Genome-wide Association of Yorkie with Chromatin and Chromatin-Remodeling Complexes
Open accessAbstract
The Hippo pathway regulates growth through the transcriptional coactivator Yorkie, but how Yorkie promotes transcription remains poorly understood. We address this by characterizing Yorkie's association with chromatin and by identifying nuclear partners that effect transcriptional activation. Coimmunoprecipitation and mass spectrometry identify GAGA factor (GAF), the Brahma complex, and the Mediator complex as Yorkie-associated nuclear protein complexes. All three are required for Yorkie's transcriptional activation of downstream genes, and GAF and the Brahma complex subunit Moira interact directly with Yorkie. Genome-wide chromatin-binding experiments identify thousands of Yorkie sites, most of which are associated with elevated transcription, based on genome-wide analysis of messenger RNA and histone H3K4Me3 modification. Chromatin binding also supports extensive functional overlap between Yorkie and GAF. Our studies suggest a widespread role for Yorkie as a regulator of transcription and identify recruitment of the chromatin-modifying GAF protein and BRM complex as a molecular mechanism for transcriptional activation by Yorkie.
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Drosophila Yki regulates transcription by binding to promoter regions of genes.
“Like YAP, Drosophila Yki is known to regulate transcription by binding to promoter regions of genes (76).”
From A Tumour-Specific Molecular Network Promotes Tumour Growth in <i>Drosophila</i> by Enforcing a JNK-YKI Feedforward Loop (2023) · cites this paper as [76]
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- Authors
- Oh, H., Slattery, M., Ma, L., Crofts, A., White, K. P., Mann, R. S., & Irvine, K. D.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- University of Chicago (US)
- Columbia University (US)
- Corresponding author
- Irvine, Kenneth D.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 3
- Issue
- 2
- Pages
- 309-318
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC3633442
- OpenAlex
- W2090698584
- Cited by
- 145
- References
- 48
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 10 · 2023: 7 · 2022: 5 · 2021: 12 · 2020: 11 · 2019: 15 · 2018: 9 · 2017: 9 · 2016: 12 · 2015: 12 · 2014: 17 · 2013: 11
- FWCI
- 10.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Howard Hughes Medical Institute
- National Human Genome Research Institute (U01HG004264)
- National Institute of General Medical Sciences (R01GM058575, P50GM081892, R01GM054510, GM078620, R01GM078620)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- Yorkie, Hippo signaling pathway, transcriptional activation, GAGA factor, Moira, Mediator complex, chromatin remodeling, chromatin binding, histone H3K4me3, transcriptional coactivator, growth regulation
- MeSH terms
- YAP-Signaling Proteins, Animals, Chromatin, DNA-Binding Proteins, Drosophila, Histones, Nuclear Proteins, Protein Binding, RNA, Messenger, Transcription Factors, Wings, Animal, Transcriptional Activation, Trans-Activators, Genome, Cell Cycle Proteins, Drosophila Proteins, RNA Interference, RNA, Small Interfering, Chromatin Assembly and Disassembly, Mediator Complex
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