Cited by 143Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation14-3-3 protein interactions

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Phosphorylation by the β-Catenin/MAPK Complex Promotes 14-3-3-Mediated Nuclear Export of TCF/POP-1 in Signal-Responsive Cells in C. elegans

Open access

Lo, Miao-Chia, Gay, Frédérique, Odom, Raanan, Shi, Yang, Lin, Rueyling·2004·Cell

DOI 10.1016/s0092-8674(04)00203-x

Open this paper in CoChat — free account Open PDF

Abstract

In C. elegans embryos, a Wnt/MAPK signaling pathway downregulates the TCF/LEF transcription factor POP-1, resulting in a lower nuclear level in signal-responsive cells compared to their sisters. Although the beta-catenin WRM-1 is required for POP-1 downregulation, a direct interaction between these two proteins does not seem to be required, as the beta-catenin-interacting domain of POP-1 is dispensable for both POP-1 downregulation and function in early embryos. We show here that WRM-1 downregulates POP-1 by promoting its phosphorylation by the MAP kinase LIT-1 and subsequent nuclear export via a 14-3-3 protein, PAR-5. In signal-responsive cells, we also detect a concurrent upregulation of nuclear LIT-1 that is dependent on Wnt/MAPK signaling. Our results suggest a model whereby Wnt/MAPK signaling downregulates POP-1 levels in responsive cells, in part by increasing nuclear LIT-1 levels, thereby increasing POP-1 phosphorylation and PAR-5-mediated nuclear export.

Integrity signals

Registry

Crossref · 10.1016/s0092-8674(04)00203-x

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Wnt signaling and cancer
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals
Fornerod, M. W. J., Ohno, M., Yoshida, M., & Mattaj, I. W. (1997) · Cell · doi:10.1016/s0092-8674(00)80371-2 · Cited by 2,086
Specific interference by ingested dsRNA
Timmons, L., & Fire, A. Z. (1998) · Nature · doi:10.1038/27579 · Cited by 1,938
14-3-3 Proteins: Structure, Function, and Regulation
Fu, H., Subramanian, R. R., & Masters, S. C. (2000) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.617 · Cited by 1,596
CRM1 is responsible for intracellular transport mediated by the nuclear export signal
Fukuda, M., Asano, S., Nakamura, T., Adachi, M., Yoshida, M., Yanagida, M., & Nishida, E. (1997) · Nature · doi:10.1038/36894 · Cited by 1,213
Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor
Stade, K., Ford, C. S., Guthrie, C., & Weis, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80370-0 · Cited by 1,145
Creation of Low-Copy Integrated Transgenic Lines in Caenorhabditis elegans
Praitis, V., Casey, E., Collar, D. C., & Austin, J. (2001) · Genetics · doi:10.1093/genetics/157.3.1217 · Cited by 817
Drosophila Tcf and Groucho interact to repress Wingless signalling activity
Cavallo, R. A., Cox, R. T., Moline, M. M., Roose, J., Polevoy, G. A., Clevers, H., Peifer, M., & Bejsovec, A. (1998) · Nature · doi:10.1038/26982 · Cited by 730
Evidence for a Role of CRM1 in Signal-Mediated Nuclear Protein Export
Ossareh‐Nazari, B., Bachelerie, F., & Dargemont, C. (1997) · Science · doi:10.1126/science.278.5335.141 · Cited by 713
Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos
Rocheleau, C. E., Downs, W. D., Lin, R., Wittmann, C., Bei, Y., Cha, Y.-H., Ali, M., Priess, J. R., & Mello, C. C. (1997) · Cell · doi:10.1016/s0092-8674(00)80531-0 · Cited by 660
Self-citation

Show all 38 references

Sorted by citations

Wnt/β-Catenin Signaling in Development and Disease
Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568
The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325
TCF/LEFs and Wnt Signaling in the NucleusPreprint
Cadigan, K. M., & Waterman, M. L. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007906 · Cited by 780
The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress responsePreprint
Inoue, H., Hisamoto, N., An, J. H., Oliveira, R. D. P., Nishida, E., Blackwell, T. K., & Matsumoto, K. (2005) · Genes & Development · doi:10.1101/gad.1324805 · Cited by 443
Diversity of LEF/TCF action in development and disease
Arce, L., Yokoyama, N. N., & Waterman, M. L. (2006) · Oncogene · doi:10.1038/sj.onc.1210056 · Cited by 449
Systematic Discovery of New Recognition Peptides Mediating Protein Interaction Networks
Neduva, V., Linding, R., Su-Angrand, I., Stark, A., Masi, F. D., Gibson, T. J., Lewis, J., Serrano, L., & Russell, R. B. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030405 · Cited by 359
The C. elegans intestine
McGhee, J. D. (2007) · WormBook · doi:10.1895/wormbook.1.133.1 · Cited by 354
Wnt signaling
Eisenmann, D. M. (2005) · WormBook · doi:10.1895/wormbook.1.7.1 · Cited by 297
In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators
Lien, W., Polak, L., Lin, M., Lay, K., Zheng, D., & Fuchs, E. V. (2014) · Nature Cell Biology · doi:10.1038/ncb2903 · Cited by 215
The way Wnt works: Components and mechanism
Saito‐Diaz, K., Chen, T. W., Wang, X., Thorne, C. A., Wallace, H. A., Page, A. W., & Lee, E. N. (2012) · Growth Factors · doi:10.3109/08977194.2012.752737 · Cited by 223
Opposing Wnt Pathways Orient Cell Polarity during Organogenesis
Green, J. L., Inoue, T., & Sternberg, P. W. (2008) · Cell · doi:10.1016/j.cell.2008.06.026 · Cited by 182
Wnt Signaling in Vertebrate Axis SpecificationPreprint
Hikasa, H., & Sokol, S. Y. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007955 · Cited by 178
Regulation of TCF3 by Wnt-Dependent Phosphorylation during Vertebrate Axis Specification
Hikasa, H., Ezan, J., Itoh, K., Li, X., Klymkowsky, M. W., & Sokol, S. Y. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.09.005 · Cited by 165
Regulation of Wnt/β‐catenin signaling by protein kinases
Verheyen, E. M., & Gottardi, C. J. (2009) · Developmental Dynamics · doi:10.1002/dvdy.22019 · Cited by 165
Multiple functions of the noncanonical Wnt pathway
Gómez‐Orte, E., Sáenz‐Narciso, B., Moreno, S., & Cabello, J. (2013) · Trends in Genetics · doi:10.1016/j.tig.2013.06.003 · Cited by 153
Notch signaling in the C. elegans embryo
Priess, J. R. (2005) · WormBook · doi:10.1895/wormbook.1.4.1 · Cited by 147
A β-Catenin Identified by Functional Rather Than Sequence Criteria and Its Role in Wnt/MAPK Signaling
Kidd, A. R., Miskowski, J. A., Siegfried, K. R., Sawa, H., & Kimble, J. E. (2005) · Cell · doi:10.1016/j.cell.2005.03.029 · Cited by 144
Proteomic analysis identifies that 14-3-3ζ interacts with β-catenin and facilitates its activation by Akt
Tian, Q., Feetham, M. C., Tao, W. A., He, X., Li, L., Aebersold, R. H., & Hood, L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406499101 · Cited by 146
How do they do Wnt they do?: regulation of transcription by the Wnt/β‐catenin pathway
Archbold, H. C., Yang, Y., Chen, L., & Cadigan, K. M. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02293.x · Cited by 149
Chibby cooperates with 14-3-3 to regulate β-catenin subcellular distribution and signaling activity
Li, F., Mofunanya, A., Harris, K., & Takemaru, K. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200709091 · Cited by 147
The regulated assembly of a PKCɛ complex controls the completion of cytokinesis
Saurin, A. T., Durgan, J., Cameron, A. J. M., Faisal, A., Marber, M. S., & Parker, P. J. (2008) · Nature Cell Biology · doi:10.1038/ncb1749 · Cited by 134
The C. elegans pharynx: a model for organogenesis
Mango, S. E. (2007) · WormBook · doi:10.1895/wormbook.1.129.1 · Cited by 126
Two βs or not two βs: regulation of asymmetric division by β-catenin
Mizumoto, K., & Sawa, H. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.08.004 · Cited by 123
A New Look at TCF and β-Catenin through the Lens of a Divergent C. elegans Wnt Pathway
Phillips, B. T., & Kimble, J. E. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.07.002 · Cited by 119
C. elegans TCF protein, POP-1, converts from repressor to activator as a result of Wnt-induced lowering of nuclear levels
Shetty, P. V., Lo, M., Robertson, S. M., & Lin, R. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.07.008 · Cited by 117
Self-citation
The myogenic potency of HLH-1 reveals wide-spread developmental plasticity in early C. elegans embryos
Fukushige, T., & Krause, M. (2005) · Development · doi:10.1242/dev.01774 · Cited by 112
Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer
Shulewitz, M. J., Soloviev, I., Wu, T., Koeppen, H., Polakis, P. G., & Sakanaka, C. (2006) · Oncogene · doi:10.1038/sj.onc.1209470 · Cited by 111
Wnt signaling in C. elegans
Sawa, H., & Korswagen, H. C. (2013) · WormBook · doi:10.1895/wormbook.1.7.2 · Cited by 105
Genetic redundancy in endoderm specification within the genus Caenorhabditis
Maduro, M., Hill, R. J., Heid, P. J., Newman-Smith, E. D., Zhu, J., Priess, J. R., & Rothman, J. H. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.05.016 · Cited by 110
TCFs and Wnt/β-catenin Signaling
Cadigan, K. M. (2012) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-386499-4.00001-x · Cited by 108
Armadillo-related proteins promote lateral root development in Arabidopsis
Coates, J. C., Laplaze, L., & Haseloff, J. P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507575103 · Cited by 106
Looking beyond the Wnt pathway for the deep nature of β‐catenin
Fagotto, F. (2013) · EMBO Reports · doi:10.1038/embor.2013.45 · Cited by 107
Phosphorylation of TCF Proteins by Homeodomain-interacting Protein Kinase 2
Hikasa, H., & Sokol, S. Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.185280 · Cited by 102
Cortical β-Catenin and APC Regulate Asymmetric Nuclear β-Catenin Localization during Asymmetric Cell Division in C. elegans
Mizumoto, K., & Sawa, H. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.01.004 · Cited by 99
Mechanisms of Wnt signaling and control
Grainger, S. J., & Willert, K. (2018) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1422 · Cited by 103
Binary cell fate specification duringC. elegansembryogenesis driven by reiterated reciprocal asymmetry of TCF POP-1 and its coactivatorβ-catenin SYS-1
Huang, S., Shetty, P. V., Robertson, S. M., & Lin, R. (2007) · Development · doi:10.1242/dev.008268 · Cited by 99
Self-citation
The Wnt effector POP-1 and the PAL-1/Caudal homeoprotein collaborate with SKN-1 to activate C. elegans endoderm development
Maduro, M., Kasmir, J. J., Zhu, J., & Rothman, J. H. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.06.022 · Cited by 92
Wnt Regulates Spindle Asymmetry to Generate Asymmetric Nuclear β-Catenin in C. elegans
Sugioka, K., Mizumoto, K., & Sawa, H. (2011) · Cell · doi:10.1016/j.cell.2011.07.043 · Cited by 86
Asymmetric cortical and nuclear localizations of WRM-1/β-catenin during asymmetric cell division in C. elegansPreprint
Takeshita, H., & Sawa, H. (2005) · Genes & Development · doi:10.1101/gad.1322805 · Cited by 82
Wnt signaling drives WRM-1/β-catenin asymmetries in early C. elegans embryosPreprint
Nakamura, K., Kim, S. Y., Ishidate, T., Bei, Y., Pang, K. M., Shirayama, M., Trzepacz, C., Brownell, D. R., & Mello, C. C. (2005) · Genes & Development · doi:10.1101/gad.1323705 · Cited by 81
Wnt signaling and neural stem cells: caught in the Wnt web
Michaelidis, T. M., & Lie, D. C. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0476-5 · Cited by 84
Nemo‐like kinase induces apoptosis and inhibits androgen receptor signaling in prostate cancer cells
Emami, K. H., Brown, L. G., Pitts, T. E. M., Sun, X., Vessella, R. L., & Corey, E. (2009) · The Prostate · doi:10.1002/pros.20998 · Cited by 69
Sequential Signaling Crosstalk Regulates Endomesoderm Segregation in Sea Urchin Embryos
Sethi, A. J., Wikramanayake, R. M., Angerer, R. C., Range, R., & Angerer, L. M. (2012) · Science · doi:10.1126/science.1212867 · Cited by 66
Maternal deployment of the embryonic SKN-1 → MED-1,2 cell specification pathway in C. elegans
Maduro, M., Broitman-Maduro, G., Mengarelli, I., & Rothman, J. H. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.029 · Cited by 63
Cell Biology of theCaenorhabditis elegansNucleus
Cohen‐Fix, O., & Askjaer, P. (2017) · Genetics · doi:10.1534/genetics.116.197160 · Cited by 56
Wnt signaling controls the stem cell-like asymmetric division of the epithelial seam cells during C. elegans larval development
Gleason, J. E., & Eisenmann, D. M. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.09.005 · Cited by 60
Control of Cell Polarity and Asymmetric Division in C. elegans
Sawa, H. (2012) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-394592-1.00003-x · Cited by 59
A novel noncanonical Wnt pathway is involved in the regulation of the asymmetric B cell division in C. elegans
Wu, M., & Herman, M. A. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2005.12.024 · Cited by 60
The Molecular Basis of Organ Formation: Insights From theC. elegansForegut
Mango, S. E. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175411 · Cited by 59
The Caenorhabditis elegans intestine
McGhee, J. D. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.93 · Cited by 58
Nemo-like kinase (NLK) acts downstream of Notch/Delta signalling to downregulate TCF during mesoderm induction in the sea urchin embryo
Röttinger, E., Croce, J., Lhomond, G., Besnardeau, L., Gache, C., & Lepage, T. (2006) · Development · doi:10.1242/dev.02603 · Cited by 54
Specification of theC. elegansMS blastomere by the T-box factor TBX-35
Broitman-Maduro, G., Lin, K. T.-H., Hung, W. W. K., & Maduro, M. (2006) · Development · doi:10.1242/dev.02475 · Cited by 54
A Wnt kinase network alters nuclear localization of TCF-1 in colon cancer
Najdi, R., Syed, A. O., Arce, L., Theisen, H., Ting, J.-H., Atcha, F. A., Nguyen, A. V., Martinez, M. E., Holcombe, R. F., Edwards, R. A., et al. (2009) · Oncogene · doi:10.1038/onc.2009.271 · Cited by 53
The NK-2 class homeodomain factor CEH-51 and the T-box factor TBX-35 have overlapping function inC. elegansmesoderm development
Broitman-Maduro, G., Owraghi, M., Hung, W. W. K., Kuntz, S., Sternberg, P. W., & Maduro, M. (2009) · Development · doi:10.1242/dev.038307 · Cited by 52
Opposing Activities of LIT-1/NLK and DAF-6/Patched-Related Direct Sensory Compartment Morphogenesis in C. elegans
Oikonomou, G., Perens, E. A., Lu, Y., Watanabe, S., Jørgensen, E. M., & Shaham, S. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001121 · Cited by 48
The Nesprin Family Member ANC-1 Regulates Synapse Formation and Axon Termination by Functioning in a Pathway with RPM-1 and β-Catenin
Tulgren, E. D., Turgeon, S. M., Opperman, K. J., & Grill, B. J. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004481 · Cited by 48
Notch signaling in the division of germ layers in bilaterian embryos
Favarolo, M. B., & López, S. L. (2018) · Mechanisms of Development · doi:10.1016/j.mod.2018.06.005 · Cited by 44
Atypical Transcriptional Activation by TCF via a Zic Transcription Factor in C. elegans Neuronal Precursors
Murgan, S., Kari, W., Rothbächer, U., Torres, M., Mélénec, P., Hobert, O., & Bertrand, V. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.04.018 · Cited by 45
Structure and evolution of the C. elegans embryonic endomesoderm network
Maduro, M. (2008) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2008.07.013 · Cited by 43
-Catenin-Dependent Wnt Signaling in C. elegans: Teaching an Old Dog a New TrickPreprint
Jackson, B. M., & Eisenmann, D. M. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007948 · Cited by 44
Quantitative Differences in Nuclear β-catenin and TCF Pattern Embryonic Cells in C. elegans
Zacharias, A. L., Walton, T., Preston, E. A., & Murray, J. I. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005585 · Cited by 42
Crosstalk between a Nuclear Receptor and β-Catenin Signaling Decides Cell Fates in the C. elegans Somatic Gonad
Asahina, M., Valenta, T., Macůrková, M., Kořínek, V., & Jindra, M. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.06.003 · Cited by 42
β‐Catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions
Kanamori, T., Inoue, T., Sakamoto, T., Gengyo‐Ando, K., Tsujimoto, M., Mitani, S., Sawa, H., Aoki, J., & Arai, H. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.102 · Cited by 43
MOM-5 Frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions
Hawkins, N., Ellis, G. C., Bowerman, B. A., & Garriga, G. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.05.024 · Cited by 40
lin-17/Frizzled and lin-18 regulate POP-1/TCF-1 localization and cell type specification during C. elegans vulval development
Deshpande, R., Inoue, T., Priess, J. R., & Hill, R. J. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.10.020 · Cited by 38
Wnt signaling controls temporal identities of seam cells in Caenorhabditis elegans
Ren, H., & Zhang, H. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.07.002 · Cited by 36
Distinct DNA Binding Sites Contribute to the TCF Transcriptional Switch in C. elegans and Drosophila
Bhambhani, C., Ravindranath, A. J., Mentink, R. A., Chang, M. V., Betist, M. C., Yang, Y. X., Koushika, S. P., Korswagen, H. C., & Cadigan, K. M. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004133 · Cited by 35
Asymmetric localizations of LIN-17/Fz and MIG-5/Dsh are involved in the asymmetric B cell division in C. elegans
Wu, M., & Herman, M. A. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.12.002 · Cited by 33
The tumor suppressor APC differentially regulates multiple beta-catenins through the function of Axin and casein kinase 1alpha during C. elegans asymmetric stem cell divisions
Baldwin, A. T., & Phillips, B. T. (2014) · Journal of Cell Science · doi:10.1242/jcs.146514 · Cited by 33
Reevaluation of the Role of the med-1 and med-2 Genes in Specifying the Caenorhabditis elegans Endoderm
Goszczynski, B., & McGhee, J. D. (2005) · Genetics · doi:10.1534/genetics.105.044909 · Cited by 33
Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans
Harandi, O. F., & Ambros, V. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422852112 · Cited by 31
Flightless‐I, a gelsolin family member and transcriptional regulator, preferentially binds directly to activated cytosolic CaMK‐II
Seward, M. E., Easley, C. A., McLeod, J. J. A., Myers, A. L., & Tombes, R. M. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.06.037 · Cited by 32
A conserved Six–Eya cassette acts downstream of Wnt signaling to direct non-myogenic versus myogenic fates in the C. elegans postembryonic mesoderm
Amin, N. M., Lim, S.-E., Shi, H., Chan, T. L., & Liu, J. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.05.538 · Cited by 32
The long and the short of Wnt signaling in C. elegans
Hardin, J. D., & King, R. S. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.06.006 · Cited by 32
Cyclin D Regulation of a Sexually Dimorphic Asymmetric Cell Division
Tilmann, C., & Kimble, J. E. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.09.004 · Cited by 28
Centrosome-Associated Degradation Limits β-Catenin Inheritance by Daughter Cells after Asymmetric Division
Vora, S. M., & Phillips, B. T. (2015) · Current Biology · doi:10.1016/j.cub.2015.02.020 · Cited by 29
Distinct and mutually inhibitory binding by two divergent β-catenins coordinates TCF levels and activity inC. elegans
Yang, X., Huang, S., Lo, M., Mizumoto, K., Sawa, H., Xu, W., Robertson, S. M., & Lin, R. (2011) · Development · doi:10.1242/dev.069054 · Cited by 28
Self-citation
Wnt and CDK-1 regulate cortical release of WRM-1/β-catenin to control cell division orientation in early Caenorhabditis elegans embryos
Kim, S. Y., Ishidate, T., Sharma, R., Soto, M. C., Conte, D., Mello, C. C., & Shirayama, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300769110 · Cited by 27
Wnt Signaling Polarizes C. elegans Asymmetric Cell Divisions During Development
Lam, A. K., & Phillips, B. T. (2017) · Results and problems in cell differentiation · doi:10.1007/978-3-319-53150-2_4 · Cited by 25
Dictyostelium Development: A Prototypic Wnt Pathway?
Harwood, A. J. (2008) · Methods in molecular biology · doi:10.1007/978-1-60327-469-2_2 · Cited by 26
Development of the C. elegans digestive tract
Kormish, J. D., Gaudet, J., & McGhee, J. D. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.04.012 · Cited by 24
Cyclin E and CDK2 Repress the Terminal Differentiation of Quiescent Cells after Asymmetric Division in C. elegans
Fujita, M., Takeshita, H., & Sawa, H. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000407 · Cited by 25
Wnt signaling through T-cell factor phosphorylation
Sokol, S. Y. (2011) · Cell Research · doi:10.1038/cr.2011.86 · Cited by 24
The N- or C-terminal domains of DSH-2 can activate the C. elegans Wnt/β-catenin asymmetry pathway
King, R. S., Maiden, S. L., Hawkins, N., Kidd, A. R., Kimble, J. E., Hardin, J. D., & Walston, T. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.01.017 · Cited by 22
The β-catenin HMP-2 functions downstream of Src in parallel with the Wnt pathway in early embryogenesis of C. elegans
Sumiyoshi, E., Takahashi, S., Obata, H., Sugimoto, A., & Kohara, Y. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.04.034 · Cited by 21
Repression of Wnt signaling by a Fer-type nonreceptor tyrosine kinase
Putzke, A. P., & Rothman, J. H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006600107 · Cited by 21
β‐catenin‐driven binary cell fate decisions in animal development
Bertrand, V. (2016) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.228 · Cited by 21
Uncoupling Different Characteristics of the C. elegans E Lineage from Differentiation of Intestinal Markers
Robertson, S. M., Medina, J., & Lin, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106309 · Cited by 20
Self-citation
Axin Family of Scaffolding Proteins in Development: Lessons from C. elegans
Mallick, A., Taylor, S. K. B., Ranawade, A., & Gupta, B. P. (2019) · Journal of Developmental Biology · doi:10.3390/jdb7040020 · Cited by 20
C. elegans pur alpha, an activator of end-1, synergizes with the Wnt pathway to specify endoderm
Witze, E. S., Jeffery, E. D., Hunt, D. F., & Rothman, J. H. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.11.015 · Cited by 20
Combinatorial decoding of the invariant C. elegans embryonic lineage in space and time
Zacharias, A. L., & Murray, J. I. (2016) · genesis · doi:10.1002/dvg.22928 · Cited by 22
A Cell Fate Switch in the Caenorhabditis elegans Seam Cell Lineage Occurs Through Modulation of the Wnt Asymmetry Pathway in Response to Temperature Increase
Hintze, M., Koneru, S. L., Gilbert, S. P. R., Katsanos, D., Lambert, J., & Barkoulas, M. (2020) · Genetics · doi:10.1534/genetics.119.302896 · Cited by 14
CEH-20/Pbx and UNC-62/Meis function upstream of rnt-1/Runx to regulate asymmetric divisions of the C. elegans stem-like seam cells
Hughes, S., Brabin, C., Appleford, P. J., & Woollard, A. C. S. (2013) · Biology Open · doi:10.1242/bio.20134549 · Cited by 17
Specification of neurons through asymmetric cell divisions
Sawa, H. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.09.014 · Cited by 17
Stressful development: integrating endoderm development, stress, and longevity
Ewe, C. K., Alok, G., & Rothman, J. H. (2020) · Developmental Biology · doi:10.1016/j.ydbio.2020.12.002 · Cited by 13
Mechanisms of lineage specification in Caenorhabditis elegans
Liu, J., & Murray, J. I. (2023) · Genetics · doi:10.1093/genetics/iyad174 · Cited by 14
PPIP5K2 promotes colorectal carcinoma pathogenesis through facilitating DNA homologous recombination repair
Cao, C., Ling, H., Han, K., Lu, X., Cai, M., Cao, J., Zhou, J., Xiang, Z., Chen, J., Li, S., et al. (2021) · Oncogene · doi:10.1038/s41388-021-02052-5 · Cited by 14
CACN-1/Cactin Plays a Role in Wnt Signaling in C. elegans
LaBonty, M., Szmygiel, C., Byrnes, L. E., Hughes, S., Woollard, A. C. S., & Cram, E. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101945 · Cited by 15
A network model for the specification of vulval precursor cells and cell fusion control in Caenorhabditis elegans
Weinstein, N., & Mendoza, L. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00112 · Cited by 14
Extracellular signal-regulated kinase 2 (ERK-2) mediated phosphorylation regulates nucleo-cytoplasmic shuttling and cell growth control of Ras-associated tumor suppressor protein, RASSF2
Kumari, G., & Mahalingam, S. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.06.013 · Cited by 14

Authors: Lo, M.-C., Gay, F., Odom, R., Shi, Y., & Lin, R.
Affiliations: The University of Texas Southwestern Medical Center (US)
Harvard University (US)
Corresponding author: Lin, Rueyling
ORCID: Lo, Miao-Chia
Shi, Yang
Lin, Rueyling
Venue: Cell
Publisher: Elsevier BV
Published: 2004-04
Volume: 117
Issue: 1
Pages: 95-106
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(04)00203-x
OpenAlex: W2157756800
Cited by: 138
References: 38
Citations by year: 2026: 1 · 2025: 3 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 5 · 2016: 2 · 2015: 6 · 2014: 10 · 2013: 9 · 2012: 9
FWCI: 4.94
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3394 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (HD37933)
March of Dimes Foundation (GM58012, FY01-265)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › 14-3-3 protein interactions
Keywords: β-catenin, POP-1, TCF/LEF transcription factors, 14-3-3 proteins, protein phosphorylation, nuclear export, Caenorhabditis elegans embryo, transcriptional downregulation
MeSH terms: Animals, Cell Differentiation, Cell Nucleus, Cytoskeletal Proteins, DNA-Binding Proteins, Embryo, Nonmammalian, High Mobility Group Proteins, Membrane Proteins, Phosphorylation, Tyrosine 3-Monooxygenase, Trans-Activators, Down-Regulation, Caenorhabditis elegans, Protein Serine-Threonine Kinases, Protein Structure, Tertiary, MAP Kinase Signaling System, Active Transport, Cell Nucleus, Caenorhabditis elegans Proteins, Macromolecular Substances, 14-3-3 Proteins, beta Catenin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Phosphorylation by the β-Catenin/MAPK Complex Promotes 14-3-3-Mediated Nuclear Export of TCF/POP-1 in Signal-Responsive Cells in C. elegans

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks