Cited by 820Genetics, Aging, and Longevity in Model OrganismsMetabolism, Diabetes, and CancerNeurobiology and Insect Physiology Research

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan

Open access

Libina, Nataliya, Berman, Jennifer R., Kenyon, Cynthia·2003·Cell

DOI 10.1016/s0092-8674(03)00889-4

Open this paper in CoChat — free account Open PDF

Abstract

In C. elegans, the transcription factor DAF-16 promotes longevity in response to reduced insulin/IGF-1 signaling or germline ablation. In this study, we have asked how different tissues interact to specify the lifespan of the animal. We find that several tissues act as signaling centers. In particular, DAF-16 activity in the intestine, which is also the animal's adipose tissue, completely restores the longevity of daf-16(-) germline-deficient animals, and increases the lifespans of daf-16(-) insulin/IGF-1-pathway mutants substantially. Our findings indicate that DAF-16 may control two types of downstream signals: DAF-16 activity in signaling cells upregulates DAF-16 in specific responding tissues, possibly via regulation of insulin-like peptides, and also evokes DAF-16-independent responses. We suggest that this network of tissue interactions and feedback regulation allows the tissues to equilibrate and fine-tune their expression of downstream genes, which, in turn, coordinates their rates of aging within the animal.

Integrity signals

Registry

Crossref · 10.1016/s0092-8674(03)00889-4

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The embryonic cell lineage of the nematode Caenorhabditis elegans
Sulston, J. E., Schierenberg, E., White, J. G., & Thomson, J. N. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90201-4 · Cited by 4,199
Post-embryonic cell lineages of the nematode, Caenorhabditis elegans
Sulston, J. E., & Horvitz, H. R. (1977) · Developmental Biology · doi:10.1016/0012-1606(77)90158-0 · Cited by 3,479
A C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387
Self-citation
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., & Kenyon, C. (2003) · Nature · doi:10.1038/nature01789 · Cited by 2,280
Self-citation
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., & Ruvkun, G. (1997) · Nature · doi:10.1038/40194 · Cited by 1,935
Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
Fraser, A. G., Kamath, R. S., Zipperlen, P., Martinez-Campos, M., Sohrmann, M., & Ahringer, J. (2000) · Nature · doi:10.1038/35042517 · Cited by 1,761
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
Hsu, A.-L., Murphy, C. T., & Kenyon, C. (2003) · Science · doi:10.1126/science.1083701 · Cited by 1,513
Self-citation
daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans
Lin, K., Dorman, J. B., Rodan, A. R., & Kenyon, C. J. (1997) · Science · doi:10.1126/science.278.5341.1319 · Cited by 1,501
Self-citation
Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans
Kamath, R. S., Martinez-Campos, M., Zipperlen, P., Fraser, A. G., & Ahringer, J. (2000) · Genome biology · doi:10.1186/gb-2000-2-1-research0002 · Cited by 1,332

Show all 58 references

Sorted by citations

Items 301–400 of 820

Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian Brain
Parrella, E., & Longo, V. D. (2010) · The Scientific World JOURNAL · doi:10.1100/tsw.2010.8 · Cited by 53
ETS-4 Is a Transcriptional Regulator of Life Span in Caenorhabditis elegans
Thyagarajan, B., Blaszczak, A. G., Chandler, K. J., Watts, J. L., Johnson, W. E., & Graves, B. J. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001125 · Cited by 51
Genes and Longevity of Lifespan
Bin-Jumah, M. N., Nadeem, M. S., Gilani, S. J., Al-Abbasi, F. A., Ullah, I., Alzarea, S. I., Ghoneim, M. M., Alshehri, S., Ud-Din, A., Murtaza, B. N., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031499 · Cited by 52
Neurotoxicity of bisphenol A exposure on Caenorhabditis elegans induced by disturbance of neurotransmitter and oxidative damage
Wang, Y., Gai, T., Zhang, L., Chen, L., Wang, S., Ye, T., & Zhang, W. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114617 · Cited by 51
Biological resilience and aging: Activation of stress response pathways contributes to lifespan extension
Soo, S. K., Rudich, Z. D., Ko, B., Moldakozhayev, A., AlOkda, A., & Raamsdonk, J. M. V. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101941 · Cited by 58
TATN-1 Mutations Reveal a Novel Role for Tyrosine as a Metabolic Signal That Influences Developmental Decisions and Longevity in Caenorhabditis elegans
Ferguson, A. A., Roy, S. S., Kormanik, K., Kim, Y.-S., Dumas, K. J., Ritov, V. B., Matern, D., Hu, P. J., & Fisher, A. L. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1004020 · Cited by 49
Dietary extra-virgin olive oil rich in phenolic antioxidants and the aging process: long-term effects in the rat
Jacomelli, M., Pitozzi, V., Zaid, M. M., Larrosa, M., Tonini, G., Martini, A., Urbani, S., Taticchi, A., Servili, M., Dolara, P., et al. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.12.014 · Cited by 51
The Mediator complex of Caenorhabditis elegans: insights into the developmental and physiological roles of a conserved transcriptional coregulator
Grants, J. M., Goh, G. Y. S., & Taubert, S. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv037 · Cited by 50
Two Membrane-Associated Tyrosine Phosphatase Homologs Potentiate C. elegans AKT-1/PKB Signaling
Hu, P. J., Xu, J., & Ruvkun, G. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0020099 · Cited by 51
Reserpine modulates neurotransmitter release to extend lifespan and alleviate age-dependent Aβ proteotoxicity in Caenorhabditis elegans
Saharia, K., Arya, U., Kumar, R., Sahu, R., Das, C. K., Gupta, K., Dwivedi‐Agnihotri, H., & Subramaniam, J. R. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.12.006 · Cited by 49
Nutritional and hormonal regulation of the TOR effector 4E‐binding protein (4E‐BP) in the mosquito Aedes aegypti
Roy, S. G., & Raikhel, A. S. (2011) · The FASEB Journal · doi:10.1096/fj.11-189969 · Cited by 50
Effects of Korean ginseng berry on skin antipigmentation and antiaging via FoxO3a activation
Kim, J., Cho, S. Y., Kim, S. H., Cho, D., Kim, S., Park, C., Shimizu, T., Cho, J. Y., Seo, D. B., & Shin, S. S. (2016) · Journal of Ginseng Research · doi:10.1016/j.jgr.2016.05.005 · Cited by 53
CEH-60/PBX and UNC-62/MEIS Coordinate a Metabolic Switch that Supports Reproduction in C. elegans
Dowen, R. H. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.03.002 · Cited by 47
SKN-1 Is a Negative Regulator of DAF-16 and Somatic Stress Resistance in Caenorhabditis elegans
Deng, J., Dai, Y., Tang, H., & Pang, S. (2020) · G3 Genes Genomes Genetics · doi:10.1534/g3.120.401203 · Cited by 52
Antistress and anti-aging activities of Caenorhabditis elegans were enhanced by Momordica saponin extract
Lin, C., Chen, Y., Lin, Y., Wang, X., Hu, L., Cao, Y., & Chen, Y. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02338-6 · Cited by 54
Caenorhabditis elegans reproductive aging: Regulation and underlying mechanisms
Luo, S., & Murphy, C. T. (2010) · genesis · doi:10.1002/dvg.20694 · Cited by 50
Stimulation of Movement in a Quiescent, Hibernation-Like Form of Caenorhabditis elegans by Dopamine Signaling
Gaglia, M. M., & Kenyon, C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3429-08.2009 · Cited by 49
Self-citation
Integrin‐linked kinase modulates longevity and thermotolerance in C. elegans through neuronal control of HSF ‐1
Kumsta, C., Ching, T., Nishimura, M., Davis, A. E. M., Gelino, S., Catan, H. H., Yu, X., Chu, C., Ong, B., Panowski, S. H., et al. (2013) · Aging Cell · doi:10.1111/acel.12189 · Cited by 53
Resveratrol Attenuates Radiation Damage in Caenorhabditis elegans by Preventing Oxidative Stress
Ye, K., Ji, C., Lu, X., Ni, Y., Gao, C., Xiao-Hui, C. H. E. N., Zhao, Y., Gu, G., & Guo, X. (2010) · Journal of Radiation Research · doi:10.1269/jrr.10009 · Cited by 50
Autophagy in C. elegans development
Palmisano, N. J., & Meléndez, A. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.04.009 · Cited by 53
Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs
Iser, W. B., Gami, M. S., & Wolkow, C. A. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2006.04.467 · Cited by 48
The Transcriptome of Trichuris suis – First Molecular Insights into a Parasite with Curative Properties for Key Immune Diseases of Humans
Cantacessi, C., Young, N. D., Nejsum, P. L., Jex, A. R., Campbell, B. E., Hall, R. S., Thamsborg, S. M., Scheerlinck, J. Y., & Gasser, R. B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023590 · Cited by 48
Effect of ionic strength on bioaccumulation and toxicity of silver nanoparticles in Caenorhabditis elegans
Yang, Y., Xu, G., Xu, S., Chen, S., Xu, A., & Wu, L. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.09.008 · Cited by 48
DAF‐2/insulin IGF‐1 receptor regulates motility during aging by integrating opposite signaling from muscle and neuronal tissues
Roy, C., Molin, L., Alcolei, A., Solyga, M., Bonneau, B., Vachon, C., Bessereau, J., & Solari, F. (2022) · Aging Cell · doi:10.1111/acel.13660 · Cited by 47
The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans
Estevez, A. O., Morgan, K. L., Szewczyk, N. J., Gems, D., & Estevez, M. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2013.12.012 · Cited by 47
RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans
Seo, M., Seo, K., Hwang, W., Koo, H. J., Hahm, J., Yang, J., Han, S. K., Hwang, D., Kim, S., Jang, S. K., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1505451112 · Cited by 46
Mutations in Nonessential eIF3k and eIF3l Genes Confer Lifespan Extension and Enhanced Resistance to ER Stress in Caenorhabditis elegans
Cattie, D. J., Richardson, C. E., Reddy, K. C., Ness-Cohn, E., Droste, R., Thompson, M. K., Gilbert, W. V., & Kim, D. H. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006326 · Cited by 47
The Microbiome Mediates Environmental Effects on Aging
Finlay, B. B., Pettersson, S., Melby, M. K., & Bosch, T. C. G. (2019) · BioEssays · doi:10.1002/bies.201800257 · Cited by 48
Energy restriction and aging
Smith, J. V., Heilbronn, L. K., & Ravussin, É. (2004) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200411000-00005 · Cited by 46
Roles of the Developmental Regulator unc-62/Homothorax in Limiting Longevity in Caenorhabditis elegans
Nostrand, E. L. V., Sánchez-Blanco, A., Wu, B., Nguyen, A., & Kim, S. K. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003325 · Cited by 47
Role of insulin/insulin-like growth factor 1 signaling pathway in longevity
Cheng, C.-L. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i13.1891 · Cited by 51
Octopamine connects nutrient cues to lipid metabolism upon nutrient deprivation
Tao, J., Ma, Y., Yang, Z., Zou, C., & Zhang, K. (2016) · Science Advances · doi:10.1126/sciadv.1501372 · Cited by 47
Mechanism of Different Stereoisomeric Astaxanthin in Resistance to Oxidative Stress in Caenorhabditis elegans
Liu, X., Luo, Q., Cao, Y., Goulette, T., Liu, X. Z., & Xiao, H. (2016) · Journal of Food Science · doi:10.1111/1750-3841.13417 · Cited by 49
Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans
Rieckher, M., Markaki, M., Princz, A., Schumacher, B., & Tavernarakis, N. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.009 · Cited by 46
Regulation of germline stem cell proliferation downstream of nutrient sensing.
Narbonne, P., & Roy, R. (2006) · Cell Division · doi:10.1186/1747-1028-1-29 · Cited by 44
Differential Regulation of the Heat Shock Factor 1 and DAF-16 by Neuronal nhl-1 in the Nematode C. elegans
Volovik, Y., Moll, L., Marques, F. C., Maman, M., Bejerano‐Sagie, M., & Cohen, E. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.028 · Cited by 45
Lifespan extension by peroxidase and dual oxidase-mediated ROS signaling through pyrroloquinoline quinone in C. elegans
Sasakura, H., Moribe, H., Nakano, M., Ikemoto, K., Takeuchi, K., & Mori, I. (2017) · Journal of Cell Science · doi:10.1242/jcs.202119 · Cited by 46
Production of YP170 Vitellogenins Promotes Intestinal Senescence in Caenorhabditis elegans
Sornda, T., Ezcurra, M., Kern, C. C., Galimov, E. R., Au, C., de la Guardia, Y., & Gems, D. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz067 · Cited by 44
Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells
Warkad, M. S., Kim, C.-H., Kang, B.-G., Park, S.-H., Jung, J., Feng, J., Inci, G., Kim, S.-C., Suh, H., Lim, S. S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-93270-0 · Cited by 45
Effects of Sex and Insulin/Insulin-Like Growth Factor-1 Signaling on Performance in an Associative Learning Paradigm in Caenorhabditis elegans
Vellai, T., McCulloch, D., Gems, D., & Kovács, A. (2006) · Genetics · doi:10.1534/genetics.106.061499 · Cited by 44
Metabolism, ubiquinone synthesis, and longevityPreprint
Aguilaniu, H., Durieux, J., & Dillin, A. G. (2005) · Genes & Development · doi:10.1101/gad.1366505 · Cited by 44
Reproductive Suicide: Similar Mechanisms of Aging in C. elegans and Pacific Salmon
Gems, D., Kern, C. C., Nour, J., & Ezcurra, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.688788 · Cited by 49
Influence of oral supplementation with sesamin on longevity of Caenorhabditis elegans and the host defense
Yaguchi, Y., Komura, T., Kashima, N., Tamura, M., Kage‐Nakadai, E., Saeki, S., Terao, K., & Nishikawa, Y. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0671-6 · Cited by 43
Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling inC. elegans
Kumar, N., Jain, V., Singh, A., Jagtap, U., Verma, S., & Mukhopadhyay, A. (2015) · Oncotarget · doi:10.18632/oncotarget.6282 · Cited by 42
Measurements of Physiological Stress Responses in C. Elegans
Bar‐Ziv, R., Frakes, A. E., Higuchi‐Sanabria, R., Bolas, T., Frankino, P. A., Gildea, H. K., Metcalf, M. G., & Dillin, A. G. (2020) · Journal of Visualized Experiments · doi:10.3791/61001 · Cited by 46
Cell nonautonomous roles of NHR‐49 in promoting longevity and innate immunity
Naim, N., Amrit, F. R. G., Ratnappan, R., DelBuono, N., Loose, J. A., & Ghazi, A. (2021) · Aging Cell · doi:10.1111/acel.13413 · Cited by 43
The DAF-16 FOXO Transcription Factor Regulates natc-1 to Modulate Stress Resistance in Caenorhabditis elegans, Linking Insulin/IGF-1 Signaling to Protein N-Terminal Acetylation
Warnhoff, K., Murphy, J. T., Kumar, S., Schneider, D. L., Peterson, M., Hsu, S., Guthrie, J. M., Robertson, J. D., & Kornfeld, K. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004703 · Cited by 42
Innate immunity mediated longevity and longevity induced by germ cell removal converge on the C-type lectin domain protein IRG-7
Yunger, E., Safra, M., Levi‐Ferber, M., Haviv‐Chesner, A., & Henis‐Korenblit, S. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006577 · Cited by 41
Superoxide dismutase SOD-1 modulates C. elegans pathogen avoidance behavior
Horspool, A. M., & Chang, H. C.-H. (2017) · Scientific Reports · doi:10.1038/srep45128 · Cited by 42
Muscle-Specific Histone H3K36 Dimethyltransferase SET-18 Shortens Lifespan of Caenorhabditis elegans by Repressing daf-16a Expression
Su, L., Li, H., Huang, C., Zhao, T., Zhang, Y., Ba, X., Li, Z., Zhang, Y., Huang, B., Lü, J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.029 · Cited by 43
Novel Bioactive Peptides from Meretrix meretrix Protect Caenorhabditis elegans against Free Radical-Induced Oxidative Stress through the Stress Response Factor DAF-16/FOXO
Jia, W., Peng, Q., Su, L., Yu, X., Ma, C. W., Liang, M., Yin, X., Zou, Y., & Huang, Z. (2018) · Marine Drugs · doi:10.3390/md16110444 · Cited by 42
Loss of flavin adenine dinucleotide (FAD) impairs sperm function and male reproductive advantage in C. elegans
Yen, C., Ruter, D. L., Turner, C. D., Pang, S., & Curran, S. P. (2020) · eLife · doi:10.7554/elife.52899 · Cited by 42
The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity
Heimbucher, T., Liu, Z., Bossard, C., McCloskey, R. J., Carrano, A. C., Riedel, C. G., Tanasă, B., Klammt, C., Fonslow, B. R., Riera, C. E., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.002 · Cited by 42
A Krüppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans
Carrano, A. C., Dillin, A. G., & Hunter, T. R. (2014) · Nature Communications · doi:10.1038/ncomms4772 · Cited by 41
Ageing, Neuronal Connectivity and Brain Disorders: An Unsolved Ripple Effect
Bano, D., Agostini, M., Melino, G., & Nicotera, P. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8164-6 · Cited by 43
Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP–mediated feedforward loop
Lee, Y., Jung, Y., Jeong, D., Hwang, W., Ham, S., Park, H. H., Kwon, S., Ashraf, J. M., Murphy, C. T., & Lee, S. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202006174 · Cited by 40
FoxO3 deficiency in cortical astrocytes leads to impaired lipid metabolism and aggravated amyloid pathology
Du, S., Jin, F., Maneix, L., Gedam, M., Xu, Y., Catic, A., Wang, M. C., & Zheng, H. (2021) · Aging Cell · doi:10.1111/acel.13432 · Cited by 43
Targets of DAF-16 involved in Caenorhabditis elegans adult longevity and dauer formation
Jensen, V. L., Gallo, M., & Riddle, D. L. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.06.058 · Cited by 40
Caenorhabditis elegans as a model system to study aging of learning and memory
Murakami, S. (2007) · Molecular Neurobiology · doi:10.1007/bf02700625 · Cited by 41
Mitochondrial respiration and reactive oxygen species in C. elegans
Sedensky, M. M., & Morgan, P. G. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.06.056 · Cited by 40
Formation of a combined Ca/Cd toxicity on lifespan of nematode Caenorhabditis elegans
Wang, D., Liu, P., Yang, Y., & Shen, L. (2010) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2010.05.002 · Cited by 40
Insulin/Insulin-Like Growth Factor Signaling Controls Non-Dauer Developmental Speed in the Nematode Caenorhabditis elegans
Ruaud, A., Katic, I., & Bessereau, J. (2010) · Genetics · doi:10.1534/genetics.110.123323 · Cited by 40
RNAi screens to identify components of gene networks that modulate aging in Caenorhabditis elegans
Ni, Z., & Lee, S. S. (2010) · Briefings in Functional Genomics · doi:10.1093/bfgp/elp051 · Cited by 40
Lactobacillus paracasei HII01 enhances lifespan and promotes neuroprotection in Caenorhabditis elegans
Kumaree, K. K., Prasanth, M. I., Sivamaruthi, B. S., Kesika, P., Tencomnao, T., Chaiyasut, C., & Prasansuklab, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-43846-9 · Cited by 41
Neuronal functions of FOXO/DAF-16
Kim, S. Y., & Webb, A. E. (2016) · Nutrition and Healthy Aging · doi:10.3233/nha-160009 · Cited by 41
Cell-autonomous and non-autonomous roles of daf-16 in muscle function and mitochondrial capacity in aging C. elegans
Wang, H., Webster, P., Chen, L., & Fisher, A. L. (2019) · Aging · doi:10.18632/aging.101914 · Cited by 41
Gene-diet interactions and aging in C. elegans
Yen, C. A., & Curran, S. P. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.02.012 · Cited by 38
Exploring the function of protein kinases in schistosomes: perspectives from the laboratory and from comparative genomics
Walker, A. J., Ressurreição, M., & Rothermel, R. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00229 · Cited by 30
Feeding State, Insulin and NPR-1 Modulate Chemoreceptor Gene Expression via Integration of Sensory and Circuit Inputs
Gruner, M., Nelson, D., Winbush, A., Hintz, R., Ryu, L., Chung, S., Kim, K., Gabel, C. V., & van der Linden, A. M. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004707 · Cited by 38
DAF-16/FoxO and DAF-12/VDR control cellular plasticity both cell-autonomously and via interorgan signaling
Aghayeva, U. F., Bhattacharya, A., Sural, S., Jaeger, E. C. B., Churgin, M. A., Fang-Yen, C. M., & Hobert, O. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001204 · Cited by 38
Inhibition of a eukaryotic initiation factor ( eIF2Bδ ,/F11A3.2) during adulthood extends lifespan in Caenorhabditis elegans
Tohyama, D., Yamaguchi, A., & Yamashita, T. (2008) · The FASEB Journal · doi:10.1096/fj.08-112953 · Cited by 37
Genetic and molecular characterization of CLK-1/mCLK1, a conserved determinant of the rate of aging
Stepanyan, Z., Hughes, B. G., Cliché, D. O., Camp, D., & Hekimi, S. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.06.041 · Cited by 38
Neuronal Inputs and Outputs of Aging and Longevity
Alcedo, J., Flatt, T., & PASYUKOVA, E. G. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00071 · Cited by 39
Nonautonomous Regulation of Neuronal Migration by Insulin Signaling, DAF-16/FOXO, and PAK-1
Kennedy, L. M., Pham, S. C. D. L., & Grishok, A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.07.045 · Cited by 39
The Roles of Cellular and Organismal Aging in the Development of Late-Onset Maladies
Marques, F. C., Volovik, Y., & Cohen, E. (2014) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040508 · Cited by 38
Stressed-Induced TMEM135 Protein Is Part of a Conserved Genetic Network Involved in Fat Storage and Longevity Regulation in Caenorhabditis elegans
Exil, V. J., Ávila, D. S., Benedetto, A., Exil, E. A., Adams, M. R., Au, C., & Aschner, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014228 · Cited by 37
Autophagy in neuronal cell loss: a road to death
Takács‐Vellai, K., Bayci, A., & Vellai, T. (2006) · BioEssays · doi:10.1002/bies.20489 · Cited by 37
DAF-21/Hsp90 is required for C. elegans longevity by ensuring DAF-16/FOXO isoform A function
Somogyvári, M., Gecse, E., & Sőti, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-30592-6 · Cited by 36
Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans
Wang, F., Dai, Y., Zhu, X., Chen, Q., Zhu, H., Zhou, B. Z., Tang, H., & Pang, S. (2021) · Nature Communications · doi:10.1038/s41467-021-25398-6 · Cited by 37
FOXO and related transcription factors binding elements in the regulation of neurodegenerative disorders
Oli, V., Gupta, R. V., & Kumar, P. (2021) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2021.102012 · Cited by 36
A 44 bp intestine-specific hermaphrodite-specific enhancer from the C. elegans vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2 /insulin signaling and by the TGF-β/Sma/Mab pathway
Goszczynski, B., Captan, V. V., Danielson, A. M., Lancaster, B. R., & McGhee, J. D. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.02.031 · Cited by 37
Emerging Omics Approaches in Aging Research
Lorusso, J. S., Sviderskiy, O., & Labunskyy, V. M. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7163 · Cited by 39
Public and private mechanisms of life extension in Caenorhabditis elegans
Houthoofd, K., & Vanfleteren, J. R. (2007) · Molecular Genetics and Genomics · doi:10.1007/s00438-007-0225-1 · Cited by 35
Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegansPreprint
Son, H. G., Seo, K., Seo, M., Park, S., Ham, S., An, S. W. A., Choi, E. S., Lee, Y., Baek, H., Kim, E., et al. (2018) · Genes & Development · doi:10.1101/gad.317362.118 · Cited by 37
Regulation of longevity by genes required for the functions of AIY interneuron in nematode Caenorhabditis elegans
Shen, L., Hu, Y., Cai, T., Lin, X.-F., & Wang, D. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.10.005 · Cited by 35
FoxO6 regulates Hippo signaling and growth of the craniofacial complex
Sun, Z. Q., da Fontoura, C. S. G., Moreno, M., Holton, N. E., Sweat, M., Sweat, Y. Y., Lee, M. K., Arbon, J., Bidlack, F. B., Thedens, D. R., et al. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007675 · Cited by 35
Immunity-longevity tradeoff neurally controlled by GABAergic transcription factor PITX1/UNC-30
Otarigho, B., & Aballay, A. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109187 · Cited by 36
Selenite protects C aenorhabditis elegans from oxidative stress via DAF ‐16 and TRXR ‐1
Li, W.-H., Shi, Y., Chang, C., Huang, C., & Liao, V. H. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300404 · Cited by 34
ASM-3 Acid Sphingomyelinase Functions as a Positive Regulator of the DAF-2/AGE-1 Signaling Pathway and Serves as a Novel Anti-Aging Target
Kim, Y.-S., & Sun, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045890 · Cited by 34
Cell-Nonautonomous Signaling of FOXO/DAF-16 to the Stem Cells of Caenorhabditis elegans
Qi, W., Huang, X., Neumann‐Haefelin, E., Schulze, E., & Baumeister, R. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002836 · Cited by 33
Early experiences mediate distinct adult gene expression and reproductive programs in Caenorhabditis elegans
Ow, M. C., Borziak, K., Nichitean, A. M., Dorus, S., & Hall, S. E. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007219 · Cited by 34
Syringaresinol Reverses Age-Related Skin Atrophy by Suppressing FoxO3a-Mediated Matrix Metalloproteinase–2 Activation in Copper/Zinc Superoxide Dismutase–Deficient Mice
Kim, J., Toda, T., Watanabe, K., Shibuya, S., Ozawa, Y., Izuo, N., Cho, S., Seo, D. B., Yokote, K., & Shimizu, T. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.10.012 · Cited by 33
Nuclear lipid droplets and nuclear damage in Caenorhabditis elegans
Mosquera, J. V., Bacher, M. C., & Priess, J. R. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009602 · Cited by 34
Competing forces maintain the Hydra metaorganism
Deines, P., Lachnit, T., & Bosch, T. C. G. (2017) · Immunological Reviews · doi:10.1111/imr.12564 · Cited by 35
Insulin signaling regulates the toxicity of traffic-related PM2.5on intestinal development and function in nematode Caenorhabditis elegans
Yang, R., Zhao, Y., Yu, X., Lin, Z., Xi, Z., Rui, Q., & Wang, D. (2014) · Toxicology Research · doi:10.1039/c4tx00131a · Cited by 33
Protein disulfide isomerase PDI-6 regulates Wnt secretion to coordinate inter-tissue UPRmt activation and lifespan extension in C. elegans
Li, X., Li, J., Zhu, D., Zhang, N., Hao, X., Zhang, W., Zhang, Q., Liu, Y., Wu, X., & Tian, Y. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110931 · Cited by 33
Enhancing a search for traditional medicinal plants with anthelmintic action by using wild type and stress reporter Caenorhabditis elegans strains as screening tools
Kumarasingha, R., Palombo, E. A., Bhave, M. R., Yeo, T. C., Lim, D. S. L., Tu, C.-L., Shaw, J. M., & Boag, P. R. (2014) · International Journal for Parasitology · doi:10.1016/j.ijpara.2014.01.008 · Cited by 33
Control of cell-fate plasticity and maintenance of multipotency by DAF-16/FoxO in quiescent Caenorhabditis elegans
Karp, X., & Greenwald, I. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222377110 · Cited by 33
MDL-1, a growth- and tumor-suppressor, slows aging and prevents germline hyperplasia and hypertrophy in C. elegans
Riesen, M., Feyst, I., Rattanavirotkul, N., Ezcurra, M., Tullet, J. M. A., Papatheodorou, I., Ziehm, M., Au, C., Gilliat, A. F., Hellberg, J. E. E. U., et al. (2014) · Aging · doi:10.18632/aging.100638 · Cited by 37
Clove essential oil confers antioxidant activity and lifespan extension in C. elegans via the DAF-16/FOXO transcription factor
Zhang, L., Gu, B., & Wang, Y. (2020) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2020.108938 · Cited by 32

Authors: Libina, N., Berman, J. R., & Kenyon, C.
Affiliations: University of California, San Francisco (US)
Corresponding author: Kenyon, Cynthia
ORCID: Kenyon, Cynthia
Venue: Cell
Publisher: Elsevier BV
Published: 2003-11
Volume: 115
Issue: 4
Pages: 489-502
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(03)00889-4
OpenAlex: W2066660409
Cited by: 820
References: 58
Citations by year: 2026: 19 · 2025: 32 · 2024: 41 · 2023: 15 · 2022: 35 · 2021: 53 · 2020: 39 · 2019: 35 · 2018: 48 · 2017: 36 · 2016: 42 · 2015: 24 · 2014: 44 · 2013: 40 · 2012: 33
FWCI: 9.40
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3546 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG11816)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: DAF-16, Caenorhabditis elegans, lifespan regulation, insulin/IGF-1 signaling, intestine, adipose tissue, tissue-specific gene regulation, insulin-like peptides, aging, transcription factors
MeSH terms: Adipose Tissue, Aging, Animals, Insulin, Insulin-Like Growth Factor I, Intestinal Mucosa, Longevity, Mosaicism, Organ Specificity, Receptor, Insulin, RNA, Messenger, Stress, Physiological, Transcription Factors, Signal Transduction, Caenorhabditis elegans, Gene Deletion, Germ-Line Mutation, Gene Expression Regulation, Developmental, Gene Expression Profiling, Caenorhabditis elegans Proteins, Animals, Genetically Modified, Forkhead Transcription Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks