The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.
Mesd Encodes an LRP5/6 Chaperone Essential for Specification of Mouse Embryonic Polarity
Open accessAbstract
Specification of embryonic polarity and pattern formation in multicellular organisms requires inductive signals from neighboring cells. One approach toward understanding these interactions is to study mutations that disrupt development. Here, we demonstrate that mesd, a gene identified in the mesoderm development (mesd) deletion interval on mouse chromosome 7, is essential for specification of embryonic polarity and mesoderm induction. MESD functions in the endoplasmic reticulum as a specific chaperone for LRP5 and LRP6, which in conjunction with Frizzled, are coreceptors for canonical WNT signal transduction. Disruption of embryonic polarity and mesoderm differentiation in mesd-deficient embryos likely results from a primary defect in WNT signaling. However, phenotypic differences between mesd-deficient and wnt3(-)(/)(-) embryos suggest that MESD may function on related members of the low-density lipoprotein receptor (LDLR) family, whose members mediate diverse cellular processes ranging from cargo transport to signaling.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“More recently, two groups have identified a novel specialized chaperone for members of the LDLR family, termed Mesd (mesoderm development) in mouse (Hsieh et al., 2003) and Boca in Drosophila (Culi and Mann, 2003).”
From Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding (2005) · cites this paper as Hsieh et al., 2003
In the citing paper
“LDLR family members also have a specific requirement for the molecular ER chaperone boca (Drosophila melanogaster), and its mammlian orthologue Mesd, for folding and trafficking to the cell surface.50−52”
Citations
Cites
Site-directed mutagenesis by overlap extension using the polymerase chain reaction
Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., & Pease, L. R. (1989) · Gene · doi:10.1016/0378-1119(89)90358-2 · Cited by 7,354
Predicting subcellular localization of proteins based on their N-terminal amino acid sequence.
Emanuelsson, O., Nielsen, H., Brunak, S., & von Heijne, G. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3903 · Cited by 4,419
Nakai, K., & Horton, P. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01336-x · Cited by 2,181
A C-terminal signal prevents secretion of luminal ER proteins
Munro, S., & Pelham, H. R. B. (1987) · Cell · doi:10.1016/0092-8674(87)90086-9 · Cited by 1,721
An LDL-receptor-related protein mediates Wnt signalling in mice
Pinson, K. I., Brennan, J., Monkley, S. J., Avery, B. J., & Skarnes, W. C. (2000) · Nature · doi:10.1038/35035124 · Cited by 1,086
Molecular genetics of the LDL receptor gene in familial hypercholesterolemia
Hobbs, H. H., Brown, M. S., & Goldstein, J. L. (1992) · Human Mutation · doi:10.1002/humu.1380010602 · Cited by 921
Requirement for Wnt3 in vertebrate axis formation
Liu, P., Wakamiya, M., Shea, M. J., Albrecht, U., Behringer, R. R., & Bradley, A. (1999) · Nature Genetics · doi:10.1038/11932 · Cited by 900
Conlon, F. L., Lyons, K. M., Takaesu, N. T., Barth, K. S., Kispert, A., Herrmann, B. G., & Robertson, E. J. (1994) · Development · doi:10.1242/dev.120.7.1919 · Cited by 772
Axis Development and Early Asymmetry in Mammals
Beddington, R. S. P., & Robertson, E. J. (1999) · Cell · doi:10.1016/s0092-8674(00)80560-7 · Cited by 746
Mouse gastrulation: the formation of a mammalian body plan
Tam, P., & Behringer, R. R. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00123-8 · Cited by 594
Research works printed but not linked: 1
- Hogan, B., Beddington, R., Costantini, F., and Lacy, E. (1994). Manipulating the Mouse Embryo: A Laboratory Manual, Volume 1, Second Edition (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press).
Cited by
Sorted by citations
Wnt/β-Catenin Signaling in Development and Disease
Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568
The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325
Wnt signalling and its impact on development and cancer
Klaus, A., & Birchmeier, W. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2389 · Cited by 1,595
LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
He, X., Semenov, M., Tamai, K., & Zeng, X. (2004) · Development · doi:10.1242/dev.01117 · Cited by 1,044
Bänziger, C., Soldini, D., Schütt, C., Zipperlen, P., Hausmann, G., & Basler, K. (2006) · Cell · doi:10.1016/j.cell.2006.02.049 · Cited by 764
Protein Folding and Modification in the Mammalian Endoplasmic Reticulum
Braakman, I., & Bulleid, N. J. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062209-093836 · Cited by 722
Frizzled and LRP5/6 Receptors for Wnt/ -Catenin SignalingPreprint
MacDonald, B. T., & He, X. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007880 · Cited by 640
A Mechanism for Wnt Coreceptor Activation
Tamai, K., Zeng, X., Liu, C., Zhang, X., Harada, Y., Chang, Z., & He, X. (2004) · Molecular Cell · doi:10.1016/s1097-2765(03)00484-2 · Cited by 490
STRUCTURE AND PHYSIOLOGIC FUNCTION OF THE LOW-DENSITY LIPOPROTEIN RECEPTOR
Jeon, H., & Blacklow, S. C. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133354 · Cited by 310
Cong, F., Schweizer, L., & Varmus, H. (2004) · Development · doi:10.1242/dev.01318 · Cited by 317
Decreased BMD and Limb Deformities in Mice Carrying Mutations in Both Lrp5 and Lrp6
Holmen, S. L., Giambernardi, T. A., Diegel, C. R., Buckner-Berghuis, B. D., Resau, J. H., Hess, J. F., Glatt, V., Bouxsein, M., Ai, M., Warman, M. L., et al. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040907 · Cited by 344
Neurogenesis and Alzheimer's disease: At the crossroads
Lazarov, O., & Marr, R. A. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.08.009 · Cited by 340
Nusse, R. (2003) · Development · doi:10.1242/dev.00821 · Cited by 334
Caveolin Is Necessary for Wnt-3a-Dependent Internalization of LRP6 and Accumulation of β-Catenin
Yamamoto, H., Komekado, H., & Kikuchi, A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.07.003 · Cited by 302
The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice
Kelly, O., Pinson, K. I., & Skarnes, W. C. (2004) · Development · doi:10.1242/dev.01137 · Cited by 295
Ai, M., Holmen, S. L., Hul, W. V., Williams, B. O., & Warman, M. L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.12.4946-4955.2005 · Cited by 252
Chaperone Activity of Protein O -Fucosyltransferase 1 Promotes Notch Receptor Folding
Okajima, T., Xu, A., Lei, L., & Irvine, K. D. (2005) · Science · doi:10.1126/science.1108995 · Cited by 243
Bourhis, E., Tam, C., Franke, Y., Bazán, J. F., Ernst, J. A., Hwang, J., Costa, M., Cochran, A. G., & Hannoush, R. N. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.092130 · Cited by 230
LRP5 Mutations Linked to High Bone Mass Diseases Cause Reduced LRP5 Binding and Inhibition by SOST
Semënov, M. V., & He, X. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609509200 · Cited by 221
Versatility of the Endoplasmic Reticulum Protein Folding Factory
van Anken, E., & Braakman, I. (2005) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230591008161 · Cited by 219
Where Wnts Went: The Exploding Field of Lrp5 and Lrp6 Signaling in Bone
Williams, B. O., & Insogna, K. L. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081235 · Cited by 213
LRP5 and Wnt Signaling: A Union Made for Bone
Johnson, M. L., Harnish, K., Nusse, R., & Hul, W. V. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040816 · Cited by 211
LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy
Liu, C., Prior, J. L., Piwnica-Worms, D. R., & Bu, G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911220107 · Cited by 211
Regulation of Lrp6 phosphorylation
Niehrs, C., & Shen, J. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0329-3 · Cited by 195
Wang, Z., Shu, W., Lu, M. M., & Morrisey, E. E. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.12.5022-5030.2005 · Cited by 194
Yamamoto, A., Nagano, T., Takehara, S., Hibi, M., & Aizawa, S. (2005) · Cell · doi:10.1016/j.cell.2004.11.051 · Cited by 191
Morkel, M., Huelsken, J., Wakamiya, M., Ding, J., van de Wetering, M., Clevers, H. C., Taketo, M. M., Behringer, R. R., Shen, M. M., & Birchmeier, W. (2003) · Development · doi:10.1242/dev.00859 · Cited by 189
Wnt signaling in bone metabolism
Kubota, T., Michigami, T., & Ozono, K. (2009) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-009-0064-8 · Cited by 187
Clinical and Molecular Findings in Osteoporosis-Pseudoglioma Syndrome
Ai, M., Heeger, S., Bartels, C. F., & Schelling, D. K. (2005) · The American Journal of Human Genetics · doi:10.1086/497706 · Cited by 184
Osteogenesis Imperfecta: Mechanisms and Signaling Pathways Connecting Classical and Rare OI Types
Jovanovic, M., Ram, G. G., & Marini, J. C. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab017 · Cited by 182
Abrami, L., Kunz, B., Iacovache, I., & van der Goot, F. G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710389105 · Cited by 171
CD44 functions in Wnt signaling by regulating LRP6 localization and activation
Schmitt, M., Metzger, M., Gradl, D., Davidson, G. R., & Orian‐Rousseau, V. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.156 · Cited by 171
Potential role of the low-density lipoprotein receptor family as mediators of cellular drug uptake
Chung, N., & Wasan, K. M. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.12.003 · Cited by 165
The LRP5 High-Bone-Mass G171V Mutation Disrupts LRP5 Interaction with Mesd
Zhang, Y., Wang, Y., Li, X., Zhang, J., Mao, J., Li, Z., Zheng, J., Li, L., Harris, S., & Wu, D. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.11.4677-4684.2004 · Cited by 142
Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling
Sheng, R., Kim, H., Lee, H., Xin, Y., Chen, Y., Tian, W., Cui, Y., Choi, J.-C., Doh, J., Han, J.-K., et al. (2014) · Nature Communications · doi:10.1038/ncomms5393 · Cited by 157
Ettenberg, S. A., Charlat, O., Daley, M., Liu, S., Vincent, K. J., Stuart, D. D., Schuller, A. G., Yuan, J., Ospina, B., Green, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007428107 · Cited by 155
Formation and Segmentation of the Vertebrate Body Axis
Bénazéraf, B., & Pourquié, O. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155703 · Cited by 151
The Binding Between Sclerostin and LRP5 is Altered by DKK1 and by High-Bone Mass LRP5 Mutations
Balemans, W., Piters, E., Cleiren, E., Ai, M., Wesenbeeck, L. V., Warman, M. L., & Hul, W. V. (2008) · Calcified Tissue International · doi:10.1007/s00223-008-9130-9 · Cited by 148
Funa, N. S., Schachter, K. A., Lerdrup, M., Ekberg, J., Hess, K., Dietrich, N., Honoré, C., Hansen, K. H., & Semb, H. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.03.008 · Cited by 145
The Wnt signaling pathway and bone metabolism
Johnson, M. L., & Kamel, M. A. (2007) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32816e06f9 · Cited by 140
Culi, J., & Mann, R. S. (2003) · Cell · doi:10.1016/s0092-8674(02)01279-5 · Cited by 119
Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling
Chen, S., Bubeck, D., MacDonald, B. T., Liang, W., Mao, J.-H., Malinauskas, T., Llorca, Ó., Aricescu, A. R., Siebold, C., He, X., et al. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.09.007 · Cited by 136
Wnt signaling in cardiovascular physiology
Marinou, K., Christodoulides, C., Antoniades, C. A., & Koutsilieris, M. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.06.001 · Cited by 136
A Novel Mechanism for Wnt Activation of Canonical Signaling through the LRP6 Receptor
Liu, G., Bafico, A., Harris, V., & Aaronson, S. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5825-5835.2003 · Cited by 136
Wnt signaling in bone and muscle
Rudnicki, M. A., & Williams, B. O. (2015) · Bone · doi:10.1016/j.bone.2015.02.009 · Cited by 132
Gastrula organiser and embryonic patterning in the mouse
Robb, L., & Tam, P. (2004) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2004.04.005 · Cited by 129
Wnt Signaling in Mammalian Development: Lessons from Mouse GeneticsPreprint
Wang, J., Sinha, T., & Wynshaw-Boris, A. J. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007963 · Cited by 126
A Secreted Tyrosine Kinase Acts in the Extracellular Environment
Bordoli, M. R., Yum, J., Breitkopf, S. B., Thon, J. N., Italiano, J. E., Xiao, J., Worby, C. A., Wong, S.-K., Lin, G., Edenius, M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.048 · Cited by 125
The canonical Wnt pathway in early mammalian embryogenesis and stem cell maintenance/differentiation
Wang, J., & Wynshaw-Boris, A. J. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.07.013 · Cited by 125
Is Wnt signalling the final common pathway leading to bone formation?
Milat, F., & Ng, K. W. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.06.002 · Cited by 123
Low-density lipoprotein receptor structure and folding
Gent, J., & Braakman, I. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4090-3 · Cited by 123
The LDL receptor: how acid pulls the trigger
Beglova, N., & Blacklow, S. C. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.03.007 · Cited by 120
Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway
Liu, B., Staron, M. M., Hong, F., Wu, B. X., Sun, S., Morales, C., Crosson, C. E., Tomlinson, S., Kim, I., Wu, D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302933110 · Cited by 119
Fei, C., Li, Z., Li, C., Chen, Y., Chen, Z., He, X., Mao, L., Wang, X., Zeng, R., & Li, L. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00418-13 · Cited by 112
Carter, M. D., Chen, X., Slowinska, B., Minnerath, S., Glickstein, S. B., Shi, L., Campagne, F., Weinstein, H., & Ross, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501963102 · Cited by 104
Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94
Ansa-Addo, E. A., Thaxton, J. E., Hong, F., Wu, B. X., Zhang, Y., Fugle, C. W., Metelli, A., Riesenberg, B., Williams, K. M., Gewirth, D. T., et al. (2016) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026616666160413141613 · Cited by 101
Holdsworth, G., Slocombe, P. M., Doyle, C., Sweeney, B., Veverka, V., Riche, K. L., Franklin, R. J., Compson, J. E., Brookings, D. C., Turner, J., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.350108 · Cited by 98
Balemans, W., Devogelaer, J., Cleiren, E., Piters, E., Caussin, E., & Hul, W. V. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070211 · Cited by 97
Kremen is required for neural crest induction inXenopusand promotes LRP6-mediated Wnt signaling
Hassler, C., Cruciat, C., Huang, Y., Kuriyama, S., Mayor, R., & Niehrs, C. (2007) · Development · doi:10.1242/dev.005942 · Cited by 86
Rodenburg, K. W., & VANDERHORST, D. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.07.002 · Cited by 85
Wnt signaling and neural stem cells: caught in the Wnt web
Michaelidis, T. M., & Lie, D. C. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0476-5 · Cited by 84
Update on the Genetics of Osteogenesis Imperfecta
Jovanovic, M., & Marini, J. C. (2024) · Calcified Tissue International · doi:10.1007/s00223-024-01266-5 · Cited by 83
Weekes, M. P., Antrobus, R., Talbot, S., Hör, S., Simecek, N., Smith, D. L., Bloor, S., Randow, F., & Lehner, P. J. (2012) · Journal of Proteome Research · doi:10.1021/pr201135e · Cited by 82
Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis
Barrow, J. R., Howell, W. D., Rule, M. C., Hayashi, S., Thomas, K. R., Capecchi, M. R., & McMahon, A. P. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.09.030 · Cited by 81
Tortelote, G. G., Hernández‐Hernández, J. M., Quaresma, A. J. C., Nickerson, J. A., Imbalzano, A. N., & Rivera‐Pérez, J. A. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.10.013 · Cited by 80
Francis, K. R., Ton, A. N., Xin, Y., O'Halloran, P. E., Wassif, C. A., Malik, N., Williams, I. M., Cluzeau, C. V. M., Trivedi, N. S., Pavan, W. J., et al. (2016) · Nature Medicine · doi:10.1038/nm.4067 · Cited by 80
Salicioni, A. M., Gaultier, A., Brownlee, C., Cheezum, M. K., & Gonias, S. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306625200 · Cited by 80
Bauer, R., Plieschnig, J. A., Finkes, T., Riegler, B., Hermann, M., & Schneider, W. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.393090 · Cited by 78
Kubota, T., Michigami, T., Sakaguchi, N., Kokubu, C., Suzuki, A., Namba, N., Sakai, N., Nakajima, S., Imai, K., & Ozono, K. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080512 · Cited by 78
Wnt/β-catenin signaling and body plan formation in mouse embryos
Marikawa, Y. (2006) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2006.04.003 · Cited by 78
Impact of WNT signaling on tissue lineage differentiation in the early mouse embryo
Tanaka, S., Kojima, Y., Yamaguchi, Y. L., Nishinakamura, R., & Tam, P. (2011) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2011.01292.x · Cited by 77
HER2 in Breast Cancer Stemness: A Negative Feedback Loop towards Trastuzumab Resistance
Nami, B., & Wang, Z. (2017) · Cancers · doi:10.3390/cancers9050040 · Cited by 77
Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmonary Hypertension
Calvier, L., Herz, J., & Hansmann, G. (2022) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2021.09.011 · Cited by 76
Dkk1 Stabilizes Wnt Co-Receptor LRP6: Implication for Wnt Ligand-Induced LRP6 Down-Regulation
Li, Y., Lü, W., King, T. D., Liu, C., Bijur, G. N., & Bu, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011014 · Cited by 76
Hua, Y., Yang, Y., Li, Q., He, X., Zhu, W., Wang, J., & Gan, X. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004434 · Cited by 75
Porcn-dependent Wnt signaling is not required prior to mouse gastrulation
Biechele, S., Cockburn, K., Lanner, F., Cox, B., & Rossant, J. (2013) · Development · doi:10.1242/dev.094458 · Cited by 74
Coaxing the LDL Receptor Family into the Fold
Herz, J., & Marschang, P. (2003) · Cell · doi:10.1016/s0092-8674(03)00073-4 · Cited by 74
Canopy1, a Novel Regulator of FGF Signaling around the Midbrain-Hindbrain Boundary in Zebrafish
Hirate, Y., & Okamoto, H. (2006) · Current Biology · doi:10.1016/j.cub.2006.01.055 · Cited by 74
LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis
Ren, D., Chen, J., Li, Z., Yan, H., Yin, Y., Wo, D., Zhang, J., Ao, L., Chen, B., Ito, T. K., et al. (2015) · Nature Communications · doi:10.1038/ncomms7906 · Cited by 72
RAP Uses a Histidine Switch to Regulate Its Interaction with LRP in the ER and Golgi
Lee, D., Walsh, J. D., MIKHAILENKO, I. A., Yu, P., Migliorini, M., Wu, Y., Krueger, S., Curtis, J. E., Harris, B., Lockett, S., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.04.011 · Cited by 72
Complexity of the Wnt/β‑catenin pathway: Searching for an activation model
Tortelote, G. G., dos Reis, R. R., Mendes, F. A., & Abreu, J. G. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.08.008 · Cited by 71
A Role for the WNT Co-Receptor LRP6 in Pathogenesis and Therapy of Epithelial Cancers
Raisch, J., Côté-Biron, A., & Rivard, N. (2019) · Cancers · doi:10.3390/cancers11081162 · Cited by 69
Signaling regulation during gastrulation: Insights from mouse embryos and in vitro systems
Morgani, S. M., & Hadjantonakis, A. (2019) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2019.11.011 · Cited by 68
Role of Wnt Co-Receptor LRP6 in Triple Negative Breast Cancer Cell Migration and Invasion
Ma, J., Lü, W., Chen, D., Xu, B., & Li, Y. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25956 · Cited by 67
Protein folding includes oligomerization – examples from the endoplasmic reticulum and cytosol
Christis, C., Lubsen, N. H., & Braakman, I. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06590.x · Cited by 67
Mest/Peg1 inhibits Wnt signalling through regulation of LRP6 glycosylation
Jung, H., Lee, S. K., & Jho, E. (2011) · Biochemical Journal · doi:10.1042/bj20101512 · Cited by 66
Larance, M., Kirkwood, K. J., Tinti, M., Murillo, A. B., Ferguson, M. A. J., & Lamond, A. I. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.o115.055467 · Cited by 65
Autosomal-Recessive Mutations in MESD Cause Osteogenesis Imperfecta
Moosa, S., Yamamoto, G. L., Garbes, L., Keupp, K., Beleza‐Meireles, A., Moreno, C., Valadares, E. R., de Sousa, S. B., Maia, S., Saraiva, J., et al. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.08.008 · Cited by 65
Regulation of LRP-1 expression: Make the point
Emonard, H., Théret, L., Bennasroune, A. H., & Dedieu, S. (2014) · Pathologie Biologie · doi:10.1016/j.patbio.2014.02.002 · Cited by 53
A gene network establishing polarity in the early mouse embryo
Ang, S., & Constam, D. B. (2004) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2004.04.009 · Cited by 63
Migliorini, M. M., Behre, E., Brew, S. A., Ingham, K. C., & Strickland, D. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212592200 · Cited by 61
Arkell, R. M., Fossat, N., & Tam, P. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.03.001 · Cited by 60
Lapébie, P., Ruggiero, A., Barreau, C., Chevalier, S., Chang, P., Dru, P., Houliston, E., & Momose, T. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004590 · Cited by 59
Wynshaw-Boris, A. J. (2012) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-394592-1.00007-7 · Cited by 58
Differential requirements for β-catenin during mouse development
Rudloff, S., & Kemler, R. (2012) · Development · doi:10.1242/dev.085597 · Cited by 57
Cui, C., Zhao, W., Chen, J., Wang, J., & Li, Q. (2006) · Protein Expression and Purification · doi:10.1016/j.pep.2006.05.019 · Cited by 56
Wnt signaling: the good and the bad
Chen, X., Yang, J., Evans, P. M., & Liu, C. (2008) · Acta Biochimica et Biophysica Sinica · doi:10.1111/j.1745-7270.2008.00440.x · Cited by 56
Novel mutations affecting LRP5 splicing in patients with osteoporosis-pseudoglioma syndrome (OPPG)
Laine, C. M., Chung, B.-D., Susic, M., Prescott, T., Semler, O., Fiskerstrand, T., D’Eufemia, P., Castori, M., Pekkinen, M., Sochett, E. B., et al. (2011) · European Journal of Human Genetics · doi:10.1038/ejhg.2011.42 · Cited by 55
Mutation in EGFP Domain of LDL Receptor-Related Protein 6 Impairs Cellular LDL Clearance
Liu, W., Mani, S., Davis, N. R., Sarrafzadegan, N., Kavathas, P., & Mani, A. (2008) · Circulation Research · doi:10.1161/circresaha.108.183863 · Cited by 55
Jeong, W., & Jho, E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.714330 · Cited by 54
Metadata
- Authors
- Hsieh, J.-C., Lee, L., Zhang, L., Wefer, S., Brown, K., DeRossi, C., Wines, M. E., Rosenquist, T., & Holdener, B. C.
- Affiliations
- Stony Brook University (US)
- Corresponding author
- Holdener, Bernadette C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 112
- Issue
- 3
- Pages
- 355-367
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2052749020
- Cited by
- 237
- References
- 39
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 10 · 2021: 9 · 2020: 5 · 2019: 8 · 2018: 4 · 2017: 7 · 2016: 9 · 2015: 5 · 2014: 14 · 2013: 13 · 2012: 18
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM053964)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD53964)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Oncology › Renal and related cancers
- Keywords
- LRP5, LRP6, molecular chaperones, embryonic polarity, mesoderm induction, Wnt/β-catenin signaling, Frizzled receptors, endoplasmic reticulum, mesoderm differentiation, Wnt3, low-density lipoprotein receptor family, mouse embryo
- MeSH terms
- Congenital Abnormalities, Animals, Cell Differentiation, Embryo, Mammalian, Endoplasmic Reticulum, Female, Genes, Lethal, Male, Mesoderm, Mutation, Phenotype, Proteins, Receptors, LDL, Signal Transduction, Cell Polarity, Mice, Knockout, Molecular Chaperones, Body Patterning, COS Cells, LDL-Receptor Related Proteins, Wnt Proteins, Mice, Low Density Lipoprotein Receptor-Related Protein-6, Low Density Lipoprotein Receptor-Related Protein-5, Wnt3 Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review