Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan

The embryonic cell lineage of the nematode Caenorhabditis elegans

Sulston, J. E., Schierenberg, E., White, J. G., & Thomson, J. N. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90201-4 · Cited by 4,199

Post-embryonic cell lineages of the nematode, Caenorhabditis elegans

Sulston, J. E., & Horvitz, H. R. (1977) · Developmental Biology · doi:10.1016/0012-1606(77)90158-0 · Cited by 3,479

A C. elegans mutant that lives twice as long as wild type

Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., & Kenyon, C. (2003) · Nature · doi:10.1038/nature01789 · Cited by 2,280

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., & Ruvkun, G. (1997) · Nature · doi:10.1038/40194 · Cited by 1,935

Functional genomic analysis of C. elegans chromosome I by systematic RNA interference

Fraser, A. G., Kamath, R. S., Zipperlen, P., Martinez-Campos, M., Sohrmann, M., & Ahringer, J. (2000) · Nature · doi:10.1038/35042517 · Cited by 1,761

Regulation of aging and age-related disease by DAF-16 and heat-shock factor

Hsu, A.-L., Murphy, C. T., & Kenyon, C. (2003) · Science · doi:10.1126/science.1083701 · Cited by 1,513

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

Lin, K., Dorman, J. B., Rodan, A. R., & Kenyon, C. J. (1997) · Science · doi:10.1126/science.278.5341.1319 · Cited by 1,501

Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans

Kamath, R. S., Martinez-Campos, M., Zipperlen, P., Fraser, A. G., & Ahringer, J. (2000) · Genome biology · doi:10.1186/gb-2000-2-1-research0002 · Cited by 1,332

Regulatory Mechanisms of Aging Through the Nutritional and Metabolic Control of Amino Acid Signaling in Model Organisms

Obata, F., & Miura, M. (2024) · Annual Review of Genetics · doi:10.1146/annurev-genet-111523-102042 · Cited by 18

A homeostatic gut-to-brain insulin antagonist restrains neuronally stimulated fat loss

Liu, C., Khan, A., Seban, N., Littlejohn, N. K., Shah, A., & Srinivasan, S. (2024) · Nature Communications · doi:10.1038/s41467-024-51077-3 · Cited by 19

Mutations of the Electron Transport Chain Affect Lifespan and ROS Levels in C. elegans

Ősz, F., Nazir, A., Takács‐Vellai, K., & Farkas, Z. (2025) · Antioxidants · doi:10.3390/antiox14010076 · Cited by 17

Regulation of aging by unc-13 and sbt-1 in Caenorhabditis elegans is temperature-dependent

He, K.-W., Shen, L., Zhou, W., & Wang, D. (2009) · Neuroscience Bulletin · doi:10.1007/s12264-009-6123-2 · Cited by 16

The lin-4 Gene Controls Fat Accumulation and Longevity in Caenorhabditis elegans

Zhu, C., Ji, C., Zhang, C., Gao, C., Zhu, J., Qin, D., Kou, C., Zhu, G.-Z., Shi, C., & Guo, X. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11124814 · Cited by 16

A fucose containing polymer-rich fraction from the brown alga Ascophyllum nodosum mediates lifespan increase and thermal-tolerance in Caenorhabditis elegans, by differential effects on gene and protein expression

Kandasamy, S., Khan, W., Evans, F., Critchley, A. T., Zhang, J., Fitton, J. H., Stringer, D. N., Gardiner, V.-A., & Prithiviraj, B. (2013) · Food & Function · doi:10.1039/c3fo60050e · Cited by 16

Stressful development: integrating endoderm development, stress, and longevity

Ewe, C. K., Alok, G., & Rothman, J. H. (2020) · Developmental Biology · doi:10.1016/j.ydbio.2020.12.002 · Cited by 13

Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson's disease

Senchuk, M. M., Raamsdonk, J. M. V., & Moore, D. J. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105267 · Cited by 16

Younger for Longer: Insulin Signalling, Immunity and Ageing

Amrit, F. R. G., & May, R. C. (2010) · Current Aging Science · doi:10.2174/1874609811003030166 · Cited by 15

Central nervous system promotes thermotolerance via FoxO/DAF-16 activation through octopamine and acetylcholine signaling in Caenorhabditis elegans

Furuhashi, T., & Sakamoto, K. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.02.076 · Cited by 15

Handbook of Immunosenescence

Nicoletti, C., & Gulisano, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1 · Cited by 15

The GATA transcription factor/ MTA ‐1 homolog egr‐1 promotes longevity and stress resistance in C aenorhabditis elegans

Zimmerman, S. M., & Kim, S. K. (2013) · Aging Cell · doi:10.1111/acel.12179 · Cited by 18

Mendelian randomization analyses implicate biogenesis of translation machinery in human agingPreprint

Javidnia, S., Cranwell, S., Mueller, S. H., Selman, C., Tullet, J. M. A., Kuchenbaecker, K. B., & Alic, N. (2022) · Genome Research · doi:10.1101/gr.275636.121 · Cited by 16

A metabolic regulatory network for the Caenorhabditis elegans intestine

Bhattacharya, S., Horowitz, B. B., Zhang, J., Li, X., Zhang, H., Giese, G. E., Holdorf, A. D., & Walhout, A. J. M. (2022) · iScience · doi:10.1016/j.isci.2022.104688 · Cited by 14

Comparison of physiological functions of antagonistic insulin-like peptides, INS-23 and INS-18, in Caenorhabditis elegans

Matsunaga, Y., Matsukawa, T., Iwasaki, T., Nagata, K., & Kawano, T. (2018) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2017.1415749 · Cited by 16

Endogenous DAF-16 spatiotemporal activity quantitatively predicts lifespan extension induced by dietary restriction

Huayta, J., Crapster, J. P., & San‐Miguel, A. (2023) · Communications Biology · doi:10.1038/s42003-023-04562-2 · Cited by 15

A variant in PPP4R3A protects against alzheimer‐related metabolic decline

Christopher, L., Napolioni, V., Khan, R. R., Han, S. S., Greicius, M. D., & Initiative, A. D. N. (2017) · Annals of Neurology · doi:10.1002/ana.25094 · Cited by 15

Regulation of Age-related Decline by Transcription Factors and Their Crosstalk with the Epigenome

Zhou, X., Sen, I., Lin, X.-X., & Riedel, C. G. (2018) · Current Genomics · doi:10.2174/1389202919666180503125850 · Cited by 15

NSBP-1 mediates the effects of cholesterol on insulin/IGF-1 signaling in Caenorhabditis elegans

Cheong, M. C., Lee, H., Na, K., Joo, H.-J., Avery, L., You, Y., & Paik, Y. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1221-0 · Cited by 15

Molecular characterization and functional analysis of BdFoxO gene in the oriental fruit fly, Bactrocera dorsalis (Diptera: Tephritidae)

Wu, Y.-B., Yang, W., Xie, Y., Xu, K.-K., Tian, Y., Yuan, G., & Wang, J. (2015) · Gene · doi:10.1016/j.gene.2015.12.029 · Cited by 13

Saponins extracted by ultrasound from Zizyphus jujuba Mil var. spinosa leaves exert resistance to oxidative damage in Caenorhabditis elegans

Sun, Y. P., Zhang, Y., Qi, W., Xie, J., & Cui, X. (2020) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-020-00653-4 · Cited by 13

Integration of Stress Signaling in Caenorhabditis elegans Through Cell-Nonautonomous Contributions of the JNK Homolog KGB-1

Liu, L., Ruediger, C. T., & Shapira, M. (2018) · Genetics · doi:10.1534/genetics.118.301446 · Cited by 13

Neuronal Diseases: Small Heat Shock Proteins Calm Your Nerves

Perng, M. D., & Quinlan, R. A. (2004) · Current Biology · doi:10.1016/j.cub.2004.07.047 · Cited by 13

Neuroendocrine regulation of fat metabolism by autophagy gene atg‐18 in C. elegans dauer larvae

Jia, R., Zhang, J., & Jia, K. (2019) · FEBS Open Bio · doi:10.1002/2211-5463.12708 · Cited by 12

Forkhead box O proteins: steering the course of stem cell fate

Cheng, M., Nie, Y., Song, M., Chen, F., & Yu, Y. H. (2024) · Cell Regeneration · doi:10.1186/s13619-024-00190-1 · Cited by 13

The role of kinesin-1 in neuronal dense core vesicle transport, locomotion and lifespan regulation in C. elegans

Gavrilova, A., Boström, A., Nickolay Korabel, A., Fedotov, S. P., Poulin, G. B., & Allan, V. (2024) · Journal of Cell Science · doi:10.1242/jcs.262148 · Cited by 12

Spatial function of the oxidative DNA damage response in radiation induced bystander effects in intra- and inter-system of Caenorhabditis elegans

Li, Q., Shi, J., Chen, L., Zhan, F., Yuan, H., Wang, J., Xu, A., & Wu, L. (2017) · Oncotarget · doi:10.18632/oncotarget.17229 · Cited by 12

Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity

Shioda, T., Takahashi, I., Ikenaka, K., Fujita, N., Kanki, T., Oka, T., Mochizuki, H., Antebi, A., Yoshimori, T., & Nakamura, S. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2221553120 · Cited by 12

Delayed innocent bystander cell death following hypoxia in Caenorhabditis elegans

Sun, C.-L., Kim, E. S., & Crowder, C. M. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.176 · Cited by 12

Cell cycle controls stress response and longevity in C. elegans

Dottermusch, M., Lakner, T., Peyman, T., Klein, M., Walz, G., & Neumann‐Haefelin, E. (2016) · Aging · doi:10.18632/aging.101052 · Cited by 12

The protein kinase MBK-1 contributes to lifespan extension in daf-2 mutant and germline-deficient Caenorhabditis elegans

Mack, H. I. D., Zhang, P., Fonslow, B. R., & Yates, J. R. (2017) · Aging · doi:10.18632/aging.101244 · Cited by 12

Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans ’ Lifespan

Zhang, P., Zhai, Y., Cregg, J. M., Ang, K. K. H., Arkin, M. R., & Kenyon, C. J. (2019) · G3 Genes Genomes Genetics · doi:10.1534/g3.119.400618 · Cited by 12

Redefining proteostasis transcription factors in organismal stress responses, development, metabolism, and health

Jones, L., Chen, Y., & van Oosten‐Hawle, P. (2020) · Biological Chemistry · doi:10.1515/hsz-2019-0385 · Cited by 13

Signaling pathway of insulin and insulin-like growth factor 1 (IGF-1) as a potential regulator of lifespan

Chistyakova, O. V. (2008) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093008010015 · Cited by 12

Comment on "Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body"

Tatar, M. (2005) · Science · doi:10.1126/science.1104721 · Cited by 12

Astaxanthin extends lifespan via altered biogenesis of the mitochondrial respiratory chain complex IIIPreprint

Hoffman, R., Sultan, L. D., Saada, A., Hirschberg, J., Ostersetzer‐Biran, O., & Gruenbaum, Y. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/698001 · Cited by 12

Reserpine requires the D2-type receptor, dop-3, and the exoribonuclease, eri-1, to extend the lifespan in C. elegans

Saharia, K., Kumar, R., Gupta, K., Mishra, S., & Subramaniam, J. R. (2016) · Journal of Biosciences · doi:10.1007/s12038-016-9652-7 · Cited by 9

mRNA decapping is an evolutionarily conserved modulator of neuroendocrine signaling that controls development and ageing

Borbolis, F., Rallis, J., Kanatouris, G., Kokla, N., Karamalegkos, A., Vasileiou, C., Vakaloglou, K. M., Diallinas, G., Stravopodis, D. J., Zervas, C. G., et al. (2020) · eLife · doi:10.7554/elife.53757 · Cited by 11

Quantification of tissue-specific protein translation in whole C. elegans using O-propargyl-puromycin labeling and fluorescence microscopy

Somers, H. M., Fuqua, J. H., Bonnet, F. X. A., & Rollins, J. A. (2022) · Cell Reports Methods · doi:10.1016/j.crmeth.2022.100203 · Cited by 11

Changing ROS, NAD and AMP: A path to longevity via mitochondrial therapeutics

Lushchak, O. V., Gospodaryov, D. V., Strilbytska, O. M., & Bayliak, M. M. (2023) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2023.03.005 · Cited by 11

Regulation of defective mitochondrial DNA accumulation and transmission in C. elegans by the programmed cell death and aging pathways

Flowers, S. E., Kothari, R., Cleuren, Y. N. T., Alcorn, M. R., Ewe, C. K., Alok, G., Fiallo, S. L., Joshi, P. M., & Rothman, J. H. (2023) · eLife · doi:10.7554/elife.79725 · Cited by 12

UNC-49 is a redox-sensitive GABA A receptor that regulates the mitochondrial unfolded protein response cell nonautonomously

Pohl, F., Germann, A. L., Mao, J., Hou, S., Bakare, B., Lin, P. K. T., Yates, K., Nonet, M. L., Akk, G., Kornfeld, K., et al. (2023) · Science Advances · doi:10.1126/sciadv.adh2584 · Cited by 10

Neuronal IL-17 controls Caenorhabditis elegans developmental diapause through CEP-1/p53

Godthi, A., Min, S., Das, S., Cruz-Corchado, J., Deonarine, A., Misel‐Wuchter, K., Issuree, P. D. A., & Prahlad, V. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2315248121 · Cited by 11

DHS-21, a dicarbonyl/ l -xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans

Le, T. S., Ko, K., Cho, J. H., Singaravelu, G., Chatterjee, I., Choi, T.-W., Song, H., Yu, J.-R., Park, B.-J., Lee, S.-K., et al. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.062 · Cited by 11

Uncoupling the Trade-Off between Somatic Proteostasis and Reproduction in Caenorhabditis elegans Models of Polyglutamine Diseases

Shemesh, N., Shai, N., Meshnik, L., Katalan, R., & Ben‐Zvi, A. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00101 · Cited by 12

Isoflurane Exposure in Juvenile Caenorhabditis elegans Causes Persistent Changes in Neuron Dynamics

Wirak, G. S., Gabel, C. V., & Connor, C. W. (2020) · Anesthesiology · doi:10.1097/aln.0000000000003335 · Cited by 11

Mutually exclusive dendritic arbors in C. elegans neurons share a common architecture and convergent molecular cues

Androwski, R. J., Asad, N., Wood, J. G., Hofer, A., Locke, S., Smith, C. M., Rose, B., & Schroeder, N. E. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1009029 · Cited by 11

The C. elegans Homolog of RBBP6 (RBPL-1) Regulates Fertility through Controlling Cell Proliferation in the Germline and Nutrient Synthesis in the Intestine

Huang, P., Ma, X., Zhao, Y., & Miao, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058736 · Cited by 11

Uncoupling of pathways that promote postmitotic life span and apoptosis from replicative immortality of Caenorhabditis elegans germ cells

Ahmed, S. C. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00244.x · Cited by 11

Nuclear hormone receptors as mediators of metabolic adaptability following reproductive perturbations

Ratnappan, R., Ward, J. D., Yamamoto, K. R., & Ghazi, A. (2016) · Worm · doi:10.1080/21624054.2016.1151609 · Cited by 9

Gene expression changes reveal patterns of aging in the rat digestive tract

Englander, E. W. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.06.005 · Cited by 11

Models of insulin signalling and longevity

Piper, M. D. W., Selman, C., McElwee, J. J., & Partridge, L. (2005) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2005.11.001 · Cited by 11

Decoding lifespan secrets: the role of the gonad in Caenorhabditis elegans aging

Pires‐daSilva, A., Kelleher, R., & Reynoldson, L. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1380016 · Cited by 11

Insulin signaling in the aging of healthy and proteotoxically stressed mechanosensory neurons

Scerbak, C., Vayndorf, E. M., Parker, J. A., Néri, C., Driscoll, M., & Taylor, B. E. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00212 · Cited by 12

Effect of 9,12-Octadecadiynoic Acid on Neurobehavioral Development in Caenorhabditis elegans

Chen, T., Chao, H., Wu, C., Lai, Y.-R., Chen, C., Yoshioka, T., Hsu, W., & Tsai, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168917 · Cited by 10

Anabolic Function Downstream of TOR Controls Trade-offs Between Longevity and Reproduction at the Level of Specific Tissues in C. elegans

Howard, A. C., Mir, D. A., Snow, S., Horrocks, J., Sayed, H., Ma, Z., & Rogers, A. N. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.725068 · Cited by 9

Knockdown of neuronal DAF-15/Raptor promotes healthy aging in C. elegans

Zang, X., Wang, Q., Zhang, H., Zhang, Y., Wang, Z., Wu, Z., & Chen, D. (2023) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2023.11.002 · Cited by 10

Considering Caenorhabditis elegans Aging on a Temporal and Tissue Scale: The Case of Insulin/IGF-1 Signaling

Fabrizio, P., Alcolei, A., & Solari, F. (2024) · Cells · doi:10.3390/cells13030288 · Cited by 10

Epigallocatechin Gallate (EGCG) from Green Tea (Camellia sinensis) and Other Natural Products Mediate Stress Resistance and Slows Down Aging Processes in Caenorhabditis elegans

Wink, M., & Abbas, S. (2012) · Tea in Health and Disease Prevention · doi:10.1016/b978-0-12-384937-3.00093-8 · Cited by 10

pkc‐1regulatesdaf‐2insulin/IGF signalling‐dependent control of dauer formation inCaenorhabditis elegans

Monje, J. M., Brokate-Llanos, A. M., Pérez‐Jiménez, M. M., Fidalgo, M. A., & Muñoz, M. J. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00747.x · Cited by 10

Light Sheet Microscopy to Measure Protein Dynamics

Rieckher, M. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25451 · Cited by 10

Linalool odor stimulation improves heat stress tolerance and decreases fat accumulation in nematodes

Hirano, N., & Sakamoto, K. (2018) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2018.1518699 · Cited by 10

Detrimental effects of fructose on mitochondria in mouse motor neurons and onC. eleganshealthspan

Lodha, D., Rajasekaran, S., Jayavelu, T., & Subramaniam, J. R. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1853413 · Cited by 10

HandKAchip - Hands-free killing assay on a chip

Lee, K. S., Lee, L. E., & Levine, E. (2016) · Scientific Reports · doi:10.1038/srep35862 · Cited by 10

Microbial Interactions with Caenorhabditis elegans: Lessons from a Model Organism

Gravato-Nobre, M. J., & Hodgkin, J. (2011) · Springer eBooks · doi:10.1007/978-1-4020-9648-8_3 · Cited by 10

Combinatorial transcriptomic and genetic dissection of insulin/ IGF ‐1 signaling‐regulated longevity in Caenorhabditis elegans

Ham, S., Kim, S. S., Park, S., Kwon, H. C., Ha, S. G., Bae, Y., Lee, G., & Lee, S. (2024) · Aging Cell · doi:10.1111/acel.14151 · Cited by 9

Model systems to the rescue

Alper, S. (2010) · Communicative & Integrative Biology · doi:10.4161/cib.3.5.12561 · Cited by 10

Longevity Regulation by Insulin/IGF-1 Signalling

An, S. W. A., Artan, M., Park, S., Altıntaş, Ö., & Lee, S. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-44703-2_4 · Cited by 9

Chromosome dosage as a life span determinant in Caenorhabiditis elegans

Hartman, P. S., & Ishii, N. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.06.001 · Cited by 9

CAP protein superfamily members in Toxocara canis

Stroehlein, A. J., Young, N. D., Hall, R. S., Korhonen, P. K., Hofmann, A., Sternberg, P. W., Jabbar, A., & Gasser, R. B. (2016) · Parasites & Vectors · doi:10.1186/s13071-016-1642-y · Cited by 9

Angiostrongylus cantonensis daf-2 regulates dauer, longevity and stress in Caenorhabditis elegans

Yan, B., Sun, W., Shi, X., Huang, L., Chen, L., Wang, S., Yan, L., Liang, S., & Huang, H. (2017) · Veterinary Parasitology · doi:10.1016/j.vetpar.2017.04.025 · Cited by 9

Dissecting cause and effect in host-microbiome interactions using the combined worm-bug model system

Ezcurra, M. (2018) · Biogerontology · doi:10.1007/s10522-018-9752-x · Cited by 11

Purple corn extract (PCE) alleviates cigarette smoke (CS)-induced DNA damage in rodent blood cells by activation of AMPK/Foxo3a/MnSOD pathway

Kim, W.-S., Kim, C.-H., Lee, J.-M., Jeon, J.-H., Kang, B.-G., Warkad, M. S., Inci, G., Suh, H., Lim, S. S., Kim, S.-C., et al. (2021) · Animal Cells and Systems · doi:10.1080/19768354.2021.1883734 · Cited by 9

Detection of Mitochondrial Toxicity of Environmental Pollutants UsingCaenorhabditis elegans

Maurer, L. L., Luz, A. L., & Meyer, J. N. (2018) · Wiley eBooks · doi:10.1002/9781119329725.ch43 · Cited by 9

Different gametogenesis states uniquely impact longevity in Caenorhabditis elegans

Chaturbedi, A., & Lee, S. S. (2025) · Nature Communications · doi:10.1038/s41467-025-64341-x · Cited by 8

Insulin/IGF-dependent Wnt signaling promotes formation of germline tumors and other developmental abnormalities following early-life starvation in Caenorhabditis elegans

Shaul, N. C., Jordan, J. M., Falsztyn, I. B., & Baugh, L. R. (2022) · Genetics · doi:10.1093/genetics/iyac173 · Cited by 8

Developmental disruption of the mitochondrial fission gene drp-1 extends the longevity of daf-2 insulin/IGF-1 receptor mutant

Traa, A., González, A. A. T., & Raamsdonk, J. M. V. (2024) · GeroScience · doi:10.1007/s11357-024-01276-z · Cited by 12

Physiological evaluation and transcriptomic and proteomic analyses to reveal the anti-aging and reproduction-promoting mechanisms of glycitein in Caenorhabditis elegans

Lei, J., Cao, L., Li, Y., Kan, Q., Yang, L., Dai, W., Liu, G., Fu, J., Chen, Y., Huang, Q., et al. (2024) · Food & Function · doi:10.1039/d4fo02271h · Cited by 8

CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegans

Li, Y., Finkbeiner, S., Ganner, A., Gerber, J. P., Klein, M., Grafe, M., Kandzia, J., Thien, A., Thedieck, K., Breves, G., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24039 · Cited by 8

Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling

Segref, A., Vakkayil, K. L., Padvitski, T., Li, Q., Kroef, V., Lormann, J., Koerner, L., Finger, F., & Hoppe, T. (2022) · Nature Communications · doi:10.1038/s41467-022-33467-7 · Cited by 8

Insulin-Like Peptides

Antonova‐Koch, Y., Riehle, M. A., Arik, A. J., & Brown, M. R. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-385095-9.00038-5 · Cited by 8

Infection and Immune Response in the Nematode Caenorhabditis elegans Elicited by the Phytopathogen Xanthomonas

Bai, Y., Zhi, D., Li, C., Liu, D., Zhang, J., Tian, J., Wang, X., Ren, H. J., & Li, H. (2014) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1401.01017 · Cited by 8

Longevity control by the nervous system: Sensory perception, stress response and beyond

Lin, C.-T., He, C.-W., Huang, T., & Pan, C. (2017) · Translational Medicine of Aging · doi:10.1016/j.tma.2017.07.001 · Cited by 9

Temporal pattern of neuronal insulin release during Caenorhabditis elegans aging: Role of redox homeostasis

Minniti, A. N., Arriagada, H., Zúñiga, S., Bravo‐Zehnder, M., Alfaro, I. E., & Aldunate, R. (2018) · Aging Cell · doi:10.1111/acel.12855 · Cited by 8

Multilayered regulation of longevity in Caenorhabditis elegans

Bong, D., Kwon, H. C., & Lee, S. (2025) · Molecules and Cells · doi:10.1016/j.mocell.2025.100308 · Cited by 9

Sex‐specific growth and lifespan effects of germline removal in the dioecious nematode Caenorhabditis remanei

Lind, M. I., Mautz, B. S., Carlsson, H., Hinas, A., Gudmunds, E., & Maklakov, A. A. (2024) · Aging Cell · doi:10.1111/acel.14290 · Cited by 9

Mild Muscle Mitochondrial Fusion Distress Extends Drosophila Lifespan through an Early and Systemic Metabolome Reorganization

Tapia, A., Palomino‐Schätzlein, M., Roca, M., Lahoz, A., Pineda‐Lucena, A., Amo, V. L. D., & Galindo, M. I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212133 · Cited by 9

Programmed and non-programmed theories of aging

Mitteldorf, J. (2010) · Russian Journal of General Chemistry · doi:10.1134/s107036321007042x · Cited by 7

Response to Comment on "Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body"

Giannakou, M. E., Goss, M. W., Jünger, M. A., Hafen, E., Leevers, S. J., & Partridge, L. (2005) · Science · doi:10.1126/science.1104733 · Cited by 7

HSF1 Regulation in Aging and Its Role in Longevity

Shemesh, N., & Ben‐Zvi, A. (2016) · Springer eBooks · doi:10.1007/978-4-431-55852-1_5 · Cited by 7

Demonstrating Improved Multiple Transport‐Mean‐Free‐Path Imaging Capabilities of Light Sheet Microscopy in the Quantification of Fluorescence Dynamics

Rieckher, M., Psycharakis, S. E., Ancora, D., Liapis, E., Zacharopoulos, A. D., Ripoll, J., Tavernarakis, N., & Zacharakis, G. (2017) · Biotechnology Journal · doi:10.1002/biot.201700419 · Cited by 7

A Receptor Tyrosine Kinase Network Regulates Neuromuscular Function in Response to Oxidative Stress in Caenorhabditis elegans

Kim, S., & Sieburth, D. (2019) · Genetics · doi:10.1534/genetics.119.302026 · Cited by 7

Caenorhabditis elegans: Evaluation of Nanoparticle Toxicity

Kumar, S., & Suchiang, K. (2020) · Springer eBooks · doi:10.1007/978-981-15-1702-0_17 · Cited by 7

Influences of Germline Cells on Organismal Lifespan and Healthspan

Amrit, F. R. G., & Ghazi, A. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-44703-2_6 · Cited by 6

DPFF‐1 transcription factor deficiency causes the aberrant activation of MPK‐1 and meiotic defects in the Caenorhabditis elegans germline

Villanueva‐Chimal, E., Salinas, L. S., Fernández-Cárdenas, L. P., Huelgas‐Morales, G., Cabrera‐Wrooman, A., & Navarro, R. E. (2017) · genesis · doi:10.1002/dvg.23072 · Cited by 7

Caenorhabditis elegans development requires mitochondrial function in the nervous system

Ndegwa, S., & Lemire, B. D. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.108 · Cited by 7

Inside Insulin Signaling, Communication Is Key to Long Life

Antebi, A. (2004) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2004.23.pe25 · Cited by 7

Further Extension of Lifespan by Unc-43/CaMKII and Egl-8/PLCβ Mutations in Germline-Deficient Caenorhabditis elegans

Mack, H. I. D., Buck, L. G., Skalet, S., Kremer, J., Li, H., & Mack, E. (2022) · Cells · doi:10.3390/cells11223527 · Cited by 6

Inhibition of PAR-1 delays aging via activating AMPK in C. elegans

Wu, D., Cai, W., Zhang, X., Lan, J., Zou, L., Chen, S. J., Wu, Z., & Chen, D. (2020) · Aging · doi:10.18632/aging.104180 · Cited by 6

Trimethylamine modulates dauer formation, neurodegeneration, and lifespan through tyra‐3/daf‐11 signaling in Caenorhabditis elegans

Khanna, A., Sellegounder, D., Kumar, J., Chamoli, M., Vargas, M., Chinta, S. J., Rane, A., Nelson, C. S., Peiris, T. H., Brem, R. B., et al. (2021) · Aging Cell · doi:10.1111/acel.13351 · Cited by 6

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

Lin, K., Hsin, H., Libina, N., & Kenyon, C. J. (2001) · Nature Genetics · doi:10.1038/88850 · Cited by 1,027

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., & Kenyon, C. (2003) · Nature · doi:10.1038/nature01789 · Cited by 2,280

Neuronal DAF-16-to-intestinal DAF-16 communication underlies organismal lifespan extension in C. elegans

Uno, M., Tani, Y., Nono, M., Okabe, E., Kishimoto, S., Takahashi, C., Abe, R., Kurihara, T., & Nishida, E. (2021) · iScience · doi:10.1016/j.isci.2021.102706 · Cited by 54

Transcriptional regulation of Caenorhabditis elegansFOXO/DAF-16 modulates lifespan

Bansal, A., Kwon, E., Conte, D., Liu, H., Gilchrist, M. J., MacNeil, L. T., & Tissenbaum, H. A. (2014) · Longevity & Healthspan · doi:10.1186/2046-2395-3-5 · Cited by 62

Direct and Indirect Gene Regulation by a Life-Extending FOXO Protein in C. elegans: Roles for GATA Factors and Lipid Gene Regulators

Zhang, P., Judy, M. E., Lee, S., & Kenyon, C. J. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.013 · Cited by 167