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Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan
Open accessAbstract
In C. elegans, the transcription factor DAF-16 promotes longevity in response to reduced insulin/IGF-1 signaling or germline ablation. In this study, we have asked how different tissues interact to specify the lifespan of the animal. We find that several tissues act as signaling centers. In particular, DAF-16 activity in the intestine, which is also the animal's adipose tissue, completely restores the longevity of daf-16(-) germline-deficient animals, and increases the lifespans of daf-16(-) insulin/IGF-1-pathway mutants substantially. Our findings indicate that DAF-16 may control two types of downstream signals: DAF-16 activity in signaling cells upregulates DAF-16 in specific responding tissues, possibly via regulation of insulin-like peptides, and also evokes DAF-16-independent responses. We suggest that this network of tissue interactions and feedback regulation allows the tissues to equilibrate and fine-tune their expression of downstream genes, which, in turn, coordinates their rates of aging within the animal.
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“Importantly, reduced IIS specifically in the nervous system is sufficient to extend lifespan in several model systems.”
From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [65]
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Additional file 13 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314321
Additional file 15 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314327
Additional file 3 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314345
Additional file 3 of An insulin-like signalling pathway model for Fasciola gigantica
Wu, D., Yang, Y., Yang, Y., Li, L., Fu, S., Wang, L., Tan, L., Lu, X., Zhang, W., & Di, W. (2024) · Figshare · doi:10.6084/m9.figshare.26731312
Additional file 18 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314336
Additional file 8 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314360
Additional file 9 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314363
Additional file 10 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314303
Additional file 1 of An insulin-like signalling pathway model for Fasciola gigantica
Wu, D., Yang, Y., Yang, Y., Li, L., Fu, S., Wang, L., Tan, L., Lu, X., Zhang, W., & Di, W. (2024) · Figshare · doi:10.6084/m9.figshare.25998631
Additional file 12 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314315
Additional file 4 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314348
Additional file 7 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314357
Additional file 14 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314324
Additional file 6 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314354
Additional file 17 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314333
Additional file 2 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314342
Additional file 16 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314330
Additional file 11 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314309
Additional file 1 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314339
Additional file 2 of An insulin-like signalling pathway model for Fasciola gigantica
Wu, D., Yang, Y., Yang, Y., Li, L., Fu, S., Wang, L., Tan, L., Lu, X., Zhang, W., & Di, W. (2024) · Figshare · doi:10.6084/m9.figshare.25998635
Additional file 5 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314351
Metadata
- Authors
- Libina, N., Berman, J. R., & Kenyon, C.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Kenyon, Cynthia
- ORCID
- Kenyon, Cynthia
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 115
- Issue
- 4
- Pages
- 489-502
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2066660409
- Cited by
- 820
- References
- 58
- Citations by year
- 2026: 19 · 2025: 32 · 2024: 41 · 2023: 15 · 2022: 35 · 2021: 53 · 2020: 39 · 2019: 35 · 2018: 48 · 2017: 36 · 2016: 42 · 2015: 24 · 2014: 44 · 2013: 40 · 2012: 33
- FWCI
- 9.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3546 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG11816)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- DAF-16, Caenorhabditis elegans, lifespan regulation, insulin/IGF-1 signaling, intestine, adipose tissue, tissue-specific gene regulation, insulin-like peptides, aging, transcription factors
- MeSH terms
- Adipose Tissue, Aging, Animals, Insulin, Insulin-Like Growth Factor I, Intestinal Mucosa, Longevity, Mosaicism, Organ Specificity, Receptor, Insulin, RNA, Messenger, Stress, Physiological, Transcription Factors, Signal Transduction, Caenorhabditis elegans, Gene Deletion, Germ-Line Mutation, Gene Expression Regulation, Developmental, Gene Expression Profiling, Caenorhabditis elegans Proteins, Animals, Genetically Modified, Forkhead Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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