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Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan
Open accessAbstract
In C. elegans, the transcription factor DAF-16 promotes longevity in response to reduced insulin/IGF-1 signaling or germline ablation. In this study, we have asked how different tissues interact to specify the lifespan of the animal. We find that several tissues act as signaling centers. In particular, DAF-16 activity in the intestine, which is also the animal's adipose tissue, completely restores the longevity of daf-16(-) germline-deficient animals, and increases the lifespans of daf-16(-) insulin/IGF-1-pathway mutants substantially. Our findings indicate that DAF-16 may control two types of downstream signals: DAF-16 activity in signaling cells upregulates DAF-16 in specific responding tissues, possibly via regulation of insulin-like peptides, and also evokes DAF-16-independent responses. We suggest that this network of tissue interactions and feedback regulation allows the tissues to equilibrate and fine-tune their expression of downstream genes, which, in turn, coordinates their rates of aging within the animal.
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“Importantly, reduced IIS specifically in the nervous system is sufficient to extend lifespan in several model systems.”
From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [65]
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Cites
The embryonic cell lineage of the nematode Caenorhabditis elegans
Sulston, J. E., Schierenberg, E., White, J. G., & Thomson, J. N. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90201-4 · Cited by 4,199
Post-embryonic cell lineages of the nematode, Caenorhabditis elegans
Sulston, J. E., & Horvitz, H. R. (1977) · Developmental Biology · doi:10.1016/0012-1606(77)90158-0 · Cited by 3,479
A C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387
Self-citationGenes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., & Kenyon, C. (2003) · Nature · doi:10.1038/nature01789 · Cited by 2,280
Self-citationKimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250
Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., & Ruvkun, G. (1997) · Nature · doi:10.1038/40194 · Cited by 1,935
Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
Fraser, A. G., Kamath, R. S., Zipperlen, P., Martinez-Campos, M., Sohrmann, M., & Ahringer, J. (2000) · Nature · doi:10.1038/35042517 · Cited by 1,761
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
Hsu, A.-L., Murphy, C. T., & Kenyon, C. (2003) · Science · doi:10.1126/science.1083701 · Cited by 1,513
Self-citationLin, K., Dorman, J. B., Rodan, A. R., & Kenyon, C. J. (1997) · Science · doi:10.1126/science.278.5341.1319 · Cited by 1,501
Self-citationKamath, R. S., Martinez-Campos, M., Zipperlen, P., Fraser, A. G., & Ahringer, J. (2000) · Genome biology · doi:10.1186/gb-2000-2-1-research0002 · Cited by 1,332
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Worming pathways to and from DAF-16/FOXO
Mukhopadhyay, A., Oh, S. W., & Tissenbaum, H. A. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.05.020 · Cited by 198
The search for DAF-16/FOXO transcriptional targets: Approaches and discoveries
Murphy, C. T. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.06.040 · Cited by 189
Longevity and stress in Caenorhabditis elegans
Zhou, K. I., Pincus, Z., & Slack, F. J. (2011) · Aging · doi:10.18632/aging.100367 · Cited by 196
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Ezcurra, M., Benedetto, A., Sornda, T., Gilliat, A. F., Au, C., Zhang, Q., van Schelt, S., Petrache, A. L., Wang, H., de la Guardia, Y., et al. (2018) · Current Biology · doi:10.1016/j.cub.2018.06.035 · Cited by 185
Reactive Oxygen Species and Aging in Caenorhabditis elegans : Causal or Casual Relationship?
Raamsdonk, J. M. V., & Hekimi, S. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3215 · Cited by 186
The temporal scaling of Caenorhabditis elegans ageing
Stroustrup, N., Anthony, W. E., Nash, Z. M., Gowda, V., Gomez, A., López-Moyado, I. F., Apfeld, J., & Fontana, W. (2016) · Nature · doi:10.1038/nature16550 · Cited by 196
Nussbaum-Krammer, C. I., Neto, M. F., Brielmann, R. M., Pedersen, J. S., & Morimoto, R. I. (2015) · Journal of Visualized Experiments · doi:10.3791/52321 · Cited by 195
Murphy, C. T., Lee, S., & Kenyon, C. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709613104 · Cited by 186
Self-citationMeissner, B., Boll, M., Daniel, H., & Baumeister, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403415200 · Cited by 171
Oxidative Stress Regulation of Stem and Progenitor Cells
Pervaiz, S., Taneja, R., & Ghaffari, S. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2804 · Cited by 176
Spontaneous Age-Related Neurite Branching in Caenorhabditis elegans
Tank, E. M. H., Rodgers, K. E., & Kenyon, C. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6606-10.2011 · Cited by 175
Self-citationSystemic stress signalling: understanding the cell non-autonomous control of proteostasis
Taylor, R. C., Berendzen, K. M., & Dillin, A. G. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3752 · Cited by 178
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Luong, N., Davies, C. R., Wessells, R. J., Graham, S. M., King, M. T., Veech, R. L., Bodmer, R., & Oldham, S. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.013 · Cited by 173
Chondrogianni, N., Georgila, K., Kourtis, N., Tavernarakis, N., & Gonos, E. S. (2014) · The FASEB Journal · doi:10.1096/fj.14-252189 · Cited by 173
Senchuk, M. M., Dues, D. J., Schaar, C. E., Johnson, B. K., Madaj, Z., Bowman, M. J., Winn, M. E., & Raamsdonk, J. M. V. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007268 · Cited by 184
Lin, X.-X., Sen, I., Janssens, G. E., Zhou, X., Fonslow, B. R., Edgar, D., Stroustrup, N., Swoboda, P., Yates, J. R., Ruvkun, G., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06624-0 · Cited by 179
The ELT-2 GATA-factor and the global regulation of transcription in the C. elegans intestine
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Zhang, P., Judy, M. E., Lee, S., & Kenyon, C. J. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.013 · Cited by 167
Self-citationPadmanabhan, S., Mukhopadhyay, A., Narasimhan, S. D., Tesz, G. J., Czech, M., & Tissenbaum, H. A. (2009) · Cell · doi:10.1016/j.cell.2009.01.025 · Cited by 170
Quantitative In Vivo Redox Sensors Uncover Oxidative Stress as an Early Event in Life
Knoefler, D., Thamsen, M., Koniczek, M., Niemuth, N. J., Diederich, A.-K., & Jakob, U. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.06.016 · Cited by 175
Corby‐Harris, V., Drexler, A., de Jong, L. W., Antonova, Y., Pakpour, N., Ziegler, R., Ramberg, F. B., Lewis, E. E., Brown, J. M., Luckhart, S., et al. (2010) · PLoS Pathogens · doi:10.1371/annotation/738ac91f-8c41-4bf5-9a39-bddf0b777a89 · Cited by 169
Regulation of reproduction and longevity by nutrient-sensing pathways
Templeman, N. M., & Murphy, C. T. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201707168 · Cited by 175
Vitale, G., Pellegrino, G., Vollery, M., & Hofland, L. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00027 · Cited by 166
Control of intestinal bacterial proliferation in regulation of lifespan in Caenorhabditis elegans
Portal‐Celhay, C., Bradley, E., & Blaser, M. J. (2012) · BMC Microbiology · doi:10.1186/1471-2180-12-49 · Cited by 166
Forsythe, M. E., Love, D. C., Lazarus, B. D., Kim, E. J., Prinz, W. A., Ashwell, G., Krause, M., & Hanover, J. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601931103 · Cited by 164
Matyash, V., Entchev, E. V., Mende, F., Wilsch‐Bräuninger, M., Thiele, C., Schmidt, A. W., Knölker, H., Ward, S. F., & Kurzchalia, T. V. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020280 · Cited by 164
A pathway that links reproductive status to lifespan in Caenorhabditis elegans
Kenyon, C. J. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05640.x · Cited by 163
Self-citationDietary Restriction Extends Lifespan through Metabolic Regulation of Innate Immunity
Wu, Z., Isik, M., Moroz, N., Steinbaugh, M. J., Zhang, P., & Blackwell, T. K. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.02.013 · Cited by 163
Insulin/IGF1 Signaling Inhibits Age-Dependent Axon Regeneration
Byrne, A. B., Walradt, T. J., Gardner, K. E., Hubbert, A., Reinke, V., & Hammarlund, M. (2014) · Neuron · doi:10.1016/j.neuron.2013.11.019 · Cited by 163
The role of insulin and IGF-1 signaling in longevity
Katić, M., & Kahn, C. R. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4297-y · Cited by 163
Endocrine regulation of aging and reproduction in Drosophila
Toivonen, J. M., & Partridge, L. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.07.005 · Cited by 164
Intestinal epithelial barrier functions in ageing
Branca, J. J. V., Gulisano, M., & Nicoletti, C. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100938 · Cited by 165
daf-16 Protects the Nematode Caenorhabditis elegans During Food Deprivation
Henderson, S. T., Bonafè, M., & Johnson, T. E. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.5.444 · Cited by 155
Morrow, G., Battistini, S., Zhang, P., & Tanguay, R. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400357200 · Cited by 157
Piper, M. D. W., Selman, C., McElwee, J. J., & Partridge, L. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01906.x · Cited by 159
A metabolic signature of long life in Caenorhabditis elegans
Fuchs, S., Bundy, J. G., Davies, S. K., Viney, J. M., Swire, J. S., & Leroi, A. M. (2010) · BMC Biology · doi:10.1186/1741-7007-8-14 · Cited by 152
Shao, H., Han, Z., Krasteva, N. A., & Wang, D. (2019) · Nanotoxicology · doi:10.1080/17435390.2018.1530395 · Cited by 148
Corby‐Harris, V., Drexler, A., de Jong, L. W., Antonova, Y., Pakpour, N., Ziegler, R., Ramberg, F. B., Lewis, E. E., Brown, J. M., Luckhart, S., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001003 · Cited by 148
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Baugh, L. R., & Hu, P. J. (2020) · Genetics · doi:10.1534/genetics.120.303565 · Cited by 141
Frakes, A. E., Metcalf, M. G., Tronnes, S. U., Bar‐Ziv, R., Durieux, J., Gildea, H. K., Kandahari, N., Monshietehadi, S., & Dillin, A. G. (2020) · Science · doi:10.1126/science.aaz6896 · Cited by 146
The DAF‐2 insulin‐like signaling pathway independently regulates aging and immunity in C. elegans
Evans, E., Chen, W. C., & Tan, M. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00435.x · Cited by 143
Genetics of Longevity and Aging
Vijg, J., & Suh, Y. (2005) · Annual Review of Medicine · doi:10.1146/annurev.med.56.082103.104617 · Cited by 142
Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases
Du, S., & Zheng, H. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00700-7 · Cited by 152
Cabreiro, F., Ackerman, D., Doonan, R., Araiz, C., Back, P., Papp, D., Braeckman, B. P., & Gems, D. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.07.020 · Cited by 145
McGhee, J. D., Fukushige, T., Krause, M., Minnema, S. E., Goszczynski, B., Gaudet, J., Kohara, Y., Bossinger, O., Zhao, Y., Khattra, J. S., et al. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.11.034 · Cited by 144
FoxO6 regulates memory consolidation and synaptic functionPreprint
Salih, D. A. M., Rashid, A. J., Colas, D., de la Torre-Ubieta, L., Zhu, R. P., Morgan, A. A., Santo, E. E., Ucar, D., Devarajan, K., Cole, C. J., et al. (2012) · Genes & Development · doi:10.1101/gad.208926.112 · Cited by 136
Curtis, C. N., Landis, G. N., Folk, D. G., Wehr, N. B., Hoe, N., Waskar, M., Abdueva, D. A., Skvortsov, D., Ford, D., Luu, A., et al. (2007) · Genome biology · doi:10.1186/gb-2007-8-12-r262 · Cited by 135
Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex
Ghazi, A., Henis-Korenblit, S., & Kenyon, C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700638104 · Cited by 134
Self-citationA conserved ubiquitination pathway determines longevity in response to diet restriction
Carrano, A. C., Liu, Z., Dillin, A. G., & Hunter, T. R. (2009) · Nature · doi:10.1038/nature08130 · Cited by 132
Wei, Y., & Kenyon, C. J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524727113 · Cited by 132
Self-citationIntegrating the stress response: lessons for neurodegenerative diseases from C. elegans
Prahlad, V., & Morimoto, R. I. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.11.002 · Cited by 136
Intertissue Control of the Nucleolus via a Myokine-Dependent Longevity Pathway
Demontis, F., Patel, V. K., Swindell, W. R., & Perrimon, N. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.05.001 · Cited by 133
Dues, D. J., Andrews, E. K., Schaar, C. E., Bergsma, A. L., Senchuk, M. M., & Raamsdonk, J. M. V. (2016) · Aging · doi:10.18632/aging.100939 · Cited by 141
New genes that extend Caenorhabditis elegans ’ lifespan in response to reproductive signals
McCormick, M. A., Chen, K., Ramaswamy, P., & Kenyon, C. J. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00768.x · Cited by 135
Self-citationChen, D., Li, P. W.-L., Goldstein, B. A., Cai, W., Thomas, E. L., Chen, F., Hubbard, A., Melov, S., & Kapahi, P. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.11.018 · Cited by 134
Biology of the Caenorhabditis elegans Germline Stem Cell System
Hubbard, E. J. A., & Schedl, T. (2019) · Genetics · doi:10.1534/genetics.119.300238 · Cited by 118
C. elegans rrf-1 Mutations Maintain RNAi Efficiency in the Soma in Addition to the Germline
Kumsta, C., & Hansen, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035428 · Cited by 134
Vitellogenins - Yolk Gene Function and Regulation in Caenorhabditis elegans
Perez, M. F., & Lehner, B. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01067 · Cited by 127
Caenorhabditis elegans as a model for understanding ROS function in physiology and disease
Miranda‐Vizuete, A., & Veal, E. A. (2016) · Redox Biology · doi:10.1016/j.redox.2016.12.020 · Cited by 129
Autophagy-mediated longevity is modulated by lipoprotein biogenesis
Seah, N., Filho, C. D. D. M., Petrashen, A. P., Henderson, H. R., Laguer, J., Gonzalez, J., Dillin, A. G., Hansen, M., & Lapierre, L. R. (2015) · Autophagy · doi:10.1080/15548627.2015.1127464 · Cited by 118
C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO
Wang, Y., Oh, S. W., Deplancke, B., Luo, J., Walhout, A. J. M., & Tissenbaum, H. A. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.05.005 · Cited by 121
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
Curran, S. P., Wu, X., Riedel, C. G., & Ruvkun, G. (2009) · Nature · doi:10.1038/nature08106 · Cited by 120
Caenorhabditis elegans HCF-1 Functions in Longevity Maintenance as a DAF-16 Regulator
Li, J., Ebata, A., Dong, Y., Rizki, G., Iwata, T., & Lee, S. S. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060233 · Cited by 118
Ray, A., Martinez, B., Berkowitz, L. A., Caldwell, G. A., & Caldwell, K. A. (2014) · Cell Death and Disease · doi:10.1038/cddis.2013.513 · Cited by 118
Genetics, Life Span, Health Span, and the Aging Process in Caenorhabditis elegans
Tissenbaum, H. A. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls088 · Cited by 125
Characterization of the Drosophila Gene‐Switch system in aging studies: a cautionary tale
Poirier, L., Shane, A., Zheng, J., & Seroude, L. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00421.x · Cited by 117
RNA polymerase III limits longevity downstream of TORC1
Filer, D., Thompson, M. A., Takhaveev, V., Dobson, A. J., Kotronaki, I., Green, J. W. M., Heinemann, M., Tullet, J. M. A., & Alic, N. (2017) · Nature · doi:10.1038/nature25007 · Cited by 118
Murakami, H., Bessinger, K., Hellmann, J. L., & Murakami, S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3600-04.2005 · Cited by 114
Reproduction and longevity: secrets revealed by C. elegans
Mukhopadhyay, A., & Tissenbaum, H. A. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.12.004 · Cited by 118
Regulation of longevity by the reproductive system
Antebi, A. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.09.009 · Cited by 115
The trifecta of aging in Caenorhabditis elegans
Wolff, S., & Dillin, A. G. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.06.054 · Cited by 115
Shemesh, N., Shai, N., & Ben‐Zvi, A. (2013) · Aging Cell · doi:10.1111/acel.12110 · Cited by 110
A central role for ceramide in the age‐related acceleration of apoptosis in the female germline
Perez, G. I., Jurisicova, A., Matikainen, T., Moriyama, T., Kim, M.-R., Takai, Y., Pru, J. K., Kolesnick, R., & Tilly, J. L. (2005) · The FASEB Journal · doi:10.1096/fj.04-2903fje · Cited by 114
Nutrition and Healthy Ageing: Calorie Restriction or Polyphenol-Rich “MediterrAsian” Diet?
Pallauf, K., Giller, K., Huebbe, P., & Rimbach, G. H. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/707421 · Cited by 116
Heterotypic Signals from Neural HSF-1 Separate Thermotolerance from Longevity
Douglas, P. M., Baird, N. A., Simic, M., Tronnes, S. U., McCormick, M. A., Wolff, S., Kennedy, B. K., & Dillin, A. G. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.026 · Cited by 113
Hung, W., Wang, Y., Chitturi, J., & Zhen, M. (2014) · Development · doi:10.1242/dev.103846 · Cited by 112
Ghazi, A., Henis‐Korenblit, S., & Kenyon, C. J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000639 · Cited by 116
Self-citationRole of gut microbiota in aging-related health decline: insights from invertebrate models
Clark, R. I., & Walker, D. W. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2671-1 · Cited by 121
Direct in vivo imaging of ferrous iron dyshomeostasis in ageing Caenorhabditis elegans
James, S., Roberts, B. R., Hare, D. J., de Jonge, M. D., Birchall, I. E., Jenkins, N. L., Cherny, R. A., Bush, A. I., & McColl, G. (2015) · Chemical Science · doi:10.1039/c5sc00233h · Cited by 110
Papp, D., Lenti, K., Módos, D., Fazekas, D., Dúl, Z., Türei, D., Földvári-Nagy, L., Nussinov, R., Csermely, P., & Korcsmaros, T. D. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.05.016 · Cited by 109
Gami, M. S., & Wolkow, C. A. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00188.x · Cited by 110
Mueller, M. M., Castells-Roca, L., Babu, V., Ermolaeva, M. A., Müller, R.-U., Frommolt, P., Williams, A. B., Greiss, S., Schneider, J. I., Benzing, T., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3071 · Cited by 108
DAF-16-Dependent Suppression of Immunity During Reproduction inCaenorhabditis elegans
Miyata, S., Begun, J., Troemel, E. R., & Ausubel, F. M. (2008) · Genetics · doi:10.1534/genetics.107.083923 · Cited by 109
Organ-specific mediation of lifespan extension: More than a gut feeling?
Rera, M., Azizi, M. J., & Walker, D. W. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.05.003 · Cited by 106
Corton, J. C., & Brown-Borg, H. M. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.12.1494 · Cited by 106
The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals
Lemieux, M. E., Yang, X. M., Jardine, K. E., He, X., Jacobsen, K. X., Staines, W. A., Harper, M., & McBurney, M. W. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.04.006 · Cited by 109
Biological evidence for inheritance of exceptional longevity
Atzmon, G., Rincon, M., Rabizadeh, P., & Barzilai, N. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.08.026 · Cited by 104
Antonova, Y., Arik, A. J., Moore, W., Riehle, M. A., & Brown, M. R. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-384749-2.10002-0 · Cited by 107
Variable Pathogenicity Determines Individual Lifespan in Caenorhabditis elegans
Sánchez-Blanco, A., & Kim, S. K. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002047 · Cited by 107
Cell non-autonomous regulation of health and longevity
Miller, H. A., Dean, E. S., Pletcher, S. D., & Leiser, S. F. (2020) · eLife · doi:10.7554/elife.62659 · Cited by 102
Hsu, A., Feng, Z., Hsieh, M.-Y., & Xu, X. Z. S. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.12.007 · Cited by 103
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Metadata
- Authors
- Libina, N., Berman, J. R., & Kenyon, C.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Kenyon, Cynthia
- ORCID
- Kenyon, Cynthia
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 115
- Issue
- 4
- Pages
- 489-502
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2066660409
- Cited by
- 820
- References
- 58
- Citations by year
- 2026: 19 · 2025: 32 · 2024: 41 · 2023: 15 · 2022: 35 · 2021: 53 · 2020: 39 · 2019: 35 · 2018: 48 · 2017: 36 · 2016: 42 · 2015: 24 · 2014: 44 · 2013: 40 · 2012: 33
- FWCI
- 9.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3546 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG11816)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- DAF-16, Caenorhabditis elegans, lifespan regulation, insulin/IGF-1 signaling, intestine, adipose tissue, tissue-specific gene regulation, insulin-like peptides, aging, transcription factors
- MeSH terms
- Adipose Tissue, Aging, Animals, Insulin, Insulin-Like Growth Factor I, Intestinal Mucosa, Longevity, Mosaicism, Organ Specificity, Receptor, Insulin, RNA, Messenger, Stress, Physiological, Transcription Factors, Signal Transduction, Caenorhabditis elegans, Gene Deletion, Germ-Line Mutation, Gene Expression Regulation, Developmental, Gene Expression Profiling, Caenorhabditis elegans Proteins, Animals, Genetically Modified, Forkhead Transcription Factors
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