Cited by 820Genetics, Aging, and Longevity in Model OrganismsMetabolism, Diabetes, and CancerNeurobiology and Insect Physiology Research

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Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan

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Libina, Nataliya, Berman, Jennifer R., Kenyon, Cynthia·2003·Cell

DOI 10.1016/s0092-8674(03)00889-4

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Abstract

In C. elegans, the transcription factor DAF-16 promotes longevity in response to reduced insulin/IGF-1 signaling or germline ablation. In this study, we have asked how different tissues interact to specify the lifespan of the animal. We find that several tissues act as signaling centers. In particular, DAF-16 activity in the intestine, which is also the animal's adipose tissue, completely restores the longevity of daf-16(-) germline-deficient animals, and increases the lifespans of daf-16(-) insulin/IGF-1-pathway mutants substantially. Our findings indicate that DAF-16 may control two types of downstream signals: DAF-16 activity in signaling cells upregulates DAF-16 in specific responding tissues, possibly via regulation of insulin-like peptides, and also evokes DAF-16-independent responses. We suggest that this network of tissue interactions and feedback regulation allows the tissues to equilibrate and fine-tune their expression of downstream genes, which, in turn, coordinates their rates of aging within the animal.

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Authors: Libina, N., Berman, J. R., & Kenyon, C.
Affiliations: University of California, San Francisco (US)
Corresponding author: Kenyon, Cynthia
ORCID: Kenyon, Cynthia
Venue: Cell
Publisher: Elsevier BV
Published: 2003-11
Volume: 115
Issue: 4
Pages: 489-502
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(03)00889-4
OpenAlex: W2066660409
Cited by: 820
References: 58
Citations by year: 2026: 19 · 2025: 32 · 2024: 41 · 2023: 15 · 2022: 35 · 2021: 53 · 2020: 39 · 2019: 35 · 2018: 48 · 2017: 36 · 2016: 42 · 2015: 24 · 2014: 44 · 2013: 40 · 2012: 33
FWCI: 9.40
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3546 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG11816)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: DAF-16, Caenorhabditis elegans, lifespan regulation, insulin/IGF-1 signaling, intestine, adipose tissue, tissue-specific gene regulation, insulin-like peptides, aging, transcription factors
MeSH terms: Adipose Tissue, Aging, Animals, Insulin, Insulin-Like Growth Factor I, Intestinal Mucosa, Longevity, Mosaicism, Organ Specificity, Receptor, Insulin, RNA, Messenger, Stress, Physiological, Transcription Factors, Signal Transduction, Caenorhabditis elegans, Gene Deletion, Germ-Line Mutation, Gene Expression Regulation, Developmental, Gene Expression Profiling, Caenorhabditis elegans Proteins, Animals, Genetically Modified, Forkhead Transcription Factors

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Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan

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