for receptor-associated protein in somatostatin modulation, Neuroscience, 88, 687, 10.1016/S0306-4522(98)00272-3 · DOI
  52. Wehrli, 2000, Arrow encodes an LDL-receptor-related protein essential for Wingless signalling, Nature, 407, 527, 10.1038/35035110 · DOI
  53. Williams, 1991, Control of Drosophila wing and haltere development by the nuclear vestigial gene product, Genes Dev., 5, 2481, 10.1101/gad.5.12b.2481 · DOI
  54. Willnow, 1995, Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo, Proc. Natl. Acad. Sci. USA, 92, 4537, 10.1073/pnas.92.10.4537 · DOI · Paper page
  55. Wines, 2001, Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis, Genomics, 72, 88, 10.1006/geno.2000.6466 · DOI
  56. Zecca, 1996, Direct and long range action of a Wingless morphogen gradient, Cell, 87, 833, 10.1016/S0092-8674(00)81991-1 · DOI

Cited by

Sorted by citations

Metadata

Authors
Culi, J., & Mann, R. S.
Venue
Cell
Publisher
Elsevier BV
Published
2003-02
Volume
112
Issue
3
Pages
343-354
ISSN
0092-8674
DOI
10.1016/s0092-8674(02)01279-5
Cited by
119
References
2
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review